Compositions Comprising One or More (Bio)-Alkanediols with Antioxidants

ABSTRACT

The present invention is in the field of antioxidants and relates to cosmetic or pharmaceutical, preferably dermatological, compositions or homecare product comprising or consisting of a synergistic combination of a specific antioxidant and an effective amount of 1,2-heptanediol and/or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols and the use of said compositions as a cosmetic, for personal care, as a pharmaceutical or homecare product, in particular for scavenging reactive oxygen species (ROS), for inhibition matrix metalloproteinases expression and/or for inhibiting interleukin 8 (IL-8) secretion. Additionally, the present invention relates to the use of 1,2-heptanediol and/or 2,3-heptanediol or of a specific alkanediol or a mixture of two or more different specific alkanediols for enhancing the antioxidative effect of an antioxidant in a cosmetic or pharmaceutical, preferably dermatological, composition or homecare product, and/or for enhancing the antioxidative effect of a cosmetic or pharmaceutical, preferably dermatological, composition upon application.

TECHNICAL FIELD

The present invention is in the field of antioxidants and relates tocosmetic or pharmaceutical, preferably dermatological, compositions orhomecare products comprising or consisting of a synergistic combinationof a specific antioxidant and an effective amount of 1,2-heptanedioland/or 2,3-heptanediol or of a specific alkanediol or a mixture of twoor more different specific alkanediols and the use of said compositionsas a cosmetic, for personal care, as a pharmaceutical or a homecareproduct, in particular for scavenging reactive oxygen species (ROS), forinhibition matrix metalloproteinases expression and/or for inhibitinginterleukin 8 (IL-8) secretion. Additionally, the present inventionrelates to the use of 1,2-heptanediol and/or 2,3-heptanediol or of aspecific alkanediol or a mixture of two or more different specificalkanediols for enhancing the antioxidative effect of an antioxidant ina cosmetic or pharmaceutical, preferably dermatological, composition orhomecare product, and/or for enhancing the antioxidative effect of acosmetic or pharmaceutical, preferably dermatological, composition uponapplication.

BACKGROUND ART

Oxidation of lipids, primarily unsaturated fatty acids, in cosmetic orpharmaceutical or food is a key factor that needs to be controlled andprevented, because it affects both the nutritional value of the productand the health of the consumer. Oxidation of unsaturated fatty acids bythe action of atmospheric oxygen begins with free radical chainreactions, generating highly reactive peroxides and hydroperoxides.

In turn, these peroxides and hydroperoxides react with substratespresent in the matrix and result in carboxylic acids, aldehydes andketones, among other, which alter the sensory properties of theproductions and potentially compromise the consumer health. For thisreason, antioxidants are widely used by the industry to prevent or delaythe onset of oxidative breakdown.

Oxidative cell damage, particularly damage to the genetic material, isone of the most dangerous environmental influences, constituting aparticular danger to the human organism. High-energy radiation,particularly in combination with oxygen, creates highly reactiveradicals which are also referred to as “reactive oxygen species (ROS)”,which are, for example, capable of changing the DNA such that thymine isoxidized to form thymine glycol, or guanine is oxidized to form8-oxoguanine (8-OxoG). Specifically, the latter one is an aggressivemutagenic substance, because during the replication opposite an 8-OxoGboth the normal cytosine nucleotide and, preferably, an adeninenucleotide may be incorporated. Incorrect transversion is one of thecauses of cell defects and, eventually, of cancer. Oxidative stresstriggered by ROS will also lead to accelerated skin ageing, which isregularly observed when people excessively expose themselves to UVradiation (for example, in tanning centers).

It is therefore obvious that there is considerable interest inprotecting the human organism against such oxidative damage. Forexample, this may be performed by administering substances which quenchradicals, whereby these so-called antioxidants can be ingested orally,either together with the food or separately as dietary supplements, orbe topically applied, for example, in cosmetic products that are broughtin contact with the skin.

Various natural or synthetic substances have proven their effectivenessas antioxidants. Besides vitamin C (ascorbic acid) the most well-knowninclude the different carotene derivatives (e.g. beta carotene,lycopene, luteine) and, particularly, vitamin E and its derivatives(tocopherol, tocopheryl acetate and tocopheryl palmitate). Anotherimportant group is constituted by the polyphenols, specifically theanthocyanins and isoflavones, which are contained, for example, in avariety of red fruits.

There is continued interest in the market to improve both the potentialand the range of efficiency of such antioxidants, either by achieving ahigher performance with the same amounts or, vice versa, by achievingthe same performance with lower amounts.

When searching for antioxidant agents it must be taken into account thatthe substances used in the cosmetic or pharmaceutical sector must betoxicologically acceptable, well tolerated by the skin, stable,especially in the customary cosmetic and/or pharmaceutical formulations,substantially and preferably odourless and able to be preparedinexpensively, i.e. using standard methods.

However, there is no clear dependency between the chemical structure ofa substance, on the one hand, and its capability in reducingautoxidation, on the other hand, which makes the search for suitablesubstances more difficult. Furthermore, there is no predictablerelationship between antioxidant performance, toxicologicalacceptability, tolerability and the stability of a substance.

It is therefore an object of the present invention to provide a cosmeticor pharmaceutical, preferably dermatological, composition or homecareproduct comprising an antioxidant such that is shows an increasedantioxidant performance either in order to prevent the compositionitself from oxidation or to protect the human organism, for exampleskin, upon application against oxidative damage.

A further object of the present invention is to provide a substance,which enhances the antioxidative effect of an antioxidant, for examplein a cosmetic or pharmaceutical, preferably dermatological, composition,and/or which enhance the antioxidative effect of a cosmetic orpharmaceutical, preferably dermatological, composition upon application.

Furthermore, it is an object of the present invention to provide asubstance by which the amount of an antioxidant in a cosmetic orpharmaceutical, preferably dermatological, composition or homecareproduct can be reduced.

Surprisingly it has been found that the addition of an effective amountof 1,2-heptanediol and/or 2,3-heptanediol or a specific alkanediol or amixture of two or more different specific alkanediols as defined hereinto a composition comprising an antioxidant show a strong synergy withrespect to the antioxidant performance as demonstrated by the tests inthe following examples.

Additionally, it has been observed that the overall amount ofantioxidant in a composition comprising an antioxidant can besignificantly reduced by the addition of an effective amount of1,2-heptanediol and/or 2,3-heptanediol or a specific alkanediol or amixture of two or more different specific alkanediols as defined herein.

SUMMARY OF THE INVENTION

In order to accomplish the above problem, the present invention providesin a first aspect a cosmetic or pharmaceutical, preferablydermatological, composition or homecare product, comprising orconsisting of

-   -   (a1) 1,2-heptanediol;    -   (b1) at least one antioxidant; and    -   (c1) optionally at least one active substance for a cosmetic or        pharmaceutical composition or homecare product and/or additive;    -   or    -   (a2) 2,3-heptanediol;    -   (b2) at least one antioxidant; and    -   (c2) optionally at least one active substance for a cosmetic or        pharmaceutical composition or homecare product and/or additive;    -   or    -   (a3) a mixture comprising 1,2-heptanediol and 2,3-heptanediol;    -   (b3) at least one antioxidant; and    -   (c3) optionally at least one active substance for a cosmetic or        pharmaceutical composition or homecare product and/or additive.

In a second aspect, the present invention provides a cosmetic orpharmaceutical composition or homecare product, comprising or consistingof

-   -   (a) at least one linear alkanediol having a carbon chain of 5 to        14 carbon atoms or a mixture comprising at least one first        linear alkanediol having a carbon chain of 5 to 14 carbon atoms        and one or more second linear alkanediol having a carbon chain        of 5 to 14 carbon atoms which is different from the first linear        alkanediol;    -   (b) at least one antioxidant; and    -   (c) optionally at least one active substance for a cosmetic or        pharmaceutical composition or homecare product and/or additive.

In a further aspect, the present invention provides for the use of thecomposition as a cosmetic, for personal care, in particular for skin,hair, scalp and nail care, as a pharmaceutical, as a homecare product orfor animal care.

In a further aspect, the present invention provides for the use of1,2-heptanediol and/or 2,3-heptanediol or at least one linear alkanediolor a mixture comprising at least one first linear alkanediol and one ormore second linear alkanediol for enhancing the antioxidative effect ofan antioxidant in a cosmetic or pharmaceutical composition or homecareproduct and/or for enhancing the antioxidative effect of a cosmetic orpharmaceutical composition or homecare product upon application, and/orfor enhancing the ROS scavenging performance of an antioxidant asdefined in claim 10; and/or for enhancing the inhibition of theinterleukin 8 (IL-8) secretion by an antioxidant; and/or for enhancingthe inhibition of the matrix metal proteinases expression by anantioxidant.

DESCRIPTION OF FIGURES

FIGS. 1 a and 1 b are diagrams showing the ROS scores of differentcompositions comprising tocopherol and/or a 1,2-alkanediol or a2,3-alkanediol according to the present invention in a lipophilic testsystem.

FIGS. 2 a and 2 b are diagrams showing the ROS scores of differentcompositions comprising tocopherol and/or a 1,2-alkanediol or a2,3-alkanediol according to the present invention in anaqueous/alcoholic test system.

FIG. 3 is a diagram showing the ROS reducing capacity of tocopherol,1,2-heptanediol, and a mixture thereof.

FIG. 4 is a diagram showing the ROS reducing capacity of Carnosine(Dragosine®), 1,2-heptanediol, and a mixture thereof.

FIG. 5 is a diagram showing the ROS reducing capacity of Retinol,1,2-heptanediol, and a mixture thereof.

FIG. 6 is a diagram showing the ROS reducing capacity of Green TeaExtract, 1,2-heptanediol, and a mixture thereof.

FIG. 7 is a diagram showing the ROS reducing capacity of ZingiberOfficinale (Ginger) Root Extract, 1,2-heptanediol, and a mixturethereof.

FIG. 8 is a diagram showing the ROS reducing capacity ofHydroxypinacolone Retinoate, 1,2-heptanediol, and a mixture thereof.

FIG. 9 is a diagram showing the ROS reducing capacity of beta-aspartylarginine, 1,2-heptanediol, and a mixture thereof.

FIG. 10 is a diagram showing the ROS reducing capacity of ZingiberOfficinale (Ginger) Root Extract, 2,3-octancediol, and a mixturethereof.

FIG. 11 is a diagram showing the ROS reducing capacity of ZingiberOfficinale (Ginger) Root Extract, 1,2-octanediol plus 2,3-octancediol,and a mixture thereof.

FIG. 12 is a diagram showing the IL-8 reducing capacity of1,2-heptanediol, Retinol, and a mixture thereof.

FIG. 13 is a diagram showing the delta IP values of tocopherol,tocopherol and 1,2-heptanediol and tocopherol and a blend of1,2-heptanediol and 2,3-heptanediol (95:5).

FIG. 14 is a diagram showing the delta IP values of tocopherol and1,2-heptanediol, tocopherol and 2,3-heptanediol and tocopherol and ablend of 1,2-heptanediol and 2,3-heptanediol (98:2).

FIG. 15 is a diagram showing the delta IP values of tocopherol and1,2-heptanediol, tocopherol and 2,3-heptanediol and tocopherol and ablend of 1,2-heptanediol and 2,3-heptanediol (99:1).

FIG. 16 is a diagram showing the delta IP values of tocopherol and1,2-hexanediol, tocopherol and 2,3-hexanediol and tocopherol and a blendof 1,2-hexanediol and 2,3-hexanediol (95:5).

FIG. 17 is a diagram showing the delta IP values of tocopherol and1,2-hexanediol, tocopherol and 2,3-hexanediol and tocopherol and a blendof 1,2-hexanediol and 2,3-hexanediol (50:50).

FIG. 18 is a diagram showing the delta IP values of tocopherol and1,2-octanediol, tocopherol and 2,3-octanediol and tocopherol and a blendof 1,2-octanediol and 2,3-octanediol (50:50).

FIG. 19 is a diagram showing the delta IP values of tocopherol and1,2-decanediol, tocopherol and 2,3-decanediol and tocopherol and a blendof 1,2-decanediol and 2,3-decanediol (95:5).

FIG. 20 is a diagram showing the delta IP values of tocopherol and1,2-decanediol, tocopherol and 2,3-decanediol and tocopherol and a blendof 1,2-decanediol and 2,3-decanediol (50:50).

FIG. 21 is a diagram showing the delta IP values of tocopherol and1,2-heptanediol, tocopherol and 2,3-hexanediol and tocopherol and ablend of 1,2-heptanediol and 2,3-hexanediol (50:50).

FIG. 22 is a diagram showing the delta IP values of tocopherol and1,2-heptanediol, tocopherol and 2,3-octanediol and tocopherol and ablend of 1,2-heptanediol and 2,3-otanediol (95:5).

FIG. 23 is a diagram showing the delta IP values of tocopherol and1,2-nonanediol, tocopherol and 2,3-nonanediol and tocopherol and a blendof 1,2-nonanediol and 2,3-nonanediol (50:50).

FIG. 24 is a diagram showing the delta IP values of Symdecanox HA and1,2-heptanediol, Symdecanox HA and 2,3-heptanediol and Symdexanox HA anda blend of 1,2-heptanediol and 2,3-heptanediol (95:5).

FIG. 25 is a diagram showing the delta IP values of Symdecanox HA and1,2-octanediol, Symdecanox HA and 2,3-octanediol and Symdexanox HA and ablend of 1,2-octanediol and 2,3-octanediol (95:5).

FIG. 26 is a diagram showing the delta IP values of PentaerythritylTetra-di-t-butyl Hydroxyhydrocinnamate and 1,2-heptanediol,Pentaerythrityl Tetra-di-t-butyl Hydroxyhydrocinnamate and2,3-heptanediol and Pentaerythrityl Tetra-di-t-butylHydroxyhydrocinnamate and a blend of 1,2-heptanediol and 2,3-heptanediol(95:5).

FIG. 27 is a diagram showing the delta IP values of Hydroxyacetophenoneand 1,2-heptanediol and Hydroxyacetophenone and 2,3-heptanediol.

FIG. 28 is a diagram showing the delta IP values of Ascorbyl Palmitateand 1,2-heptanediol and Ascorbyl Palmitate and 2,3-heptanediol.

FIG. 29 is a diagram showing the ROS scores of different compositionscomprising Dihydroavenanthramide D and 1,2-heptanediol or2,3-heptanediol or blend of 1,2-heptanediol and 2,3-heptanediolaccording to the present invention in an aqueous/alcoholic test system.

FIG. 30 is a diagram showing the ROS scores of different compositionscomprising Cannabidiol and 1,2-heptanediol or 2,3-heptanediol or a blendof 1,2-heptanediol and 2,3-heptanediol according to the presentinvention in an aqueous/alcoholic test system.

DETAILED DESCRIPTION OF THE INVENTION

The present invention is specified in the appended claims. The inventionitself, and its preferred variants, other objects and advantages, arehowever also apparent from the following detailed description inconjunction with the accompanying examples and figures.

In a first aspect, the present invention relates to a cosmetic orpharmaceutical composition or homecare product, comprising or consistingof:

-   -   (a1) 1,2-heptanediol;    -   (b2) at least one antioxidant; and    -   (c3) optionally at least one active substance for a cosmetic or        pharmaceutical composition or homecare product and/or additive.

Alternatively, the present invention relates in a first aspect to acosmetic or pharmaceutical composition or homecare product, comprisingor consisting of:

-   -   (a2) 2,3-heptanediol;    -   (b2) at least one antioxidant; and    -   (c2) optionally at least one active substance for a cosmetic or        pharmaceutical composition or homecare product and/or additive.

In a further alternative, the present invention relates in a firstaspect to a cosmetic or pharmaceutical composition or homecare product,comprising or consisting of:

-   -   (a1) a mixture comprising 1,2-heptanediol and 2,3-heptanediol;    -   (b2) at least one antioxidant; and    -   (c3) optionally at least one active substance for a cosmetic or        pharmaceutical composition or homecare product and/or additive.

In a second aspect, the present invention relates to a cosmetic orpharmaceutical composition or homecare product, comprising or consistingof:

-   -   (a) at least one linear alkanediol having a carbon chain of 5 to        14 carbon atoms or a mixture comprising at least one first        linear alkanediol having a carbon chain of 5 to 14 carbon atoms        and one or more second linear alkanediol having a carbon chain        of 5 to 14 carbon atoms which is different from the first linear        alkanediol;    -   (b) at least one antioxidant; and    -   (c) optionally at least one active substance for a cosmetic or        pharmaceutical composition or homecare product and/or additive.

In a more preferred variant of the second aspect of the presentinvention, the present invention relates to a cosmetic or pharmaceuticalcomposition, comprising or consisting of:

-   -   (a′) a mixture comprising at least one first linear alkanediol        having a carbon chain of 5 to 14 carbon atoms and one or more        second linear alkanediol having a carbon chain of 5 to 14 carbon        atoms, wherein the number of the carbon atoms of the first and        the second alkanediol is either same or different;    -   (b′) at least one antioxidant; and    -   (c′) optionally at least one active substance for a cosmetic or        pharmaceutical composition or homecare product and/or additive.

The term “comprising” means that the named components are essential, butother components may be added and is still embraced by the presentinvention.

The term “consisting of” as used according to the present inventionmeans that the total amount of components (a) to (c) adds up to 100% byweight, based on the total weight of the cosmetic or pharmaceuticalcomposition or homecare product, and signifies that the subject matteris closed-ended and can only include the limitations that are expresslyrecited.

Whenever reference is made to “comprising” it is intended to cover bothmeanings as alternatives, that is the meaning can be either “comprising”or “consisting of”, unless the context dictates otherwise.

The term “at least one . . . ” means that the cosmetic or pharmaceuticalcomposition or homecare product according to the present invention cancomprise either one or a mixture of two, three, four, five, six or evenmore different of the respective components following said term.

The term “optionally” means that the subsequently described compound maybut need not to be present in the composition, and that the descriptionincludes variants, were the compound is included or variants, were thecompound is absent.

Alkanediols are glycols, i.e. any of a class of organic compoundsbelonging to the alcohol family; in the molecule of a glycol, twohydroxyl (—OH) groups are attached to different carbon atoms of a carbonchain.

The component (a) in the cosmetic or pharmaceutical composition orhomecare product according to the first aspect of the present inventionis either 1,2-heptanediol (a1) or 2,3-heptanediol (a2), or a mixture ofboth heptanediols, i.e. 1,2-heptanediol plus 2,3-heptanediol (a3).

1,2-heptandediol belongs to the category of alkanediols and is astraight chain alkanediol with the general formula:

It has a carbon chain with 7 carbon atoms and the two functional OHgroups of the alkanediol are in alpha, beta position and chemicallybonded to the C1 and C2 carbon atoms in the alkanediol chain.

2,3-heptanediol belongs to the category of alkanediols and is a straightchain alkanediol with the general formula:

It has a carbon chain with 7 carbon atoms and the two functional OHgroups of the alkanediol are in beta,gamma position and chemicallybonded to the C2 and C3 carbon atoms in the alkanediol chain.

Straight chain 1,2-alkanediols have been used for more than 15 years asmultifunctional actives. Short chain 1,2-alkanediols are amphiphiliccompounds and thus, like 1,2-pentanediol and 1,2-hexanediol, are solubleboth in water and cosmetic oils. In contrast, 1,2-octanediol tends toprecipitate or recrystallize in oily solutions. On the other hand,1,2-decanediol is a solid and soluble only in cosmetic oils. Apart frommoisturizing, some 1,2-alkanediols are used as viscosity modifiers.

The component (a) in the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the present inventionis in a first alternative at least one linear alkanediol having a carbonchain of 5 to 14 carbon atoms.

Moreover, in a second alternative of this second aspect, the component(a) may include a first linear alkanediol in combination with a secondlinear alkanediol, preferably at least one first linear alkanediolhaving a carbon chain of 5 to 14 carbon atoms and at least one secondlinear alkanediol having a carbon chain of 5 to 14 carbon atoms.Therefore, the invention also entails a mixture of a first and a secondalkanediol as described herein.

Since the first linear alkanediol of the invention can be selected fromthe same lists and types of compounds as the linear alkanediol accordingto the first alternative of the second aspect, in the following,reference is made to the linear alkanediol in general, which can also bethe first linear alkanediol. In mixtures of first and second linearalkanediols, where these are specifically different, the specific terms“first” and “second” will be used to distinguish the two alkanediolcomponents.

As used in this document, the phrase “at least one linear alkanediol” or“at least one first linear alkanediol” means that the composition cancomprise one linear alkanediol having a carbon chain of 5 to 14 carbonatoms or can comprise one first linear alkanediol having a carbon chainof 5 to 14 carbon atoms or can comprise more than one linear alkanediolor can comprise more than one first linear alkanediol having a carbonchain of 5 to 14 carbon atoms, i.e. two, three, four or more differentlinear alkanediols or first linear alkanediols having a carbon chain of5 to 14 carbon atoms.

The linear alkanediol or the first linear alkanediol consist of a chainof 5 to 14 carbon atoms joined to each other by single covalent bondswith two OH functional groups attached to two different carbon atoms inthe chain.

The at least one linear alkanediol or the at least one first linearalkanediol having a carbon chain of 5 to 14 carbon atoms in the cosmeticor pharmaceutical composition or homecare product according to thesecond aspect of the present invention is preferably selected from thegroup consisting of pentanediol, hexanediol heptanediol, octanediol,nonanediol, decanediol, undecanediol, dodecanediol, tridecanediol,tetradecanediol, and mixtures thereof.

In a preferred variant, the at least one linear alkanediol or the atleast one first linear alkanediol is selected from the group consistingof pentanediol, hexanediol, heptanediol, octanediol, nonanediol,decanediol, undecanediol, dodecanediol and tridecanediol.

In a more preferred variant, the at least one linear alkanediol or theat least one first linear alkanediol is selected from the groupconsisting of alkanediols having an uneven number of carbon atoms of 5to 13, i.e. pentanediol, heptanediol, nonanediol, undecanediol andtridecanediol.

In a still more preferred variant, the at least one linear alkanediol orthe at least one first linear alkanediol is selected from the groupconsisting of alkanediols having an uneven number of carbon atoms of 7,9, 11 and 13, i.e. heptanediol, nonanediol, undecanediol andtridecanediol, or is selected from the group consisting of alkanediolshaving an uneven number of carbon atoms of 9 and 11, i.e. nonanediol andundecanediol, or is selected from the group consisting of alkanediolshaving an uneven number of carbon atoms of 9 and 13, i.e. nonanediol andtridecanediol, or is selected from the group consisting of alkanediolshaving an uneven number of carbon atoms of 11 and 13, i.e. undecanedioland tridecanediol.

In a still more preferred variant, the at least one linear alkanediol orthe at least one first linear alkanediol is either pentanediol,hexanediol, heptanediol, nonanediol or octanediol.

In a most preferred variant, the at least one linear alkanediol or theat least first linear alkanediol is heptanediol or nonanediol.

In an alternative, the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the present inventioncomprises a mixture comprising at least one first linear alkanediolhaving a carbon chain of 5 to 14 carbon atoms with one or more secondlinear alkanediol having a carbon chain of 5 to 14 carbon atoms which isdifferent from the first linear alkanediol.

This means that the alkanediol mixture is a mixture of at least onefirst linear alkanediol having a carbon chain of 5 to 14 carbon atomsand one or more, i.e., two, three, four or more second linear alkanediolhaving a carbon chain of 5 to 14 carbon atoms. In this alternative, thefirst linear alkanediol can be any of the alkanediols as describedherein for the linear alkanediol in general and in particular for thefirst alternative of the second aspect.

For example, the mixture can include one first linear alkanediol withone, two, three or more second linear alkanediols; or the mixture caninclude two first linear alkanediols with one, two, three or more secondlinear alkanediols, etc. with the proviso, that in each mixture, thefirst linear alkanediol and the second linear alkanediol are differentfrom each other.

The phrase “different from each other means” that the first linearalkanediol and the second linear alkanediol in the mixture are eitherdifferent with regard to the length of their carbon chain, i.e., numberof the carbon atoms, and/or with regard to their constitutionalisomerism or with regard to their stereoisomerism.

Likewise, the number of the carbon atoms of the first linear alkanedioland the second linear alkanediol in the mixture can also be same. Forexample, the first linear alkanediol and the second linear alkanediolhave a carbon chain of 7 carbon atoms, but the first linear alkanedioland the second linear alkanediol are different with regard to theirconstitutional isomerism or with regard to their stereoisomerism.

The second linear alkanediol preferably consists of a chain of 5 to 14carbon atoms joined to each other by single covalent bonds with two OHfunctional groups attached to two different carbon atoms in the chain.

The at least one second linear alkanediol having a carbon chain of 5 to14 carbon atoms in the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the present inventionis selected from the group consisting of pentanediol, hexanediol,heptanediol, octanediol, nonanediol, decanediol, undecanediol,dodecanediol, tridecanediol and tetradecanediol.

In a preferred variant, the at least one second linear alkanediol isselected from the group consisting of pentanediol, hexanediol,heptanediol, octanediol, nonanediol, decanediol, undecanediol,dodecanediol and tridecanediol. If both the first and the secondalkanediol is for example heptanediol, then the second linear alkanediolheptanediol is a different constitutional isomer or stereoisomer fromthe first linear alkanediol.

In a more preferred variant, the at least one second linear alkanediolis selected from the group consisting of pentanediol, hexanediol,heptanediol, octanediol and nonanediol, most preferably heptanediol,octanediol and nonanediol.

The term “alkanediol” within the context of the present invention alsoincludes its constitutional isomers or position isomers. Constitutionalisomers are compounds that have the same molecular formula and differentconnectivity. Position isomers, a particular form of constitutionalisomerism, are structural isomers that can be viewed as differing onlyon the position of a functional group on a parent structure, which inthis case is the position of the two alcohol functions.

Depending on the number of the carbon atoms of the carbon chain of thealkanediol, there are various position isomers of the alkanediol:(x,x+1) constitutional isomers; (x,x+2) constitutional isomers; (x,x+3)constitutional isomers; etc. and alpha,omega constitutional isomers whenthe alcohol functions are at the terminal ends of the carbon chain,wherein x stands for the number of the carbon atom in the alkanediolchain, to which the OH groups of the alkanediol are chemically bonded.For example: if x is 1, the two OH groups of the alkanediol arechemically bonded to the C1 and C2 carbon atoms in the alkanediol chain;if x is 2, the two OH groups of the alkanediol are chemically bonded tothe C2 and C3 carbon atoms in the alkanediol chain, etc.

In the (x,x+1) constitutional isomers, the two OH functional groups arevicinal attached to two different adjacent carbon atoms in the chain. Inthe (x,x+2) constitutional isomers, the two OH functional groups areattached to two different carbon atoms in the chain where the two carbonatoms are separated by one C atom. In the (x,x+3) constitutionalisomers, the two OH functional groups are attached to two differentcarbon atoms in the chain where the two carbon atoms are separated bytwo C atoms. In the alpha,omega constitutional isomers, the twofunctional groups are attached to the first C atom and to the terminal Catom.

In a preferred variant of the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the linear alkanediol having a carbon chain of 5 to 14 carbonatoms, is preferably a vicinal (x,x+1) diol, selected from the groupconsisting of a 1,2-diol, 2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1)diols, and mixtures thereof, preferably an alpha,beta 1,2 constitutionalisomer.

In a preferred variant of the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the first linear alkanediol and/or the second linearalkanediol having a carbon chain of 5 to 14 carbon atoms is a vicinal(x,x+1) diol, selected from the group consisting of a 1,2-diol,2,3-diol, 3,4-diol, 4,5-diol, further (x,x+1) diols, and mixturesthereof, preferably an alpha,beta 1,2 constitutional isomer.

In a further preferred variant of the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention, the linear alkanediol having a carbon chain of 5 to14 carbon atoms, is preferably a non-vicinal (x,x+2) diol, selected fromthe group consisting of a 1,3-diol, 2,4-diol, 3,5-diol, further (x,x+2)diols, and mixtures thereof, preferably an alpha,gamma 1,3constitutional isomer.

In a preferred variant of the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the first linear alkanediol and/or the second linearalkanediol having a carbon chain of 5 to 14 carbon atoms is anon-vicinal (x,x+2) diol, selected from the group consisting of a1,3-diol, 2,4-diol, 3,5-diol, 4,6-diol, further (x,x+2) diols, andmixtures thereof, preferably an alpha,gamma 1,3-consitutional isomer.

In a further preferred variant of the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention, the linear alkanediol having a carbon chain of 5 to14 carbon atoms, is preferably a non-vicinal (x,x+3) diol, selected fromthe group consisting of a 1,4 diol, 2,5 diol, further (x,x+3) diols, andmixtures thereof, preferably an alpha,delta 1,4 constitutional isomer.

In a preferred variant of the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the first linear alkanediol and/or the second linearalkanediol having a carbon chain of 5 to 14 carbon atoms is anon-vicinal (x,x+3) diol, selected from the group consisting of a 1,4diol, 2,5 diol, further (x,x+3) diols, and mixtures thereof, preferablyan alpha,delta 1,4 constitutional isomer.

In a preferred variant of the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the invention, thelinear alkanediol or the first linear alkanediol and/or the secondlinear alkanediol is preferably an alpha,omega alkanediol, morepreferably, 1,7-heptanediol or 1,8-octanediol.

According to the present invention, vicinal (x,x+1) diols are mostpreferred, such as alpha,beta or beta,gamma or gamma,delta etc.

Particularly preferred are non-vicinal (x,x+2) diols such asalpha,gamma, beta,delta etc. due to their steric arrangement optimum ofthe two OH groups and the conjugate system resulting therefrom, whichmakes them particularly suitable for stabilizing or quenching orscavenging of the radicals generated in oxidative processes as describedabove.

In a still preferred variant of the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention, the linear alkanediol and in particular the firstlinear alkanediol and/or the second linear alkanediol, is a1,2-alkanediol, a 2,3-alkanediol, a 3,4-alkanediol, a 1,3-alkanediol, ormixtures thereof, more preferred a 2,3-alkanediol or a 1,3-alkanediol.

The 1,2-alkanediols of the linear alkanediol, in particular the firstlinear alkanediol having a carbon chain of 5 to 14 carbon atoms and/orthe second linear alkanediol having a carbon chain of 5 to 14 carbonatoms, can preferably be those as represented by the following formulae:

The 2,3-alkanediols of the linear alkanediol of the invention, inparticular the first linear alkanediol having a carbon chain of 5 to 14carbon atoms and/or the second linear alkanediol having a carbon chainof 5 to 14 carbon atoms, can preferably be those as represented by thefollowing formulae:

The 3,4-alkanediols of the linear alkanediol, preferably the firstlinear alkanediol having a carbon chain of 5 to 14 carbon atoms and/orthe second linear alkanediol having a carbon chain of 5 to 14 carbonatoms, can preferably be those as represented by the following formulae:

In a preferred variant, the cosmetic or pharmaceutical compositionaccording to the second aspect of the present invention comprises amixture comprising at least one first linear alkanediol having a carbonchain of 5 to 14 carbon atoms and one or more second linear alkanediolhaving a carbon chain of 5 to 14 carbon atoms wherein the number of thecarbon atoms of the first and the second alkanediol is either same ordifferent.

If both, the first and the second alkanediol have the same number ofcarbon atoms, such an alkanediol combination is herein also referred toas “homo alkanediol mixture” or “homo combination”. For example, thefirst linear alkanediol and the second linear alkanediol have a carbonchain of 7 carbon atoms, but the first linear alkanediol and the secondlinear alkanediol are different with regard to their constitutionalisomerism or with regard to their stereoisomerism.

If the first and the second alkanediol have a different number of carbonatoms, such an alkanediol combination is herein also referred to as“hetero alkanediol mixture” or “hetero combination”. For example, thefirst linear alkanediol has a carbon chain of 7 carbon atoms and thesecond linear alkanediol has a carbon chain of 8 carbon atoms. However,beyond that, the first linear alkanediol and the second linearalkanediol can be different with regard to their constitutionalisomerism or with regard to their stereoisomerism.

In a preferred variant of the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the linear alkanediol or the first linear alkanediol isselected from the group consisting of: 1,2-pentanediol, 2,3-pentanediol,3,4-pentanediol, 1,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol,3,4-hexanediol, 1,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol,3,4-heptanediol, 1,3-heptanediol, 1,2-octanediol, 2,3-octanediol,3,4-octanediol, 1,3-octanediol, 1,2-nonanediol, 2,3-nonanediol,3,4-nonanediol, 1,3-nonanediol, 1,2-decanediol, 2,3-decanediol,3,4-decanediol, 1,3-decanediol, 1,2-undecanediol, 2,3-undecanediol,3,4-undecanediol, 1,3-undecanediol, 1,2-dodecanediol, 2,3-dodecanediol,3,4-dodecanediol, 1,3-dodecanediol, 1,2-tridecanediol,2,3-tridecanediol, 3,4-tridecanediol, 1,3-tridecanediol, and mixturesthereof.

Of the aforesaid linear alkanediols or the first linear alkanediols, thefollowing (x,x+1) constitutional isomers are preferred: 1,2-pentanediol,2,3-pentanediol, 1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol,2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol,2,3-undecanediol, 2,3-dodecanediol, 2,3-tridecanediol or mixturesthereof. Said alkanediols are liquid at a purity of 90 to 99%.

Of the aforesaid liquid alkanediols 1,2-pentanediol, 2,3-pentanediol,1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol,2,3-octanediol, 2,3-nonanediol or mixtures of said liquid alkanediolsare particularly preferred. Said alkanediols can be easier incorporatedinto semi-finished products or final products containing an antioxidant.

Of the aforesaid linear alkanediols or the first linear alkanediols, thefollowing (x,x+2) constitutional isomers are preferred: 1,3-octanediol,1,3-nonanediol, 1,3-decanediol, or 1,3-undecanediol, most preferred1,3-nonanediol or 1,3-undecanediol.

In a more preferred variant, the at least one linear alkanediol or theat least one first linear alkanediol is selected from the groupconsisting of 1,2-alkanediols having an uneven number of carbon atoms of5 to 13, i.e. 1,2-pentanediol, 1,2-heptanediol, 1,2-nonanediol,1,2-undecanediol and 1,2-tridecanediol.

In a more preferred variant, the linear alkanediol or the first linearalkanediol is selected from the group consisting of 1,2-alkanediolshaving an uneven number of carbon atoms of 7, 9, 11 and 13, i.e.1,2-heptanediol, 1,2-nonanediol, 1,2-undecanediol or 1,2-tridecanediol,or is selected from the group consisting of 1,2-alkanediols having anuneven number of carbon atoms of 9 and 11, i.e. 1,2-nonanediol and1,2-undecanediol, or is selected from the group consisting of1,2-alkanediols having an uneven number of carbon atoms of 9 and 13,i.e. 1,2-nonanediol and 1,2-tridecanediol, or is selected from the groupconsisting of 1,2-alkanediols having an uneven number of carbon atoms of11 and 13, i.e. 1,2-undecanediol and 1,2-tridecanediol.

In a more preferred variant, the at least one linear alkanediol or theat least one first linear alkanediol is selected from the groupconsisting of 2,3-alkanediols having an uneven number of carbon atoms of5 to 13, i.e. 2,3-pentanediol, 2,3-heptanediol, 2,3-nonanediol,2,3-undecanediol and 2,3-tridecanediol.

In a still more preferred variant, the linear alkanediol or the firstlinear alkanediol is selected from the group consisting of2,3-alkanediols having an uneven number of carbon atoms of 7, 9, 11 and13, i.e. 2,3-heptanediol, 2,3-nonanediol, 2,3-undecanediol or2,3-tridecanediol, or is selected from the group consisting of2,3-alkanediols having an uneven number of carbon atoms of 9 and 11,i.e. 2,3-nonanediol and 2,3-undecanediol, or is selected from the groupconsisting of 2,3-alkanediols having an uneven number of carbon atoms of9 and 13, i.e. 2,3-nonanediol and 2,3-tridecanediol, or is selected fromthe group consisting of 2,3-alkanediols having an uneven number ofcarbon atoms of 11 and 13, i.e. 2,3-undecanediol and 2,3-tridecanediol.

In a further preferred variant of the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention, the linear alkanediol or the first linear alkanediolis selected from the group consisting of: 1,2-pentanediol,2,3-pentanediol, 3,4-pentanediol, 1,2-hexanediol, 2,3-hexanediol,3,4-hexanediol 1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol,1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,2nonanediol,2,3-nonanediol, 3,4-nonanediol, and mixtures thereof.

More preferred, in the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the linear alkanediol or the first linear alkanediol isselected from the group consisting of 1,2-pentanediol, 2,3-pentanedioland mixtures thereof or is selected from the group consisting of1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol, and mixtures thereof.However, the linear alkanediol or the first linear alkanediol can alsopreferably be selected from the group consisting of 1,2-octanediol,2,3-octanediol, 3,4-octanediol, and mixtures thereof.

Even more preferred, in the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the linear alkanediol or the first linear alkanediol is analpha,beta or a beta,gamma diol as either 1,2-heptanediol,2,3-heptanediol, or a mixture thereof. However, the linear alkanediol orthe first linear alkanediol can also preferably be an alpha,beta or abeta,gamma 1,2-octanediol, 2,3-octanediol, or a mixture thereof. Amixture comprising 1,2-heptanediol and 2,3-octanediol or a mixture of1,2-octanediol and 2,3-heptanediol is also possible.

Most preferred, the linear alkanediol or the first linear alkanediol is1,2-heptanediol or 1,2-octanediol.

Likewise, in a further preferred variant of the cosmetic orpharmaceutical composition or homecare product according to the secondaspect of the present invention, the linear alkanediol or the firstlinear alkanediol is selected from the group consisting of:

-   -   1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol,    -   1,2-decanediol, 2,3-decanediol, 3,4-decanediol,    -   1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol, and        mixtures thereof.

More preferred, in the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the linear alkanediol or the first linear alkanediol isselected from the group consisting of 1,2-nonanediol, 2,3-nonanediol,3,4-nonanediol, and mixtures thereof, or can also be preferably selectedfrom the group consisting of 1,2-decanediol, 2,3-decanediol,3,4-decanediol, and mixtures thereof, or can also be preferably selectedfrom the group consisting of 1,2-undecanediol, 2,3-undecanediol,3,4-undecanediol, and mixtures thereof.

Even more preferred, in the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the linear alkanediol or the first linear alkanediol is analpha,beta or a beta,gamma diol as either 1,2-nonanediol,2,3-nonanediol, or a mixture thereof. However, the linear alkanediol orthe first linear alkanediol can also preferably be 1,2-decanediol,2,3-decanediol, or a mixture thereof.

Additionally, the linear alkanediol or the first linear alkanediol canalso preferably be 1,2-undecanediol, 2,3-undecanediol, or a mixturethereof. A mixture of 1,2-nonanediol and/or 2,3-decanediol and/or2,3-undecanediol or a mixture of 1,2-decanediol and/or 2,3-nonanedioland/or 2,3-undecanediol or a mixture of 1,2-undecanediol and/or2,3-nonanediol and 2,3-decanediol is also possible.

In a preferred variant of the cosmetic or pharmaceutical composition orhomecareproduct according to the second aspect of the present invention,the second linear alkanediol is selected from the group consisting of:

-   -   1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol,        1,3-pentanediol,    -   1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol, 1,3-hexanediol,    -   1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol,        1,3-heptanediol,    -   1,2-octanediol, 2,3-octanediol, 3,4-octanediol, 1,3-octanediol,    -   1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, 1,3-nonanediol,    -   1,2-decanediol, 2,3-decanediol, 3,4-decanediol, 1,3-decanediol,    -   1,2-undecanediol, 2,3-undecanediol, 3,4-undecanediol,        1,3-undecanediol,    -   1,2-dodecanediol, 2,3-dodecanediol, 3,4-dodecanediol,        1,3-dodecanediol,    -   1,2-tridecanediol, 2,3-tridecanediol, 3,4-tridecanediol,        1,3-tridecanediol, and mixtures thereof.

Of the aforesaid second linear alkanediols, the following (x,x+1)constitutional isomers are preferred: 1,2-pentanediol, 2,3-pentanediol,1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol,2,3-octanediol, 2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol,2,3-dodedcanediol, or 2,3-tridecanediol. Said alkanediols are liquid ata purity of 90 to 99%.

Of the aforesaid liquid alkanediols 1,2-pentanediol, 2,3-pentanediol,1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol,2,3-octanediol, 2,3-nonanediol or mixtures of said liquid alkanediolsare particularly preferred. Said alkanediols can be easier incorporatedinto semi-finished products or final products containing an antioxidant.

Of the aforesaid linear alkanediols or the first linear alkanediols, thefollowing (x,x+2) constitutional isomers are particularly preferred:1,3-octanediol, 1,3-nonanediol, 1,3-decanediol, or 1,3-undecanediol,most preferred 1,3-nonanediol or 1,3-undecanediol.

In a more preferred variant, the second linear alkanediol is selectedfrom the group consisting of 1,2-alkanediols having an uneven number ofcarbon atoms of 5 to 13, i.e. 1,2-pentanediol, 1,2-heptanediol,1,2-nonanediol, 1,2-undecanediol and 1,2-tridecanediol.

In a more preferred variant, the second linear alkanediol is selectedfrom the group consisting of 1,2-alkanediols having an uneven number ofcarbon atoms of 7, 9, 11 and 13, i.e. 1,2-heptanediol, 1,2-nonanediol,1,2-undecanediol and 1,2-tridecanediol, or is selected from the groupconsisting of 1,2-alkanediols having an uneven number of carbon atoms of9 and 11, i.e. 1,2-nonanediol and 1,2-undecanediol, or is selected fromthe group consisting of 1,2-alkanediols having an uneven number ofcarbon atoms of 9 and 13, i.e. 1,2-nonanediol and 1,2-tridecanediol, oris selected from the group consisting of 1,2-alkanediols having anuneven number of carbon atoms of 11 and 13, i.e. 1,2-undecanediol and1,2-tridecanediol.

In a more preferred variant, the second linear alkanediol is selectedfrom the group consisting of 2,3-alkanediols having an uneven number ofcarbon atoms of 5 to 13, i.e. 2,3-pentanediol, 2,3-heptanediol,2,3-nonanediol, 2,3-undecanediol and 2,3-tridecanediol.

In a still more preferred variant, the second linear alkanediol isselected from the group consisting of 2,3-alkanediols having an unevennumber of carbon atoms of 7, 9, 11 and 13, i.e. 2,3-heptanediol,2,3-nonanediol, 2,3-undecanediol and 2,3-tridecanediol, or is selectedfrom the group consisting of 2,3-alkanediols having an uneven number ofcarbon atoms of 9 and 11, i.e. 2,3-nonanediol and 2,3-undecanediol, oris selected from the group consisting of 2,3-alkanediols having anuneven number of carbon atoms of 9 and 13, i.e. 2,3-nonanediol and2,3-tridecanediol, or is selected from the group consisting of2,3-alkanediols having an uneven number of carbon atoms of 11 and 13,i.e. 2,3-undecanediol and 2,3-tridecanediol.

In a more preferred variant of the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention, the second linear alkanediol is selected from thegroup consisting of:

-   -   1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol,    -   1,2-hexanediol, 2,3-hexanediol, 3,4-hexanediol,    -   1,2-heptanediol, 2,3-heptanediol, 3,4-heptanediol,    -   1,2-octanediol, 2,3-octanediol, 3,4-octanediol,    -   1,2-nonanediol, 2,3-nonanediol, 3,4-nonanediol, and mixtures        thereof.

More preferred, in the cosmetic or pharmaceutical composition orhomecare product according to the second aspect of the presentinvention, the second linear alkanediol is selected from the groupconsisting of 1,2-pentanediol, 2,3-pentanediol, 3,4-pentanediol, andmixtures thereof. However, the second linear alkanediol can alsopreferably be selected from the group consisting of 1,2-hexanediol,2,3-hexanediol, 3,4-hexanediol, and mixtures thereof or can alsopreferably be selected from the group consisting of 1,2-heptanediol,2,3-heptanediol, 3,4-heptanediol, and mixtures thereof.

Even more preferred, in the cosmetic or pharmaceutical compositionaccording to the second aspect of the present invention, the secondlinear alkanediol is an alpha,beta or a beta,gamma diol as either1,2-pentanediol, 2,3-pentanediol or a mixture thereof. However, thesecond linear alkanediol can also preferably be 1,2-hexanediol or2,3-hexanediol or a mixture thereof. A mixture comprising1,2-pentanediol and 2,3-hexanediol or a mixture comprising2,3-pentanediol and 1,2-hexanediol is also possible.

Most preferred, the second linear alkanediol is 1,2-pentanediol or2,3-pentanediol or 1,2-hexanediol or 2,3-hexanediol or 1,2-heptanediolor 2,3-heptanediol or 2,3-octanediol or 2,3-nonanediol.

In a particularly preferred variant, the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention which comprises a mixture or a combination comprisingat least one first linear alkanediol and one or more second linearalkanediol includes any one of the following mixtures/combinations:

-   -   a mixture comprising 1,2-pentanediol and 2,3-pentanediol;    -   a mixture comprising 1,2-hexanediol and 2,3-hexanediol;    -   a mixture comprising 1,2-heptanediol and 2,3-heptanediol;    -   a mixture comprising 1,2-octanediol and 2,3-octanediol;    -   a mixture comprising 1,2-nonanediol and 2,3-nonanediol;    -   a mixture comprising 1,2-decanediol and 2,3-decanediol;    -   a mixture comprising 1,2-undecanediol and 2,3-undecanediol;    -   a mixture comprising 1,2-dodecanediol and 2,3-dodecanediol; or    -   a mixture comprising 1,2-tridecanediol and 2,3-tridecanediol.

In said homo alkanediol mixtures the first linear alkanediol and thesecond linear alkanediol have the same number of carbon atoms.

Particularly favorable is a combination including 1,2-heptanediol incombination with 2,3-heptanediol and/or 3,4-heptanediol, or acombination including 1,2-octanediol in combination with 2,3-octanedioland/or 3,4-octanediol, or a combination including 1,2-nonanediol incombination with 2,3-nonanediol and/or 3,4-nonanediol.

The addition of an alkanediol mixture according to the second aspect ofthe present invention, comprising a 1,2-alkanediol and a 2,3-alkanedioland as specified above to a composition comprising an antioxidant resultin considerably reduced ROS scores. In other words: the compositionaccording to the first or second aspect of the present inventioncomprising an antioxidant plus a blend of 1,2-alkanediol and a2,3-alkanediol has a significant increased antioxidative capacity andshows an improved ROS scavenging efficacy in comparison to thecorresponding single 1,2-alkanediol or 2,3-alkanediol substances. Thebeneficial antioxidative properties are demonstrated by the followingexamples.

Said antioxidative effect is found for the homo mixture including1,2-pentanediol and 2,3-pentanediol and leads to a better ROS score.

The same effect can also be observed for the homo mixture including1,2-hexanediol and 2,3-hexanediol.

The homo mixture including 1,2-heptanediol and 2,3-heptanediol is alsobeneficial due to its improved ROS scavenging effect which results in areduced ROS score.

The alkanediol mixture comprising 1,2-octanediol and 2,3-octanediol oran alkanediol mixture comprising 1,2-nonanediol and 2,3-nonanediol areparticularly advantageous, since have also a remarkable ROS scavengingeffect.

Also the alkanediol mixture comprising 1,2-decanediol and 2,3-decanediolor the alkanediol mixture comprising 1,2-undecanediol and2,3-undecanediol show a significant antioxidative capacity.

An improved antioxidative effect is also true for an alkanediol mixtureincluding 1,2-dodecanediol and 2,3-dodecanediol or an alkanediol mixtureincluding 1,2-tridecanediol and 2,3-tridecanediol. The mixtures of saidalkanediol mixture and an antioxidant result in a better ROS score.

The afore specified homo alkane diol mixtures including a 1,2-alkanedioland the corresponding 2,3-alkanediol display a significant antioxidativecapacity when used with an antioxidant. This means that the compositionis more stable against oxidative degradation.

Hence, a stable cosmetic or pharmaceutical formulation or homecareproduct can be obtained. With improvement of the storage stability theshelf life of the cosmetic or pharmaceutical preparation composition orhomecare product can be considerably prolonged.

Additionally, with the admixture of the corresponding liquid2,3-alkanediol, even in small amounts, to a solid 1,2-alkanediol, thesolid 1,2-alkanedioles, such as 1,2-octanediol, 1,2-nonanediol etc., canbe solved, resulting in a liquid alkanediol mixture. The 2,3-alkanediolserves as solvent for the solid 1,2-alkanediols. Such liquid mixtureshave the benefit that firstly the availability of the solid1,2-alkanediol in the mixture is improved and secondly the incorporationof the solid 1,2-alkanediol in semi-finished products or final productsis facilitated. This effect is particularly favorably for emulsions, inwhich lipophilic 1,2-alkanediols having a carbon chain of 8 or morecarbon atoms, when used alone, tend to migrate into the oil phase ortend to precipitate or recrystallize.

With the solution of the solid 1,2-octanediol in the liquid2,3-octanediol or of the solid 1,2-nonanediol in the liquid2,3-nonanediol, the availability of the 1,2-octanediol or 1,2-nonanediolcan be likewise improved in the end use.

Thus, with the afore-mentioned properties of the specified alkanediolmixtures including a 1,2-alkanediol and the respective 2,3-alkanediolthe processability in formulations can be improved.

Hence, a good compromise can be achieved when the alkanediol mixture iscombined in such a way as to maintain the antioxidative effect, whileimproving processability in formulations. The above specified1,2-alkanediol and corresponding 2,3-alkanediol combinations solve thisbalancing problem over the 1,2-alkanediol substances or 2,3-alkanediolsubstances alone. This is well achieved by combinations such ascomprising 1,2-pentanediol and 2,3-pentanediol but also for1,2-hexanediol and 2,3-hexandiol. Also, combinations such as comprising1,2-heptanediol and 2,3-heptanediol, but also 1,2-octanediol and2,3-octanediol show this effect. The same also counts for 1,2-nonanediolin combination with 2,3-nonanediol, but also for 1,2-decanediol incombination with 2,3-decanediol.

The afore specified homo alkanediol mixtures including a 1,2-alkanedioland the corresponding 2,3-alkanediol display a remarkably synergisticantioxidative efficacy and are clearly superior to the individuallycorresponding 1,2-alkanediols or 2,3-alkanediols and having the sameconcentration.

In a particularly preferred variant, the cosmetic or pharmaceuticalcomposition according to the second aspect of the present inventionwhich comprises a mixture or a combination comprising at least one firstlinear alkanediol and one or more second linear alkanediol thus includesany one of the following combinations:

-   -   1,2-pentanediol in combination with one of 1,2-hexanediol,        1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   1,2-hexanediol in combination with one of 1,2-pentanediol,        1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   1,2-heptanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   1,2-octanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   1,2-nonanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   1,2-decanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   1,2-undecanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-dodecanediol, or 1,2-tridecanediol;    -   1,2-dodecanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-undecanediol, or 1,2-tridecanediol;    -   1,2-tridecanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-undecanediol, or 1,2-doedecanediol;    -   2,3-pentanediol in combination with one of 1,2-hexanediol,        1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   2,3-hexanediol in combination with one of 1,2-pentanediol,        1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   2,3-heptanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   2,3-octanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-nonanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   2,3-nonanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-decanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   2,3-decanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-undecanediol, 1,2-doedecanediol, or 1,2-tridecanediol;    -   2,3-undecanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-dodecanediol, or 1,2-tridecanediol;    -   2,3-dodecanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-undecanediol, or 1,2-tridecanediol; or    -   2,3-tridecanediol in combination with one of 1,2-pentanediol,        1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-undecanediol, or 1,2-dodecanediol;    -   2,3-pentanediol in combination with one of 2,3-hexanediol,        2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol;    -   2,3-hexanediol in combination with one of 2,3-pentanediol,        2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol;    -   2,3-heptanediol in combination with one of 2,3-pentanediol,        2,3-hexanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol;    -   2,3-octanediol in combination with one of 2,3-pentanediol,        2,3-hexanediol, 2,3-heptanediol, 2,3-nonanediol, 2,3-decanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol;    -   2,3-nonanediol in combination with one of 2,3-pentanediol,        2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-decanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol;    -   2,3-decanediol in combination with one of 2,3-pentanediol,        2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol;    -   2,3-undecanediol in combination with one of 2,3-pentanediol,        2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol,        2,3-decanediol, 2,3-dodecanediol, or 2,3-tridecanediol;    -   2,3-dodecanediol in combination with one of 2,3-pentanediol,        2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol,        2,3-decanediol, 2,3-undecanediol, or 2,3-tridecanediol; or    -   2,3-tridecanediol in combination with one of 2,3-pentanediol,        2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol,        2,3-decanediol, 2,3-undecanediol, or 2,3-dodecanediol.

In a particular preferred variant, the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention which comprises a mixture or a combination comprisingat least one first linear alkanediol and one or more second linearalkanediol thus may include any of the following mixtures/combinations:

-   -   a mixture comprising 1,2-heptanediol and 1,2-pentanediol;    -   a mixture comprising 1,2-heptanediol and 1,2-hexanediol;    -   a mixture comprising 1,2-heptanediol and 1,2-octanediol;    -   a mixture comprising 1,2-heptanediol and 1,2-nonanediol;    -   a mixture comprising 1,2-heptanediol and 1,2-decanediol;    -   a mixture comprising 1,2-heptanediol and 1,2-undecanediol;    -   a mixture comprising 1,2-heptanediol and 1,2-dodecanediol; or a        mixture comprising 1,2-heptanediol and 1,2-tridecanediol.

In a particular preferred variant, the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention which comprises a mixture or a combination comprisingat least one first linear alkanediol and one or more second linearalkanediol thus may include any of the following mixtures/combinations:

-   -   a mixture comprising 1,2-heptanediol and 2,3-pentanediol;    -   a mixture comprising 1,2-heptanediol and 2,3-hexanediol;    -   a mixture comprising 1,2-heptanediol and 2,3-octanediol;    -   a mixture comprising 1,2-heptanediol and 2,3-nonanediol;    -   a mixture comprising 1,2-heptanediol and 2,3-decanediol;    -   a mixture comprising 1,2-heptanediol and 2,3-undecanediol;    -   a mixture comprising 1,2-heptanediol and 2,3-dodecanediol; or a        mixture comprising 1,2-heptanediol and 2,3-tridecanediol.

In a particular preferred variant, the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention which comprises a mixture or a combination comprisingat least one first linear alkanediol and one or more second linearalkanediol thus may include any of the following mixtures/combinations:

-   -   1,2-pentanediol and 2,3-pentanediol;    -   1,2-pentanediol and 2,3-hexanediol;    -   1,2-pentanediol and 2,3-heptanediol;    -   1,2-pentanediol and 2,3-octanediol;    -   1,2-pentanediol and 2,3-nonanediol;    -   1,2-pentanediol and 2,3-decanediol;    -   1,2-pentanediol and 2,3-undecanediol;    -   1,2-pentanediol and 2,3-dodecanediol;    -   1,2-pentanediol and 2,3-tridecanediol;    -   1,2-hexanediol and 2,3-pentanediol;    -   1,2-hexanediol and 2,3-hexanediol;    -   1,2-hexanediol and 2,3-heptanediol;    -   1,2-hexanediol and 2,3-octanediol;    -   1,2-hexanediol and 2,3-nonanediol;    -   1,2-hexanediol and 2,3-decanediol;    -   1,2-hexanediol and 2,3-undecanediol;    -   1,2-hexanediol and 2,3-dodecanediol;    -   1,2-hexanediol and 2,3-tridecanediol;    -   1,2-heptanediol and 2,3-pentanediol;    -   1,2-heptanediol and 2,3-hexanediol;    -   1,2-heptanediol and 2,3-heptanediol;    -   1,2-heptanediol and 2,3-octanediol;    -   1,2-heptanediol and 2,3-nonanediol;    -   1,2-heptanediol and 2,3-decanediol;    -   1,2-heptanediol and 2,3-undecanediol;    -   1,2-heptanediol and 2,3-dodecanediol;    -   1,2-heptanediol and 2,3-tridecanediol;    -   1,2-octanediol and 2,3-pentanediol;    -   1,2-octanediol and 2,3-hexanediol;    -   1,2-octanediol and 2,3-heptanediol;    -   1,2-octanediol and 2,3-octanediol;    -   1,2-octanediol and 2,3-nonanediol;    -   1,2-octanediol and 2,3-decanediol;    -   1,2-octanediol and 2,3-undecanediol;    -   1,2-octanediol and 2,3-dodecanediol;    -   1,2-octanediol and 2,3-tridecanediol;    -   1,2-nonanediol and 2,3-pentanediol;    -   1,2-nonanediol and 2,3-hexanediol;    -   1,2-nonanediol and 2,3-heptanediol;    -   1,2-nonanediol and 2,3-octanediol;    -   1,2-nonanediol and 2,3-nonanediol;    -   1,2-nonanediol and 2,3-decanediol;    -   1,2-nonanediol and 2,3-undecanediol;    -   1,2-nonanediol and 2,3-dodecanediol;    -   1,2-nonanediol and 2,3-tridecanediol;    -   1,2-decanediol and 2,3-pentanediol;    -   1,2-decanediol and 2,3-hexanediol;    -   1,2-decanediol and 2,3-heptanediol;    -   1,2-decanediol and 2,3-octanediol;    -   1,2-decanediol and 2,3-nonanediol;    -   1,2-decanediol and 2,3-decanediol;    -   1,2-decanediol and 2,3-undecanediol;    -   1,2-decanediol and 2,3-dodecanediol;    -   1,2-decanediol and 2,3-tridecanediol;    -   1,2-undecanediol and 2,3-pentanediol;    -   1,2-undecanediol and 2,3-hexanediol;    -   1,2-undecanediol and 2,3-heptanediol;    -   1,2-undecanediol and 2,3-octanediol;    -   1,2-undecanediol and 2,3-nonanediol;    -   1,2-undecanediol and 2,3-decanediol;    -   1,2-undecanediol and 2,3-undecanediol;    -   1,2-undecanediol and 2,3-dodecanediol;    -   1,2-undecanediol and 2,3-tridecanediol; or    -   1,2-dodecanediol and 2,3-pentanediol;    -   1,2-dodecanediol and 2,3-hexanediol;    -   1,2-dodecanediol and 2,3-heptanediol;    -   1,2-dodecanediol and 2,3-octanediol;    -   1,2-dodecanediol and 2,3-nonanediol;    -   1,2-dodecanediol and 2,3-decanediol;    -   1,2-dodecanediol and 2,3-undecanediol;    -   1,2-dodecanediol and 2,3-dodecanediol;    -   1,2-dodecanediol and 2,3-tridecanediol.

In a particular preferred variant, the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention which comprises a mixture or a combination comprisingat least one first linear alkanediol and one or more second linearalkanediol thus may include any of the following mixtures/combinations:

-   -   2,3-pentanediol and 2,3-hexanediol;    -   2,3-pentanediol and 2,3-heptanediol;    -   2,3-pentanediol and 2,3-octanediol;    -   2,3-pentanediol and 2,3-nonanediol;    -   2,3-pentanediol and 2,3-decanediol;    -   2,3-pentanediol and 2,3-undecanediol;    -   2,3-pentanediol and 2,3-dodecanediol;    -   2,3-pentanediol and 2,3-tridecanediol;    -   2,3-hexanediol and 2,3-pentanediol;    -   2,3-hexanediol and 2,3-heptanediol;    -   2,3-hexanediol and 2,3-octanediol;    -   2,3-hexanediol and 2,3-nonanediol;    -   2,3-hexanediol and 2,3-decanediol;    -   2,3-hexanediol and 2,3-undecanediol;    -   2,3-hexanediol and 2,3-dodecanediol;    -   2,3-hexanediol and 2,3-tridecanediol;    -   2,3-heptanediol and 2,3-pentanediol;    -   2,3-heptanediol and 2,3-hexanediol;    -   2,3-heptanediol and 2,3-octanediol;    -   2,3-heptanediol and 2,3-nonanediol;    -   2,3-heptanediol and 2,3-decanediol;    -   2,3-heptanediol and 2,3-undecanediol;    -   2,3-heptanediol and 2,3-dodecanediol;    -   2,3-heptanediol and 2,3-tridecanediol;    -   2,3-octanediol and 2,3-pentanediol;    -   2,3-octanediol and 2,3-hexanediol;    -   2,3-octanediol and 2,3-heptanediol;    -   2,3-octanediol and 2,3-nonanediol;    -   2,3-octanediol and 2,3-decanediol;    -   2,3-octanediol and 2,3-undecanediol;    -   2,3-octanediol and 2,3-dodecanediol;    -   2,3-octanediol and 2,3-tridecanediol;    -   2,3-nonaediol and 2,3-pentanediol;    -   2,3-nonaediol and 2,3-hexanediol;    -   2,3-nonaediol and 2,3-heptanediol;    -   2,3-nonaediol and 2,3-octanediol;    -   2,3-nonanediol and 2,3-decanediol;    -   2,3-nonanediol and 2,3-undecanediol;    -   2,3-nonanediol and 2,3-dodecanediol;    -   2,3-nonanediol and 2,3-tridecanediol;    -   2,3-decanediol and 2,3-pentanediol;    -   2,3-decanediol and 2,3-hexanediol;    -   2,3-decanediol and 2,3-heptanediol;    -   2,3-decanediol and 2,3-octanediol;    -   2,3-decanediol and 2,3-nonaediol;    -   2,3-decanediol and 2,3-decanediol;    -   2,3-decanediol and 2,3-undecanediol;    -   2,3-decanediol and 2,3-dodecanediol;    -   2,3-decanediol and 2,3-tridecanediol;    -   2,3-undecanediol and 2,3-pentanediol;    -   2,3-undecanediol and 2,3-hexanediol;    -   2,3-undecanediol and 2,3-heptanediol;    -   2,3-undecanediol and 2,3-octanediol;    -   2,3-undecanediol and 2,3-nonaediol;    -   2,3-undecanediol and 2,3-decanediol;    -   2,3-undecanediol and 2,3-dodecanediol;    -   2,3-undecanediol and 2,3-tridecanediol; or    -   2,3-dodecanediol and 2,3-tridecanediol.

Particularly favorable is a mixture or a combination including2,3-hexanediol and 2,3-heptanediol or a mixture including 2,3-hexanedioland 2,3-octanediol or a mixture including 2,3-heptanediol and2,3-octanediol.

In a very particularly preferred variant, the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention which comprises a mixture or a combination comprisingat least one first linear alkanediol and one or more second linearalkanediol thus includes any one of the following mixtures/combinations:

-   -   1,3-octanediol in combination with 1,2-hexanediol and/or        2,3-hexanediol; or    -   1,3-octanediol in combination with 1,2-heptanediol and/or        2,3-heptanediol; or    -   1,3-octanediol in combination with 1,2-octanediol and/or        2,3-octanediol; or    -   1,3-nonanediol in combination with 1,2-hexanediol and/or        2,3-hexanediol; or    -   1,3-nonanediol in combination with 1,2-heptanediol and/or        2,3-heptanediol; or    -   1,3-nonanediol in combination with 1,2-octanediol and/or        2,3-octanediol; or    -   1,3-decanediol in combination with 1,2-hexanediol and/or        2,3-hexanediol; or    -   1,3-decanediol in combination with 1,2-heptanediol and/or        2,3-heptanediol; or    -   1,3-decanediol in combination with 1,2-octanediol and/or        2,3-octanediol; or    -   1,3-undecanediol in combination with 1,2-hexanediol and/or        2,3-hexanediol; or    -   1,3-undecanediol in combination with 1,2-heptanediol and/or        2,3-heptanediol; or    -   1,3-undecanediol in combination with 1,2-octanediol and/or        2,3-octanediol.

In the hetero alkanediol mixtures described before the first linearalkanediol and the second linear alkanediol have a different number ofcarbon atoms.

The above specified hetero alkanediol mixtures according to the secondaspect of the present invention, comprising a first linear alkanedioland a second linear alkanediol are characterized in that they have asignificant antioxidative capacity and a superior ROS scavengingactivity. In other words: the composition according to the second aspectof the present invention comprising an antioxidant plus a blend of afirst linear alkanediol and a second linear alkanediol has a significantantioxidative capacity and shows an improved ROS scavenging efficacy incomparison to the corresponding single alkanediol substances.

The use of a hetero alkanediol mixture comprising 1,2-hexanediol and2,3-octanediol in combination with an antioxidant shows an improved ROSscavenging efficacy.

An antioxidative effect is found for the hetero alkanediol mixturecomprising 1,2-octanediol and 2,3-hexanediol compared to thecorresponding single first linear alkanediol and second linearalkanediol substances.

The hetero alkane mixture comprising 1,2-octanediol and 2,3-heptanediolis also beneficial since it has a particular antioxidation improvingeffect of antioxidants compared to the corresponding single first linearalkanediol and second linear alkanediol substances.

Furthermore, a distinct improvement in ROS score can be observed for thefollowing specified alkanediol mixtures, namely a mixture of alkanediolsincluding 1,2-pentanediol and 2,3-hexanediol; or a mixture including1,2-pentanediol and 1,2-heptanediol; or a mixture including1,2-pentanediol and 2,3-heptanediol; or a mixture including1,2-pentanediol and 2,3-octanediol; or a mixture including1,2-pentanediol and 1,2-nonanediol; or a mixture including1,2-pentanediol and 2,3-nonanediol, compared to the corresponding singlefirst linear alkanediol and second linear alkanediol substances. All ofthe afore specified hetero alkane diol mixtures including a first linearalkanediol and a second linear alkanediol display a remarkable ROSscavenging effect.

An improved ROS score can also be observed for a hetero alkanediolmixture comprising 1,2-pentanediol and 2,3-hexanediol when used with anantioxidant compared to the individual 1,2-alkanediol or 2,3-alkanediol.

Also, the alkanediol mixture comprising 1,2-pentanediol and1,2-heptanediol show a significant improvement in antioxiative capacity.

An improved antioxidative effect is also observed for a combination ofan antioxidant and a hetero alkanediol mixture comprising1,2-pentanediol and 2,3-heptanediol compared to the corresponding singlefirst linear alkanediol and second linear alkanediol substances.

An improvement or the ROS score can also be observed for the heteroalkanediol mixture comprising 1,2-pentanediol and 2,3-octanediolcompared to the corresponding single first linear alkanediol and secondlinear alkanediol substances.

Said improvement of the antioxidative effect is also found for thealkanediol mixture comprising 1,2-pentanediol and 1,2-nonanediolcompared to the corresponding single first linear alkanediol and secondlinear alkanediol substances.

Also, the hetero alkanediol mixture including 1,2-pentanediol and2,3-nonanediol is effective in improving the antioxidative effect whenused with an antioxidant.

Furthermore, a significant antioxidative capacity and improved ROS scorecan also be observed for mixtures comprising at least one first linearalkanediol and one or more second linear alkanediol according to thesecond aspect of the present invention, namely a mixture of alkanediolsincluding 1,2-heptanediol and 1,2-octanediol or a mixture of alkanediolsincluding 1,2-heptanediol and 2,3-octanediol or a mixture of alkanediolsincluding 1,2-heptanediol and 1,2-nonanediol or a mixture of alkanediolsincluding 1,2-heptanediol and 2,3-nonanediol compared to thecorresponding single first linear alkanediol and second linearalkanediol substances of the alkanediol mixtures.

All of the afore specified hetero alkane diol mixtures including a firstlinear alkanediol and a second linear alkanediol in combination with anantioxidant leads to a better ROS score display an improved solubilitytowards solid UV filters.

Said antioxidative effect is found for the hetero alkanediol mixtureincluding 1,2-heptanediol and 2,3-octanediol.

The improved antioxidative efficacy is well achieved by combinationswith the hetero alkanediol mixture such as including 1,2-heptanediol and2,3-nonanediol but also for 1,2-heptanediol and 1,2-nonanediol.

Hence, with the use of one hetero alkanediol mixtures as specifiedherein, a stable cosmetic or pharmaceutical formulation composition orhomecare product can be achieved. With the improvement of the storagestability the shelf life of the cosmetic or pharmaceutical compositionor homecare product can be considerable prolonged.

In a preferred variant according to the second aspect of the presentinvention in the cosmetic or pharmaceutical composition or the homecareproduct the linear alkanediol is selected from the group consisting of2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol,2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol,2,3-tridecanediol, and mixtures thereof.

In a more preferred variant of the cosmetic or pharmaceuticalcomposition or the homecare product according to the second aspect ofthe present invention, the linear alkanediol is selected from the groupconsisting of 2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol,2,3-octanediol, 2,3-nonanediol, and mixtures thereof.

Surprisingly, the addition of 2,3-pentanediol, 2,3-hexanediol,2,3-heptanediol as well as other 2,3-alkanediols such as 2,3-octanediol,2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol and2,3-tridecanediol to a cosmetic or pharmaceutical preparation orhomecare product boosts the antioxidative effect of an antioxidantresulting in a better ROS score compared to the corresponding1,2-alkanediols such as 1,2-pentanediol, 1,2-hexanediol,1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol etc.

With the improvement of the antioxidative effect the shelf life of thecosmetic or pharmaceutical preparation or homecare product canconsiderably be improved by using the 2,3-alkanediols as specified.

In addition, the 2,3-alkanediols as specified above have the benefit tobe liquids, whereby their incorporation in semi-finished products orfinal products can be facilitated and their availability in saidproducts can be increased. Additionally, in an emulsion the2,3-alkanediols remain in the water phase and can develop theirantimicrobial activity directly where contamination with microorganismsoccurs and do not tend to migrate into the oil phase.

Hence, a good compromise can be achieved when the active mixture iscombined in such a way as to maintain the antimicrobial effect, whileimproving processability in formulations. The above specified2,3-alkanediols solve this balancing problem over the solid1,2-alkanediol substances.

In a particularly advantageous variant according to the second aspect ofthe present invention, the linear alkanediol or the first linearalkanediol or the second linear alkanediol is a liquid alkanediol.

The term “liquid alkanediol” within the context of the present inventionmeans an alkanediol component which is liquid at room or ambienttemperature and under normal pressure, i.e., standard RTP conditions.

In a very preferred variant according to the second aspect of thepresent invention, the linear alkanediol or the first linear alkanediolor the second linear alkanediol is a liquid alkanediol selected from thegroup consisting of 1,2-pentanediol, 2,3-pentanediol, 1,2-hexanediol,2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol, 2,3-octanediol,2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, and mixtures thereof.

Of the aforesaid liquid alkanediols, 1,2-pentanediol, 2,3-pentanediol,1,2-hexanediol, 2,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol,2,3-octanediol, 2,3-nonanediol or mixtures thereof are most preferred.

In a most particularly advantageous variant according to the secondaspect of the present invention, the linear alkanediol or the firstlinear alkanediol or the second linear alkanediol are characterized by amaximum water solubility of less than or equal to 10% by weight. In apreferred variant, the maximum water solubility of the linear alkanediolor the first linear alkanediol or the second linear alkanediol is lessthan or equal to 10% by weight and more than or equal to 1.2% by weight.More preferred, the maximum water solubility of the linear alkanediol orthe first linear alkanediol or the second linear alkanediol is less thanor equal to 5% by weight and more than or equal to 1.4% by weight.

Preferably, the alkanediol with said water solubility is selected fromthe group consisting of 1,2-heptanediol, 2,3-heptanediol,2,3-octanediol, and mixtures thereof.

The water solubility of a substance is the saturation mass concentrationof the substance in water at a given temperature. The determination ofthe solubility in water relates to essentially pure substances which arestable in water and not volatile. The determination of the watersolubility of the alkanediols is further described in the followingExample 7.

The term “alkanediol” within the context of the present invention alsoincludes its stereoisomers. Stereoisomers are molecules that have thesame molecular formula and differ only in how their atoms are arrangedin three-dimensional space. In accordance with said definition, thelinear alkanediol of the invention and the first linear alkanediolhaving a carbon chain of 5 to 14 carbon atoms or the second linearalkanediol having a carbon chain of 5 to 14 carbon atoms as describedabove in detail encompass the following stereoisomers:

1,2-alkanediol stereoisomers:

-   -   (2S)-pentane-1,2-diol,    -   (2S)-hexane-1,2-diol,    -   (2S)-heptane-1,2-diol,    -   (2S)-octane-1,2-diol,    -   (2S)-nonane-1,2-diol,    -   (2S)-decane-1,2-diol,    -   (2S)-undecane-1,2-diol    -   (2S)-dodecane-1,2-diol,    -   (2S)-tridecane-1,2-diol,    -   (2S)-tetradecane-1,2-diol,    -   (2R)-pentane-1,2-diol,    -   (2R)-hexane-1,2-diol,    -   (2R)-heptane-1,2-diol,    -   (2R)-octane-1,2-diol,    -   (2R)-nonane-1,2-diol,    -   (2R)-decane-1,2-diol,    -   (2R)-undecane-1,2-diol,    -   (2R)-dodecane-1,2-diol,    -   (2R)-tridecane-1,2-diol,    -   (2R)-tetradecane-1,2-diol,    -   2,3-alkanediol stereoisomers:    -   (2S,3S)-pentane-2,3-diol,    -   (2S,3S)-hexane-2,3-diol,    -   (2S,3S)-heptane-2,3-diol,    -   (2S,3S)-octane-2,3-diol,    -   (2S,3S)-nonane-2,3-diol,    -   (2S,3S)-decane-2,3-diol,    -   (2S,3S)-undecane-2,3-diol    -   (2S,3S)-dodecane-2,3-diol,    -   (2S,3S)-tridecane-2,3-diol,    -   (2S,3S)-tetradecane-2,3-diol,    -   (2R,3R)-pentane-2,3-diol,    -   (2R,3R)-hexane-2,3-diol,    -   (2R,3R)-heptane-2,3-diol,    -   (2R,3R)-octane-2,3-diol,    -   (2R,3R)-nonane-2,3-diol,    -   (2R,3R)-decane-2,3-diol,    -   (2R,3R)-undecane-2,3-diol,    -   (2R,3R)-dodecane-2,3-diol,    -   (2R,3R)-tridecane-2,3-diol,    -   (2R,3R)-tetradecane-2,3-diol,    -   (2S,3R)-pentane-2,3-diol,    -   (2S,3R)-hexane-2,3-diol,    -   (2S,3R)-heptane-2,3-diol,    -   (2S,3R)-octane-2,3-diol,    -   (2S,3R)-nonane-2,3-diol,    -   (2S,3R)-decane-2,3-diol,    -   (2S,3R)-undecane-2,3-diol,    -   (2S,3R)-dodecane-2,3-diol,    -   (2S,3R)-tridecane-2,3-diol,    -   (2S,3R)-tetradecane-2,3-diol,    -   (2R,3S)-pentane-2,3-diol,    -   (2R,3S)-hexane-2,3-diol,    -   (2R,3S)-heptane-2,3-diol,    -   (2R,3S)-octane-2,3-diol,    -   (2R,3S)-nonane-2,3-diol,    -   (2R,3S)-decane-2,3-diol,    -   (2R,3S)-undecane-2,3-diol,    -   (2R,3S)-dodecane-2,3-diol,    -   (2R,3S)-tridecane-2,3-diol, and    -   (2R,3S)-tetradecane-2,3-diol.

3,4-alkanediol stereoisomers:

-   -   (3R,4R)-hexane-3,4-diol,    -   (3R,4R)-heptane-3,4-diol,    -   (3R,4R)-octane-3,4-diol,    -   (3R,4R)-nonane-3,4-diol,    -   (3R,4R)-decane-3,4-diol,    -   (3R,4R)-undecane-3,4-diol,    -   (3R,4R)-dodecane-3,4-diol,    -   (3R,4R)-tridecane-3,4-diol,    -   (3R,4R)-tetradecane-3,4-diol,    -   (3S,4S)-hexane-3,4-diol,    -   (3S,4S)-heptane-3,4-diol,    -   (3S,4S)-octane-3,4-diol,    -   (3S,4S)-nonane-3,4-diol,    -   (3S,4S)-decane-3,4-diol,    -   (3S,4S)-undecane-3,4-diol,    -   (3S,4S)-dodecane-3,4-diol,    -   (3S,4S)-tridecane-3,4-diol,    -   (3S,4S)-tetradecane-3,4-diol,    -   (3R,4S)-hexane-3,4-diol,    -   (3R,4S)-heptane-3,4-diol,    -   (3R,4S)-octane-3,4-diol,    -   (3R,4S)-nonane-3,4-diol,    -   (3R,4S)-decane-3,4-diol,    -   (3R,4S)-undecane-3,4-diol,    -   (3R,4S)-dodecane-3,4-diol,    -   (3R,4S)-tridecane-3,4-diol,    -   (3R,4S)-tetradecane-3,4-diol,    -   (3S,4R)-hexane-3,4-diol,    -   (3S,4R)-heptane-3,4-diol,    -   (3S,4R)-octane-3,4-diol,    -   (3S,4R)-nonane-3,4-diol,    -   (3S,4R)-decane-3,4-diol,    -   (3S,4R)-undecane-3,4-diol,    -   (3S,4R)-dodecane-3,4-diol,    -   (3S,4R)-tridecane-3,4-diol, and    -   (3S,4R)-tetradecane-3,4-diol.

In the context of the present text, the terms “1,2-diol” and “2,3-diol”or “3,4-diol” includes both the corresponding S-configured enantiomersand also the R-enantiomers as well as arbitrary mixtures of these S- andR-configured enantiomers, i.e. mixtures of racemates of the respectivediols.

The alkanediol mixture of the cosmetic or pharmaceutical composition orhomecare product according to the first aspect of the present inventionaccording to the first aspect of the present invention comprises the1,2-heptanediol and the 2,3-heptanediol in a ratio in a range of 50:50to 99.9:0.1, preferably in a ratio in a range of 75:25 to 99:1, morepreferred in a ratio in a range of 80:20 to 98:2, still more preferredin a ratio in a range of 90:10 to 95:5.

In the cosmetic or pharmaceutical composition according to the firstaspect of the present invention, 1,2-heptanediol and 2,3-heptanediol arecomprised in the mixture preferably in a ratio in a range of 98:2 to99.9:0.1.

In the homecare products according to the first aspect of the presentinvention, 1,2-heptanediol and 2,3-heptanediol are comprised in thealkanediol mixture preferably in a ratio in a range of 95:5 to 99.9:0.1.

1,2-heptanediol and 2,3-heptanediol are comprised in the mixture of thecosmetic or pharmaceutical composition or homecare product according tothe first aspect of the present invention preferred in a ratio of ≥95:≤5, more preferred in a ratio of ≥96: ≤4; still more preferred in aratio of ≥97: ≤3, and most preferred in a ratio of ≥98: ≤2.

Most of all the mixture of the cosmetic or pharmaceutical composition orhomecare product according to the first aspect of the present inventioncomprises 1,2-heptanediol and 2,3-heptanediol in a ratio of 95: ≤5,including the ratios ≥95.5: ≤4.5; ≥96: ≤4; ≥96.5: ≤3.5; ≥97≤3; ≥97.5:2,5and ≥98.0: ≤2.0.

Even more preferred the alkanediol mixture of the cosmetic orpharmaceutical composition or homecare product according to the firstaspect of the present invention comprises 1,2-heptanediol and2,3-heptanediol in a ratio of ≥98: ≤2, including the ratios of≥98.1:≤1.9; ≥98.2: ≤0.8; ≥98.3: ≤1.7; ≥98.4:≤1.6; ≥98.5: ≤1.5;≥98.6:≤1.4; ≥98.7:≤1.3; ≥98.8:≤1.2; ≥98.9:≤1.1; ≥99:≤1.0; ≥99.1:≤0.9;≥99.2: ≤0.8; ≥99.3:≤0.7; ≥99.4:≤0.6; ≥99.5:≤0.5; ≥99.6:≤0.4; ≥99.7≤0.3;≥99.8: ≤0.2 and ≥99.9:≤0.1.

The first linear alkanediol and the second linear alkanediol as definedin detail above are present in the alkanediol mixture according to thesecond aspect of the present invention in a ratio in a range of 50:50 to99.9:0.1, preferably in a ratio in a range of 75:25 to 99:1, morepreferred in a ratio in a range of 80:20 to 98:2, still more preferredin a ratio in a range of 90:10 to 95:5.

In the cosmetic or pharmaceutical preparation according to the secondaspect of the present invention, the first linear alkanediol and thesecond linear alkanediol are comprised in the mixture preferably in aratio in a range of 98:2 to 99.9:0.1.

In the homecare products according to second aspect of the presentinvention, the first linear alkanediol and the second linear alkanediolare comprised in the alkanediol mixture preferably in a ratio in a rangeof 95:5 to 99.9:0.1.

The first linear alkanediol and the second linear alkanediol arecomprised in the mixture of the cosmetic or pharmaceutical compositionor homecare product according to the second aspect of the presentinvention preferred in a ratio of ≥95:≤5, more preferred in a ratio of≥96:≤4; still more preferred in a ratio of ≥97:≤3, and most preferred ina ratio of ≥98:≤2.

Most of all the alkanediol mixture of the cosmetic or pharmaceuticalcomposition or homecare product according to the second aspect of thepresent invention comprises the first linear alkanediol and the secondlinear alkanediol in a ratio of ≥95:≤5, including the ratios ≥95.5:≤4.5;≥96:≤4; ≥96.5:≤3.5; ≥97:≤3; ≥97.5:2,5 and ≥98.0:≤2.0.

Even more preferred, the alkanediol mixture of the cosmetic orpharmaceutical composition or homecare product according to the secondaspect of the present invention comprises the first linear alkanedioland the second linear alkanediol in a ratio of ≥98: ≤2, including theratios of ≥98.1:≤1.9; ≥98.2:≤1.8; ≥98.3: ≤1.7; ≥98.4:≤1.6; ≥98.5:≤1.5;≥98.6≤1.4; ≥98.7:≤1.3; ≥98.8: ≤1.2; ≥98.9:≤1.1; ≥99: ≤1.0; ≥99.1: ≤0.9;≥99.2:≤0.8; ≥99.3:≤0.7; ≥99.4:≤0.6; 99.5:≤0.5; ≥99.6: ≤0.4; ≥99.7:≤0.3;≥99.8:≤0.2 and ≥99.9:≤0.1.

Alternatively, said ratio ranges for the first and second alkanediol areswitched, such that the second alkanediol is the main component and thefirst alkanediol is the secondary component.

In an advantageous variant according to the second aspect of the presentinvention, the mixture comprises as first linear alkanediol an1,2-alkanediol, such as 1,2-pentanediol, 1,2-hexanediol,1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, 1,2-decanediol,1,2-undecanediol, 1,2-dodecanediol, or 1,2-tridecanediol and as secondlinear alkanediol the corresponding 2,3-alkanediols, such as2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol,2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol, or2,3-tridecanediol in a ratio in a range of 50:50 to 99.9:0.1, preferablyin a ratio in a range of 75:25 to 99:1, more preferred in a ratio in arange of 80:20 to 98:2, still more preferred in a ratio in a range of90:10 to 95:5.

Likewise, for said specific mixtures, the further ratios or ranges ofratios as defined above in general for the first linearalkanediol:second linear alkanediol are also applicable.

In a still further variant, according to the second aspect of thepresent invention, the mixture comprises as first linear alkanediol an2,3-alkanediol, such as 2,3-pentanediol, 2,3-hexanediol,2,3-heptanediol, 2,3-octanediol, 2,3-nonanediol, 2,3-decanediol,2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol and as secondlinear alkanediol the corresponding 1,2-alkanediols, such as1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol,1,2-nonanediol, 1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol, or1,2-tridecanediol in a ratio in a range of 50:50 to 99.9:0.1, preferablyin a ratio in a range of 75:25 to 99:1, more preferred in a ratio in arange of 80:20 to 98:2, still more preferred in a ratio in a range of90:10 to 95:5.

Likewise, for said specific mixtures, the further ratios or ranges ofratios as defined above in general for the first linearalkanediol:second linear alkanediol are also applicable.

In a more advantageous variant according to the second aspect of thepresent invention, in the mixtures comprising a combination of a1,2-alkanediol as first linear alkandediol and the corresponding2,3-alkanediol as second linear alkanediol, such as

-   -   1,2-pentanediol and 2,3-pentanediol, or    -   1,2-hexanediol and 2,3-hexanediol, or    -   1,2-heptanediol and 2,3-heptanediol, or    -   1,2-octanediol and 2,3-octanediol, or    -   1,2-nonanediol and 2,3-nonanediol, or    -   1,2-decanediol and 2,2-decanediol, or    -   1,2-undecanediol and 2,3-undecenaediol, or    -   1,2-dodecanediol and 2,3-dodecanediol, or    -   1,2-tridecanediol and 2,3-tridecanediol,        the first linear alkanediol and the second linear alkanediol are        present in a ratio in a range of 50:50 to 99.9:0.1, preferably        in a ratio in a range of 75:25 to 99:1, more preferred in a        ratio in a range of 80:20 to 98:2, still more preferred in ratio        in a range of 90:10 to 95:5.

Likewise, for said mixtures, the ratios of first linearalkanediol:second linear alkanediol or ranges of ratios as describedabove are also applicable.

By these mixing ratios the afore mentioned mixtures show an improved ROSscore when combined with an antioxidant in comparison to thecorresponding single alkanediol substances as it is described anddemonstrated in the experimental part.

In a more advantageous variant according to the second aspect of thepresent invention, in the mixtures comprising as first linear alkanediola 2,3-alkanediol and as second linear alkanediol the corresponding1,2-alkanediols, such as mixtures including

-   -   2,3-pentanediol and 1,2-pentanediol, or    -   2,3-hexanediol and 1,2-hexanediol, or    -   2,3-heptanediol and 1,2-heptanediol, or    -   2,3-octanediol and 1,2-octanediol, or    -   2,3-nonanediol and 1,2-nonanediol, or    -   2,3-decanediol and 1,2-decanediol, or    -   2,3-undecanediol and 1,2-undecenaediol, or    -   2,3-dodecanediol and 1,2-dodecanediol, or    -   2,3-tridecanediol and 1,2-tridecanediol,        the first linear alkanediol and the second linear alkanediol are        present in a ratio in a range of 50:50 to 99.9:0.1, preferably        in a ratio in a range of 75:25 to 99:1, more preferred in a        ratio in a range of 80:20 to 98:2 or still more preferred in a        ratio in a range of 90:10 to 95:5.

Likewise for said specific mixtures, the further ratios or ranges ofratios as defined above in general for the first linearalkanediol:second linear alkanediol are also applicable.

By these mixing ratios the afore mentioned mixtures show an improved ROSscore when combined with an antioxidant in comparison to thecorresponding single alkanediol substances.

A preferred variant according to the second aspect the present inventionalso encompasses a mixture including as first linear alkanediol1,2-hexanediol and as second linear alkanediol 2,3-octanediol or amixture including as first linear alkanediol 1,2-octanediol and assecond linear alkanediol 2,3-hexanediol or a mixture including as firstlinear alkanediol 1,2-octanediol and and as second linear alkanediol2,3-heptandeiol either in a ratio in a range of 50:50 to 99.9:0.1,preferably in a ratio in a range of 75:25 to 99:1, more preferred in aratio in a range of 80:20 to 98:2 or still more preferred in a ratio ina range of 90:10 to 95:5.

Likewise for said specific mixtures, the further ratios or ranges ofratios as defined above in general for the first linearalkanediol:second linear alkanediol are also applicable.

By these mixing ratios the afore mentioned mixtures show an improved ROSscore when combined with an antioxidant in comparison to thecorresponding single alkanediol substances.

In a further beneficial variant according to the second aspect of thepresent invention, the mixtures comprise a first linear alkanediol and asecond linear alkanediol, such as mixtures including

-   -   1,2-pentanediol and 2,3-hexanediol; or    -   1,2-pentanediol and 1,2-heptanediol; or    -   1,2-pentanediol and 2,3-heptanediol; or    -   1,2-pentanediol and 2,3-octanediol; or    -   1,2-pentanediol and 1,2-nonanediol; or    -   1,2-pentanediol and 2,3-nonanediol,        wherein the first linear alkanediol and the second linear        alkanediol are present in a ratio in a range of 50:50 to        99.9:0.1, preferably in a ratio in a range of 75:25 to 99:1,        more preferred in a ratio in a range of 80:20 to 98:2 or still        more preferred in a ratio in a range of 90:10 to 95:5.

Likewise, for said specific mixtures, the further ratios or ranges ofratios as defined above in general for the first linearalkanediol:second linear alkanediol are also applicable.

By these mixing ratios the afore mentioned mixtures show an improved ROSscore when combined with an antioxidant in comparison to thecorresponding single alkanediol substances.

A particularly preferred variant according to the second aspect thepresent invention also encompasses a mixture including as first linearalkanediol 1,2-heptanediol and as second linear alkanediol1,2-octanediol or a mixture including as first linear alkanediol1,2-heptanediol and as second linear alkanediol 2,3-octanediol or amixture including as first linear alkanediol 1,2-heptanediol and assecond linear alkanediol 1,2-nonanediol or a mixture including as firstlinear alkanediol 1,2-heptanediol and as second linear alkanediol2,3-nonanediol wherein the first linear alkanediol and the second linearalkanediol are present in a ratio in a range of 50:50 to 99.9:0.1,preferably in a ratio in a range of 75:25 to 99:1, more preferred in aratio in a range of 80:20 to 98:2 or still more preferred in a ratio ina range of 90:10 to 95:5.

Likewise, for said specific mixtures, the further ratios or ranges ofratios as defined above in general for the first linearalkanediol:second linear alkanediol are also applicable.

By these mixing ratios the afore mentioned mixtures show an improved ROSscore when combined with an antioxidant in comparison to thecorresponding single alkanediol substances.

The alkanediols are obtained either by synthesis from petrochemical orother fossil fuel sources by known methods such as olefinbishydroxylation, hydrolysis from epoxide or various chemicaltransformations or from bioderived feedstock by fermentation or frombio-based natural and renewable feedstock such as biomass by catalyticsynthesis as it is described in US 2019/0241491 A1 and US 2020/0189995A1. The alkanediols used according to the present invention compriseeither petrochemically derived and biobased natural and renewablefeedstock derived alkanediols. Preferably, the alkanediols are frombio-based sources and are thus bio-alkanediols.

The compound (b) of the cosmetic or pharmaceutical composition orhomecare product according to the first aspect or the second aspect ofthe present invention relates to an antioxidant.

The term “antioxidant” as used in this document refers to a substance orcomposition which significantly delays, prevents or even inhibitsoxidation. Antioxidants react with free radicals, reducing them tostable, unreactive products. Oxidation is a chemical reaction thatproduces free radicals chain reactions which generate highly reactiveperoxides and hydroperoxides. In turn, these peroxides andhydroperoxides react with substrates present in a cosmetic compositionor in food which result in decomposition products such as carboxylicacids, aldehydes and ketones, among other, which alter the sensoryproperties of the productions and lead to degradation of thecomposition.

Antioxidants play an important physiological role as radical scavenger.In the organism antioxidants inactivate biologically important reactivefree radicals or other reactive oxygen species (ROS) which excessivelyoccurrence leads to oxidative stress. In a biological context, reactiveoxygen species (ROS) are formed as a natural by-product of the normalmetabolism of oxygen and have important roles in cell signalling andhomeostasis. However, at times of environmental stress (for example UVor heat exposure), ROS levels can increase dramatically.

Oxidative stress occurs either when excess ROS are produced in cells,which could overwhelm the normal antioxidant capacity, or whenantioxidant defence mechanisms are impaired. Reactive oxygen species(ROS) are chemically reactive species containing oxygen. Examples of ROSinclude superoxide anions (O₂ ^(·−), hydroxyl (OH^(·)), peroxyl (RO₂^(·)) alkoxyl (RO^(·)) radicals, and non-radical compounds such ashydrogen peroxide (H₂O₂), hypochlorous acid (HOCl) and organicperoxides, which can be produced from either endogenous source (forexample mitochondrial electron transport chain, cytochrome P450monooxygenases, and NADPH oxidases) or exogenous sources (for examplepollutants, drugs, xenobiotics and radiation). ROS toxicity affectsmajor cellular components and contributes to significant protein, lipidand DNA damage, inflammation, cell and tissue injury, and apoptosis.

There is compelling evidence that oxidative stress plays a major role inthe pathogenesis and progression of major human diseases, includinginflammatory diseases, and that it is also implicated in aging. It notonly directly damages the cellular structures of the skin but alsoenhances dermal inflammation and weakens the skin barrier function andenables infections by microbial pathogens. According to the free radicaltheory of aging, oxidative damage initiated by reactive oxygen species(ROS) is a major contributor to the functional decline that ischaracteristic of aging. Oxidative stress is a major underlying cause ofneurodegenerative and neuroinflammatory disorders.

Interleukin 8 (IL-8) or CXCL8 is a chemokine produced by macrophages andother cell types such as epithelial cells, airway smooth muscle cellsand endothelial cells. In humans, the interleukin-8 protein is encodedby the IL-8 gene. IL-8 is initially produced as a precursor peptide of99 amino acids long which then undergoes cleavage to create severalactive IL-8 isoforms. In culture, a 72 amino acid peptide is the majorform secreted by all kinds of cells. IL-8 is a key mediator associatedwith inflammation where it plays a key role in neutrophil recruitmentand neutrophil degranulation. As an example, it has been cited as apro-inflammatory mediator in gingivitis, psoriasis and other diseases.

Interleukin-8 secretion is increased by various kinds of stressincluding UV and oxidative stress, which thereby cause the recruitmentof inflammatory cells and induces a further increase in oxidant stressmediators, making it a key parameter in localized inflammation.

UV irradiation induces increased synthesis and expression of matrixmetalloproteinases (MMPs) in human skin, which is stimulated by thegeneration of excess reactive oxygen species (ROS), and plays a criticalrole in photoaging. Chronic or long-term exposure to UV radiationdisrupts the normal skin structure leading to a host of skin issuesincluding premature skin aging (photoaging) and skin cancer (photocarcinogenesis). MMPs are zinc-containing endopeptidases with a broadrange of substrate specificities. Based on their structure and substratespecificity, they can be categorized into five main subgroups, namely(1) collagenases (MMP-1, MMP-8 and MMP-13); (2) gelatinases (MMP-2 andMMP-9); (3) stromelysins (MMP-3, MMP-10 and MMP-11); (4) matrilysins(MMP-7 and MMP-26); and (5) membrane-type (MT) MMPs (MMP-14, MMP-15, andMMP-16). They are secreted by keratinocytes and dermal fibroblasts inresponse to multiple stimuli such as oxidative stress, UV radiation, andcytokines. To date, MMPs have been identified that play important rolesin various pathophysiological processes including photoaging, woundhealing, skeletal growth and remodeling, arthritis, inflammation,angiogenesis, and cancer.

MMPs are responsible for degrading the extracellular matrix (ECM)proteins such as collagen, fibronectin, elastin, and proteoglycans,contributing to photoaging. Increased MMP activity is an importantfactor influencing the development of age-related changes in skin.Degradation of collagen is normally regulated by MMPs and by theactivity of their natural inhibitors, tissue inhibitors ofmetalloproteinases. In the skin, epidermal keratinocytes and dermalfibroblasts mainly secrete MMP-1 (interstitial collagenase orcollagenase 1), a collagenase that degrades collagens into specificfragments Other MMPs such as gelatinase further hydrolyse thesefragments, ultimately impairing the function of the collagen-richdermis. The alterations made to the ECM by MMPs contributes to skinwrinkling, a characteristic of premature skin aging.

With the use of an antioxidant, the above-described oxidation process ina product or the above described biochemically reactions caused byoxidative stress and excess reactive oxygen species (ROS) can be downregulated.

The cosmetic or pharmaceutical composition or homecare product accordingto the first or second aspect of the present invention encompasses atleast one antioxidant selected from the group consisting ofdimethylmethoxy chromanol, arbutin, amino acids (for example glycine,histidine, tyrosine, tryptophan) and their derivatives (for exampleacetylcysteine), tert-butylhydroquinone, caffeic acid, chlorogenic acid,imidazoles (for example urocanic acid) and their derivatives,cannabinoids, cannabidiol and its extracts (Cannabis sativa seed oil,Cannabis sativa extract), cannabinol, kojic acid, peptides such asD,L-carnosine, D-carnosine, L-carnosine and their derivatives (forexample anserine), hydroxyphenyl propamidobenzoic acid(dihydroavenanthramide D), diethylhexyl syringylidene malonate,phenylethyl resorcinol, gallic acid and their derivatives, quercetin,hydroxyacetophenone, rosmarinic acid, carotenoids, carotenes (forexample α-carotene, β-carotene, lycopene), phytoene, phytofluene andtheir derivatives, lipoic acid and its derivatives (for exampledihydrolipoic acid), aurothioglucose, propylthiouracil and other thiols(for example thioredoxin, glutathione, cysteine, cystine, cystamine andtheir glycosyl, N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl,palmitoyl, oleyl, γ-linoleyl, cholesteryl and glyceryl esters) and theirsalts, dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butylhydroxyhydrocinnamate, distearyl thiodipropionate, thiodipropionic acidand their derivatives (esters, ethers, peptides, lipids, nucleotides,nucleosides and salts) as well as sulphoximine compounds (for examplebuthionine sulphoximines, lactobacillus (ferment, filtrate, lysate),homocysteine sulphoximines, buthionine sulphones, penta-, hexa-,hepta-thionine sulphoximine) in very low tolerated doses, and also(metal) chelating agents (for example α-hydroxy fatty acids, palmiticacid, phytic acid, lactoferrin, α-hydroxy acids (for example citricacid, lactic acid, malic acid), humic acid, bile acid, bile extracts,bilirubin, biliverdin, hinokitiol, EDTA, EGTA, Trisodium DicarboxymethylAlaninate, MGDA (methylglycinic diacetic acid), GLDA (Glutamic aciddiacetic acid)) and their derivatives, unsaturated fatty acids and theirderivatives (for example γ-linolenic acid, linoleic acid, oleic acid),folic acid and its derivatives, ubiquinone and ubiquinol and theirderivatives, triethyl citrate, Vitamin C and its derivatives (forexample ascorbyl palmitate, magnesium ascorbyl phosphate, ascorbylacetate), tocopherols and their derivatives (for example α-tocopherol,ß-tocopherol, γ-tocopherol, δ-tocopherol, tocopheryl acetate),dexpanthenol, Vitamin A and its derivatives (for example Vitamin Apalmitate, Hydroxypinacolone Retinoate) and also coniferyl benzoate ofbenzoin resin, rutinic acid and its derivatives, ferrulic acid and itsderivatives, butylhydroxytoluene, butylhydroxyanisole,hydroxymethoxyphenyl decanone, nordihydroguaiacic acid,nordihydroguaiaretic acid, allantoin, tropolone,trihydroxybutyrophenone, uric acid and its derivatives, urea, mannoseand its derivatives, hydroxy acetophenone (ortho/para), zinc and itsderivatives (for example ZnO, ZnSO₄), beta-aspartyl arginine, seleniumand its derivatives (such as selenium methionine), Vitis Vinifera(Grape) seed extract, oat extract, Cichorium intubybus (chicory) leafextract, Leon-topodium Alpinum extract, green tea extract, Curcumin,Zingiber Officinalis (Ginger) Root) Extract, Silymarin, stilbenes andtheir derivatives (such as stilbene oxide, trans-stilbene oxide) as wellas the derivatives of said antioxidants, such as salts, esters, ethers,sugars, nucleotides, nucleosides, peptides and lipids, and mixtures oftwo or more of said antioxidants.

In a more preferred variant, the antioxidant of the cosmetic orpharmaceutical composition or homecare product of the present inventionis selected from the group consisting of dimethylmethoxy chromanol,hydroxyacetophenone, acorbic acid and its salts, hydroxymethoxyphenyldecanone, beta-aspartyl arginine, uric acid, urea, hydroxypinacoloneretinoate, vitamin A and vitamin A derivatives, butylhydroxytoluol(BHT), butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,ascorbyl palmitate, ascorbyl phosphate and salts thereof, carnosine,rutin, tocopherol, tocopheryl acetate, ubiquinone-10, dilaurylthiodipropionate, pentaerythrityl tetra-di-t-butylhydroxyhydrocinnamate, triethyl citrate, diethylhexyl syringylidenemalonate, lactobacillus (ferment, filtrate, lysate), cannabinoids,cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis sativaextract), cannabinol, hydroxyphenyl propamidobenzoic acid(dihydroavenanthramide D), green tea extract, Zingiber Officinalis(Ginger) root extract, tropolone, allantoin, and mixtures of two or moreof said antioxidants.

In a particularly preferred variant, the antioxidant of the cosmetic orpharmaceutical composition of the present invention is tocopherol ortocopheryl acetate. Also preferred is dimethylmethoxy chromanol.

From the above antioxidants, the following antioxidants are inparticular preferred for the use in anti-wrinkle or anti-agingcompositions: tocopherol or a derivative thereof, and/or vitamin A or aderivative thereof, and/or vitamin C or a derivative thereof, carnosineor a derivative thereof, or Zingiber Officinale (Ginger) Root Extract.

Still more preferred from the above antioxidants are antioxidantsselected from the group consisting of cannabinoids, cannabidiol and itsextracts (Cannabis sativa seed oil, Cannabis sativa extract),cannabinol, hydroxyphenyl propamidobenzoic acid (dihydroavenanthramideD).

The aforesaid antioxidants can be used either as a single component orin combination with one or more further antioxidants as specified above.

In a preferred advantageously variant, the cosmetic or pharmaceuticalcomposition or homecare product according to the first or second aspectof the present invention comprises one of the following combinations ofcomponents (a) and (b):

-   -   1,2-pentanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-hexanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-heptanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-octanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-nonanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-decanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabidiol and its extracts (Cannabis sativa seed oil,        Cannabis sativa extract), green tea extract, zingiber        officinalis(ginger) root extract, tropolone, allantoin, and        mixtures of two or more of said antioxidants; or    -   1,2-undecanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-dodecanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-tridecanediol plus one or more antioxidants selected from        the group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   2,3-pentanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   2,3-hexanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   2,3-heptanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   2,3-octanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   2,3-nonanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   2,3-decanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   2,3-undecanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   2,3-dodecanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   2,3-tridecanediol plus one or more antioxidants selected from        the group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-heptanediol in combination with 2,3-heptanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-heptanediol in combination with one or more of        1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol or        1,2-tridecanediol, plus one or more antioxidants selected from        the group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),    -   hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-heptanediol in combination with one or more of        2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol,        2,3-octanediol, 2,3-nonanediol, 2,3-decanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol plus        one or more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-pentanediol in combination with 2,3-pentanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-hexanediol in combination with 2,3-hexanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-octanediol in combination with 2,3-octanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-nonanediol in combination with 2,3-nonanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-decanediol in combination with 2,3-decanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-undecanediol in combination with 2,3-undecanediol plus one        or more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-dodecanediol in combination with 2,3-dodecanediol plus one        or more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-tridecanediol in combination with 2,3-tridecanediol plus one        or more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,3-octanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,3-nonanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,3-decanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,3-dodecanediol plus one or more antioxidants selected from the        group consisting of dimethylmethoxy chromanol,        hydroxyacetophenone, acorbic acid and its salts,        hydroxymethoxyphenyl decanone, beta-aspartyl arginine, uric        acid, urea, hydroxypinacolone retinoate, vitamin A and vitamin A        derivatives, butylhydroxytoluol (BHT), butylhydroxyanisol (BHA),        hydroxyphenyl propamidobenzoic acid, ascorbyl palmitate,        ascorbyl phosphate and salts thereof, carnosine, rutin,        tocopherol, tocopheryl acetate, ubiquinone-10, dilauryl        thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-hexanediol in combination with 2,3-octanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-octanediol in combination with 2,3-hexanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-octanediol in combination with 2,3-heptanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-pentanediol in combination with 2,3-hexanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-pentanediol in combination with 1,2-heptanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-pentanediol in combination with 2,3-heptanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-pentanediol in combination with 2,3-octanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-pentanediol in combination with 1,2-nonanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-pentanediol in combination with 2,3-nonanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-heptanediol in combination with 1,2-octanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-heptanediol in combination with 2,3-octanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-heptanediol in combination with 1,2-nonanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants; or    -   1,2-heptanediol in combination with 2,3-nonanediol plus one or        more antioxidants selected from the group consisting of        dimethylmethoxy chromanol, hydroxyacetophenone, acorbic acid and        its salts, hydroxymethoxyphenyl decanone, beta-aspartyl        arginine, uric acid, urea, hydroxypinacolone retinoate, vitamin        A and vitamin A derivatives, butylhydroxytoluol (BHT),        butylhydroxyanisol (BHA), hydroxyphenyl propamidobenzoic acid,        ascorbyl palmitate, ascorbyl phosphate and salts thereof,        carnosine, rutin, tocopherol, tocopheryl acetate, ubiquinone-10,        dilauryl thiodipropionate, pentaerythrityl tetra-di-t-butyl        hydroxyhydrocinnamate, triethyl citrate, diethylhexyl        syringylidene malonate, lactobacillus (ferment, filtrate,        lysate), cannabinoids, cannabidiol and its extracts (Cannabis        sativa seed oil, Cannabis sativa extract), cannabinol,        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        green tea extract, zingiber officinalis (ginger) root extract,        tropolone, allantoin, and mixtures of two or more of said        antioxidants.

More preferred combinations of component (a) and (b) in the cosmetic orpharmaceutical composition or homecare product according to the first orsecond aspect of the present invention, preferably in cosmetic orpharmaceutical compositions for anti-wrinkle or anti-aging preventionand/or treatment are:

-   -   1,2-pentanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-hexanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-heptanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-octanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-nonanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-decanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-undecanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-dodecanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-tridecanediol plus tocopherol or a derivative thereof,        and/or vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   2,3-pentanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof        and/or Zingiber Officinale (Ginger) Root Extract; or    -   2,3-hexanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   2,3-heptanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   2,3-octanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   2,3-nonanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   2,3-decanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   2,3-undecanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   2,3-dodecanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   2,3-tridecanediol plus tocopherol or a derivative thereof,        and/or vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-heptanediol in combination with 2,3-heptanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-heptanediol in combination with one or more of        1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol or        1,2-tridecanediol, plus tocopherol or a derivative thereof,        and/or vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-heptanediol in combination with one or more of        2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol,        2,3-octanediol, 2,3-nonanediol, 2,3-decanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-hexanediol in combination with 2,3-hexanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-octanediol in combination with 2,3-octanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-nonanediol in combination with 2,3-nonanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-decanediol in combination with 2,3-decanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-undecanediol in combination with 2,3-undecanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-dodecanediol in combination with 2,3-dodecanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-tridecanediol in combination with 2,3-tridecanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; ortocopherol and/or vitamin A        and/or carnosine; or    -   1,3-octanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,3-nonanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,3-decanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,3-undecanediol plus tocopherol or a derivative thereof, and/or        vitamin A or a derivative thereof, and/or vitamin C or a        derivate thereof, and/or carnosine or a derivative thereof,        and/or Zingiber Officinale (Ginger) Root Extract; or    -   1,2-hexanediol in combination with 2,3-octanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-octanediol in combination with 2,3-hexanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-octanediol in combination with 2,3-heptanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-pentanediol in combination with 2,3-hexanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-pentanediol in combination with 1,2-heptanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-pentanediol in combination with 2,3-heptanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-pentanediol in combination with 2,3-octanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-pentanediol in combination with 1,2-nonanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-pentanediol in combination with 2,3-nonanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-heptanediol in combination with 1,2-octanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-heptanediol in combination with 2,3-octanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-heptanediol in combination with 1,2-nonanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract; or    -   1,2-heptanediol in combination with 2,3-nonanediol plus        tocopherol or a derivative thereof, and/or vitamin A or a        derivative thereof, and/or vitamin C or a derivate thereof,        and/or carnosine or a derivative thereof, and/or Zingiber        Officinale (Ginger) Root Extract.        Alternatively, in the above combinations the b) component for        the antioxidant can also be dimethylmethoxy chromanol.

Still more preferred combinations of component (a) and (b) in thecosmetic, pharmaceutical composition or homecare product according tothe first or second aspect of the present invention are:

-   -   1,2-pentanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-hexanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-heptanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-octanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-nonanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-decanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-undecanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-dodecanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-tridecanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   2,3-pentanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   2,3-hexanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   2,3-heptanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   2,3-octanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   2,3-nonanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   2,3-decanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   2,3-undecanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   2,3-dodecanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   2,3-tridecanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-heptanediol in combination with 2,3-heptanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-heptanediol in combination with one or more of        1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol or        1,2-tridecanediol, plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-heptanediol in combination with one or more of        2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol,        2,3-octanediol, 2,3-nonanediol, 2,3-decanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-hexanediol in combination with 2,3-hexanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-octanediol in combination with 2,3-octanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-nonanediol in combination with 2,3-nonanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-decanediol in combination with 2,3-decanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-undecanediol in combination with 2,3-undecanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-dodecanediol in combination with 2,3-dodecanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-tridecanediol in combination with 2,3-tridecanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,3-octanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,3-nonanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,3-decanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,3-undecanediol plus hydroxyphenyl propamidobenzoic acid        (dihydroavenanthramide D), and/or cannabinoids, and/or        cannabidiol and its extracts (Cannabis sativa seed oil, Cannabis        sativa extract), and/or cannabinol; or    -   1,2-hexanediol in combination with 2,3-octanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-octanediol in combination with 2,3-hexanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-octanediol in combination with 2,3-heptanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-pentanediol in combination with 2,3-hexanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-pentanediol in combination with 1,2-heptanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-pentanediol in combination with 2,3-heptanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-pentanediol in combination with 2,3-octanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-pentanediol in combination with 1,2-nonanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-pentanediol in combination with 2,3-nonanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-heptanediol in combination with 1,2-octanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-heptanediol in combination with 2,3-octanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-heptanediol in combination with 1,2-nonanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol; or    -   1,2-heptanediol in combination with 2,3-nonanediol plus        hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),        and/or cannabinoids, and/or cannabidiol and its extracts        (Cannabis sativa seed oil, Cannabis sativa extract), and/or        cannabinol.        Alternatively, in the above combinations the b) component for        the antioxidant can also be dimethylmethoxy chromanol.

In a most preferred variant, the cosmetic or pharmaceutical compositionor homecare product according to the first or second aspect of thepresent invention comprises one of the following combinations ofcomponents (a) and (b):

-   -   1,2-hexanediol plus tocopherol or a derivative thereof; or    -   1,2-heptanediol plus tocopherol or a derivative thereof; or    -   1,2-octanediol plus tocopherol or a derivative thereof; or    -   1,2-nonanediol plus tocopherol or a derivative thereof; or    -   1,2-decanediol plus tocopherol or a derivative thereof; or    -   1,2-undecanediol plus tocopherol or a derivative thereof; or    -   1,2-dodecanediol plus tocopherol or a derivative thereof; or    -   1,2-tridecanediol plus tocopherol or a derivative thereof; or    -   2,3-hexanediol plus tocopherol or a derivative thereof; or    -   2,3-heptanediol plus tocopherol or a derivative thereof; or    -   2,3-octanediol plus tocopherol or a derivative thereof; or    -   2,3-nonanediol plus tocopherol or a derivative thereof; or    -   2,3-decanediol plus tocopherol or a derivative thereof; or    -   2,3-undecanediol plus tocopherol or a derivative thereof; or    -   2,3-dodecanediol plus tocopherol or a derivative thereof; or    -   2,3-tridecanediol plus tocopherol or a derivative thereof; or    -   1,2-heptanediol in combination with 2,3-heptanediol plus        tocopherol or a derivative thereof; or    -   1,2-heptanediol in combination with one or more of        1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol, 1,2-nonanediol,        1,2-decanediol, 1,2-undecanediol, 1,2-dodecanediol or        1,2-tridecanediol, plus tocopherol or a derivative thereof; or    -   1,2-heptanediol in combination with one or more of        2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol,        2,3-octanediol, 2,3-nonanediol, 2,3-decanediol,        2,3-undecanediol, 2,3-dodecanediol, or 2,3-tridecanediol plus        tocopherol or a derivative thereof; or    -   1,2-hexanediol in combination with 2,3-hexanediol plus        tocopherol or a derivative thereof; or    -   1,2-octanediol in combination with 2,3-octanediol plus        tocopherol or a derivative thereof; or    -   1,2-nonanediol in combination with 2,3-nonanediol plus        tocopherol or a derivative thereof; or    -   1,2-decanediol in combination with 2,3-decanediol plus        tocopherol or a derivative thereof; or    -   1,2-undecanediol in combination with 2,3-undecanediol plus        tocopherol or a derivative thereof; or    -   1,2-dodecanediol in combination with 2,3-dodecanediol plus        tocopherol or a derivative thereof; or    -   1,2-tridecanediol in combination with 2,3-tridecanediol plus        tocopherol or a derivative thereof; or    -   1,3-octanediol plus tocopherol or a derivative thereof; or    -   1,3-nonanediol plus tocopherol or a derivative thereof; or    -   1,3-decanediol plus tocopherol or a derivative thereof; or    -   1,3-undecanediol plus tocopherol or a derivative thereof; or    -   1,2-hexanediol in combination with 2,3-octanediol plus        tocopherol or a derivative thereof; or    -   1,2-octanediol in combination with 2,3-hexanediol plus        tocopherol or a derivative thereof; or    -   1,2-octanediol in combination with 2,3-heptanediol plus        tocopherol or a derivative thereof; or    -   1,2-pentanediol in combination with 2,3-hexanediol plus        tocopherol or a derivative thereof; or    -   1,2-pentanediol in combination with 1,2-heptanediol plus        tocopherol or a derivative thereof; or    -   1,2-pentanediol in combination with 2,3-heptanediol plus        tocopherol or a derivative thereof; or    -   1,2-pentanediol in combination with 2,3-octanediol plus        tocopherol or a derivative thereof; or    -   1,2-pentanediol in combination with 1,2-nonanediol plus        tocopherol or a derivative thereof; or    -   1,2-pentanediol in combination with 2,3-nonanediol plus        tocopherol or a derivative thereof; or    -   1,2-heptanediol in combination with 1,2-octanediol plus        tocopherol or a derivative thereof; or    -   1,2-heptanediol in combination with 2,3-octanediol plus        tocopherol or a derivative thereof; or    -   1,2-heptanediol in combination with 1,2-nonanediol plus        tocopherol or a derivative thereof; or    -   1,2-heptanediol in combination with 2,3-nonanediol plus        tocopherol or a derivative thereof.        Alternatively, in the above combinations the b) component for        the antioxidant can also be dimethylmethoxy chromanol.

Of the above combinations, the combinations with 1,2-heptanediol,1,2-octanediol or 2,3-alkanediols, in particular 2,3-heptanediole or2,3-octanediole, or mixtures comprising a 1,2-alkanediol and a2,3-alkanediol, especially a mixture including 1,2-heptanediol and2,3-heptanediol or a mixture including 1,2-octanediol and 2,3-octanediolresult in distinguished antioxidant performance, as it is demonstratedby the following examples.

The above-defined specific combinations of components (a) and (b) can becombined again with one or more further component(s) as described lateron.

The cosmetic or pharmaceutical, in particular dermatological,composition as defined herein, are preferably based on a carrier, whichcomprises at least one oil phase. However, preparations solely based onwater or water/alcohol or water/glycol are likewise possible or evenpreferred.

The oil phase or oil component in the cosmetic or pharmaceutical,preferably dermatological, composition according to the presentinvention which may be suitable are for example plant oils,hydrocarbons, fatty alcohols, fatty acid esters, liquid UV filters, ormixtures of two or more of the aforesaid oil components.

The oil phase or oil component in the cosmetic or pharmaceutical,preferably dermatological, composition according to the presentinvention is preferably a plant oil and even more preferably a liquidplant oil. It can also advantageously be a mixture of two or more plantoils components, especially liquid plant oil mixtures.

Plant oils or vegetable oils are oils extracted from seeds, or lessoften, from other parts of fruits. Like animal fats, plant oils aremixtures of triglycerides. Soybean oil, rapeseed oil and cocoa butterare examples of plant oils from seeds. Olive oil, palm oil and rice branoil are examples of oils from other parts of fruits. In common usage,plant oil or vegetable oil may refer exclusively to vegetable fats whichare liquid at room temperature or at 35 to 37° C. skin temperature.Vegetable oils are usually edible.

The term “plant oils” also includes unsaturated plant oils. Unsaturatedoils or vegetable oils can be transformed through partial or complete“hydrogenation” into oils of higher melting point. The hydrogenationprocess involves “sparging” the oil at high temperature and pressurewith hydrogen in the presence of a catalyst, typically a powdered nickelcompound. As each carbon-carbon double-bond is chemically reduced to asingle bond, two hydrogen atoms each form single bonds with the twocarbon atoms. The elimination of double bonds by adding hydrogen atomsis called saturation; as the degree of saturation increases, the oilprogresses toward being fully hydrogenated. An oil may be hydrogenatedto increase resistance to rancidity (oxidation) or to change itsphysical characteristics. As the degree of saturation increases, theoil's viscosity and melting point increase.

In a preferred variant, the plant oil is selected from the groupconsisting of Persea Gratissima (Avocado Oil), Abies Alba Seed Oil,Acacia Victoriae Seed Oil, Actinidia Chinensis (Kiwi) Seed Oil,Amaranthus Hypochondriacus Seed Oil, Arachis Hypogaea (Peanut) Oil,Astrocaryum Murumuru Seed Butter, Astrocaryum Tucuma Seed Butter,Astrocaryum Tucuma Seed Oil, Astrocaryum Vulgare Fruit Oil, AstrocaryumVulgare Kernel Oil, Avena Sativa (Oat) Kernel Oil, Brassica Alba SeedOil, Brassica Campestris (Rapeseed) Seed Oil, Butyrospermum Parkii(Shea) Butter, Butyrospermum Parkii (Shea) Oil, Calendula OfficinalisSeed Oil, Calophyllum Inophyllum Seed Oil, Calophyllum Tacamahaca SeedOil, Camellia Oleifera Seed Oil, Camellia Reticulata Seed Oil, CamelliaSinensis Seed Oil, Cannabis Sativa Seed Oil, Cannabis Sativa Seed/StemOil, Canola Oil, Carthamus Tinctorius (Safflower) Seed Oil, ChlorellaVulgaris Oil, Citrullus Lanatus (Watermelon) Seed Oil, CitrusAurantifolia (Lime) Seed Oil, Citrus Aurantium Dulcis (Orange) Seed Oil,Citrus Grandis (Grapefruit) Seed Oil, Cocos Nucifera (Coconut) Oil,Cocos Nucifera (Coconut) Seed Butter, Coffea Arabica (Coffee) Seed Oil,Chlorella Oil (biotech), Corylus Americana (Hazelnut) Seed Oil, CorylusAvellana (Hazelnut) Seed Oil, Cucumis Melo (Melon) Seed Oil, CucumisSativus (Cucumber) Seed Oil, Cucurbita Pepo (Pumpkin) Seed Oil, ElaeisGuineensis (Palm) Oil, Elaeis (Palm) Fruit Oil, Glycine Soja (Soybean)Oil, Gossypium Herbaceum (Cotton) Seed Oil, Gossypium Hirsutum (Cotton)Seed Oil, Helianthus Annuus (Sunflower) Seed Oil, Macadamia IntegrifoliaSeed Oil, Macadamia Ternifolia Seed Oil, Mangifera Indica (Mango) SeedButter, Mangifera Indica (Mango) Seed Oil, Melissa Officinalis Seed Oil,Microalgae Oil, Moringa Oleifera Seed Oil, Moringa Peregrina Seed Oil,Oenothera Biennis (Evening Primrose) Oil, Olea Europaea (Olive) FruitOil, Olus Oil, Orbignya Oleifera Seed Oil, Orbignya Speciosa Kernel Oil,Oryza Sativa (Rice) Bran/Germ Oil, Oryza Sativa (Rice) Bran Oil, OryzaSativa (Rice) Germ Oil, Oryza Sativa (Rice) Lipids, Oryza Sativa (Rice)Seed Oil, Papaver Somniferum Seed Oil, Passiflora Edulis Seed Oil,Persea Gratissima (Avocado) Butter, Persea Gratissima (Avocado) Oil,Prunus Amygdalus Dulcis (Sweet Almond) Oil, Prunus Armeniaca (Apricot)Kernel Oil, Prunus Persica (Peach) Kernel Oil, Punica Granatum Seed Oil,Pyrus Malus (Apple) Seed Oil, Ricinoleic/Caproic/Caprylic/CapricTriglyceride(s), Ricinus Communis (Castor) Seed Oil, Rosa Canina FruitOil, Rosa Moschata Seed Oil, Rubus Idaeus (Raspberry) Seed Oil, SesamumIndicum (Sesame) Seed Butter, Soybean Glycerides, Theobroma Cacao(Cocoa) Seed Butter, Theobroma Grandiflorum Seed Butter, TriticumVulgare (Wheat) Bran Lipids, Triticum Vulgare (Wheat) Germ Oil, VitisVinifera (Grape) Seed Oil, Zea Mays (Corn) Germ Oil, and Zea Mays (Corn)Oil.

In a particular preferred variant, the cosmetic or pharmaceutical,preferably dermatological, composition according to the first aspect orthe second aspect of the present invention comprises as oil component aplant oil, selected from the group consisting of Caprylic CapricTriglycerides, Helianthus Annuus (Sunflower) Seed Oil, SimmondsiaChinensis ((Jojoba) Seed Oil, Olea Europaea (Olive) Fruit Oil, Arganiaspinosa kernel oil (Argan oil), Prunus Amygdalus Dulcis (Sweet Almond)Oil, Persea Gratissima (Avocado Oil), Butyrospermum Parkii (Shea)Butter, Cocos Nucifera (Coconut) Oil, Theobroma Cacao (Cocoa) SeedButter, and mixtures of two or more of the aforesaid plant oils.

The plant oil can be used either as a single component or in mixturewith one or more further different plant oil(s) as specified above.

Hydrocarbons (mineral oils) are in general organic compounds consistingentirely of hydrogen and carbon. As defined by IUPAC nomenclature ororganic chemistry, the classifications for hydrocarbons are:

-   -   1. Saturated hydrocarbons are the simplest of the hydrocarbon        species. They are composed entirely of single bonds and are        saturated with hydrogen. The formula for acyclic saturated        hydrocarbons (i.e., alkanes) is C_(n)H_(2n+2). The most general        form of saturated hydrocarbons is C_(n)H_(2n+2(1−r)), where r is        the number of rings. Those with exactly one ring are the        cycloalkanes. Saturated hydrocarbons are the basis of petroleum        fuels and are found as either linear or branched species.    -   2. Unsaturated hydrocarbons have one or more double or triple        bonds between carbon atoms. Those with double bond are called        alkenes. Those with one double bond have the formula C_(n)H₂n        (assuming non-cyclic structures). Those containing triple bonds        are called alkynes. Those with one triple bond have the formula        C_(n)H_(2 n−2).    -   3. Aromatic hydrocarbons, also known as arenes, are hydrocarbons        that have at least one aromatic ring.

Hydrocarbons can be inter alia liquids (e.g. hexane and benzene), waxesor low melting solids (e.g. paraffin wax and naphthalene). The term‘aliphatic’ refers to non-aromatic hydrocarbons. Saturated aliphatichydrocarbons are sometimes referred to as “paraffins”. Mineral oils andwaxes are mixtures of predominantly saturated hydrocarbons consisting ofstraight-chain, branched and ring structures with carbon chain lengthsgreater than C14. Mineral oils and waxes are chemical substancesprepared from naturally occurring crude petroleum oil. They mainlyconsist of mineral oil saturated hydrocarbons (MOSH) and mineral oilaromatic hydrocarbons (MOAN). Hydrocarbons have been used for manydecades in skin and lip care cosmetic products due to their excellentskin tolerance as well as their high protecting and cleansingperformance and broad viscosity options. In contrast to vegetable oils,mineral oils are non-allergenic since they are highly stable and notsusceptible to oxidation or rancidity.

In a preferred variant, the hydrocarbon as the oil component of thecosmetic or pharmaceutical, preferably dermatological, composition ofthe present invention is selected from the group consisting of undecane,tridecane, mineral oil, petrolatum, squalane, isohexadecane, C7-C8isoparaffin, C8-C9 isoparaffin, C9-C11 isoparaffin, C9-C12 isoparaffin,C9-C13 isoparaffin, C9-C14 isoparaffin, C9-C16 isoparaffin, C10-C11isoparaffin, C10-C12 isoparaffin, C10-C13 isoparaffin, C11-C12isoparaffin, C11-C13 isoparaffin, C11-C14 isoparaffin, C12-C14isoparaffin, C12-C15 isoparaffin, C12-C20 isoparaffin, C13-C14isoparaffin, C13-C16 isoparaffin, C14-C16 isoparaffin, C15-C19isoparaffin, and C18-C70 isoparaffin.

In a particular preferred variant, the oil component of the cosmetic orpharmaceutical, preferably dermatological, composition of the presentinvention is a hydrocarbon selected from the group consisting ofhydrocarbons, petrolatum, squalane, isohexadecane, C13-C14 isoparaffin,and mixtures of two or more of the aforesaid hydrocarbons.

The hydrocarbon can be used either as a single component or in mixturewith one or more further different hydrocarbon(s) as specified above.

A fatty alcohol (or long-chain alcohol) is usually ahigh-molecular-weight, straight-chain primary alcohol, but can alsorange from as few as 4 to 6 carbons to as many as 22 to 26, derived fromnatural fats and oils. The precise chain length varies with the source.Some commercially important fatty alcohols are lauryl, stearyl and oleylalcohols. They are colourless oily liquids (for smaller carbon numbers)or waxy solids, although impure samples may appear yellow. Fattyalcohols usually have an even number of carbon atoms and a singlealcohol group (—OH) attached to the terminal carbon. Some areunsaturated and some are branched. Most fatty alcohols in nature arefound as waxes which are esters with fatty acids and fatty alcohols. Thetraditional sources of fatty alcohols have largely been variousvegetable oils and these remain a large-scale feedstock. The alcoholsare obtained from the triglycerides (fatty acid triesters), which formthe bulk of the oil. The process involves the transesterification of thetriglycerides to give methyl esters which are then hydrogenated to givethe fatty alcohols. Fatty alcohols are also prepared from petrochemicalsources. In the Ziegler process, ethylene is oligomerized usingtriethylaluminium followed by air oxidation. Alternatively, ethylene canbe oligomerized to give mixtures of alkenes, which are subjected tohydroformylation, this process affording odd-numbered aldehyde, which issubsequently hydrogenated. Fatty alcohols are mainly used in theproduction of detergents and surfactants. They are components also ofcosmetic solvents. They find use as co-emulsifiers, emollients andthickeners in cosmetics.

In a preferred variant, the fatty alcohol as the oil component of thecosmetic or pharmaceutical, preferably dermatological, composition ofthe present invention is selected from the group consisting of phenylpropanol, dimethyl phenylbutanol, hexyldecanol, octyldodecanol,octyldecanol, tridecylalcohol, isostearyl alcohol, phenylisohexanol,phenylpropanol, trimethylbenzenepropanol, isoamylalcohol, isostearylalcohol, and isotridecyl alcohol.

The fatty alcohol can be used either as a single component or in mixturewith one or more further different fatty alcohol(s) as specified above.

A fatty acid ester is a type of ester that results from the combinationof a fatty acid with an alcohol. When the alcohol component is glycerol,the fatty acid esters produced can be monoglycerides, diglycerides ortriglycerides. Fatty acid esters have a conditioning effect of softeningthe skin to create a smoothing sensation. They are also added tocosmetics to dissolve high-polarity active ingredients and UV absorbers.Esters of straight-chain fatty acids and lower alcohols are effectivefor dissolving slightly soluble ingredients for oils with a light touchduring application. Isostearic acids and other liquid oils with branchedfatty acids and unsaturated fatty acids are commonly used as emollients.Higher fatty acid esters and esters of higher alcohols with relativelyhigh melting points are added to skin creams to adjust the applicationtouch.

In a preferred variant, the fatty acid ester as the oil component of thecosmetic or pharmaceutical, preferably dermatological, composition ofthe present invention is selected from the group consisting of C12-C15Alkyl Benzoate, Capric/Lauric/Myristic/Oleic Triglyceride,Caprylic/Capric Triglyceride, Caprylic/Capric/Lauric Triglyceride,Caprylic/Capric/Linoleic Triglyceride, Caprylic/Capric/Myristic/StearicTriglyceride, Caprylic/Capric/Palmitic/Stearic Triglyceride,Caprylic/Capric/Stearic Triglyceride, Caprylic/Capric/SuccinicTriglyceride, Caprylyl Caprylate, Cetearyl Ethylhexanoate, CetearylIsononanoate, Cetearyl Nonanoate, Coco-Caprylate, Decyl Cocoate, DecylOleate, Dicaprylyl Carbonate, Diethyl Succinate, Diethylhexyl2,6-Naphthalate, Diethylhexyl Carbonate, Dibutyl Adipate, DiisopropylAdipate, Dipropylheptyl Carbonate, Ethyl Laurate, EthylhexylIsononanoate, Ethylhexyl Palmitate, Ethylhexyl Stearate, GlycerylCaprylate Caprate, Glyceryl Caprylate, Glyceryl Laurate, GlycerylTriacetyl Hydroxystearate, Glyceryl Triacetyl Ricinoleate, HexylLaurate, Isoamyl acetate, Isoamyl Cocoate, Isopropyl Palmitate,Isosorbide Dicaprylate, Isopropyl Myristate, Myristyl Myristate,Oleic/Linoleic Triglyceride, Oleic/Palmitic Triglyceride,Oleic/Palmitic/Lauric/Myristic/Linoleic Triglyceride, PropanediolCaprylate, Ricinoleic/Caproic/Caprylic/Capric Triglyceride,Oleostearine, Oleyl Erucate, Palmitic/Stearic Triglyceride, PropanediolDicaprylate Caprate, Propylheptyl Caprylate, Stearyl Heptanoate/StearylCaprylate, Triheptanoin, Trihydroxystearin, Triisononanoin,Triisopalmitin, Triisostearin, Trilaurin, Trilinolein, Trilinolenin,Trimyristin, Triolein, Tripalmitin, Tripalmitolein, Tripelargonin,Triricinolein, and Tristearin.

In a particular preferred variant, the oil component of the cosmetic orpharmaceutical, preferably dermatological, composition of the presentinvention is a fatty acid ester selected from the group consisting ofC12-C15 Alkyl Benzoate, Caprylic/Capric Triglyceride, CaprylylCaprylate, Cetearyl Ethylhexanoate, Cetearyl Isononanoate, CetearylNonanoate, Coco-Caprylate, Decyl Cocoate, Decyl Oleate, DicaprylylCarbonate, Diethylhexyl 2,6-Naphthalate, Dibutyl Adipate, DiisopropylAdipate, Ethyl Laurate, Ethylhexyl Isononanoate, Ethylhexyl Palmitate,Ethylhexyl Stearate, Glyceryl Caprylate, Glyceryl Laurate, HexylLaurate, Isoamyl Cocoate, Isopropyl Palmitate, Isopropyl Myristate,Myristyl Myristate, Propanediol Caprylate, Oleyl Erucate,Palmitic/Stearic Triglyceride, Propanediol Dicaprylate Caprate,Trihydroxystearin, Triisostearin, Triisononanoin, Tristearin, andmixtures of two or more of the aforesaid fatty acid esters.

The fatty acid ester can be used either as a single component or inmixture with one or more further different fatty acid ester(s) asspecified above.

An UV filter is a compound or a mixture of compounds that block orabsorb ultraviolet (UV) light. Since excessive UV radiation can causesunburn, photoaging, and skin cancer, care products such as sunscreenusually include a classification for the specific wavelengths theyfilter. UV classifications include UVA (320-400 nm), UVB (290-320 nm)and UVC (200-280 nm). UV-absorbing compounds are used not only insunscreen, but also in other personal care products, such as lipstick,shampoo, hair spray, body wash, toilet soap, and insect repellent.Chemical filters protect against UV radiation by absorbing, reflecting,or scattering. Reflection and scattering are accomplished by inorganicphysical UV filters, such as titanium dioxide (TiO₂) and zinc oxide(ZnO). Absorption, mainly of UVB, is done by organic UV filters, whichare known as chemical UV filters.

In a preferred variant, the liquid UV filter as the oil component of thecosmetic or pharmaceutical, preferably dermatological, composition ofthe present invention is selected from the group consisting ofOctocrylene, Ethylhexyl Salicylate, Homosalate, EthylhexylMethoxycinnamate, Isoamyl p-Methoxycinnamate, Camphor BenzalkoniumMethosulfate, Polyarylamidomethyl Benzylidene Camphor, IsooctylMethoxycionnamate, Ethylhexyl Triazone, Drometrizole Trisiloxane,Diethylhexyl Butamido Triazone, 3-Benzylidene Camphor, Octyl Salicylate,Ethylhexyl Dimethyl PABA, Bis-Ethylhexyloxyphenol MethoxyphenylTriazine, Polysilicone-15, Diethylamino Hydroxybenzoyl Hexyl benzoate,N,N,N-Trimethyl-4-(2-oxoborn-3-ylidenemethyl) anilinium methyl sulfate,Benzoic acid-2-hydroxy-3,3,5-trimethylcyclohexyl ester/Homosalate,2-Cyano-3,3-diphenyl acrylic acid, 2-Ethylhexyl ester/Octocrilene,2-Ethylhexyl-4-m ethoxycinnamate/Octinoxate, EthoxylatedEthyl-4-aminobenzoate, 2-Ethylhexyl salicylate/Octisalate,2-Ethylhexyl-4-(dimethylamino)benzoate/Padimate 0 (USAN: BAN),2,2′-Methylene-bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethyl-butyl)phenol)/Bisoctrizole,and Dimethicodiethylbenzalmalonate. The UV filter can be used either asa single component or in mixture with one or more further different UVfilter (s) as specified above.

In a particular preferred variant the oil component of the cosmetic orpharmaceutical, preferably dermatological, composition of the presentinvention is a liquid UV filter selected from the group consisting ofOctocrylene, Ethylhexyl Salicylate, Homosalate, EthylhexylMethoxycinnamate, Isoamyl p-Methoxycinnamate,N,N,N-Trimethyl-4-(2-oxoborn-3-ylidenemethyl) anilinium methyl sulfate,Benzoic acid-2-hydroxy-3,3,5-trimethylcyclohexyl ester/Homosalate,2-Cyano-3,3-diphenyl acrylic acid, 2-Ethylhexyl ester/Octocrilene,2-Ethylhexyl-4-methoxycinnamate/Octinoxate, EthoxylatedEthyl-4-aminobenzoate, 2-Ethylhexyl salicylate/Octisalate,2-Ethylhexyl-4-(dimethylamino)benzoate/Padimate 0 (USAN: BAN),2,2′-Methylene-bis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethyl-butyl)phenol)/Bisoctrizole,Dimethicodi-ethylbenzalmalonate, and mixtures of two or more of theaforesaid UV filters.

In addition to the oil phase or oil component as defined before, thecosmetic or pharmaceutical, preferably dermatological, compositionaccording to the present invention preferably includes one or morefurther oil bodies. Suitable oil bodies, which form constituents of theO/W emulsions, are, for example, Guerbet alcohols based on fattyalcohols having 6 to 18, preferably 8 to 10, carbon atoms, esters oflinear C5-C22 fatty acids with linear or branched C5-C22 fatty alcoholsor esters of branched C1-C13 carboxylic acids with linear or branchedC6-C22 fatty alcohols, such as, for example, myristyl myristate,myristyl palmitate, myristyl stearate, myristyl isostearate, myristyloleate, myristyl behenate, myristyl erucate, cetyl myristate, cetylpalmitate, cetyl stearate, cetyl isostearate, cetyl oleate, cetylbehenate, cetyl erucate, stearyl myristate, stearyl palmitate, stearylstearate, stearyl isostearate, stearyl oleate, stearyl behenate, stearylerucate, isostearyl myristate, isostearyl palmitate, isostearylstearate, isostearyl isostearate, isostearyl oleate, isostearylbehenate, isostearyl oleate, oleyl myristate, oleyl palmitate, oleylstearate, oleyl isostearate, oleyl oleate, oleyl behenate, oleylerucate, behenyl myristate, behenyl palmitate, behenyl stearate, behenylisostearate, behenyl oleate, behenyl behenate, behenyl erucate, erucylmyristate, erucyl palmitate, erucyl stearate, erucyl isostearate, erucyloleate, erucyl behenate and erucyl erucate. Also suitable are esters oflinear C6-C22 fatty acids with branched alcohols, in particular2-ethylhexanol, esters of C18-C38 alkylhydroxy carboxylic acids withlinear or branched C6-C22 fatty alcohols, in particular Dioctyl Malate,esters of linear and/or branched fatty acids with polyhydric alcohols(such as, for example, propylene glycol, dimerdiol or trimertriol)and/or Guerbet alcohols, triglycerides based on C6-C10 fatty acids,liquid mono-/di-/triglyceride mixtures based on C6-C18 fatty acids,esters of C6-C22 fatty alcohols and/or Guerbet alcohols with aromaticcarboxylic acids, in particular benzoic acid, esters of C2-C12dicarboxylic acids with linear or branched alcohols having 1 to 22carbon atoms or polyols having 2 to 10 carbon atoms and 2 to 6 hydroxylgroups, vegetable oils, branched primary alcohols, substitutedcyclohexanes, linear and branched CC-C22 fatty alcohol carbonates, suchas, for example, Dicaprylyl Carbonate (Cetiol® CC), Guerbet carbonates,based on fatty alcohols having 6 to 18, preferably 8 to 10, carbonatoms, esters of benzoic acid with linear and/or branchedC₆-C₂₂-alcohols (e.g. Finsolv® TN), linear or branched, symmetrical orasymmetrical dialkyl ethers having 6 to 22 carbon atoms per alkyl group,such as, for example, dicaprylyl ether (Cetiol® OE), ring-openingproducts of epoxidized fatty acid esters with polyols, silicone oils(cyclomethicones, silicone methicone grades, etc.) and/or aliphatic ornaphthenic hydrocarbons, such as, for example, squalane, squalene ordialkylcyclohexanes.

Within the context of the present invention, it is also possible and insome cases advantageous, to combine the cosmetic or pharmaceutical, inparticular dermatological, composition according to the first or secondaspect of the present invention with other active substances, adjuvantsor additives. The cosmetically or pharmaceutically active agents and/oradjuvants and/or additives can in some instances provide one or morethan one benefit or operate via more than one mode of action.

Thus, optionally, other conventional cosmetically and/orpharmaceutically active substances, adjuvants or additives, as furtherdescribed below, may be added as component (c), i.e., in order to obtaina ready-for-use cosmetic or pharmaceutical, preferably dermatological,composition or formulation.

The cosmetic or pharmaceutical, preferably dermatologi-cal, compositionaccording to the present invention can advantageously be combined withother cosmetically or pharmaceutically active agents and/or adjuvantsand/or additives or auxiliaries, such as are customarily used in suchcompositions, such as for example abrasives, anti-acne agents, agentsagainst ageing of the skin, anti-cellulitis agents, anti-dandruffagents, anti-inflammatory agents, anti-microbial agents,irritation-preventing agents, irritation-inhibiting agents,antioxidants, astringents, odor absorbers, perspiration-inhibitingagents, antiseptic agents, anti-statics, binders, buffers, carriermaterials, chelating agents, cell stimulants, cleansing agents,depilatory agents, surface-active substances, deodorizing agents,antiperspirants, softeners, emulsifiers, enzymes, enzyme inhibitors,essential oils, fibers, film-forming agents, fixatives, foam-formingagents, foam stabilizers, substances for preventing foaming, foamboosters, gelling agents, gel-forming agents, hair care agents,hair-setting agents, hair-straightening agents, moisture-donatingagents, moisturizing substances, moisture-retaining substances,bleaching agents, strengthening agents, stain-removing agents, opticallybrightening agents, impregnating agents, dirt-repellent agents, dyes,friction-reducing agents, lubricants, moisturizing creams, ointments,opacifying agents, plasticizing agents, covering agents, polish,preservatives, gloss agents, green and synthetic polymers, powders,proteins, re-oiling agents, abrading agents, silicones, skin-soothingagents, skin-cleansing agents, skin care agents, skin-healing agents,skin-lightening agents, skin-protecting agents, skin-softening agents,hair promotion agents, cooling agents, skin-cooling agents, warmingagents, skin-warming agents, stabilizers, surfactants, UV-absorbingagents, UV filters, primary sun protection factors, secondary sunprotection factors, detergents, fabric conditioning agents, suspendingagents, skin-tanning agents, actives modulating skin or hairpigmentation, matrix metalloproteinase inhibitors, skin moisturizingagents, glycosaminoglycan stimulators, TRPV1 antagonists, desquamatingagents, anti-cellulite agents or fat enhancing agents, hair growthactivators or inhibitors, thickeners, rheology additives, vitamins,oils, waxes, pearlizing waxes, fats, phospholipids, saturated fattyacids, mono- or polyunsaturated fatty acids, α-hydroxy acids,polyhydroxy fatty acids, liquefiers, dyestuffs, colour-protectingagents, pigments, anti-corrosives, fragrances or perfume oils, aromas,flavouring substances, odoriferous substances, polyols, electrolytes,organic solvents, and mixtures of two or more of the aforementionedsubstances, as further described below.

Of the above cosmetically or pharmaceutically active agents and/oradjuvants and/or additives or auxiliary agents against ageing of theskin, anti-microbial agents, chelating agents, emulsifiers, surfactants,preservatives, green and synthetic polymers, skin-cooling agents,rheology additives, oils, fragrances or perfume oils, and polyols areparticularly preferred in the preparation of cosmetic and pharmaceuticalcomposition.

Since dermatological conditions or diseases are often associated withdry skin, scratched skin, skin lesions or even inflammation, thecosmetic or pharmaceutical, preferably dermatological, compositionaccording to the present invention advantageously contains preferablyanti-inflammatories, antibacterial or antimycotic substances, substanceshaving a reddening-alleviating or itch-alleviating action, lenitivesubstances, moisturisers and/or cooling agents, osmolytes, keratolyticsubstances, nurturing substances, anti-inflammatory, antibacterial orantimycotic substances, substances having a reddening-alleviating oritch-alleviating action, lenitive substances, anti-dandruff substances,or other active compounds such as solvents, fragrances, antioxidants,preservatives, (metal) chelating agents, penetration enhancers, ormixtures of two or more of afore specified agents, as further describedbelow.

Anti-ageing actives: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present inventionpreferably contains one or more anti-ageing actives. In the context ofthe invention, anti-ageing or biogenic agents are, for exampleantioxidants, matrix metalloproteinase inhibitors (MMPI), skinmoisturizing agents, glycosaminglycan stimulators, anti-inflammatoryagents, TRPV1 antagonists and plant extracts.

Matrix Metalloproteinase Inhibitors (MMPI): A preferred cosmetic orpharmaceutical, preferably dermatological, composition according to thepresent invention comprises one or more matrix metalloproteinaseinhibitors, especially those inhibiting matrix metalloproteinasesenzymatically cleaving collagen, selected from the group consisting ofursolic acid, retinyl palmitate, propyl gallate, precocenes,6-hydroxy-7-m ethoxy-2,2-dimethyl-1(2H)-benzopyran,3,4-dihydro-6-hydroxy-7-m eth-oxy-2,2-dimethyl-1(2H)-benzopyran,benzamidine hydrochloride, the cysteine proteinase inhibitorsN-ethylmalemide and epsilon-amino-n-caproic acid of the serinproteaseinhibitors: phenylmethylsufonylfluoride, collhibin (company Pentapharm;INCI: hydrolysed rice protein), oenotherol (company Soliance; INCI:propylene glycol, aqua, Oenothera biennis root extract, ellagic acid andellagitannins, for example from pomegranate), phosphoramidonehinokitiol, EDTA, galardin, EquiStat (company Collaborative Group; applefruit extract, soya seed extract, ursolic acid, soya isoflavones andsoya proteins), sage extracts, MDI (company Atrium; INCI:glycosaminoglycans), fermiskin (company Silab/Mawi; INCI: water andlentinus edodes extract), actimp 1.9.3 (company Expanscience/Rahn; INCI:hydrolysed lupine protein), lipobelle soyaglycone (company Mibelle;INCI: alcohol, polysorbate 80, lecithin and soy isoflavones), extractsfrom green and black tea and further plant extracts, proteins orglycoproteins from soya, hydrolysed proteins from rice, pea or lupine,plant extracts which inhibit MMPs, preferably extracts from shitakemushrooms, extracts from the leaves of the Rosaceae family, sub-familyRosoideae, quite particularly extracts of blackberry leaf, as e.g.SymMatrix (company Symrise, INCI: Maltodextrin, Rubus Fruticosus(Blackberry) Leaf Extract). Preferred actives of are selected from thegroup consisting of retinyl palmitate, ursolic acid, extracts from theleaves of the Rosaceae family, sub-family Rosoideae, genistein anddaidzein.

Skin-moisturizing agents: A preferred cosmetic or pharmaceutical,preferably dermatological, composition according to the presentinvention comprises one or more skin-moisturizing agents. Preferred skinmoisturizing agents are selected from the group consisting of alkanediols or alkane triols comprising 3 to 12 carbon atoms, preferablyC3-C10-alkane diols and C3-C10-alkane triols. More preferably the skinmoisturizing agents are selected from the group consisting of glycerol,1,2-propylene glycol, 1,2-butylene glycol, 1,3-butylene glycol,1,2-pentanediol, 1,2-hexanediol, 1,2-octanediol and 1,2-decanediol.

Glycosaminoglycan stimulators: A preferred cosmetic or pharmaceutical,preferably dermatological, composition according to the presentinvention comprises one or more substances stimulating the synthesis ofglycosaminoglycans which are selected from the group consisting ofhyaluronic acid and derivatives or salts, Subliskin (Sederma, INCI:Sinorhizobium Meliloti Ferment Filtrate, Cetyl Hydroxyethylcellulose,Lecithin), Hyalufix (BASF, INCI: Water, Butylene Glycol, Alpinia galangaleaf extract, Xanthan Gum, Caprylic/Capric Triglyceride), Stimulhyal(Soliance, INCI: Calcium ketogluconate), Syn-Glycan (DSM, INCI:Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate,Glycerin, Magnesium chloride), Kalpariane (Biotech Marine), DC Upregulex(Distinctive Cosmetic Ingredients, INCI: Water, Butylene Glycol,Phospholipids, Hydrolyzed Sericin), glucosamine, N-acetyl glucosamine,retinoids, preferably retinol and vitamin A, Arctium lappa fruitextract, Eriobotrya japonica extract, Genkwanin, N-Methyl-L-serine,(−)-alpha-bisabolol or synthetic alpha-bisabolol such as e.g.Dragosantol and Dragosantol 100 from Symrise, oat glucan, Echinaceapurpurea extract and soy protein hydrolysate. Preferred actives areselected from the group consisting of hyaluronic acid and derivatives orsalts, retinol and derivatives, (−)-alpha-bisabolol or syntheticalpha-bisabolol such as e.g. Dragosantol and Dragosantol 100 fromSymrise, oat glucan, Echinacea purpurea extract, Sinorhizobium MelilotiFerment Filtrate, Calcium ketogluconate, Alpinia galanga leaf extractand tetradecyl aminobutyroylvalylaminobutyric urea trifluoroacetate.

TRPV1 antagonists: A preferred cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention comprisesone or more TRPV1 antagonsits. Suitable compounds which reduce thehypersensitivity of skin nerves based on their action as TRPV1antagonists, encompass e.g. trans-4-tert-butyl cyclohexanol, or indirectmodulators of TRPV1 by an activation of the p-receptor, e.g. acetyltetrapeptide-15, are preferred.

Plant extracts: A preferred cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention comprisesone or more plant extracts. Plant extracts, special highly active plantextract fractions and also highly pure active substances isolated fromplant extracts can also be used in the cosmetic or pharmaceutical,preferably dermatological, composition according to the presentinvention. Extracts, fractions and active substances from camomile, aloevera, Commiphora species, Rubia species, willows, willow-herb, ginger,marigold, arnica, Glycyrrhiza species, Echinacea species, Rubus speciesand pure substances such as inter alia bisabolol, apigenin,apigenin-7-glucoside, gingerols such as [6]-gingerol, paradols such as[6]-paradol, boswellic acid, phytosterols, glycyrrhizine, glabridin orlicochalcone A are particularly preferred.

Anti-inflammatory agents: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present inventionpreferably also contains anti-inflammatory and/or redness and/or itchameliorating ingredients, in particular steroidal substances of thecorticosteroid type selected from the group consisting ofhydrocortisone, dexamethasone, dexamethasone phosphate, methylprednisolone or cortisone, are advantageously used as anti-inflammatoryactive ingredients or active ingredients to relieve reddening anditching, the list of which can be extended by the addition of othersteroidal anti-inflammatories. Non-steroidal anti-inflammatories canalso be used. More particularly:

-   -   (i) steroidal anti-inflammatory substances of the corticosteroid        type, in particular hydrocortisone, hydrocortisone derivatives        such as hydrocortisone 17-butyrate, dexamethasone, dexamethasone        phosphate, methylprednisolone or cortisone,    -   (ii) non-steroidal anti-inflammatory substances, in particular        oxicams such as piroxicam or tenoxicam, salicylates such as        aspirin, disalcid, solprin or fendosal, acetic acid derivatives        such as diclofenac, fenclofenac, indomethacin, sulindac,        tolmetin or clindanac, fenamates such as mefenamic,        meclofenamic, flufenamic or niflumic, propionic acid derivatives        such as ibuprofen, naproxen or benoxaprofen, pyrazoles such as        phenylbutazone, oxyphenylbutazone, febrazone or azapropazone,    -   (iii) natural or naturally occurring anti-inflammatory        substances or substances that alleviate reddening and/or        itching, in particular extracts or fractions from camomile, Aloe        vera, Commiphora species, Rubia species, willow, willow-herb,        oats, calendula, arnica, St John's wort, honeysuckle, rosemary,        Passiflora incarnata, witch hazel, ginger or Echinacea, or        single active compounds thereof,    -   (iv) histamine receptor antagonists, serine protease inhibitors        (e.g. of Soy extracts), TRPV1 antagonists (e.g.        4-t-Butylcyclohexanol), NK1 antagonists (e.g. Aprepitant,        Hydroxyphenyl Propamidobenzoic Acid), cannabinoid receptor        agonists (e.g. Palmitoyl Ethanolamine) and TRPV3 antagonists.

Examples which can be cited here are oxicams such as piroxicam ortenoxicam; salicylates such as aspirin, disalcid, solprin or fendosal;acetic acid derivatives such as diclofenac, fenclofenac, indomethacin,sulindac, tolmetin or clindanac; fenamates such as mefenamic,meclofenamic, flufenamic or niflumic; propionic acid derivatives such asibuprofen, naproxen, benoxaprofen or pyrazoles such as phenylbutazone,oxyphenylbutazone, febrazone or azapropazone. Anthranilic acidderivatives are preferred anti-itch ingredients in a compositionaccording to the present invention.

Also useful are natural or naturally occurring anti-inflammatorymixtures of substances or mixtures of substances that alleviatereddening and/or itching, in particular extracts or fractions fromcamomile, Aloe vera, Commiphora species, Rubia species, willow,willow-herb, oats, calendula, arnica, St John's wort, honeysuckle,rosemary, Passiflora incarnata, witch hazel, ginger or Echinacea;preferably selected from the group consisting of extracts or fractionsfrom camomile, Aloe vera, oats, calendula, arnica, honeysuckle,rosemary, witch hazel, ginger or Echinacea, and/or pure substances,preferably alpha-bisabolol, apigenin, apigenin-7-glucoside, gingerols,shogaols, gingerdiols, dehydrogingerdiones, paradols, natural ornaturally occuring avenanthramides, preferably tranilast, avenanthramideA, avenanthramide B, avenanthramide C, non-natural or non-naturallyoccuring avenanthramides, preferably dihydroavenanthramide D,dihydroavenanthramide E, avenanthramide D, avenanthramide E,avenanthramide F, boswellic acid, phytosterols, glycyrrhizin, glabridinand licochalcone A; preferably selected from the group consisting ofalpha-bisabolol, natural avenanthramides, non-natural avenanthramides,preferably dihydroavenanthramide D (as described in WO 2004 047833 A1),boswellic acid, phytosterols, glycyrrhizin, and licochalcone A, and/orallantoin, panthenol, lanolin, (pseudo-)ceramides [preferably Ceramide2, hydroxypropyl bispalmitamide MEA, cetyloxypropyl glycerylmethoxypropyl myristamide, N-(1-hexadecanoyl)-4-hydroxy-L-proline(1-hexadecyl) ester, hydroxyethyl palmityl oxyhydroxypropylpalmitamide], glycosphingolipids, phytosterols, chitosan, mannose,lactose and ß-glucans, in particular 1,3->1,4-ß-glucan from oats.

When bisabolol is used in the context of the present invention it can beof natural or synthetic origin, and is preferably “alpha-bisabolol”.Preferably, the bisabolol used is synthetically prepared or natural(−)-alpha-bisabolol and/or synthetic mixed-isomer alpha-bisabolol. Ifnatural (−)-alpha-bisabolol is used, this can also be employed as aconstituent of an essential oil or of a plant extract or of a fractionthereof, for example as a constituent of (fractions of) oil or extractsof camomile or of Vanillosmopsis (in particular Vanillosmopsiserythropappa or Vanillosmopsis arborea). Synthetic alpha-bisabolol isobtainable, for example, under the name “Dragosantol” from Symrise.

In case ginger extract is used in the context of the present invention,preferably extracts of the fresh or dried ginger root are used which areprepared by extraction with methanol, ethanol, iso-propanol, acetone,ethyl acetate, carbon dioxide (CO2), hexane, methylene chloride,chloroform or other solvents or solvent mixtures of comparable polarity.The extracts are characterized by the presence of active skinirritation-reducing amounts of constituents such as e.g. gingerols,shogaols, gingerdiols, dehydrogingerdiones and/or paradols.

Physiological cooling agents: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention can beparticularly advantageously combined with one or more physiologicalcooling agent(s). The use of cooling agents can alleviate itching.Preferred individual cooling agents for use within the framework of thepresent invention are listed below. The person skilled in the art canadd many other cooling agents to this list; the cooling agents listedcan also be used in combination with one another: which are preferablyselected here from the following list: menthol and menthol derivatives(for example L-menthol, D-menthol, racemic menthol, isomenthol,neoisomenthol, neomenthol) menthylethers (for example(I-menthoxy)-1,2-propanediol, (1-menthoxy)-2-methyl-1,2-propanediol,I-menthyl-methylether), menthone glyceryl acetal, menthone glycerylketal or mixtures of both, menthylesters (for example menthylformiate,menthylacetate, menthylisobutyrate, menthyhydroxyisobutyrat,menthyllactates, L-menthyl-L-lactate, L-menthyl-D-lactate, menthyl-(2-methoxy)acetate, menthyl-(2-m ethoxyethoxy)-acetate,menthylpyroglutamate), menthylcarbonates (for examplementhylpropyleneglycolcarbonate, menthylethyleneglycolcarbonate,menthylglycerolcarbonate or mixtures thereof), the semi-esters ofmenthols with a dicarboxylic acid or derivatives thereof (for examplemono-menthylsuccinate, mono-menthylglutarate, mono-menthylmalonate,O-menthyl succinic acid ester-N,N-(dimethyl)amide, O-menthyl succinicacid ester amide), menthanecarboxylic acid amides (in this casepreferably menthanecarboxylic acid-N-ethylamide [WS3] orN^(α)-(menthanecarbonyl)glycinethylester [WS5], menthanecarboxylicacid-N-(4-cyanophenyl)amide or menthanecarboxylicacid-N-(4-cyanomethylphenyl)amide, menthanecarboxylicacid-N-(alkoxyalkyl)amides), menthone and menthone derivatives (forexample L-menthone glycerol ketal), 2,3-dimethyl-2-(2-propyl)-butyricacid derivatives (for example 2,3-dimethyl-2-(2-propyl)-butyricacid-N-methylamide [WS23]), isopulegol or its esters (I-(−)-isopulegol,I-(−)-isopulegolacetate), menthane derivatives (for examplep-menthane-3,8-diol), cubebol or synthetic or natural mixtures,containing cubebol, pyrrolidone derivatives of cycloalkyldionederivatives (for example3-methyl-2(1-pyrrolidinyl)-2-cyclopentene-1-one) or tetrahydropyrimidine-2-one (for example iciline or related compounds, as described inWO 2004/026840), further carboxamides (for exampleN-(2-(pyridin-2-yl)ethyl)-3-p-menthanecarboxamide or related compounds),(1R,2S,5R)—N-(4-Methoxyphenyl)-5-methyl-2-(1-isopropyl)cyclohexane-carboxamide[WS12], oxamates and [(1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl]2-(ethylamino)-2-oxo-acetate (X Cool). Cooling agents which arepreferred due to their particular synergistic effect are 1-menthol,d-menthol, racemic menthol, menthone glycerol acetal (trade name:Frescolat® MGA), menthyl lactate (preferably 1-menthyl lactate, inparticular 1-menthyl 1-lactate (trade name: Frescolat® ML)), substitutedmenthyl-3-carboxamides (such as menthyl-3-carboxylic acid N-ethylamide), 2-isopropyl-N-2,3-trimethyl butanamide, substituted cyclohexanecarboxamides, 3-menthoxypropane-1,2-diol, 2-hydroxyethyl menthylcarbonate, 2-hydroxypropyl menthyl carbonate and isopulegol.Particularly preferred cooling agents are 1-menthol, racemic menthol,menthone glycerol acetal (trade name: Frescolat® MGA), menthyl lactate(preferably 1-menthyl lactate, in particular 1-menthyl 1-lactate (tradename: Frescolat® ML)), 3-menthoxypropane-1,2-diol, 2-hydroxyethylmenthyl carbonate and 2-hydroxypropyl menthyl carbonate. Veryparticularly preferred cooling agents are 1-menthol, menthone glycerolacetal (trade name: Frescolat® MGA) and menthyl lactate (preferably1-menthyl lactate, in particular 1-menthyl 1-lactate (trade name:Frescolat® ML).

Moisturising and/or moisture-retaining substances: Itching occurs withparticular intensity when the skin is dry. The use of skin-moisturisingand/or moisture-retaining substances can significantly alleviateitching. The cosmetic or pharmaceutical, preferably dermatological,composition according to the present invention can thereforeadvantageously also contain one or more of the following moisturisingand/or moisture-retaining substances: sodium lactate, urea, ureaderivatives, alcohols, glycerol, diols such as propylene glycol,hexylene glycol, collagen, elastin or hyaluronic acid, diacyl adipates,petrolatum, urocanic acid, lecithin, panthenol, phytantriol, lycopene,(pseudo-)ceramides, glycosphingolipids, cholesterol, phytosterols,chitosan, chondroitin sulphate, lanolin, lanolin esters, amino acids,alpha-hydroxy acids (such as citric acid, lactic acid, malic acid) andtheir derivatives, mono-, di- and oligosaccharides such as glucose,galactose, fructose, mannose, fructose and lactose, polysugars such asR-glucans, in particular 1,3-1,4-β-glucan from oats, alpha-hydroxy fattyacids, triterpene acids such as betulinic acid or ursolic acid, andalgae extracts.

Lenitive substances: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention can alsocontain advantageously one or more lenitive substances, wherein anylenitive substances can be used which are suitable or customary incosmetic or pharmaceutical applications such as alpha-bisabolol,azulene, guaiazulene, 18-beta-glycyrrhetinic acid, allantoin, Aloe verajuice or gel, extracts of Hamamelis virginiana (witch hazel), Echinaceaspecies, Centella asiatica, chamomile, Arnica monatana, Glycyrrhizaspecies, algae, seaweed and Calendula officinalis, and vegetable oilssuch as sweet almond oil, baobab oil, olive oil and panthenol,Laureth-9, Trideceth-9 and 4-t-butylcyclohexanol.

Antibacterial or antimycotic active substances: Antibacterial orantimycotic active substances can also particularly advantageously beused in the cosmetic or pharmaceutical, preferably dermatological,composition according to the present invention, wherein anyantibacterial or antimycotic active substances can be used which aresuitable or customary in cosmetic or pharmaceutical, in particulardermatological applications. In addition to the large group ofconventional antibiotics, other products which are advantageous hereinclude those relevant to cosmetics such as in particular triclosan,climbazole, octoxyglycerin, Octopirox®(1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone2-aminoethanol salt), chitosan, farnesol, glycerol monolaurate orcombinations of said substances, which are used inter alia againstunderarm odour, foot odour or dandruff.

Anti-microbial agents: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present inventionpreferably contains one or more anti-microbioal agents. Suitableanti-microbial agents are, in principle, all substances effectiveagainst Gram-positive bacteria, such as, for example, 4-hydroxybenzoicacid and its salts and esters,N-(4-chlorophenyl)-N′-(3,4-dichlorophenyl)urea,2,4,4′-trichloro-2′-hydroxy-diphenyl ether (triclosan),4-chloro-3,5-dimethyl-phenol, 2,2′-methylenebis(6-bromo-4-chlorophenol),3-methyl-4-(1-methylethyl)phenol, 2-benzyl-4-chloro-phenol,3-(4-chlorophenoxy)-1,2-propanediol, 3-iodo-2-propynyl butylcarbamate,chlorhexidine, 3,4,4′-trichlorocarbanilide (TTC), antibacterialfragrances, thymol, thyme oil, eugenol, oil of cloves, menthol, mintoil, farnesol, phenoxyethanol, glycerol monocaprate, glycerolmonocaprylate, glycerol monolaurate (GML), diglycerol monocaprate (DMC),salicylic acid N-alkylamides, such as, for example, n-octylsalicylamideor n-decylsalicylamide.

Desquamating agents: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present inventionpreferably contains one or more desquamating agents. The expression“desquamating agent” is understood to mean any compound capable ofacting:

-   -   either directly on desquamation by promoting exfoliation, such        as β-hydroxy acids, in particular salicylic acid and its        derivatives (including 5-n-octanoylsalicylic acid); α-hydroxy        acids, such as glycolic, citric, lactic, tartaric, malic or        mandelic acids; urea; gentisic acid; oligofucoses; cinnamic        acid; extract of Sophora japonica; resveratrol and some        derivatives of jasmonic acid;    -   or on the enzymes involved in the desquamation or the        degradation of the corneodesmosomes, glycosidases, stratum        corneum chymotryptic enzyme (SCCE) or other proteases (trypsin,        chymotrypsin-like). There may be mentioned agents chelating        inorganic salts: EDTA; Trisodium Dicarboxymethyl Alaninate        (tradename Neutrol MGDA),        N-acyl-N,N′,N′-ethylenediaminetriacetic acid; aminosulphonic        compounds and in particular        (N-2-hydroxyethylpiperazine-N-2-ethane)sulphonic acid (HEPES);        derivatives of 2-oxothiazolidine-4-carboxylic acid        (procysteine); derivatives of alpha-amino acids of the glycine        type (as described in EP-0 852 949, and sodium methylglycine        diacetate marketed by BASF under the trade name TRILON M);        honey; sugar derivatives such as 0-octanoyl-6-D-maltose and        N-acetylglucosamine; chestnut extracts such as those marketed by        the company SILAB under the name Recoverine®, prickly pear        extracts such as those marketed under the name Exfolactive® by        the company SILAB, or Phytosphingosine SLC® (phytosphingosine        grafted with a salicylic acid) marketed by the company Degussa.

Desquamating agents suitable for the invention may be chosen inparticular from the group comprising sulphonic acids, calcium chelators,α-hydroxy acids such as glycolic, citric, lactic, tartaric, malic ormandelic acids; ascorbic acid and its derivatives such as ascorbylglucoside and magnesium ascorbyl phosphate; nicotinamide; urea;(N-2-hydroxyethylpiperazine-N-2-ethane)sulphonic acid (HEPES), β-hydroxyacids such as salicylic acid and its derivatives, retinoids such asretinol and its esters, retinal, retinoic acid and its derivatives,chestnut or prickly pear extracts, in particular marketed by SILAB;reducing compounds such as cysteine or cysteine precursors.

Desquamating agents which can be used are also nicotinic acid and itsesters and nicotinamide, also called vitamin B3 or vitamin PP, andascorbic acid and its precursors.

Anti-dandruff substances: In addition, the cosmetic or pharmaceutical,preferably dermatological, composition according to the presentinvention can also advantageously be used in combination with one ormore anti-dandruff substances, including triclosan, climbazole,octoxyglycerin, Octopirox®(1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone2-aminoethanol salt), chitosan, farnesol, glycerol monolaurate,Propanediol Monocaprylate or combinations of said substances, which areused inter alia against dandruff.

Further suitable anti-dandruff agents are Pirocton Olam in(1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2-(1H)-pyridinonemonoethanolamine salt), Baypival® (Climbazole), Ketoconazol®(4-acetyl-1-{4-[2-(2,4-dichlorophenyl)r-2-(1H-imidazol-1-ylmethyl)-1,3-dioxylan-c-4-ylmethoxyphenyl}-piperazine,ketoconazole, elubiol, selenium disulfide, colloidal sulfur, sulfurpolyethylene glycol sorbitan monooleate, sulfur ricinol polyethoxylate,sulfur tar distillate, salicylic acid (or in combination withhexachlorophene), undecylenic acid, monoethanolamide sulfosuccinate Nasalt, Lamepon® UD (protein/undecylenic acid condensate), zincpyrithione, aluminium pyrithione and magnesium pyrithione/dipyrithionemagnesium sulfate.

(Metal) chelating agents: A combination with one or more (metal)chelating agents can also be advantageous used in the cosmetic orpharmaceutical, preferably dermatological, composition according to thepresent invention, wherein any metal chelating agents can be used whichare suitable or customary in cosmetic or pharmaceutical applications.Preferred (metal) chelating agents include α-hydroxy fatty acids, phyticacid, lactoferrin, α-hydroxy acids, such as inter alia gluconic acid,glyceric acid, glycolic acid, isocitric acid, citric acid, lactic acid,malic acid, mandelic acid, tartaric acid, as well as humic acids, bileacids, bile extracts, bilirubin, biliverdin or EDTA, EGTA, TrisodiumDicarboxymethyl Alaninate, and their derivatives. The use of one or morechelating agent(s) improves the stability of the composition accordingto the present invention.

Emulsifiers: In addition, the cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention can alsoadvantageously contain one or more emulsifiers, including for example:

-   -   products of the addition of 2 to 30 mol ethylene oxide and/or 0        to 5 mol propylene oxide onto linear C8-22 fatty alcohols, onto        C12-22 fatty acids and onto alkyl phenols containing 8 to 15        carbon atoms in the alkyl group;    -   C_(12/18) fatty acid monoesters and diesters of addition        products of 1 to 30 mol ethylene oxide onto glycerol;    -   glycerol mono- and diesters and sorbitan mono- and diesters of        saturated and unsaturated fatty acids containing 6 to 22 carbon        atoms and ethylene oxide addition products thereof;    -   addition products of 15 to 60 mol ethylene oxide onto castor oil        and/or hydrogenated castor oil;    -   polyol esters and, in particular, polyglycerol esters such as,        for example, polyglycerol polyricinoleate, polyglycerol        poly-12-hydroxystearate or polyglycerol dimerate isostearate.        Mixtures of compounds from several of these classes are also        suitable;    -   addition products of 2 to 15 mol ethylene oxide onto castor oil        and/or hydrogenated castor oil;    -   partial esters based on linear, branched, unsaturated or        saturated C_(6/22) fatty acids, ricinoleic acid and        12-hydroxystearic acid and glycerol, polyglycerol,        pentaerythritol, dipentaerythritol, sugar alcohols (for example        sorbitol), alkyl glucosides (for example methyl glucoside, butyl        glucoside, lauryl glucoside) and polyglucosides (for example        cellulose);    -   mono-, di and trialkyl phosphates and mono-, di- and/or        tri-PEG-alkyl phosphates and salts thereof;    -   wool wax alcohols;    -   polysiloxane/polyalkyl polyether copolymers and corresponding        derivatives;    -   mixed esters of pentaerythritol, fatty acids, citric acid and        fatty alcohol and/or mixed esters of C₆₋₂₂ fatty acids, methyl        glucose and polyols, preferably glycerol or polyglycerol,    -   polyalkylene glycols and    -   glycerol carbonate.

The addition products of ethylene oxide and/or propylene oxide ontofatty alcohols, fatty acids, alkylphenols, glycerol mono- and diestersand sorbitan mono- and diesters of fatty acids or onto castor oil areknown commercially available products. They are homologue mixtures ofwhich the average degree of alkoxylation corresponds to the ratiobetween the quantities of ethylene oxide and/or propylene oxide andsubstrate with which the addition reaction is carried out. C_(12/18)fatty acid monoesters and diesters of addition products of ethyleneoxide onto glycerol are known as lipid layer enhancers for cosmeticformulations. The preferred emulsifiers are described in more detail asfollows:

Partial glycerides: Typical examples of suitable partial glycerides arehydroxystearic acid monoglyceride, hydroxystearic acid diglyceride,isostearic acid monoglyceride, isostearic acid diglyceride, oleic acidmonoglyceride, oleic acid diglyceride, ricinoleic acid monoglyceride,ricinoleic acid diglyceride, linoleic acid monoglyceride, linoleic aciddiglyceride, linolenic acid monoglyceride, linolenic acid diglyceride,erucic acid monoglyceride, erucic acid diglyceride, tartaric acidmonoglyceride, tartaric acid diglyceride, citric acid monoglyceride,citric acid diglyceride, malic acid monoglyceride, malic aciddiglyceride and technical mixtures thereof which may still contain smallquantities of triglyceride from the production process. Additionproducts of 1 to 30 and preferably 5 to 10 mol ethylene oxide onto thepartial glycerides mentioned are also suitable.

Sorbitan esters: Suitable sorbitan esters are sorbitan monoisostearate,sorbitan sesquiisostearate, sorbitan diisostearate, sorbitantriisostearate, sorbitan monooleate, sorbitan sesquioleate, sorbitandioleate, sorbitan trioleate, sorbitan monoerucate, sorbitansesquierucate, sorbitan dierucate, sorbitan trierucate, sorbitanmonoricinoleate, sorbitan sesquiricinoleate, sorbitan diricinoleate,sorbitan triricinoleate, sorbitan monohydroxystearate, sorbitansesquihydroxystearate, sorbitan dihydroxystearate, sorbitantrihydroxystearate, sorbitan monotartrate, sorbitan sesquitartrate,sorbitan ditartrate, sorbitan tritartrate, sorbitan monocitrate,sorbitan sesquicitrate, sorbitan dicitrate, sorbitan tricitrate,sorbitan monomaleate, sorbitan sesquimaleate, sorbitan dimaleate,sorbitan trimaleate and technical mixtures thereof. Addition products of1 to 30 and preferably 5 to 10 mol ethylene oxide onto the sorbitanesters mentioned are also suitable.

Polyglycerol esters: Typical examples of suitable polyglycerol estersare Polyglyceryl-2 Dipolyhydroxystearate (Dehymuls® PGPH),Polyglycerin-3-Diisostearate (Lameform® TGI), Polyglyceryl-4 Isostearate(Isolan® GI 34), Polyglyceryl-3 Oleate, Diisostearoyl Polyglyceryl-3Diisostearate (Isolan® PDI), Poly-glyceryl-3 Methylglucose Distearate(Tego Care® 450), Polyglyceryl-3 Beeswax (Cera Bellina®), Polyglyceryl-4Caprate (Polyglycerol Caprate T2010/90), Polyglyceryl-3 Cetyl Ether(Chimexane® NL), Polyglyceryl-3 Distearate (Cremophor® GS 32),Polyglyceryl Polyricinoleate (Admul® WOL 1403), Polyglyceryl DimerateIsostearate, and mixtures thereof. Examples of other suitablepolyolesters are the mono-, di- and triesters of trimethylol propane orpentaerythritol with lauric acid, cocofatty acid, tallow fatty acid,palmitic acid, stearic acid, oleic acid, behenic acid and the likeoptionally reacted with 1 to 30 mol ethylene oxide.

Anionic emulsifiers: Typical anionic emulsifiers are aliphatic C12 to C22 fatty acids, such as palmitic acid, stearic acid or behenic acid forexample, and C12 to C22 dicarboxylic acids, such as azelaic acid orsebacic acid for example.

Amphoteric emulsifiers: Other suitable emulsifiers are amphoteric orzwitterionic surfactants. Zwitterionic surfactants are surface-activecompounds which contain at least one quaternary ammonium group and atleast one carboxylate and one sulfonate group in the molecule.Particularly suitable zwitterionic surfactants are the so-calledbetaines, such as the N-alkyl-N,N-dimethyl ammonium glycinates, forexample cocoalkyl dimethyl ammonium glycinate,N-acylaminopropyl-N,N-dimethyl ammonium glycinates, for examplecocoacylaminopropyl dimethyl ammonium glycinate, and2-alkyl-3-carboxymethyl-3-hydroxyethyl imidazolines containing 8 to 18carbon atoms in the alkyl or acyl group and cocoacylaminoethylhydroxyethyl carboxymethyl glycinate. The fatty acid amide derivativeknown under the CTFA name of Cocamidopropyl Betaine is particularlypreferred. Ampholytic surfactants are also suitable emulsifiers.Ampholytic surfactants are surface-active compounds which, in additionto a C8/18 alkyl or acyl group, contain at least one free amino groupand at least one —COOH— or —SO₃H— group in the molecule and which arecapable of forming inner salts. Examples of suitable ampholyticsurfactants are N-alkyl glycines, N-alkyl propionic acids,N-alkylaminobutyric acids, N-alkyliminodipropionic acids,N-hydroxyethyl-N-alkylam idopropyl glycines, N-alkyl taurines, N-alkylsarcosines, 2-alkylaminopropionic acids and alkylaminoacetic acidscontaining around 8 to 18 carbon atoms in the alkyl group. Particularlypreferred ampholytic surfactants are N-coco-alkylaminopropionate,cocoacylaminoethyl aminopropionate and C_(12/18) acyl sarcosine.

Surfactants: The cosmetic or pharmaceutical, preferably dermatological,composition according to the present invention preferably includes oneor more anionic and/or amphoteric or zwitterionic surfactants. Typicalexamples encompass: Almondamidopropylamine Oxide, AlmondamidopropylBetaine, Aminopropyl Laurylglutamine, Ammonium C12-15 Alkyl Sulfate,Ammonium C12-16 Alkyl Sulfate, Ammonium Capryleth Sulfate, AmmoniumCocomonoglyceride Sulfate, Ammonium Coco-Sulfate, Ammonium CocoylIsethionate, Ammonium Cocoyl Sarcosinate, Ammonium C12-15 ParethSulfate, Ammonium C9-10 Perfluoroalkylsulfonate, Ammonium DinonylSulfosuccinate, Ammonium Dodecylbenzenesulfonate, Ammonium Isostearate,Ammonium Laureth-6 Carboxylate, Ammonium Laureth-8 Carboxylate, AmmoniumLaureth Sulfate, Ammonium Laureth-5 Sulfate, Ammonium Laureth-7 Sulfate,Ammonium Laureth-9 Sulfate, Ammonium Laureth-12 Sulfate, AmmoniumLauroyl Sarcosinate, Ammonium Lauryl Sulfate, Ammonium LaurylSulfosuccinate, Ammonium Myreth Sulfate, Ammonium Myristyl Sulfate,Ammonium Nonoxynol-4 Sulfate, Ammonium Nonoxynol-30 Sulfate, AmmoniumOleate, Ammonium Palm Kernel Sulfate, Ammonium Stearate, AmmoniumTallate, AMPD-Isostearoyl Hydrolyzed Collagen, AMPD-Rosin HydrolyzedCollagen, AMP-Isostearoyl Hydrolyzed Collagen, AMP-IsostearoylHydrolyzed Keratin, AMP-Isostearoyl Hydrolyzed Soy Protein,AMP-Isostearoyl Hydrolyzed Wheat Protein, Apricotamidopropyl Betaine,Arachidic Acid, Arginine Hexyldecyl Phosphate, AvocadamidopropylBetaine, Avocado Oil Glycereth-8 Esters, Babassu Acid,Babassuamidopropylamine Oxide, Babassuamidopropyl Betaine, Beeswax Acid,Behenamidopropyl Betaine, Behenamine Oxide, Beheneth-25, Beheneth-30,Behenic Acid, Behenyl Betaine, Bis-Butyldimethicone Polyglyceryl-3,Butoxynol-5 Carboxylic Acid, Butoxynol-19 Carboxylic Acid,Butyldimoniumhydroxypropyl Butylglucosides Chloride,Butyldimoniumhydroxypropyl Laurylglucosides Chloride, Butyl Glucoside,Butylglucoside Caprate, Butylglucosides Hydroxypropyltrimonium Chloride,Butyloctanoic Acid, C18-36 Acid, C20-40 Acid, C30-50 Acid, C16-22 AcidAmide MEA, Calcium Dodecylbenzenesulfonate, Calcium Lauroyl Taurate,C9-16 Alkane/Cycloalkane, C10-14 Alkyl Benzenesulfonic Acid, C12-14Alkyl Diaminoethylglycine HCL, C9-15 Alkyl Phosphate, CandidaBombicola/Glucose/Methyl Rapeseedate Ferment, Canolamidopropyl Betaine,Capric Acid, Caproic Acid, Caproyl Ethyl Glucoside,Capryl/Capramidopropyl Betaine, Capryleth-4 Carboxylic Acid, Capryleth-6Carboxylic Acid, Capryleth-9 Carboxylic Acid, Caprylic Acid, CapryloylCollagen Amino Acids, Capryloyl Glycine, Capryloyl Hydrolyzed Collagen,Capryloyl Hydrolyzed Keratin, Capryloyl Keratin Amino Acids, CapryloylSilk Amino Acids, Caprylyl/Capryl Glucoside, Caprylyl/Capryl WheatBran/Straw Glycosides, Caprylyl Glucoside, Caprylyl Glyceryl Ether,Caprylyl Pyrrolidone, Carnitine, Ceteareth-20, Ceteareth-23,Ceteareth-24, Ceteareth-25, Ceteareth-27, Ceteareth-28, Ceteareth-29,Ceteareth-30, Ceteareth-33, Ceteareth-34, Ceteareth-40, Ceteareth-50,Ceteareth-55, Ceteareth-60, Ceteareth-80, Ceteareth-100, Ceteareth-25Carboxylic Acid, Ceteareth-2 Phosphate, Ceteareth-4 Phosphate,Ceteareth-5 Phosphate, Ceteareth-10 Phosphate, Ceteth-20, Ceteth-23,Ceteth-24, Ceteth-25, Ceteth-30, Ceteth-40, Ceteth-45, Ceteth-150,Ceteth-8 Phosphate, Ceteth-10 Phosphate, Ceteth-20 Phosphate,Cetoleth-22, Cetoleth-24, Cetoleth-25, Cetoleth-30, Cetyl Betaine,Chrysanthemum Sinense Flower Extract, C12-14 Hydroxyalkyl HydroxyethylBeta-Alanine, C12-14 Hydroxyalkyl Hydroxyethyl Sarcosine, CocamidoethylBetaine, Cocamidopropylamine Oxide, Cocamidopropyl Betainamide MEAChloride, Cocamidopropyl Betaine, Cocamidopropyl Hydroxysultaine,Cocamine Oxide, Cocaminobutyric Acid, Cocaminopropionic Acid, Coceth-7Carboxylic Acid, Coceth-4 Glucoside, Cocoamphodipropionic Acid,Cocobetainamido Amphopropionate, Coco-Betaine, CocodimoniumHydroxypropyl Hydrolyzed Rice Protein, Cocodimonium HydroxypropylHydrolyzed Soy Protein, Cocodimonium Hydroxypropyl Hydrolyzed WheatProtein, Coco-Glucoside, Cocoglucosides Hydroxypropyltrimonium Chloride,Coco-Hydroxysultaine, Coco-Morpholine Oxide, Coconut Acid, Coconut OilGlycereth-8 Esters, Coco/Oleamidopropyl Betaine, Coco-Sultaine,Coco/Sunfloweramidopropyl Betaine, Cocoylcholine Methosulfate, CocoylGlutamic Acid, Cocoyl Hydrolyzed Collagen, Cocoyl Hydrolyzed Keratin,Cocoyl Hydrolyzed Oat Protein, Cocoyl Hydrolyzed Rice Protein, CocoylHydrolyzed Silk, Cocoyl Hydrolyzed Soy Protein, Cocoyl Hydrolyzed WheatProtein, Cocoyl Sarcosine, Corn Acid, Cottonseed Acid, Cottonseed OilGlycereth-8 Esters, C10-16 Pareth-1, C10-16 Pareth-2, C11-13 Pareth-6,C11-13 Pareth-9, C11-13 Pareth-10, C11-15 Pareth-30, C11-15 Pareth-40,C12-13 Pareth-1, C12-13 Pareth-23, C12-14 Pareth-5, C12-14 Pareth-9,C13-15 Pareth-21, C14-15 Pareth-8, C20-22 Pareth-30, C20-40 Pareth-40,C20-40 Pareth-95, C22-24 Pareth-33, C30-50 Pareth-40, C9-11 Pareth-6Carboxylic Acid, C9-11 Pareth-8 Carboxylic Acid, C11-15 Pareth-7Carboxylic Acid, C12-13 Pareth-5 Carboxylic Acid, C12-13 Pareth-7Carboxylic Acid, C12-13 Pareth-8 Carboxylic Acid, C12-13 Pareth-12Carboxylic Acid, C12-15 Pareth-7 Carboxylic Acid, C12-15 Pareth-8Carboxylic Acid, C12-15 Pareth-12 Carboxylic Acid, C14-15 Pareth-8Carboxylic Acid, C6-10 Pareth-4 Phosphate, C12-13 Pareth-2 Phosphate,C12-13 Pareth-10 Phosphate, C12-15 Pareth-6 Phosphate, C12-15 Pareth-8Phosphate, C12-15 Pareth-10 Phosphate, C12-16 Pareth-6 Phosphate, C4-18Perfluoroalkylethyl Thiohydroxypropyltrimonium Chloride,Cupuassuamidopropyl Betaine, DEA-C12-13 Alkyl Sulfate, DEA-C12-15 AlkylSulfate, DEA-Ceteareth-2 Phosphate, DEA-Cetyl Sulfate,DEA-Cocoamphodipropionate, DEA-C12-13 Pareth-3 Sulfate,DEA-Cyclocarboxypropyloleate, DEA-Dodecylbenzenesulfonate,DEA-Isostearate, DEA-Laureth Sulfate, DEA-Lauryl Sulfate, DEA-Linoleate,DEA-Methyl Myristate Sulfonate, DEA-Myreth Sulfate, DEA-Myristate,DEA-Myristyl Sulfate, DEA-Oleth-5 Phosphate, DEA-Oleth-20 Phosphate, DEAPG-Oleate, Deceth-7 Carboxylic Acid, Deceth-7 Glucoside, Deceth-9Phosphate, Decylamine Oxide, Decyl Betaine, Decyl Glucoside,Decyltetradeceth-30, Decyltetradecylamine Oxide, DiammoniumLauramido-MEA Sulfosuccinate, Diammonium Lauryl Sulfosuccinate,Diammonium Oleamido PEG-2 Sulfosuccinate, Dibutoxymethane, Di-CI 2-15Pareth-2 Phosphate, Di-CI 2-15 Pareth-4 Phosphate, Di-CI 2-15 Pareth-6Phosphate, Di-C12-15 Pareth-8 Phosphate, Di-CI 2-15 Pareth-10 Phosphate,Didodecyl Butanetetracarboxylate, Diethylamine Laureth Sulfate,Diethylhexyl Sodium Sulfosuccinate, Dihydroxyethyl C8-10Alkoxypropylamine Oxide, Dihydroxyethyl C9-11 Alkoxypropylamine Oxide,Dihydroxyethyl C12-15 Alkoxypropylamine Oxide, Dihydroxyethyl CocamineOxide, Dihydroxyethyl Lauramine Oxide, Dihydroxyethyl Stearamine Oxide,Dihydroxyethyl Tallowamine Oxide, Dimethicone PEG-7 Phosphate,Dimethicone PEG-10 Phosphate, Dimethicone PEG/PPG-7/4 Phosphate,Dimethicone PEG/PPG-12/4 Phosphate, Dimethicone/Polyglycerin-3Crosspolymer, Dimethicone Propyl PG-Betaine, Dimyristyl Phosphate,Dioleoylamidoethyl Hydroxyethylmonium Methosulfate, DIPA-HydrogenatedCocoate, DIPA-Lanolate, DIPA-Myristate, Dipotassium Capryloyl Glutamate,Dipotassium Lauryl Sulfosuccinate, Dipotassium Undecylenoyl Glutamate,Disodium Babassuamido MEA-Sulfosuccinate, Disodium Caproamphodiacetate,Disodium Caproamphodipropionate, Disodium Capryloamphodiacetate,Disodium Capryloamphodipropionate, Disodium Capryloyl Glutamate,Disodium Cetearyl Sulfosuccinate, Disodium Cetyl Phenyl EtherDisulfonate, Disodium Cetyl Sulfosuccinate, Disodium CocamidoMEA-Sulfosuccinate, Disodium Cocamido MIPA PEG-4 Sulfosuccinate,Disodium Cocamido MIPA-Sulfosuccinate, Disodium Cocamido PEG-3Sulfosuccinate, Disodium Coceth-3 Sulfosuccinate, DisodiumCocoamphocarboxyethylhydroxypropylsulfonate, DisodiumCocoamphodiacetate, Disodium Cocoamphodipropionate, DisodiumCoco-Glucoside Sulfosuccinate, Disodium Coco-Sulfosuccinate, DisodiumCocoyl Butyl Gluceth-10 Sulfosuccinate, Disodium Cocoyl Glutamate,Disodium C12-14 Pareth-1 Sulfosuccinate, Disodium C12-14 Pareth-2Sulfosuccinate, Disodium C12-15 Pareth Sulfosuccinate, Disodium C12-14Sec-Pareth-3 Sulfosuccinate, Disodium C12-14 Sec-Pareth-5Sulfosuccinate, Disodium C12-14 Sec-Pareth-7 Sulfosuccinate, DisodiumC12-14 Sec-Pareth-9 Sulfosuccinate, Disodium C12-14 Sec-Pareth-12Sulfosuccinate, Disodium Deceth-5 Sulfosuccinate, Disodium Deceth-6Sulfosuccinate, Disodium Decyl Phenyl Ether Disulfonate, DisodiumDihydroxyethyl Sulfosuccinylundecylenate, Disodium Ethylene DicocamidePEG-15 Disulfate, Disodium Hydrogenated Cottonseed GlycerideSulfosuccinate, Disodium Hydrogenated Tallow Glutamate, DisodiumHydroxydecyl Sorbitol Citrate, Disodium Isodecyl Sulfosuccinate,Disodium Isostearamido MEA-Sulfosuccinate, Disodium IsostearamidoMIPA-Sulfosuccinate, Disodium Isostearoamphodiacetate, DisodiumIsostearoamphodipropionate, Disodium Isostearyl Sulfosuccinate, DisodiumLaneth-5 Sulfosuccinate, Disodium Lauramido MEA-Sulfosuccinate, DisodiumLauramido MIPA Glycol Sulfosuccinate, Disodium Lauramido PEG-2Sulfosuccinate, Disodium Lauramido PEG-5 Sulfosuccinate, DisodiumLaureth-5 Carboxyamphodiacetate, Disodium Laureth-7 Citrate, DisodiumLaureth Sulfosuccinate, Disodium Laureth-6 Sulfosuccinate, DisodiumLaureth-9 Sulfosuccinate, Disodium Laureth-12 Sulfosuccinate, DisodiumLauriminobishydroxypropylsulfonate, Disodium Lauriminodiacetate,Disodium Lauriminodipropionate, Disodium LauriminodipropionateTocopheryl Phosphates, Disodium Lauroamphodiacetate, DisodiumLauroamphodipropionate, Disodium N-Lauroyl Aspartate, Disodium LauroylGlutamate, Disodium Lauryl Phenyl Ether Disulfonate, Disodium LaurylSulfosuccinate, Disodium Myristamido MEA-Sulfosuccinate, DisodiumNonoxynol-10 Sulfosuccinate, Disodium Oleamido MEA-Sulfosuccinate,Disodium Oleamido MIPA-Sulfosuccinate, Disodium Oleamido PEG-2Sulfosuccinate, Disodium Oleoamphodipropionate, Disodium Oleth-3Sulfosuccinate, Disodium Oleyl Phosphate, Disodium Oleyl Sulfosuccinate,Disodium Palmitamido PEG-2 Sulfosuccinate, Disodium Palmitoleamido PEG-2Sulfosuccinate, Disodium PEG-4 Cocamido MIPA-Sulfosuccinate, DisodiumPEG-12 Dimethicone Sulfosuccinate, Disodium PEG-8 Palm GlyceridesSulfosuccinate, Disodium PPG-2-lsodeceth-7 Carboxyamphodiacetate,Disodium Ricinoleamido MEA-Sulfosuccinate, Disodium Sitostereth-14Sulfosuccinate, Disodium Soyamphodiacetate, Disodium StearamidoMEA-Sulfosuccinate, Disodium Steariminodipropionate, DisodiumStearoamphodiacetate, Disodium Stearoyl Glutamate, Disodium StearylSulfosuccinamate, Disodium Stearyl Sulfosuccinate, Disodium2-Sulfolaurate, Disodium 2-Sulfopalmitate, Disodium TallamidoMEA-Sulfosuccinate, Disodium Tallowamido MEA-Sulfosuccinate, DisodiumTallowamphodiacetate, Disodium Tallowiminodipropionate, Disodium TallowSulfosuccinamate, Disodium Tridecylsulfosuccinate, DisodiumUndecylenamido MEA-Sulfosuccinate, Disodium Undecylenamido PEG-2Sulfosuccinate, Disodium Undecylenoyl Glutamate, Disodium WheatGermamido MEA-Sulfosuccinate, Disodium Wheat Germamido PEG-2Sulfosuccinate, Disodium Wheatgermamphodiacetate, Di-TEA-CocamideDiacetate, Di-TEA-Oleamido PEG-2 Sulfosuccinate, Di-TEA-PalmitoylAspartate, Ditridecyl Sodium Sulfosuccinate, Dodecylbenzene SulfonicAcid, Erucamidopropyl Hydroxysultaine, Ethylhexeth-3 Carboxylic Acid,Ethyl PEG-15 Cocamine Sulfate, Glyceryl Capryl Ether, HexyldecanoicAcid, Hydrogenated Coconut Acid, Hydrogenated Laneth-25, HydrogenatedMenhaden Acid, Hydrogenated Palm Acid, Hydrogenated Palm Kernel AmineOxide, Hydrogenated Tallow Acid, Hydrogenated Tallowamine Oxide,Hydrogenated Tallow Betaine, Hydrogenated Talloweth-25, HydrogenatedTallowoyl Glutamic Acid, Hydrolyzed Candida Bombicola Extract,Hydroxyceteth-60, Hydroxyethyl Acetomonium PG-Dimethicone,Hydroxyethylbutylamine Laureth Sulfate, Hydroxyethyl CarboxymethylCocamidopropylamine, Hydroxyethyl Hydroxypropyl C12-15 AlkoxypropylamineOxide, Hydroxylauryl/Hydroxymyristyl Betaine, Hydroxystearic Acid,Hydroxysuccinim idyl C10-40 Isoalkyl Acidate, Hydroxysuccinim idylC21-22 Isoalkyl Acidate, Hydroxysultaines, IPDI/PEG-15 Soyamine OxideCopolymer, IPDI/PEG-15 Soyethonium Ethosulfate Copolymer, IPDI/PEG-15Soy Glycinate Copolymer, lsoceteth-30, Isolaureth-4 Phosphate,Isopolyglyceryl-3 Dimethicone, Isopolyglyceryl-3 Dimethiconol,Isopropanolam ine Lanolate, Isopropylam ine Dodecylbenzenesulfonate,Isostearamidopropylamine Oxide, Isostearamidopropyl Betaine,Isostearamidopropyl Morpholine Oxide, Isosteareth-8, Isosteareth-16,lsosteareth-22, Isosteareth-25, Isosteareth-50, Isostearic Acid,Isostearoyl Hydrolyzed Collagen, Jojoba Oil PEG-150 Esters, Jojoba WaxPEG-80 Esters, Jojoba Wax PEG-120 Esters, Laneth-20, Laneth-25,Laneth-40, Laneth-50, Laneth-60, Laneth-75, Lanolin Acid,Lauramidopropylamine Oxide, Lauramidopropyl Betaine, LauramidopropylHydroxysultaine, Lauramine Oxide, Lauraminopropionic Acid,Laurdimoniumhydroxypropyl Decylglucosides Chloride,Laurdimoniumhydroxypropyl Laurylglucosides Chloride, Laureth-16,Laureth-20, Laureth-21, Laureth-23, Laureth-25, Laureth-30, Laureth-38,Laureth-40, Laureth-3 Carboxylic Acid, Laureth-4 Carboxylic Acid,Laureth-5 Carboxylic Acid, Laureth-6 Carboxylic Acid, Laureth-8Carboxylic Acid, Laureth-10 Carboxylic Acid, Laureth-11 Carboxylic Acid,Laureth-12 Carboxylic Acid, Laureth-13 Carboxylic Acid, Laureth-14Carboxylic Acid, Laureth-17 Carboxylic Acid, Laureth-6 Citrate,Laureth-7 Citrate, Laureth-1 Phosphate, Laureth-2 Phosphate, Laureth-3Phosphate, Laureth-4 Phosphate, Laureth-7 Phosphate, Laureth-8Phosphate, Laureth-7 Tartrate, Laurie Acid, Laurimino Bispropanediol,Lauriminodipropionic Acid, Lauroamphodipropionic Acid, LauroylBeta-Alanine, Lauroyl Collagen Amino Acids, Lauroyl EthyltrimoniumMethosulfate, Lauroyl Hydrolyzed Collagen, Lauroyl Hydrolyzed Elastin,Lauroyl Methyl Glucamide, Lauroyl Sarcosine, Lauroyl Silk Amino Acids,Lauryl Betaine, Lauryl Dimethicone/Polyglycerin-3 Crosspolymer,Lauryldimoniumhydroxypropyl Cocoglucosides Chloride, Lauryl Glucoside,Laurylglucosides Hydroxypropyltrimonium Chloride, Lauryl GlycolHydroxypropyl Ether, Lauryl Hydroxysultaine, Lauryl Malamide, LaurylMethylglucamide, Lauryl/Myristyl Glycol Hydroxypropyl Ether,Lauryl/Myristyl Wheat Bran/Straw Glycosides, Lauryl Polyglyceryl-3Polydimethylsiloxyethyl Dimethicone, Lauryl Pyrrolidone, LaurylSultaine, Linoleic Acid, Linolenic Acid, Linseed Acid, Lysine Cocoate,Macadamia Seed Oil Glycereth-8 Esters, Magnesium Coceth Sulfate,Magnesium Coco-Sulfate, Magnesium Isododecylbenzenesulfonate, MagnesiumLaureth-11 Carboxylate, Magnesium Laureth Sulfate, Magnesium Laureth-5Sulfate, Magnesium Laureth-8 Sulfate, Magnesium Laureth-16 Sulfate,Magnesium Laureth-3 Sulfosuccinate, Magnesium Lauryl HydroxypropylSulfonate, Magnesium Lauryl Sulfate, Magnesium Methyl Cocoyl Taurate,Magnesium Myreth Sulfate, Magnesium Oleth Sulfate,Magnesium/TEA-Coco-Sulfate, Manicouagan Clay, MEA-Cocoate, MEA-Laureth-6Carboxylate, MEA-Laureth Sulfate, MEA-Lauryl Sulfate, MEA PPG-6Laureth-7 Carboxylate, MEA-PPG-8-Steareth-7 Carboxylate,MEA-Undecylenate, Meroxapol 108, Meroxapol 174, Meroxapol 178, Meroxapol254, Meroxapol 255, Meroxapol 258, Meroxapol 314, Methoxy PEG-450Amidoglutaroyl Succinimide, Methoxy PEG-450 Amido HydroxysuccinimidylSuccinamate, Methoxy PEG-450 Maleimide, Methyl Morpholine Oxide,Milkamidopropyl Amine Oxide, Milkamidopropyl Betaine,Minkamidopropylamine Oxide, Minkamidopropyl Betaine, MIPA C12-15 ParethSulfate, MIPA-Dodecylbenzenesulfonate, MIPA-Laureth Sulfate, MIPA-LaurylSulfate, Mixed Isopropanolamines Lanolate, Mixed IsopropanolaminesLauryl Sulfate, Mixed Isopropanolamines Myristate, Morpholine Oleate,Morpholine Stearate, Myreth-3 Carboxylic Acid, Myreth-5 Carboxylic Acid,Myristalkonium Chloride, Myristamidopropylamine Oxide, MyristamidopropylBetaine, Myristamidopropyl Dimethylamine Phosphate, MyristamidopropylHydroxysultaine, Myristamidopropyl PG-Dimonium Chloride Phosphate,Myristamine Oxide, Myristaminopropionic Acid, Myristic Acid, MyristoylEthyltrimonium Methosulfate, Myristoyl Glutamic Acid, MyristoylHydrolyzed Collagen, Myristoyl Sarcosine, Myristyl Betaine,Myristyl/Cetyl Amine Oxide, Myristyldimoniumhydroxypropyl CocoglucosidesChloride, Myristyl Glucoside, Myristyl Phosphate, Nonoxynol-20,Nonoxynol-23, Nonoxynol-25, Nonoxynol-30, Nonoxynol-35, Nonoxynol-40,Nonoxynol-44, Nonoxynol-50, Nonoxynol-100, Nonoxynol-120, Nonoxynol-5Carboxylic Acid, Nonoxynol-8 Carboxylic Acid, Nonoxynol-10 CarboxylicAcid, Nonoxynol-3 Phosphate, Nonoxynol-4 Phosphate, Nonoxynol-6Phosphate, Nonoxynol-9 Phosphate, Nonoxynol-10 Phosphate, NonylNonoxynol-30, Nonyl Nonoxynol-49, Nonyl Nonoxynol-100, NonylNonoxynol-150, Nonyl Nonoxynol-7 Phosphate, Nonyl Nonoxynol-8 Phosphate,Nonyl Nonoxynol-9 Phosphate, Nonyl Nonoxynol-10 Phosphate, NonylNonoxynol-11 Phosphate, Nonyl Nonoxynol-15 Phosphate, Nonyl Nonoxynol-24Phosphate, Oatamidopropyl Betaine, Octoxynol-16, Octoxynol-25,Octoxynol-30, Octoxynol-33, Octoxynol-40, Octoxynol-70, Octoxynol-20Carboxylic Acid, Octyldodeceth-20, Octyldodeceth-25, Octyldodeceth-30,Oleamidopropylamine Oxide, Oleamidopropyl Betaine, OleamidopropylHydroxysultaine, Oleamine Oxide, Oleic Acid, Oleoyl Hydrolyzed Collagen,Oleoyl Sarcosine, Oleth-20, Oleth-23, Oleth-24, Oleth-25, Oleth-30,Oleth-35, Oleth-40, Oleth-44, Oleth-50, Oleth-3 Carboxylic Acid, Oleth-6Carboxylic Acid, Oleth-10 Carboxylic Acid, Oleyl Betaine,Olivamidopropylamine Oxide, Olivamidopropyl Betaine, Olive Acid, OlivoylHydrolyzed Wheat Protein, Ophiopogon Extract Stearate, OzonizedOleth-10, Ozonized PEG-10 Oleate, Ozonized PEG-14 Oleate, OzonizedPolysorbate 80, Palm Acid, Palmamidopropyl Betaine, Palmeth-2 Phosphate,Palmitam idopropylam ine Oxide, Palmitam idopropyl Betaine, PalmitamineOxide, Palmitic Acid, Palmitoyl Collagen Amino Acids, Palmitoyl Glycine,Palmitoyl Hydrolyzed Collagen, Palmitoyl Hydrolyzed Milk Protein,Palmitoyl Hydrolyzed Wheat Protein, Palmitoyl Keratin Amino Acids,Palmitoyl Oligopeptide, Palmitoyl Silk Amino Acids, Palm Kernel Acid,Palm Kernelamidopropyl Betaine, Peach Kernel Oil Glycereth-8 Esters,Peanut Acid, PEG-10 Castor Oil, PEG-40 Castor Oil, PEG-44 Castor Oil,PEG-50 Castor Oil, PEG-54 Castor Oil, PEG-55 Castor Oil, PEG-60 CastorOil, PEG-80 Castor Oil, PEG-100 Castor Oil, PEG-200 Castor Oil, PEG-11Cocamide, PEG-6 Cocamide Phosphate, PEG-4 Cocamine, PEG-8 Cocamine,PEG-12 Cocamine, PEG-150 Dibehenate, PEG-90 Diisostearate, PEG-75Dilaurate, PEG-150 Dilaurate, PEG-75 Dioleate, PEG-150 Dioleate, PEG-75Distearate, PEG-120 Distearate, PEG-150 Distearate, PEG-175 Distearate,PEG-190 Distearate, PEG-250 Distearate, PEG-30 Glyceryl Cocoate, PEG-40Glyceryl Cocoate, PEG-78 Glyceryl Cocoate, PEG-80 Glyceryl Cocoate,PEG-30 Glyceryl Isostearate, PEG-40 Glyceryl Isostearate, PEG-50Glyceryl Isostearate, PEG-60 Glyceryl Isostearate, PEG-90 GlycerylIsostearate, PEG-23 Glyceryl Laurate, PEG-30 Glyceryl Laurate, PEG-25Glyceryl Oleate, PEG-30 Glyceryl Oleate, PEG-30 Glyceryl Soyate, PEG-25Glyceryl Stearate, PEG-30 Glyceryl Stearate, PEG-40 Glyceryl Stearate,PEG-120 Glyceryl Stearate, PEG-200 Glyceryl Stearate, PEG-28 GlycerylTallowate, PEG-80 Glyceryl Tallowate, PEG-82 Glyceryl Tallowate, PEG-130Glyceryl Tallowate, PEG-200 Glyceryl Tallowate, PEG-45 HydrogenatedCastor Oil, PEG-50 Hydrogenated Castor Oil, PEG-54 Hydrogenated CastorOil, PEG-55 Hydrogenated Castor Oil, PEG-60 Hydrogenated Castor Oil,PEG-80 Hydrogenated Castor Oil, PEG-100 Hydrogenated Castor Oil, PEG-200Hydrogenated Castor Oil, PEG-30 Hydrogenated Lanolin, PEG-70Hydrogenated Lanolin, PEG-50 Hydrogenated Palmamide, PEG-2 Isostearate,PEG-3 Isostearate, PEG-4 Isostearate, PEG-6 Isostearate, PEG-8Isostearate, PEG-10 Isostearate, PEG-12 Isostearate, PEG-20 Isostearate,PEG-30 Isostearate, PEG-40 Isostearate, PEG-26 Jojoba Acid, PEG-40Jojoba Acid, PEG-15 Jojoba Alcohol, PEG-26 Jojoba Alcohol, PEG-40 JojobaAlcohol, PEG-35 Lanolin, PEG-40 Lanolin, PEG-50 Lanolin, PEG-55 Lanolin,PEG-60 Lanolin, PEG-70 Lanolin, PEG-75 Lanolin, PEG-85 Lanolin, PEG-100Lanolin, PEG-150 Lanolin, PEG-75 Lanolin Oil, PEG-2 Lauramide, PEG-3Lauramine Oxide, PEG-20 Laurate, PEG-32 Laurate, PEG-75 Laurate, PEG-150Laurate, PEG-70 Mango Glycerides, PEG-20 Mannitan Laurate, PEG-8 MethylEther Dimethicone, PEG-120 Methyl Glucose Dioleate, PEG-80 MethylGlucose Laurate, PEG-120 Methyl Glucose Trioleate, PEG-4 Montanate,PEG-30 Oleamine, PEG-20 Oleate, PEG-23 Oleate, PEG-32 Oleate, PEG-36Oleate, PEG-75 Oleate, PEG-150 Oleate, PEG-20 Palmitate, PEG-150Polyglyceryl-2 Tristearate, PEG/PPG-28/21 Acetate Dimethicone,PEG/PPG-24/18 Butyl Ether Dimethicone, PEG/PPG-3/17 Copolymer,PEG/PPG-5/35 Copolymer, PEG/PPG-8/55 Copolymer, PEG/PPG-10/30 Copolymer,PEG/PPG-10/65 Copolymer, PEG/PPG-12/35 Copolymer, PEG/PPG-16/17Copolymer, PEG/PPG-20/9 Copolymer, PEG/PPG-20/20 Copolymer,PEG/PPG-20/60 Copolymer, PEG/PPG-20/65 Copolymer, PEG/PPG-22/25Copolymer, PEG/PPG-28/30 Copolymer, PEG/PPG-30-35 Copolymer,PEG/PPG-30/55 Copolymer, PEG/PPG-35/40 Copolymer, PEG/PPG-50/40Copolymer, PEG/PPG-150/35 Copolymer, PEG/PPG-160/30 Copolymer,PEG/PPG-190/60 Copolymer, PEG/PPG-200/40 Copolymer, PEG/PPG-300/55Copolymer, PEG/PPG-20/22 Methyl Ether Dimethicone, PEG-26-PPG-30Phosphate, PEG/PPG-4/2 Propylheptyl Ether, PEG/PPG-6/2 PropylheptylEther, PEG-7/PPG-2 Propylheptyl Ether, PEG/PPG-8/2 Propylheptyl Ether,PEG/PPG-10/2 Propylheptyl Ether, PEG/PPG-14/2 Propylheptyl Ether,PEG/PPG-40/2 Propylheptyl Ether, PEG/PPG-10/2 Ricinoleate, PEG/PPG-32/3Ricinoleate, PEG-55 Propylene Glycol Oleate, PEG-25 Propylene GlycolStearate, PEG-75 Propylene Glycol Stearate, PEG-120 Propylene GlycolStearate, PEG-5 Rapeseed Sterol, PEG-10 Rapeseed Sterol, PEG-40Ricinoleamide, PEG-75 Shea Butter Glycerides, PEG-75 Shorea ButterGlycerides, PEG-20 Sorbitan Cocoate, PEG-20 Sorbitan Isostearate, PEG-40Sorbitan Lanolate, PEG-75 Sorbitan Lanolate, PEG-10 Sorbitan Laurate,PEG-40 Sorbitan Laurate, PEG-44 Sorbitan Laurate, PEG-75 SorbitanLaurate, PEG-80 Sorbitan Laurate, PEG-20 Sorbitan Oleate, PEG-80Sorbitan Palmitate, PEG-40 Sorbitan Stearate, PEG-60 Sorbitan Stearate,PEG-160 Sorbitan Triisostearate, PEG-40 Soy Sterol, PEG-2 StearamideCarboxylic Acid, PEG-9 Stearamide Carboxylic Acid, PEG-20 Stearate,PEG-23 Stearate, PEG-25 Stearate, PEG-30 Stearate, PEG-32 Stearate,PEG-35 Stearate, PEG-36 Stearate, PEG-40 Stearate, PEG-45 Stearate,PEG-50 Stearate, PEG-55 Stearate, PEG-75 Stearate, PEG-90 Stearate,PEG-100 Stearate, PEG-120 Stearate, PEG-150 Stearate, PEG-45 StearatePhosphate, PEG-20 Tallate, PEG-50 Tallow Amide, PEG-2 Tallowamide DEA,PEG-20 Tallowate, PEG-66 Trihydroxystearin, PEG-200 Trihydroxystearin,PEG-60 Tsubakiate Glycerides, Pelargonic Acid, Pentadoxynol-200,Pheneth-6 Phosphate, Poloxamer 105, Poloxamer 108, Poloxamer 182,Poloxamer 183, Poloxamer 184, Poloxamer 188, Poloxamer 217, Poloxamer234, Poloxamer 235, Poloxamer 237, Poloxamer 238, Poloxamer 288,Poloxamer 334, Poloxamer 335, Poloxamer 338, Poloxamine 908, Poloxamine1508, Polydimethylsiloxy PEG/PPG-24/19 Butyl Ether Silsesquioxane,Polydimethylsiloxy PPG-13 Butyl Ether Silsesquioxane, Polyglyceryl-6Caprate, Polyglyceryl-10 Dilaurate, Polyglyceryl-20 Heptacaprylate,Polyglyceryl-20 Hexacaprylate, Polyglyceryl-2 Lauryl Ether,Polyglyceryl-10 Lauryl Ether, Polyglyceryl-20 Octaisononanoate,Polyglyceryl-6 Pentacaprylate, Polyglyceryl-10 Pentacaprylate,Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Polyglyceryl-6Tetracaprylate, Polyglyceryl-10 Tetralaurate, Polyglyceryl-6Tricaprylate, Polyglyceryl-10 Trilaurate, Polyquaternium-77,Polyquaternium-78, Polyquaternium-79, Polyquaternium-80,Polyquaternium-81, Polyquaternium-82, Pomaderris Kumerahou Flower/LeafExtract, Poria Cocos Extract, Potassium Abietoyl Hydrolyzed Collagen,Potassium Babassuate, Potassium Behenate, Potassium C9-15 AlkylPhosphate, Potassium C11-15 Alkyl Phosphate, Potassium C12-13 AlkylPhosphate, Potassium C12-14 Alkyl Phosphate, Potassium Caprate,Potassium Capryloyl Glutamate, Potassium Capryloyl Hydrolyzed RiceProtein, Potassium Castorate, Potassium Cocoate, Potassium CocoylGlutamate, Potassium Cocoyl Glycinate, Potassium Cocoyl HydrolyzedCasein, Potassium Cocoyl Hydrolyzed Collagen, Potassium CocoylHydrolyzed Corn Protein, Potassium Cocoyl Hydrolyzed Keratin, PotassiumCocoyl Hydrolyzed Oat Protein, Potassium Cocoyl Hydrolyzed PotatoProtein, Potassium Cocoyl Hydrolyzed Rice Bran Protein, Potassium CocoylHydrolyzed Rice Protein, Potassium Cocoyl Hydrolyzed Silk, PotassiumCocoyl Hydrolyzed Soy Protein, Potassium Cocoyl Hydrolyzed WheatProtein, Potassium Cocoyl Hydrolyzed Yeast Protein, Potassium CocoylPCA, Potassium Cocoyl Sarcosinate, Potassium Cocoyl Taurate, PotassiumCornate, Potassium Cyclocarboxypropyloleate, Potassium DihydroxyethylCocamine Oxide Phosphate, Potassium Dimethicone PEG-7 Phosphate,Potassium Dodecylbenzenesulfonate, Potassium Hempseedate, PotassiumHydrogenated Cocoate, Potassium Hydrogenated Palmate, PotassiumHydrogenated Tallowate, Potassium Hydroxystearate, PotassiumIsostearate, Potassium Lanolate, Potassium Laurate, Potassium Laureth-3Carboxylate, Potassium Laureth-4 Carboxylate, Potassium Laureth-5Carboxylate, Potassium Laureth-6 Carboxylate, Potassium Laureth-10Carboxylate, Potassium Laureth Phosphate, Potassium Lauroyl CollagenAmino Acids, Potassium Lauroyl Glutamate, Potassium Lauroyl HydrolyzedCollagen, Potassium Lauroyl Hydrolyzed Pea Protein, Potassium LauroylHydrolyzed Soy Protein, Potassium Lauroyl PCA, Potassium Lauroyl PeaAmino Acids, Potassium Lauroyl Sarcosinate, Potassium Lauroyl Silk AminoAcids, Potassium Lauroyl Wheat Amino Acids, Potassium Lauryl Phosphate,Potassium Lauryl Sulfate, Potassium Linoleate, Potassium Metaphosphate,Potassium Methyl Cocoyl Taurate, Potassium Myristate, PotassiumMyristoyl Glutamate, Potassium Myristoyl Hydrolyzed Collagen, PotassiumOctoxynol-12 Phosphate, Potassium Oleate, Potassium Oleoyl HydrolyzedCollagen, Potassium Olivate, Potassium Olivoyl Hydrolyzed Oat Protein,Potassium Olivoyl Hydrolyzed Wheat Protein, Potassium Olivoyl/LauroylWheat Amino Acids, Potassium Olivoyl PCA, Potassium Palmate, PotassiumPalmitate, Potassium Palmitoyl Hydrolyzed Corn Protein, PotassiumPalmitoyl Hydrolyzed Oat Protein, Potassium Palmitoyl Hydrolyzed RiceProtein, Potassium Palmitoyl Hydrolyzed Sweet Almond Protein, PotassiumPalmitoyl Hydrolyzed Wheat Protein, Potassium Palm Kernelate, PotassiumPeanutate, Potassium Rapeseedate, Potassium Ricinoleate, PotassiumSafflowerate, Potassium Soyate, Potassium Stearate, Potassium StearoylHydrolyzed Collagen, Potassium Tallate, Potassium Tallowate, PotassiumTaurate, Potassium Taurine Laurate, Potassium Trideceth-3 Carboxylate,Potassium Trideceth-4 Carboxylate, Potassium Trideceth-7 Carboxylate,Potassium Trideceth-15 Carboxylate, Potassium Trideceth-19 Carboxylate,Potassium Trideceth-6 Phosphate, Potassium Trideceth-7 Phosphate,Potassium Tsubakiate, Potassium Undecylenate, Potassium UndecylenoylHydrolyzed Collagen, Potassium Undecylenoyl Hydrolyzed Rice Protein,PPG-30-Buteth-30, PPG-36-Buteth-36, PPG-38-Buteth-37, PPG-30-Capryleth-4Phosphate, PPG-10 Cetyl Ether Phosphate, PPG-2 C9-11 Pareth-8,PPG-1-Deceth-5, PPG-3-Deceth-2 Carboxylic Acid, PPG-30 Ethylhexeth-4Phosphate, PPG-20-Glycereth-30, PPG-2 Hydroxyethyl Coco/Isostearamide,PPG-2-Isodeceth-8, PPG-2-lsodeceth-10, PPG-2-lsodeceth-18,PPG-2-lsodeceth-25, PPG-4-lsodeceth-10, Propyltrimonium HydrolyzedCollagen, Quaternium-24, Quaternium-52, Quaternium-87, Rapeseed Acid,Rice Bran Acid, Rice Oil Glycereth-8 Esters, RicinoleamidopropylBetaine, Ricinoleic Acid, Ricinoleth-40, Safflower Acid, SapindusOahuensis Fruit Extract, Saponaria Officinalis Root Powder, Saponins,Sekken-K, Sekken-Na/K, Sekken Soji, Sekken Soji-K, Sesame OilGlycereth-8 Esters, Sesamidopropylamine Oxide, Sesamidopropyl Betaine,Shea Butteramidopropyl Betaine, Shea Butter Glycereth-8 Esters, SodiumArachidate, Sodium Arganampohoacetate, Sodium Astrocaryum Murumuruate,Sodium Avocadoate, Sodium Babassuamphoacetate, Sodium Babassuate, SodiumBabassu Sulfate, Sodium Behenate, Sodium Bisglycol Ricinosulfosuccinate,Sodium Bis-Hydroxyethylglycinate Coco-Glucosides Crosspolymer, SodiumBis-Hydroxyethylglycinate Lauryl-Glucosides Crosspolymer, SodiumBorageamidopropyl PG-Dimonium Chloride Phosphate, Sodium Butoxynol-12Sulfate, Sodium Butylglucosides Hydroxypropyl Phosphate, Sodium C13-17Alkane Sulfonate, Sodium C14-18 Alkane Sulfonate, Sodium C12-15Alkoxypropyl Iminodipropionate, Sodium C10-16 Alkyl Sulfate, SodiumC11-15 Alkyl Sulfate, Sodium C12-13 Alkyl Sulfate, Sodium C12-15 AlkylSulfate, Sodium C12-18 Alkyl Sulfate, Sodium C16-20 Alkyl Sulfate,Sodium C9-22 Alkyl Sec Sulfonate, Sodium C14-17 Alkyl Sec Sulfonate,Sodium Caprate, Sodium Caproamphoacetate, SodiumCaproamphohydroxypropylsulfonate, Sodium Caproamphopropionate, SodiumCaproyl Methyltaurate, Sodium Caprylate, Sodium Capryleth-2 Carboxylate,Sodium Capryleth-9 Carboxylate, Sodium Capryloamphoacetate, SodiumCapryloamphohydroxypropylsulfonate, Sodium Capryloamphopropionate,Sodium Capryloyl Glutamate, Sodium Capryloyl Hydrolyzed Wheat Protein,Sodium Caprylyl PG-Sulfonate, Sodium Caprylyl Sulfonate, SodiumCastorate, Sodium Ceteareth-13 Carboxylate, Sodium Cetearyl Sulfate,Sodium Ceteth-13 Carboxylate, Sodium Cetyl Sulfate, SodiumCocamidopropyl PG-Dimonium Chloride Phosphate, SodiumCocaminopropionate, Sodium Coceth Sulfate, Sodium Coceth-30 Sulfate,Sodium Cocoabutteramphoacetate, Sodium Cocoa Butterate, SodiumCocoamphoacetate, Sodium Cocoamphohydroxypropylsulfonate, SodiumCocoamphopropionate, Sodium Cocoate, Sodium Coco/Babassu/AndirobaSulfate, Sodium Coco/Babassu Sulfate, Sodium CocoglucosidesHydroxypropyl Phosphate, Sodium Cocoglucosides Hydroxypropylsulfonate,Sodium Coco-Glucoside Tartrate, Sodium Cocoglyceryl Ether Sulfonate,Sodium Coco/Hydrogenated Tallow Sulfate, Sodium Cocoiminodiacetate,Sodium Cocomonoglyceride Sulfate, Sodium Cocomonoglyceride Sulfonate,Sodium Coco PG-Dimonium Chloride Phosphate, Sodium Coco-Sulfate, SodiumCoco Sulfoacetate, Sodium Cocoyl Alaninate, Sodium Cocoyl Amino Acids,Sodium Cocoyl Collagen Amino Acids, Sodium Cocoyl Glutamate, SodiumCocoyl Glutaminate, Sodium Cocoyl Glycinate, Sodium Cocoyl/HydrogenatedTallow Glutamate, Sodium Cocoyl Hydrolyzed Collagen, Sodium CocoylHydrolyzed Keratin, Sodium Cocoyl Hydrolyzed Rice Protein, Sodium CocoylHydrolyzed Silk, Sodium Cocoyl Hydrolyzed Soy Protein, Sodium CocoylHydrolyzed Sweet Almond Protein, Sodium Cocoyl Hydrolyzed Wheat Protein,Sodium Cocoyl Hydrolyzed Wheat Protein Glutamate, Sodium CocoylIsethionate, Sodium Cocoyl Methylaminopropionate, Sodium Cocoyl OatAmino Acids, Sodium Cocoyl/Palmoyl/Sunfloweroyl Glutamate, Sodium CocoylProline, Sodium Cocoyl Sarcosinate, Sodium Cocoyl Taurate, Sodium CocoylThreoninate, Sodium Cocoyl Wheat Amino Acids, Sodium C12-14 OlefinSulfonate, Sodium C14-16 Olefin Sulfonate, Sodium C14-18 OlefinSulfonate, Sodium C16-18 Olefin Sulfonate, Sodium Cornamphopropionate,Sodium Cottonseedamphoacetate, Sodium C13-15 Pareth-8 Butyl Phosphate,Sodium C9-11 Pareth-6 Carboxylate, Sodium C11-15 Pareth-7 Carboxylate,Sodium C12-13 Pareth-5 Carboxylate, Sodium C12-13 Pareth-8 Carboxylate,Sodium C12-13 Pareth-12 Carboxylate, Sodium C12-15 Pareth-6 Carboxylate,Sodium C12-15 Pareth-7 Carboxylate, Sodium C12-15 Pareth-8 Carboxylate,Sodium C14-15 Pareth-8 Carboxylate, Sodium C12-14 Sec-Pareth-8Carboxylate, Sodium C14-15 Pareth-PG Sulfonate, Sodium C12-13 Pareth-2Phosphate, Sodium C13-15 Pareth-8 Phosphate, Sodium C9-15 Pareth-3Sulfate, Sodium C10-15 Pareth Sulfate, Sodium C10-16 Pareth-2 Sulfate,Sodium C12-13 Pareth Sulfate, Sodium C12-15 Pareth Sulfate, SodiumC12-15 Pareth-3 Sulfate, Sodium C13-15 Pareth-3 Sulfate, Sodium C12-14Sec-Pareth-3 Sulfate, Sodium C12-15 Pareth-3 Sulfonate, Sodium C12-15Pareth-7 Sulfonate, Sodium C12-15 Pareth-15 Sulfonate, Sodium Deceth-2Carboxylate, Sodium Deceth Sulfate, Sodium Decylbenzenesulfonate, SodiumDecylglucosides Hydroxypropyl Phosphate, Sodium DecylglucosidesHydroxypropylsulfonate, Sodium Dilaureth-7 Citrate, Sodium Dilaureth-10Phosphate, Sodium Dilinoleamidopropyl PG-Dimonium Chloride Phosphate,Sodium Dilinoleate, Sodium Dioleth-8 Phosphate, SodiumDodecylbenzenesulfonate, Sodium Ethyl 2-Sulfolaurate, Sodium GlycerylOleate Phosphate, Sodium Grapeseedamidopropyl PG-Dimonium ChloridePhosphate, Sodium Grapeseedamphoacetate, Sodium Grapeseedate, SodiumHempseedamphoacetate, Sodium Hexeth-4 Carboxylate, Sodium HydrogenatedCocoate, Sodium Hydrogenated Cocoyl Methyl Isethionate, SodiumHydrogenated Palmate, Sodium Hydrogenated Tallowate, Sodium HydrogenatedTallowoyl Glutamate, Sodium Hydroxylauryldimonium Ethyl Phosphate,Sodium Hydroxypropyl Palm Kernelate Sulfonate, SodiumHydroxypropylphosphate Decylglucoside Crosspolymer, SodiumHydroxypropylphosphate Laurylglucoside Crosspolymer, SodiumHydroxypropylsulfonate Cocoglucoside Crosspolymer, SodiumHydroxypropylsulfonate Decylglucoside Crosspolymer, SodiumHydroxypropylsulfonate Laurylglucoside Crosspolymer, SodiumHydroxystearate, Sodium Isostearate, Sodium Isosteareth-6 Carboxylate,Sodium Isosteareth-11 Carboxylate, Sodium Isostearoamphoacetate, SodiumIsostearoamphopropionate, Sodium N-Isostearoyl Methyltaurate, SodiumLaneth Sulfate, Sodium Lanolate, Sodium Lardate, Sodium LauramidoDiacetate, Sodium Lauraminopropionate, Sodium Laurate, Sodium Laureth-3Carboxylate, Sodium Laureth-4 Carboxylate, Sodium Laureth-5 Carboxylate,Sodium Laureth-6 Carboxylate, Sodium Laureth-8 Carboxylate, SodiumLaureth-11 Carboxylate, Sodium Laureth-12 Carboxylate, Sodium Laureth-13Carboxylate, Sodium Laureth-14 Carboxylate, Sodium Laureth-16Carboxylate, Sodium Laureth-17 Carboxylate, Sodium Laureth Sulfate,Sodium Laureth-5 Sulfate, Sodium Laureth-7 Sulfate, Sodium Laureth-8Sulfate, Sodium Laureth-12 Sulfate, Sodium Laureth-40 Sulfate, SodiumLaureth-7 Tartrate, Sodium Laurim inodipropionate, SodiumLauroamphoacetate, Sodium Lauroamphohydroxypropylsulfonate, SodiumLauroampho PG-Acetate Phosphate, Sodium Lauroamphopropionate, SodiumLauroyl Aspartate, Sodium Lauroyl Collagen Amino Acids, Sodium LauroylGlycine Propionate, Sodium Lauroyl Hydrolyzed Collagen, Sodium LauroylHydrolyzed Silk, Sodium Lauroyl Hydroxypropyl Sulfonate, Sodium LauroylIsethionate, Sodium Lauroyl Methylaminopropionate, Sodium Lauroyl MethylIsethionate, Sodium Lauroyl Millet Amino Acids, Sodium Lauroyl/MyristoylAspartate, Sodium Lauroyl Oat Amino Acids, Sodium Lauroyl Sarcosinate,Sodium Lauroyl Silk Amino Acids, Sodium Lauroyl Taurate, Sodium LauroylWheat Amino Acids, Sodium Lauryl Diethylenediaminoglycinate, SodiumLauryl Glucose Carboxylate, Sodium Laurylglucosides HydroxypropylPhosphate, Sodium Laurylglucosides Hydroxypropylsulfonate, Sodium LaurylGlycol Carboxylate, Sodium Lauryl Hydroxyacetamide Sulfate, SodiumLauryl Phosphate, Sodium Lauryl Sulfate, Sodium Lauryl Sulfoacetate,Sodium Linoleate, Sodium Macadamiaseedate, Sodium Mangoamphoacetate,Sodium Mangoseedate, Sodium/MEA Laureth-2 Sulfosuccinate, Sodium MethoxyPPG-2 Acetate, Sodium Methyl Cocoyl Taurate, Sodium Methyl LauroylTaurate, Sodium Methyl Myristoyl Taurate, Sodium Methyl Oleoyl Taurate,Sodium Methyl Palmitoyl Taurate, Sodium Methyl Stearoyl Taurate, SodiumMethyl 2-Sulfolaurate, Sodium Methyl 2-Sulfopalmitate, SodiumMethyltaurate Isopalmitamide, Sodium Methyltaurine Cocoyl Methyltaurate,Sodium Myreth Sulfate, Sodium Myristate, Sodium Myristoamphoacetate,Sodium Myristoyl Glutamate, Sodium Myristoyl Hydrolyzed Collagen, SodiumMyristoyl Isethionate, Sodium Myristoyl Sarcosinate, Sodium MyristylSulfate, Sodium Nonoxynol-6 Phosphate, Sodium Nonoxynol-9 Phosphate,Sodium Nonoxynol-1 Sulfate, Sodium Nonoxynol-3 Sulfate, SodiumNonoxynol-4 Sulfate, Sodium Nonoxynol-6 Sulfate, Sodium Nonoxynol-8Sulfate, Sodium Nonoxynol-10 Sulfate, Sodium Nonoxynol-25 Sulfate,Sodium Octoxynol-2 Ethane Sulfonate, Sodium Octoxynol-2 Sulfate, SodiumOctoxynol-6 Sulfate, Sodium Octoxynol-9 Sulfate, Sodium Oleate, SodiumOleoamphoacetate, Sodium Oleoam phohydroxypropylsulfonate, SodiumOleoamphopropionate, Sodium Oleoyl Hydrolyzed Collagen, Sodium OleoylIsethionate, Sodium Oleth Sulfate, Sodium Oleyl Methyl Isethionate,Sodium Oleyl Sulfate, Sodium Olivamphoacetate, Sodium Olivate, SodiumOlivoyl Glutamate, Sodium Palmamphoacetate, Sodium Palmate, Sodium PalmGlyceride Sulfonate, Sodium Palmitate, Sodium Palmitoyl HydrolyzedCollagen, Sodium Palmitoyl Hydrolyzed Wheat Protein, Sodium PalmitoylSarcosinate, Sodium Palm Kernelate, Sodium Palm Kerneloyl Isethionate,Sodium Palmoyl Glutamate, Sodium Passiflora Edulis Seedate, SodiumPeanutamphoacetate, Sodium Peanutate, Sodium PEG-6 Cocamide Carboxylate,Sodium PEG-8 Cocamide Carboxylate, Sodium PEG-4 Cocamide Sulfate, SodiumPEG-3 Lauramide Carboxylate, Sodium PEG-4 Lauramide Carboxylate, SodiumPEG-8 Palm Glycerides Carboxylate, Sodium Pentaerythrityl HydroxypropylIminodiacetate Dendrimer, Sodium Propoxy PPG-2 Acetate, SodiumRapeseedate, Sodium Ricebranamphoacetate, Sodium Ricinoleate, SodiumRicinoleoamphoacetate, Sodium Rose Hipsamphoacetate, Sodium Rosinate,Sodium Safflowerate, Sodium Saffloweroyl Hydrolyzed Soy Protein, SodiumSesameseedate, Sodium Sesamphoacetate, Sodium Sheabutteramphoacetate,Sodium Soyate, Sodium Soy Hydrolyzed Collagen, Sodium Stearate, SodiumStearoamphoacetate, Sodium Stearoamphohydroxypropylsulfonate, SodiumStearoamphopropionate, Sodium Stearoyl Casein, Sodium StearoylGlutamate, Sodium Stearoyl Hyaluronate, Sodium Stearoyl HydrolyzedCollagen, Sodium Stearoyl Hydrolyzed Corn Protein, Sodium StearoylHydrolyzed Silk, Sodium Stearoyl Hydrolyzed Soy Protein, Sodium StearoylHydrolyzed Wheat Protein, Sodium Stearoyl Lactalbumin, Sodium StearoylMethyl Isethionate, Sodium Stearoyl Oat Protein, Sodium Stearoyl PeaProtein, Sodium Stearoyl Soy Protein, Sodium Stearyl Dimethyl Glycine,Sodium Stearyl Sulfate, Sodium Sunflowerseedamphoacetate, SodiumSurfactin, Sodium Sweetalmondamphoacetate, Sodium Sweet Almondate,Sodium Tallamphopropionate, Sodium Tallate, Sodium Tallowamphoacetate,Sodium Tallowate, Sodium Tallow Sulfate, Sodium Tamanuseedate, SodiumTaurate, Sodium Taurine Cocoyl Methyltaurate, Sodium Taurine Laurate,Sodium/TEA-Lauroyl Collagen Amino Acids, Sodium/TEA-Lauroyl HydrolyzedCollagen, Sodium/TEA-Lauroyl Hydrolyzed Keratin, Sodium/TEA-LauroylKeratin Amino Acids, Sodium/TEA-Undecylenoyl Collagen Amino Acids,Sodium/TEA-Undecylenoyl Hydrolyzed Collagen, Sodium/TEA-UndecylenoylHydrolyzed Corn Protein, Sodium/TEA-Undecylenoyl Hydrolyzed Soy Protein,Sodium/TEA-Undecylenoyl Hydrolyzed Wheat Protein, Sodium TheobromaGrandiflorum Seedate, Sodium Trideceth-3 Carboxylate, Sodium Trideceth-4Carboxylate, Sodium Trideceth-6 Carboxylate, Sodium Trideceth-7Carboxylate, Sodium Trideceth-8 Carboxylate, Sodium Trideceth-12Carboxylate, Sodium Trideceth-15 Carboxylate, Sodium Trideceth-19Carboxylate, Sodium Trideceth Sulfate, Sodium Tridecylbenzenesulfonate,Sodium Tridecyl Sulfate, Sodium Trimethylolpropane HydroxypropylIminodiacetate Dendrimer, Sodium Undeceth-5 Carboxylate, SodiumUndecylenate, Sodium Undecylenoamphoacetate, SodiumUndecylenoamphopropionate, Sodium Undecylenoyl Glutamate, Sodium WheatGermamphoacetate, Sorbeth-160 Tristearate, Soy Acid, SoyamidopropylamineOxide, Soyamidopropyl Betaine, Soybean Oil Glycereth-8 Esters,Stearamidopropylamine Oxide, Stearamidopropyl Betaine, Stearamine Oxide,Steareth-15, Steareth-16, Steareth-20, Steareth-21, Steareth-25,Steareth-27, Steareth-30, Steareth-40, Steareth-50, Steareth-80,Steareth-100, Steareth-2 Phosphate, Steareth-3 Phosphate, Stearic Acid,Stearoxypropyltrimonium Chloride, Stearoyl Glutamic Acid, StearoylSarcosine, Stearyl Betaine, Stearyldimoniumhydroxypropyl ButylglucosidesChloride, Stearyldimoniumhydroxy-propyl Decylglucosides Chloride,Stearyldimoniumhydroxypropyl Laurylglucosides Chloride, Sulfated CastorOil, Sulfated Coconut Oil, Sulfated Glyceryl Oleate, Sulfated Olive Oil,Sulfated Peanut Oil, Sunfloweramide MEA, Sunflower Seed Acid,Sunflowerseedamidopropyl Hydroxyethyldimonium Chloride, Sunflower SeedOil Glycereth-8 Esters, Tall Oil Acid, Tallow Acid,Tallowamidopropylamine Oxide, Tallowamidopropyl Betaine,Tallowamidopropyl Hydroxysultaine, Tallowamine Oxide, Tallow Betaine,Tallow Dihydroxyethyl Betaine, Tallowoyl Ethyl Glucoside, TEA-AbietoylHydrolyzed Collagen, TEA-C12-14 Alkyl Phosphate, TEA-C10-15 AlkylSulfate, TEA-C11-15 Alkyl Sulfate, TEA-C12-13 Alkyl Sulfate, TEA-C12-14Alkyl Sulfate, TEA-C12-15 Alkyl Sulfate, TEA C14-17 Alkyl Sec Sulfonate,TEA-Canolate, TEA-Cocamide Diacetate, TEA-Cocoate, TEA-Coco-Sulfate,TEA-Cocoyl Alaninate, TEA-Cocoyl Glutamate, TEA-Cocoyl Glutaminate,TEA-Cocoyl Glycinate, TEA-Cocoyl Hydrolyzed Collagen, TEA-CocoylHydrolyzed Soy Protein, TEA-Cocoyl Sarcosinate, TEA-Dimethicone PEG-7Phosphate, TEA-Dodecylbenzenesulfonate, TEA-Hydrogenated Cocoate,TEA-Hydrogenated Tallowoyl Glutamate, TEA-Isostearate, TEA-IsostearoylHydrolyzed Collagen, TEA-Lauraminopropionate, TEA-Laurate,TEA-Laurate/Myristate, TEA-Laureth Sulfate, TEA-Lauroyl Collagen AminoAcids, TEA-Lauroyl Glutamate, TEA-Lauroyl Hydrolyzed Collagen,TEA-Lauroyl Keratin Amino Acids, TEA-Lauroyl Methylaminopropionate,TEA-Lauroyl/Myristoyl Aspartate, TEA-Lauroyl Sarcosinate, TEA-LaurylPhosphate, TEA-Lauryl Sulfate, TEA-Myristaminopropionate, TEA-Myristate,TEA-Myristoyl Hydrolyzed Collagen, TEA-Oleate, TEA-Oleoyl HydrolyzedCollagen, TEA-Oleoyl Sarcosinate, TEA-Oleyl Sulfate, TEA-Palmitate,TEA-Palm Kernel Sarcosinate, TEA-PEG-3 Cocamide Sulfate, TEA-Rosinate,TEA-Stearate, TEA-Tallate, TEA-T ridecylbenzenesulfonate,TEA-Undecylenate, TEA-Undecylenoyl Hydrolyzed Collagen, TetramethylDecynediol, Tetrasodium Dicarboxyethyl Stearyl Sulfosuccinamate,TIPA-Laureth Sulfate, TIPA-Lauryl Sulfate, TIPA-Myristate,TIPA-Stearate, Tocopheryl Phosphate, Trehalose Undecylenoate, TM-C12-15Pareth-2 Phosphate, TM-C12-15 Pareth-6 Phosphate, TM-C12-15 Pareth-8Phosphate, TM-C12-15 Pareth-10 Phosphate, Trideceth-20, Trideceth-50,Trideceth-3 Carboxylic Acid, Trideceth-4 Carboxylic Acid, Trideceth-7Carboxylic Acid, Trideceth-8 Carboxylic Acid, Trideceth-15 CarboxylicAcid, Trideceth-19 Carboxylic Acid, Trideceth-10 Phosphate,Tridecylbenzenesulfonic Acid, Trilaureth-9 Citrate, TrimethylolpropaneHydroxypropyl Bis-Hydroxyethylamine Dendrimer, Trisodium LauroamphoPG-Acetate Chloride Phosphate, Undecanoic Acid, Undeceth-5 CarboxylicAcid, Undecylenamidopropylamine Oxide, Undecylenamidopropyl Betaine,Undecylenic Acid, Undecylenoyl Collagen Amino Acids, UndecylenoylGlycine, Undecylenoyl Hydrolyzed Collagen, Undecylenoyl Wheat AminoAcids, Undecyl Glucoside, Wheat Germ Acid, Wheat GermamidopropylamineOxide, Wheat Germamidopropyl Betaine, Yucca Schidigera Leaf/Root/StemExtract, Yucca Schidigera Stem Extract, Zinc Coceth Sulfatea and ZincCoco-Sulfate.

Preservatives: For preservative purposes, the cosmetic orpharmaceutical, preferably dermatological, composition according to thepresent invention preferably includes one or more preservatives whichare suitable or customary in cosmetic or pharmaceutical, preferablydermatological, composition. Suitable and advantageously preservativesare, for example, phenoxyethanol, formaldehyde solution, parabens,pentanediol or sorbic acid.

Green and synthetic polymers: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present inventionpreferably includes one or more green or synthetic polymers. Suitablecationic polymers are, for example, cationic cellulose derivatives suchas, for example, the quaternized hydroxyethyl cellulose obtainable fromAmerchol under the name of Polymer JR 400®, cationic starch, copolymersof diallyl ammonium salts and acrylamides, quaternized vinylpyrrolidone/vinyl imidazole polymers such as, for example, Luviquat®(BASF), condensation products of polyglycols and amines, quaternizedcollagen polypeptides such as, for example, Lauryldimonium HydroxypropylHydrolyzed Collagen (Lame-quat® L, GrUnau), quaternized wheatpolypeptides, polyethyleneimine, cationic silicone polymers such as, forexample, amodimethicone, copolymers of adipic acid anddimethylaminohydroxypropyl diethylenetriamine (Cartaretine®, Sandoz),copolymers of acrylic acid with dimethyl diallyl ammonium chloride(Merquat® 550, Chemviron), polyaminopolyamides and crosslinkedwater-soluble polymers thereof, cationic chitin derivatives such as, forexample, quaternized chitosan, optionally in microcrystallinedistribution, condensation products of dihaloalkyls, for exampledibromobutane, with bis-dialkylamines, for examplebis-dimethylamino-1,3-propane, cationic guar gum such as, for example,Jaguar®CBS, Jaguar® C-17, Jaguar® C-16 of Celanese, quaternized ammoniumsalt polymers such as, for example, Mirapol®A-15, Mirapol® AD-1,Mirapol® AZ-1 of Miranol and the various polyquaternium types (forexample 5, 7, 32 or 37) which can be found in the market under thetradenames Rheocare® CC or Ultragel® 300. Suitable anionic,zwitterionic, amphoteric and nonionic polymers are, for example, vinylacetate/crotonic acid copolymers, vinyl pyrrolidone/vinyl acrylatecopolymers, vinyl acetate/butyl maleate/isobornyl acrylate copolymers,methyl vinylether/maleic anhydride copolymers and esters thereof,uncrosslinked and polyol-crosslinked polyacrylic acids, acrylamidopropyltrimethylammonium chloride/acrylate copolymers, octylacrylamide/methylmethacrylate/tert.-butylaminoethyl methacrylate/2-hydroxypropylmethacrylate copolymers, polyvinyl pyrrolidone, vinyl pyrrolidone/vinylacetate copolymers, vinyl pyrrolidone/dimethylaminoethylmethacrylate/vinyl caprolactam terpolymers and optionally derivatizedcellulose ethers and silicones. In a preferred variant, the cosmetic orpharmaceutical, preferably dermatological, composition according to thepresent invention preferably includes an uncrosslinked orpolyol-crosslinked polyacrylic acid as polymer component.

Thickening agents and/or rheology additives: The cosmetic orpharmaceutical, preferably dermatological, composition according to thepresent invention preferably includes one or more thickening agentsand/or rheology additives. Suitable thickeners are polymeric thickeners,such as Aerosil® types (hydrophilic silicas), polysaccharides, moreespecially xanthan gum, guar-guar, agar-agar, alginates and tyloses,carboxymethyl cellulose and hydroxyethyl cellulose, also relatively highmolecular weight polyethylene glycol monoesters and diesters of fattyacids, polyacrylates (for example Carbopols® [Goodrich] or Synthalens®[Sigma]), polyacrylamides, polyvinyl alcohol and polyvinyl pyrrolidone,surfactants such as, for example, ethoxylated fatty acid glycerides,esters of fatty acids with polyols, for example pentaerythritol ortrimethylol propane, narrow-range fatty alcohol ethoxylates andelectrolytes, such as sodium chloride and ammonium chloride.

Perfume oils and/or fragrances: The cosmetic or pharmaceutical,preferably dermatological, composition according to the presentinvention preferably includes one or more perfume oils and/orfragrances. Suitable perfume oils are mixtures of natural and syntheticperfumes. Natural perfumes include the extracts of blossoms (lily,lavender, rose, jasmine, neroli, ylang-ylang), stems and leaves(geranium, patchouli, petitgrain), fruits (anise, coriander, caraway,juniper), fruit peel (bergamot, lemon, orange), roots (nutmeg, angelica,celery, cardamom, costus, iris, calmus), woods (pinewood, sandalwood,guaiac wood, cedarwood, rosewood), herbs and grasses (tarragon, lemongrass, sage, thyme), needles and branches (spruce, fir, pine, dwarfpine), resins and balsams (galbanum, elemi, benzoin, myrrh, olibanum,opoponax). Animal raw materials, for example civet and beaver, may alsobe used. Typical synthetic perfume compounds are products of the ester,ether, aldehyde, ketone, alcohol and hydrocarbon type. Examples ofperfume compounds of the ester type are benzyl acetate, phenoxyethylisobutyrate, p-tert·butyl cyclohexylacetate, linalyl acetate, dimethylbenzyl carbinyl acetate, phenyl ethyl acetate, linalyl benzoate, benzylformate, ethylmethyl phenyl glycinate, allyl cyclohexyl propionate,styrallyl propionate and benzyl salicylate. Ethers include, for example,benzyl ethyl ether while aldehydes include, for example, the linearalkanals containing 8 to 18 carbon atoms, citral, citronellal,citronellyloxyacetaldehyde, cyclamen aldehyde, hydroxycitronellal,lilial and bourgeonal. Examples of suitable ketones are the ionones,beta-isomethylionone and methyl cedryl ketone. Suitable alcohols areanethol, citronellol, eugenol, isoeugenol, geraniol, linalool,phenylethyl alcohol and terpineol. The hydrocarbons mainly include theterpenes and balsams. However, it is preferred to use mixtures ofdifferent perfume compounds which, together, produce an agreeableperfume. Other suitable perfume oils are essential oils of relativelylow volatility which are mostly used as aroma components. Examples aresage oil, camomile oil, clove oil, melissa oil, mint oil, cinnamon leafoil, lime-blossom oil, juniper berry oil, vetiver oil, olibanum oil,galbanum oil, ladanum oil and lavendin oil. The following are preferablyused either individually or in the form of mixtures: bergamot oil,dihydromyrcenol, lilial, lyral, citronellol, phenylethyl alcohol,hexylcinnamaldehyde, geraniol, benzyl acetone, cyclamen aldehyde,linalool, Boisambrene Forte, Ambroxan, indole, hedione, sandelice,citrus oil, mandarin oil, orange oil, allylamyl glycolate, cyclovertal,lavendin oil, clary oil, damascone, geranium oil bourbon, cyclohexylsalicylate, Vertofix Coeur, Iso-E-Super, Fixolide NP, evernyl, iraldeingamma, phenylacetic acid, geranyl acetate, benzyl acetate, rose oxide,romillat, irotyl and floramat.

Anti-cellulite agent: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present inventionpreferably includes one or more anti-cellulite agents. Anti-celluliteagents and lipolytic agents are preferably selected from the groupconsisting of beta-adrenergic receptor agonists such as synephrine andits derivatives, and cyclohexyl carbamates. Agents enhancing or boostingthe activity of anti-cellulite agents, in particular agents whichstimulate and/or depolarise C nerve fibres, are preferably selected fromthe group consisting of capsaicin and derivatives thereof,vanillyl-nonylamid and derivatives thereof, L-carnitine, coenzym A,isoflavonoides, soy extracts, ananas extract and conjugated linoleicacid.

Fat enhancing agents: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present inventionpreferably includes one or more fat enhancing agents and/or adipogenicagents as well as agents enhancing or boosting the activity of fatenhancing agents. A fat enhancing agent is for examplehydroxymethoxyphenyl propylmethylmethoxybenzofuran (trade name: Sym3D®).

Superfatting agents and/or consistency factors: The cosmetic orpharmaceutical, preferably dermatological, composition according to thepresent invention preferably includes one or more superfatting agentsand/or consistency factors. Superfatting agents may be selected fromsuch substances as, for example, lanolin and lecithin and alsopolyethoxylated or acylated lanolin and lecithin derivatives, polyolfatty acid esters, monoglycerides and fatty acid alkanolamides, thefatty acid alkanolamides also serving as foam stabilizers. Theconsistency factors mainly used are fatty alcohols or hydroxy fattyalcohols containing 12 to 22 and preferably 16 to 18 carbon atoms andalso partial glycerides, fatty acids or hydroxy fatty acids. Acombination of these substances with alkyl oligoglucosides and/or fattyacid N-methyl glucamides of the same chain length and/or polyglycerolpoly-12-hydroxystearates is preferably used.

Pearlizing waxes: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present inventionpreferably includes one or more pearlizing waxes. Suitable pearlizingwaxes are, for example, alkylene glycol esters, especially ethyleneglycol distearate; fatty acid alkanolamides, especially cocofatty aciddiethanolamide; partial glycerides, especially stearic acidmonoglyceride; esters of polybasic, optionally hydroxysubstitutedcarboxylic acids with fatty alcohols containing 6 to 22 carbon atoms,especially long-chain esters of tartaric acid; fatty compounds, such asfor example fatty alcohols, fatty ketones, fatty aldehydes, fatty ethersand fatty carbonates which contain in all at least 24 carbon atoms,especially laurone and distearylether; fatty acids, such as stearicacid, hydroxystearic acid or behenic acid, ring opening products ofolefin epoxides containing 12 to 22 carbon atoms with fatty alcoholscontaining 12 to 22 carbon atoms and/or polyols containing 2 to 15carbon atoms and 2 to 10 hydroxyl groups, and mixtures thereof.

Silicones: In order to impart a silky, spreadable, and luxurious textureand to make skin look and feel smoother, and additionally to improveprocessability (antifoaming) the cosmetic or pharmaceutical, preferablydermatological, composition according to the present inventionpreferably includes one or more silicone(s) or silicone derative(s).Suitable silicones can be chosen from the group consisting of AcefyllineMethylsilanol Mannuronate, Acetylmethionyl Methylsilanol ElastinateAcrylates/Behenyl, Acrylate/Dimethicone Methacrylate Copolymer,Acrylates/Behenyl Methacrylate/Dimethicone Methacrylate Copolymer,Acrylates/Bis-Hydroxypropyl Dimethicone Crosspolymer,Acrylates/Dimethicone Copolymer, Acrylates/DimethiconeMethacrylate/Ethylhexyl Acrylate Copolymer, Acrylates/DimethiconolAcrylate Copolymer, Acrylates/Ethylhexyl Acrylate/DimethiconeMethacrylate Copolymer, Acrylates/Octylacrylamide/DiphenylAmodimethicone Copolymer, Acrylates/PolytrimethylsiloxymethacrylateCopolymer, Acrylates/Propyl Trimethicone Methacrylate Copolymer,Acrylates/Stearyl Acrylate/Dimethicone Methacrylate Copolymer,Acrylates/Tridecyl Acrylate/TriethoxysilylpropylMethacrylate/Dimethicone Methacrylate Copolymer,Acrylates/Trifluoropropylm ethacrylate/Polytrim ethyl SiloxymethacrylateCopolymer, Amino Bispropyl Dimethicone, AminoethylaminopropylDimethicone, Aminopropyl Dimethicone, Aminopropyl Phenyl Trimethicone,Aminopropyl Triethoxysilane, Ammonium Dimethicone PEG-7 Sulfate,Amodimethicone, Amodimethicone Hydroxystearate,Amodimethicone/Silsesquioxane Copolymer, Ascorbyl CarboxydecylTrisiloxane, Ascorbyl Methylsilanol Pectinate, Behenoxy Dimethicone,Behentrimonium Dimethicone PEG-8 Phthalate, Behenyl Dimethicone,Bisamino PEG/PPG-41/3 Aminoethyl PG-Propyl Dimethicone,Bis-Aminopropyl/Ethoxy Aminopropyl Dimethicone, Bis(Butylbenzoate)Diaminotriazine Aminopropyltrisiloxane, Bis-ButyldimethiconePolyglyceryl-3, Bis-Butyloxyamodimethicone/PEG-60 Copolymer, Bis(C13-15Alkoxy) Hydroxybutamidoamodimethicone, Bis(C13-15 Alkoxy)PG-Amodimethicone, Bis-(C1-8 Alkyl Lauroyl Lysine Decylcarboxamide)Dimethicone, Bis-Cetyl Cetyl Dimethicone, Bis-Cetyl/PEG-8 Cetyl PEG-8Dimethicone, Bis-Diphenylethyl Disiloxane, Bis-Ethyl Ethyl Methicone,Bis-Gluconamidoethylaminopropyl Dimethicone, Bis-Hydrogen Dimethicone,Bis-Hydroxyethoxypropyl Dimethicone Bis-Hydroxylauryl, Dimethicone/IPDICopolymer, Bis-Hydroxy/Methoxy Amodimethicone, Bis-HydroxypropylDimethicone Behenate, Bis-Hydroxypropyl Dimethicone/SMDI Copolymer,Bis-Isobutyl PEG-14/Amodimethicone Copolymer, Bis-IsobutylPEG-15/Amodimethicone Copolymer, Bis-IsobutylPEG/PPG-20/35/Amodimethicone Copolymer, Bis-IsobutylPEG/PPG-10/7/Dimethicone Copolymer, Bis-IsobutylPEG-24/PPG-7/Dimethicone Copolymer, Bis-PEG-1 Dimethicone, Bis-PEG-4Dimethicone, Bis-PEG-8 Dimethicone, Bis-PEG-12 Dimethicone, Bis-PEG-20Dimethicone, Bis-PEG-12 Dimethicone Beeswax, Bis-PEG-12 DimethiconeCandelillate, Bis-PEG-15 Dimethicone/IPDI Copolymer, Bis-PEG-15 MethylEther Dimethicone, Bis-PEG-18 Methyl Ether Dimethyl Silane,Bis-PEG/PPG-14/14 Dimethicone, Bis-PEG/PPG-15/5 Dimethicone,Bis-PEG/PPG-18/6 Dimethicone, Bis-PEG/PPG-20/20 Dimethicone,Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone, Bis-PEG/PPG-20/5PEG/PPG-20/5 Dimethicone, Bisphenylhexamethicone, Bis-PhenylpropylDimethicone, Bispolyethylene Dimethicone, Bis-(Polyglyceryl-3Oxyphenylpropyl) Dimethicone, Bis-(Polyglyceryl-7 Oxyphenylpropyl)Dimethicone, Bis-PPG-15 Dimethicone/IPDI Copolymer, Bis(PPG-7Undeceneth-21) Dimethicone, Bis-Stearyl Dimethicone,Bis-Trimethoxysilylethyl Tetramethyldisiloxyethyl Dimethicone,Bis-Vinyldimethicone, Bis-Vinyl Dimethicone/Dimethicone Copolymer,Borage Seed Oil PEG-7 Dimethicone Esters, Butyl Acrylate/C6-14Perfluoroalkylethyl Acrylate/Mercaptopropyl Dimethicone Copolymer, ButylAcrylate/Hydroxypropyl Dimethicone Acrylate Copolymer, Butyl DimethiconeAcrylate/Cyclohexylmethacrylate/Ethylhexyl Acrylate Copolymer,Butyldimethicone Methacrylate/Methyl Methacrylate Crosspolymer, t-ButylDimethyl Silyl Grape Seed Extract, Butyl PolydimethylsiloxylEthylene/Propylene/Vinylnorbornene Copolymer, C6-8 Alkyl C3-6 AlkylGlucoside Dimethicone, C20-24 Alkyl Dimethicone, C24-28 AlkylDimethicone, C26-28 Alkyl Dimethicone, C30-45 Alkyl Dimethicone, C30-60Alkyl Dimethicone, C32 Alkyl Dimethicone, C30-45 AlkylDimethicone/Polycyclohexene Oxide Crosspolymer, C26-28Alkyldimethylsilyl Polypropylsilsesquioxane, C30-45 AlkyldimethylsilylPolypropylsilsesquioxane, C20-24 Alkyl Methicone, C24-28 AlkylMethicone, C26-28 Alkyl Methicone, C30-45 Alkyl Methicone, C20-28 AlkylPerfluorodecylethoxy Dimethicone, C26-54 Alkyl Tetradecyl Dimethicone,Capryl Dimethicone, Caprylyl Dimethicone Ethoxy Glucoside, CaprylylMethicone, Caprylyl Trimethicone, Carboxydecyl Trisiloxane, Castor OilBis-Hydroxypropyl Dimethicone Esters Cerotyl Dimethicone, CetearylDimethicone Crosspolymer, Cetearyl Dimethicone/Vinyl DimethiconeCrosspolymer, Cetearyl Methicone, Cetrimonium Carboxydecyl PEG-8Dimethicone, Cetrimonium Dimethicone PEG-7 Phthalate, Cetyl BehenylDimethicone, Cetyl Dimethicone, Cetyl Dimethicone/Bis-VinyldimethiconeCrosspolymer, Cetyl Hexacosyl Dimethicone, Cetyloxy Dimethicone, CetylPEG-8 Dimethicone, Cetyl PEG/PPG-15/15 Butyl Ether Dimethicone, CetylPEG/PPG-7/3 Dimethicone, Cetyl PEG/PPG-10/1 Dimethicone, CetylTriethylmonium Dimethicone PEG-8 Phthalate, Cetyl TriethylmoniumDimethicone PEG-8 Succinate, Copper Acetyl Tyrosinate Methylsilanol,Copper PCA Methylsilanol, C4-14 Perfluoroalkylethoxy Dimethicone,Cycloethoxymethicone, Cycloheptasiloxane, Cyclohexasiloxane,Cyclomethicone, Cyclopentasiloxane, Cyclophenylmethicone,Cyclotetrasiloxane,mCyclovinylmethicone, Cystine Bis-PG-PropylSilanetriol, DEA PG-Propyl PEG/PPG-18/21 Dimethicone, DiisostearoylTrimethylolpropane Siloxy Silicate, Dilauroyl Trimethylolpropane SiloxySilicate, Dilinoleamidopropyl Dimethylamine Dimethicone PEG-7 Phosphate,Dimethicone, Dimethicone Crosspolymer, Dimethicone Crosspolymer-3,Dimethicone/Divinyldimethicone/Silsesquioxane Crosspolymer, DimethiconeEthoxy Glucoside, Dimethicone Hydroxypropyl Trimonium Chloride,Dimethicone/Mercaptopropyl Methicone Copolymer, Dimethicone PEG-15Acetate Dimethicone PEG-8 Adipate, Dimethicone PEG-7 Avocadoate,Dimethicone PEG-8 Avocadoate, Dimethicone PEG-8 Beeswax, DimethiconePEG-8 Benzoate, Dimethicone PEG-8 Borageate, Dimethicone PEG-7 Cocoate,Dimethicone/PEG-10 Crosspolymer, Dimethicone/PEG-10/15 Crosspolymer,Dimethicone/PEG-15 Crosspolymer, Dimethicone PEG-7 Isostearate,Dimethicone PEG-8 Isostearate, Dimethicone PEG-7 Lactate, DimethiconePEG-8 Lanolate, Dimethicone PEG-8 Laurate, Dimethicone PEG-8Meadowfoamate, Dimethicone PEG-7 Octyldodecyl Citrate, Dimethicone PEG-7Olivate, Dimethicone PEG-8 Olivate, Dimethicone PEG-7 Phosphate,Dimethicone PEG-8 Phosphate, Dimethicone PEG-10 Phosphate, DimethiconePEG-7 Phthalate, Dimethicone PEG-8 Phthalate, Dimethicone PEG-8Polyacrylate, Dimethicone PEG/PPG-20/23 Benzoate, DimethiconePEG/PPG-7/4 Phosphate, Dimethicone PEG/PPG-12/4 Phosphate, DimethiconePEG-7 Succinate, Dimethicone PEG-8 Succinate, Dimethicone PEG-7 Sulfate,Dimethicone PEG-7 Undecylenate, Dimethicone PG-Diethylmonium Chloride,Dimethicone/Phenyl Vinyl Dimethicone Crosspolymer,Dimethicone/Polyglycerin-3 Crosspolymer, Dimethicone/PPG-20Crosspolymer, Dimethicone Propylethylenediamine Behenate, DimethiconePropyl PG-Betaine, Dimethicone/Silsesquioxane Copolymer, DimethiconeSilylate, Dimethicone/Vinyl Dimethicone Crosspolymer,Dimethicone/Vinyltrimethylsiloxysilicate Crosspolymer, Dimethiconol,Dimethiconol Arginine, Dimethiconol Beeswax, Dimethiconol Behenate,Dimethiconol Borageate, Dimethiconol Candelillate, DimethiconolCarnaubate, Dimethiconol Cysteine, Dimethiconol Dhupa Butterate,Dimethiconol Fluoroalcohol Dilinoleic Acid, DimethiconolHydroxystearate, Dimethiconol Illipe Butterate, Dimethiconol/IPDICopolymer, Dimethiconol Isostearate, Dimethiconol Kokum Butterate,Dimethiconol Lactate, Dimethiconol Meadowfoamate, DimethiconolMethionine, Dimethiconol/Methylsilanol/Silicate Crosspolymer,Dimethiconol Mohwa Butterate, Dimethiconol Panthenol, Dimethiconol SalButterate, Dimethiconol/Silica Crosspolymer, Dimethiconol/SilsesquioxaneCopolymer, Dimethiconol Stearate, Dimethiconol/Stearyl, Methicone/PhenylTrimethicone Copolymer, Dimethoxysilyl EthylenediaminopropylDimethicone, Dimethylaminopropylamido PCA Dimethicone, Dimethyl OxobenzoDioxasilane, Dimethylsilanol Hyaluronate, Dioleyl TocopherylMethylsilanol, Diphenyl Amodimethicone, Diphenyl Dimethicone, DiphenylDimethicone Crosspolymer Diphenyl Dimethicone?/inyl DiphenylDimethicone/Silsesquioxane Crosspolymer, Diphenylethyl BenzyloxyDilsiloxane, Diphenylisopropyl Dimethicone, Diphenylsiloxy Phenyl/PropylTrimethicone, Diphenylsiloxy Phenyl Trimethicone Disiloxane, DisodiumAmodimethicone Disuccinamide, Disodium PEG-12 DimethiconeSulfosuccinate, Disodium PEG-8 Lauryl Dimethicone Sulfosuccinate,Divinyldimethicone/Dimethicone Copolymer, Divinyldimethicone/DimethiconeCrosspolymer, Drometrizole Trisiloxane, EthylhexylAcrylate/VP/Dimethicone Methacrylate Copolymer, Ethyl Methicone, EthylTrisiloxane, Fluoro C2-8 Alkyldimethicone, Gluconamidopropyl AminopropylDimethicone, 4-(2-Beta-Glucopyranosiloxy) Propoxy-2-Hydroxybenzophenone,Glyceryl Undecyl Dimethicone, Glycidoxy Dimethicone, HexadecylMethicone, Hexyl Dimethicone, Hexyl Methicone, Hexyltrimethoxysilane,Hydrogen Dimethicone, Hydrogen Dimethicone/Octyl SilsesquioxaneCopolymer, Hydrolyzed Collagen PG-Propyl Dimethiconol, HydrolyzedCollagen PG-Propyl Methylsilanediol, Hydrolyzed Collagen PG-PropylSilanetriol, Hydrolyzed Keratin PG-Propyl Methylsilanediol, HydrolyzedSesame Protein PG-Propyl Methylsilanediol, Hydrolyzed Silk PG-PropylMethylsilanediol, Hydrolyzed Silk PG-Propyl MethylsilanediolCrosspolymer, Hydrolyzed Soy Protein/Dimethicone PEG-7 Acetate,Hydrolyzed Soy Protein PG-Propyl Methylsilanediol, Hydrolyzed VegetableProtein PG-Propyl Silanetriol, Hydrolyzed Wheat Protein/CystineBis-PG-Propyl Silanetriol Copolymer, Hydrolyzed WheatProtein/Dimethicone PEG-7 Acetate, Hydrolyzed Wheat Protein/DimethiconePEG-7 Phosphate Copolymer, Hydrolyzed Wheat Protein PG-PropylMethylsilanediol, Hydrolyzed Wheat Protein PG-Propyl Silanetriol,Hydroxyethyl Acetomonium PG-Dimethicone, Hydroxypropyldimethicone,Hydroxypropyl Dimethicone Behenate, Hydroxypropyl DimethiconeIsostearate, Hydroxypropyl Dimethicone Stearate,Isobutylmethacrylate/Bis-Hydroxypropyl Dimethicone Acrylate Copolymer,Isobutylmethacrylate/Trifluoroethylmethacrylate/Bis-HydroxypropylDimethicone Acrylate Copolymer, Isopentyl TrimethoxycinnamateTrisiloxane, Isopolyglyceryl-3 Dimethicone, Isopolyglyceryl-3Dimethiconol, Isopropyl Titanium Triisostearate/Triethoxysilylethyl,Polydimethylsiloxyethyl Dimethicone Crosspolymer, IsostearylCarboxydecyl PEG-8 Dimethicone, Lactoyl Methylsilanol Elastinate, LaurylDimethicone, Lauryl Dimethicone PEG-15 Crosspolymer, Lauryl DimethiconePEG-10 Phosphate, Lauryl Dimethicone/Polyglycerin-3 Crosspolymer, LaurylMethicone, Lauryl PEG-8 Dimethicone, Lauryl PEG-10 Methyl EtherDimethicone, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, LaurylPEG/PPG-18/18 Methicone, Lauryl Phenylisopropyl Methicone, LaurylPhenylpropyl Methicone, Lauryl PolydimethylsiloxyethylDimethicone/Bis-Vinyldimethicone Crosspolymer, Lauryl Polyglyceryl-3Polydimethylsiloxyethyl Dimethicone, Lauryl Trimethicone,Linoleamidopropyl PG-Dimonium Chloride Phosphate Dimethicone,Methacryloyl Propyltrimethoxysilane, Methicone, MethoxyAmodimethicone/Silsesquioxane Copolymer, MethoxycinnamidopropylPolysilsesquioxane, Methoxycinnamoylpropyl Silsesquioxane Silicate,Methoxy PEG-13 Ethyl Polysilsesquioxane, Methoxy PEG/PPG-7/3 AminopropylDimethicone, Methoxy PEG/PPG-25/4 Dimethicone, Methoxy PEG-10Propyltrimethoxysilane, Methyleugenyl PEG-8 Dimethicone,Methylpolysiloxane Emulsion, Methylsilanol Acetylmethionate,Methylsilanol Acetyltyrosine, Methylsilanol Ascorbate, MethylsilanolCarboxymethyl Theophylline, Methylsilanol Carboxymethyl TheophyllineAlginate, Methylsilanol Elastinate, Methylsilanol Glycyrrhizinate,Methylsilanol Hydroxyproline, Methylsilanol Hydroxyproline Aspartate,Methylsilanol Mannuronate, Methylsilanol PCA, Methylsilanol PEG-7Glyceryl Cocoate, Methylsilanol/Silicate Crosspolymer, MethylsilanolSpirulinate, Methylsilanol Tri-PEG-8 Glyceryl Cocoate, MethylTrimethicone, Methyltrimethoxysilane, Myristylamidopropyl DimethylamineDimethicone PEG-7 Phosphate, Myristyl Methicone, Myristyl Trisiloxane,Nylon-611/Dimethicone Copolymer, PCA Dimethicone, PEG-7 Amodimethicone,PEG-8 Amodimethicone, PEG-8 Cetyl Dimethicone, PEG-3 Dimethicone, PEG-6Dimethicone, PEG-7 Dimethicone, PEG-8 Dimethicone, PEG-9 Dimethicone,PEG-10 Dimethicone, PEG-12 Dimethicone, PEG-14 Dimethicone, PEG-17Dimethicone, PEG-10 Dimethicone Crosspolymer, PEG-12 DimethiconeCrosspolymer, PEG-8 Dimethicone Dimer Dilinoleate, PEG-8Dimethicone/Dimer Dilinoleic Acid Copolymer, PEG-10 Dimethicone/VinylDimethicone Crosspolymer, PEG-8 Distearmonium Chloride PG-Dimethicone,PEG-10/Lauryl Dimethicone Crosspolymer, PEG-15/Lauryl DimethiconeCrosspolymer, PEG-15/Lauryl Polydimethylsiloxyethyl DimethiconeCrosspolymer, PEG-8 Methicone, PEG-6 Methicone Acetate, PEG-6 MethylEther Dimethicone, PEG-7 Methyl Ether Dimethicone, PEG-8 Methyl EtherDimethicone, PEG-9 Methyl Ether Dimethicone, PEG-10 Methyl EtherDimethicone, PEG-11 Methyl Ether Dimethicone, PEG-32 Methyl EtherDimethicone, PEG-8 Methyl Ether Triethoxysilane, PEG-10 NonafluorohexylDimethicone Copolymer, PEG-4 PEG-12 Dimethicone, PEG-8 PG-Coco-GlucosideDimethicone, PEG-9 Polydimethylsiloxyethyl Dimethicone, PEG/PPG-20/22Butyl Ether Dimethicone, PEG/PPG-22/22 Butyl Ether Dimethicone,PEG/PPG-23/23 Butyl Ether Dimethicone, PEG/PPG-24/18 Butyl EtherDimethicone, PEG/PPG-27/9 Butyl Ether Dimethicone, PEG/PPG-3/10Dimethicone, PEG/PPG-4/12 Dimethicone, PEG/PPG-6/4 Dimethicone,PEG/PPG-6/11 Dimethicone, PEG/PPG-8/14 Dimethicone, PEG/PPG-8/26Dimethicone, PEG/PPG-10/2 Dimethicone, PEG/PPG-12/16 Dimethicone,PEG/PPG-12/18 Dimethicone, PEG/PPG-14/4 Dimethicone, PEG/PPG-15/5Dimethicone, PEG/PPG-15/15 Dimethicone, PEG/PPG-16/2 Dimethicone,PEG/PPG-16/8 Dimethicone, PEG/PPG-17/18 Dimethicone, PEG/PPG-18/6Dimethicone, PEG/PPG-18/12 Dimethicone, PEG/PPG-18/18 Dimethicone,PEG/PPG-19/19 Dimethicone, PEG/PPG-20/6 Dimethicone, PEG/PPG-20/15Dimethicone, PEG/PPG-20/20 Dimethicone, PEG/PPG-20/23 Dimethicone,PEG/PPG-20/29 Dimethicone, PEG/PPG-22/23 Dimethicone, PEG/PPG-22/24Dimethicone, PEG/PPG-23/6 Dimethicone, PEG/PPG-25/25 Dimethicone,PEG/PPG-27/27 Dimethicone, PEG/PPG-30/10 Dimethicone, PEG/PPG-25/25Dimethicone/Acrylates Copolymer, PEG/PPG-20/22 Methyl Ether Dimethicone,PEG/PPG-24/24 Methyl Ether Glycidoxy Dimethicone, PEG/PPG-10/3 OleylEther Dimethicone, PEG/PPG-5/3 Trisiloxane, PEG-4 TrifluoropropylDimethicone Copolymer, PEG-8 Trifluoropropyl Dimethicone Copolymer,PEG-10 Trifluoropropyl Dimethicone Copolymer, PEG-8 Trisiloxane,Perfluorocaprylyl riethoxysilylethyl Methicone, PerfluorononylDimethicone, Perfluorononyl Dimethicone/Methicone/AmodimethiconeCrosspolymer, Perfluorononylethyl Carboxydecyl Behenyl Dimethicone,Perfluorononylethyl Carboxydecyl Hexacosyl Dimethicone,Perfluorononylethyl Carboxydecyl Lauryl/Behenyl Dimethicone,Perfluorononylethyl Carboxydecyl Lauryl Dimethicone, PerfluorononylethylCarboxydecyl PEG-8 Dimethicone, Perfluorononylethyl Carboxydecyl PEG-10Dimethicone, Perfluorononylethyl Dimethicone/Methicone Copolymer,Perfluorononylethyl PEG-8 Dimethicone, Perfluorononylethyl StearylDimethicone, Perfluorooctylethyl/Diphenyl Dimethicone Copolymer,Perfluorooctylethyl Triethoxysilane, PerfluorooctylethylTrimethoxysilane, Perfluorooctylethyl Trisiloxane, PerfluorooctylTriethoxysilane, PG-Amodimethicone, Phenethyl Dimethicone, PhenethylDisiloxane, Phenyl Dimethicone, Phenylisopropyl Dimethicone, PhenylMethicone, Phenyl Methiconol, Phenylpropyldimethylsiloxysilicate,Phenylpropyl Ethyl Methicone, Phenyl Propyl Trimethicone, Phenyl PropylTrimethicone/Diphenylmethicone, Phenyl Trimethicone, PlatinumDivinyldisiloxane, Polyacrylate-6, Polydiethylsiloxane,Polydimethylsiloxyethyl Dimethicone/Bis-Vinyldimethicone Crosspolymer,Polydimethylsiloxyethyl Dimethicone/Methicone Copolymer,Polydimethylsiloxy PEG/PPG-24/19 Butyl Ether Silsesquioxane,Polydimethylsiloxy PPG-13 Butyl Ether Silsesquioxane, Polyglyceryl-3Disiloxane Dimethicone, Polyglyceryl-3/Lauryl PolydimethylsiloxyethylDimethicone Crosspolymer, Polyglyceryl-3 PolydimethylsiloxyethylDimethicone, Poly(Glycol Adipate)/Bis-Hydroxyethoxypropyl DimethiconeCopolymer, Polymethylsilsesquioxane,Polymethylsilsesquioxane/Trimethylsiloxysilicate,Polyphenylsilsesquioxane, Polypropylsilsesquioxane, Polysilicone-1,Polysilicone-2, Polysilicone-3, Polysilicone-4, Polysilicone-5,Polysilicone-6, Polysilicone-7, Polysilicone-8, Polysilicone-9,Polysilicone-10, Polysilicone-11, Polysilicone-12, Polysilicone-13,Polysilicone-14, Polysilicone-15, Polysilicone-16, Polysilicone-17,Polysilicone-18, Polysilicone-19, Polysilicone-20, Polysilicone-21,Polysilicone-18 Cetyl Phosphate, Polysilicone-1 Crosspolymer,Polysilicone-18 Stearate, Polyurethane-10, Potassium Dimethicone PEG-7Panthenyl Phosphate, Potassium Dimethicone PEG-7 Phosphate, PPG-12 ButylEther Dimethicone, PPG-2 Dimethicone, PPG-12 Dimethicone, PPG-27Dimethicone, PPG-4 Oleth-10 Dimethicone, Propoxytetramethyl PiperidinylDimethicone, Propyl Trimethicone, Quaternium-80,Retinoxytrimethylsilane, Silanediol Salicylate, Silanetriol, SilanetriolArginate, Silanetriol Glutamate, Silanetriol Lysinate, SilanetriolMelaninate, Silanetriol Trehalose Ether, Silica, Silica DimethiconeSilylate, Silica Dimethyl Silylate, Silica Silylate, Silicon Carbide,Silicone Quaternium-1, Silicone Quaternium-2, Silicone Quaternium-2Panthenol Succinate, Silicone Quaternium-3, Silicone Quaternium-4,Silicone Quaternium-5, Silicone Quaternium-6, Silicone Quaternium-7,Silicone Quaternium-8, Silicone Quaternium-9, Silicone Quaternium-10,Silicone Quaternium-11, Silicone Quaternium-12, Silicone Quaternium-15,SiliconeQuaternium-16, Silicone Quaternium-16/Glycidoxy DimethiconeCrosspolymer, Silicone Quaternium-17, Silicone Quaternium-18, SiliconeQuaternium-19, Silicone Quaternium-20, Silicone Quaternium-21, SiliconeQuaternium-22, Silicone Quaternium-24, Silicone Quaternium-25,Siloxanetriol Alginate, Siloxanetriol Phytate, Simethicone, SodiumCarboxydecyl PEG-8 Dimethicone, Sodium Dimethicone PEG-7 AcetylMethyltaurate, Sodium Hyaluronate Dimethylsilanol, Sodium LactateMethylsilanol, Sodium Mannuronate Methylsilanol, Sodium PCAMethylsilanol, Sodium PG-Propyldimethicone Thiosulfate Copolymer, SodiumPG-Propyl Thiosulfate Dimethicone, Sodium PropoxyhydroxypropylThiosulfate Silica, Sorbityl Silanediol, SoyTriethoxysilylpropyldimonium Chloride, Stearalkonium Dimethicone PEG-8Phthalate, Stearamidopropyl Dimethicone, Steardimonium HydroxypropylPanthenyl PEG-7 Dimethicone Phosphate Chloride, SteardimoniumHydroxypropyl PEG-7 Dimethicone Phosphate Chloride, StearoxyDimethicone, Stearoxymethicone/Dimethicone Copolymer,Stearoxytrimethylsilane, Stearyl Aminopropyl Methicone, StearylDimethicone, Stearyl/Lauryl Methacrylate Crosspolymer, StearylMethicone, Stearyl Triethoxysilanek, Stearyl Trimethicone,Styrene/Acrylates/Dimethicone Acrylate Crosspolymer,Styrene/Acrylates/Dimethicone Copolymer, TEA-Dimethicone PEG-7Phosphate, Tetrabutoxypropyl Trisiloxane, Tetramethyl HexaphenylTetrasiloxane, Tetramethyl Tetraphenyl Trisiloxane, TocopheryloxypropylTrisiloxane, Trideceth-9 PG-Amodimethicone, Triethoxycaprylylsilane,Triethoxysilylethyl Dimethicone/Methicone Copolymer, TriethoxysilylethylPolydimethylsiloxyethyl Dimethicone, TriethoxysilylethylPolydimethylsiloxyethyl Hexyl Dimethicone, TriethoxysilylpropylcarbamoylEthoxypropyl Butyl Dimethicone, Trifluoromethyl C1-4 Alkyl Dimethicone,Trifluoropropyl Cyclopentasiloxane, Trifluoropropyl Cyclotetrasiloxane,Trifluoropropyl Dimethicone, Trifluoropropyl Dimethicone/PEG-10Crosspolymer, Trifluoropropyl Dimethicone/TrifluoropropylDivinyldimethicone Crosspolymer, Trifluoropropyl Dimethicone/VinylTrifluoropropyl, Dimethicone/Silsesquioxane Crosspolymer,Trifluoropropyl Dimethiconol,Trifluoropropyldimethyl/trimethylsiloxysilicate, TrifluoropropylMethicone, Trimethoxycaprylylsilane, Trimethoxysilyl Dimethicone,Trimethyl Pentaphenyl Trisiloxane, Trimethylsiloxyamodimethicone,Trimethylsiloxyphenyl Dimethicone, Trimethylsiloxysilicate,Trimethylsiloxysilicate/Dimethicone Crosspolymer,Trimethylsiloxysilicate/Dimethiconol Crosspolymer,Trimethylsiloxysilylcarbamoyl Pullulan, Trimethylsilyl HydrolyzedConchiolin Protein PG-Propyl Methylsilanediol Crosspolymer,Trimethylsilyl Hydrolyzed Silk PG-Propyl Methylsilanediol Crosspolymer,Trimethylsilyl Hydrolyzed Wheat Protein PG-Propyl MethylsilanediolCrosspolymer, Trimethylsilyl Pullulan, Trimethylsilyl TrimethylsiloxyGlycolate, Trimethylsilyl Trimethylsiloxy Lactate, TrimethylsilylTrimethylsiloxy Salicylate, Triphenyl Trimethicone, Trisiloxane,Tris-Tributoxysiloxymethylsilane, Undecylcrylene Dimethicone, VinylDimethicone, Vinyl Dimethicone/Lauryl Dimethicone Crosspolymer, VinylDimethicone/Methicone Silsesquioxane Crosspolymer,Vinyldimethyl/Trimethylsiloxysilicate Stearyl Dimethicone Crosspolymer,VP/Dimethiconylacrylate/Polycarbamyl/Polyglycol Ester, Zinc CarboxydecylTrisiloxane, Zinc Dimethicone PEG-8 Succinate, and mixtures thereof.

More preferably the silicones to be contained in the cosmetic orpharmaceutical, preferably dermatological, composition according to theinvention are Dimethicone, Cyclomethicone, Cyclopentasiloxane,Cyclotetrasiloxane, Phenyl Trimethicone, and Cyclohexasiloxane.

Waxes and/or stabilizers: Besides natural oils used, one or more waxesmay also be present in the cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention, moreespecially natural waxes such as, for example, candelilla wax, carnaubawax, Japan wax, espartograss wax, cork wax, guaruma wax, rice oil wax,sugar cane wax, ouricury wax, montan wax, beeswax, shellac wax,spermaceti, lanolin (wool wax), uropygial fat, ceresine, ozocerite(earth wax), petrolatum, paraffin waxes and microwaxes; chemicallymodified waxes (hard waxes) such as, for example, montan ester waxes,sasol waxes, hydrogenated jojoba waxes and synthetic waxes such as, forexample, polyalkylene waxes and polyethylene glycol waxes. Metal saltsof fatty acids such as, for example, magnesium, aluminium and/or zincstearate or ricinoleate may be used as stabilizers.

Apart from the abovementioned liquid UV filters, the cosmetic orpharmaceutical, preferably dermatological, composition as definedherein, is advantageously combined with at least one further primary sunprotection factor and/or with at least one further secondary sunprotection factor, in order to increase the SPF, i.e. to obtain a highSPF and to cover a broad UVA and UVB range.

Primary sun protection factors: Primary sun protection factors in thecontext of the invention are, for example, organic substances (lightfilters) which are liquid or crystalline at room temperature and whichare capable of absorbing ultraviolet radiation and of releasing theenergy absorbed in the form of longer-wave radiation, for example heat.

The cosmetic or pharmaceutical, preferably dermatological, compositionaccording to the invention advantageously contains at least one UV-Afilter and/or at least one UV-B filter and/or a broadband filter and/orat least one inorganic pigment. Compositions according to the inventionpreferably contain at least one UV-B filter or a broadband filter, moreparticularly preferably at least one UV-A filter and at least one UV-Bfilter. Preferred cosmetic compositions, preferably topical compositionsaccording to the present invention comprise one, two, three or more sunprotection factors selected from the group consisting of 4-aminobenzoicacid and derivatives, salicylic acid derivatives, benzophenonederivatives, dibenzoylmethane derivatives, diphenyl acrylates,3-imidazol-4-yl acrylic acid and esters thereof, benzofuran derivatives,benzylidene malonate derivatives, polymeric UV absorbers containing oneor more organosilicon radicals, cinnamic acid derivatives, camphorderivatives, trianilino-s-triazine derivatives,2-hydroxyphenylbenzotriazole derivatives, phenylbenzimidazole sulfonicacid derivatives and salts thereof, anthranilic acid menthyl esters,benzotriazole derivatives and indole derivatives.

In addition, a combination with active ingredients which penetrate intothe skin and protect the skin cells from inside against sunlight-induceddamage and reduce the level of cutaneous matrix metalloproteases isadvantageously. Preferred respective ingredients are so calledarylhydrocarbon receptor antagonists. Preferred is2-benzylidene-5,6-dimethoxy-3,3-dimethylindan-1-one.

The UV filters cited below which can be used within the context of thepresent invention are preferred but naturally are not limiting.

UV filters which are preferably used are selected from the groupconsisting of

-   -   p-aminobenzoic acid    -   p-aminobenzoic acid ethyl ester (25 mol) ethoxylated (INCI name:        PEG-25 PABA)    -   p-dimethylaminobenzoic acid-2-ethylhexyl ester    -   p-aminobenzoic acid ethyl ester (2 mol) N-propoxylated    -   p-aminobenzoic acid glycerol ester    -   salicylic acid homomenthyl ester (homosalates) (Neo        Heliopan®HMS)    -   salicylic acid-2-ethylhexyl ester (Neo Heliopan® 0S)    -   triethanolamine salicylate    -   4-isopropyl benzyl salicylate    -   anthranilic acid menthyl ester (Neo Heliopan®MA)    -   diisopropyl cinnamic acid ethyl ester    -   p-methoxycinnamic acid-2-ethylhexyl ester (Neo Heliopa®AV)    -   diisopropyl cinnamic acid methyl ester    -   p-methoxycinnamic acid isoamyl ester (Neo Heliopan®E 1000)    -   p-methoxycinnamic acid diethanolamine salt    -   p-methoxycinnamic acid isopropyl ester    -   2-phenylbenzimidazole sulfonic acid and salts (Neo Heliopan®        Hydro)    -   3-(4′-trimethylammonium) benzylidene bornan-2-one methyl sulfate    -   beta-imidazole-4(5)-acrylic acid (urocanic acid)    -   3-(4′-sulfo)benzylidene bornan-2-one and salts    -   3-(4′-methyl benzylidene)-D,L-camphor (Neo Heliopa®MBC)    -   3-benzylidene-D,L-camphor    -   N-[(2 and 4)-[2-(oxoborn-3-ylidene) methyl]benzyl] acrylamide        polymer    -   4,4′-[(6-[4-(1,1-dimethyl)aminocarbonyl)        phenylamino]-1,3,5-triazine-2,4-diyl)diimino]-bis-(benzoic        acid-2-ethylhexyl ester) (Uvasorb®HEB)    -   benzylidene malonate polysiloxane (Parsol®SLX)    -   glyceryl ethylhexanoate dimethoxycinnamate    -   dipropylene glycol salicylate    -   tris(2-ethylhexyl)-4,4′,4″-(1,3,5-triazine-2,4,6-triyltriimino)tribenzoate        (=2,4,6-trianilino-(p-carbo-2′-ethylhexyl-1′-oxy)-1,3,5-triazine)        (Uvinul®T150).

In a preferred variant the cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention comprisesa combination with one or more broadband filters which are selected fromthe group consisting of

-   2-ethylhexyl-2-cyano-3,3-diphenyl acrylate (Neo Heliopan® 303)-   ethyl-2-cyano-3,3′-diphenyl acrylate-   2-hydroxy-4-methoxybenzophenone (Neo Heliopan®BB)-   2-hydroxy-4-methoxybenzophenone-5-sulfonic acid-   dihydroxy-4-methoxybenzophenone-   2,4-dihydroxybenzophenone-   tetrahydroxybenzophenone-   2,2′-dihydroxy-4,4′-dimethoxybenzophenone-   2-hydroxy-4-n-octoxybenzophenone-   2-hydroxy-4-methoxy-4′-methyl benzophenone-   sodium hydroxymethoxybenzophenone sulfonate-   disodium-2,2′-dihydroxy-4,4′-dimethoxy-5,5′-disulfobenzophenone-   phenol,    2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3(1,3,3,3-tetramethyl-1-(trimethylsilyl)oxy)disiloxyanyl)    propyl) (Mexoryl®XL)-   2,2′-methylene    bis-(6-(2H-benzotriazol-2-yl)-4-1,1,3,3-tetramethylbutyl) phenol)    (Tinosorb® M)-   2,4-bis-[4-(2-ethylhexyloxy)-2-hydroxyphenyl]-1,3,5-triazine-   2,4-bis-[{(4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine    (Tinosorb® S)-   2,4-bis-[{(4-(3-sulfonato)-2-hydroxypropyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine    sodium salt-   2,4-bis-[{(3-(2-propyloxy)-2-hydroxypropyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine-   2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-[4-(2-methoxyethyl    carbonyl) phenylamino]-1,3,5-triazine-   2,4-bis-[{4-(3-(2-propyloxy)-2-hydroxypropyloxy)-2-hydroxy}phenyl]-6-[4-(2-ethylcarboxyl)    phenylamino]-1,3,5-triazine-   2,4-bis-[{4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-(1-methylpyrrol-2-yl)-1,3,5-triazine-   2,4-bis-[{4-tris-(trimethylsiloxysilylpropyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine-   2,4-bis-[{4-(2″-methylpropenyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine-   2,4-bis-[{4-(1′,1′,1′,3′,5′,5′,5′-heptamethylsiloxy-2″-methylpropyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine.

In a preferred variant the cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention comprisesa combination with one or more UV-A filters which are selected from thegroup consisting of

-   -   4-isopropyl dibenzoyl methane    -   terephthalylidene dibornane sulfonic acid and salts (Mexoryl®SX)    -   4-t-butyl-4′-methoxydibenzoyl methane (avobenzone)/(Neo        Heliopan® 357)    -   phenylene bis-benzimidazyl tetrasulfonic acid disodium salt (Neo        Heliopan®AP)    -   2,2′-(1,4-phenylene)-bis-(1H-benzimidazole-4,6-disulfonic acid),        monosodium salt    -   2-(4-diethylamino-2-hydroxybenzoyl) benzoic acid hexyl ester        (Uvinul® A Plus)    -   indanylidene compounds.

In a more preferred variant, the cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention comprisesa combination with one or more UV filters which are selected from thegroup consisting of:

-   -   p-aminobenzoic acid    -   3-(4′-trimethylammonium) benzylidene bornan-2-one methyl sulfate    -   salicylic acid homomenthyl ester (Neo Heliopan®CHMS)    -   2-hydroxy-4-methoxybenzophenone (Neo Heliopan®BB)    -   2-phenylbenzimidazole sulfonic acid (Neo Heliopan® Hydro)    -   terephthalylidene dibornane sulfonic acid and salts (Mexoryl®SX)    -   4-tert-butyl-4′-methoxydibenzoyl methane (Neo Heliopan®357)    -   3-(4′-sulfo)benzylidene bornan-2-one and salts    -   2-ethylhexyl-2-cyano-3,3-diphenyl acrylate (Neo Heliopan©303)    -   N-[(2 and 4)-[2-(oxoborn-3-ylidene) methyl]benzyl] acrylamide        polymer    -   p-methoxycinnamic acid-2-ethylhexyl ester (Neo Heliopan®AV)    -   p-aminobenzoic acid ethyl ester (25 mol) ethoxylated (INCI name:        PEG-25 PABA)    -   p-methoxycinnamic acid isoamyl ester (Neo Heliopan®E1000)    -   2,4,6-trianilino-(p-carbo-2′-ethylhexyl-1′-oxy)-1,3,5-triazine        (Uvinul®T150)    -   phenol,        2-(2H-benzotriazol-2-yl)-4-methyl-6-(2-methyl-3(1,3,3,3-tetramethyl-1-(trimethylsilyl)oxy)disiloxyanyl)        propyl) (Mexoryl®XL)    -   4,4′-[(6-[4-(1,1-dimethyl)aminocarbonyl)        phenylamino]-1,3,5-triazine-2,4-diyl)diimino]-bis-(benzoic        acid-2-ethylhexyl ester) (Uvasorb HEB)    -   3-(4′-methyl benzylidene)-D,L-camphor (Neo Heliopan®MBC)    -   3-benzylidene camphor    -   salicylic acid-2-ethylhexyl ester (Neo Heliopan®OS)    -   4-dimethylaminobenzoic acid-2-ethylhexyl ester (Padimate O)    -   hydroxy-4-methoxybenzophenone-5-sulfonic acid and Na salt    -   2,2′-methylene        bis-(6-(2H-benzotriazol-2-yl)-4-1,1,3,3-tetramethylbutyl)        phenol) (Tinosorb®M)    -   phenylene bis-benzimidazyl tetrasulfonic acid disodium salt (Neo        Heliopan®AP)    -   2,4-bis-[{(4-(2-ethylhexyloxy)-2-hydroxy}phenyl]-6-(4-methoxyphenyl)-1,3,5-triazine        (Tinosorb®S)    -   benzylidene malonate polysiloxane (Parsol®SLX)    -   menthyl anthranilate (Neo Heliopan®MA)    -   2-(4-diethylamino-2-hydroxybenzoyl) benzoic acid hexyl ester        (Uvinul® A Plus)    -   indanylidene compounds.

In a further preferred variant, the cosmetic or pharmaceutical,preferably dermatological, composition according to the inventioncontains a total amount of sunscreen agents, i.e. in particular UVfilters and/or inorganic pigments (UV filtering pigments) so that thecomposition according to the invention has a light protection factor ofgreater than or equal to 2 (preferably greater than or equal to 5). Suchcompositions according to the invention are particularly suitable forprotecting the skin and hair.

Secondary sun protection factors: Besides the groups of primary sunprotection factors mentioned above, secondary sun protection factors ofthe antioxidant type may also be advantageously used in the cosmetic orpharmaceutical, preferably dermatological, composition according to thepresent invention. Secondary sun protection factors of the antioxidanttype interrupt the photochemical reaction chain which is initiated whenUV rays penetrate into the skin. Typical examples are amino acids (forexample glycine, histidine, tyrosine, tryptophane) and derivativesthereof, imidazoles (for example urocanic acid) and derivatives thereof,peptides, such as D,L-carnosine, D-carnosine, L-carnosine andderivatives thereof (for example anserine), carotinoids, carotenes (forexample alpha-carotene, beta-carotene, lycopene), phytoene, phytoflueneand derivatives thereof, chlorogenic acid and derivatives thereof,liponic acid and derivatives thereof (for example dihydroliponic acid),aurothioglucose, propylthiouracil and other thiols (for examplethioredoxine, glutathione, cysteine, cystine, cystamine and glycosyl,N-acetyl, methyl, ethyl, propyl, amyl, butyl and lauryl, palmitoyl,oleyl, alpha-linoleyl, cholesteryl and glyceryl esters thereof) andtheir salts, dilaurylthiodipropionate, distearylthiodipropionate,thiodipropionic acid and derivatives thereof (esters, ethers, peptides,lipids, nucleotides, nucleosides and salts) and sulfoximine compounds(for example butionine sulfoximines, homocysteine sulfoximine, butioninesulfones, penta-, hexa- and hepta-thionine sulfoximine) in very smallcompatible dosages, also (metal) chelators (for examplealpha-hydroxyfatty acids, palmitic acid, phytic acid, lactoferrine),alpha-hydroxy acids (for example citric acid, lactic acid, malic acid),humic acid, bile acid, bile extracts, bilirubin, biliverdin, EDTA, EGTA,Trisodium Dicarboxymethyl Alaninate, and derivatives thereof,unsaturated fatty acids and derivatives thereof (for example linoleicacid, oleic acid), folic acid and derivatives thereof, ubiquinone andubiquinol and derivatives thereof, vitamin C and derivatives thereof(for example ascorbyl palmitate, Mg ascorbyl phosphate, ascorbylacetate), tocopherols and derivatives (for example vitamin E acetate),vitamin A and derivatives (vitamin A palmitate) and coniferyl benzoateof benzoin resin, rutinic acid and derivatives thereof, glycosyl rutin,ferulic acid, furfurylidene glucitol, carnosine, butyl hydroxytoluene,butyl hydroxyanisole, nordihydroguaiac resin acid, nordihydroguaiareticacid, trihydroxybutyrophenone, uric acid and derivatives thereof,mannose and derivatives thereof, superoxide dismutase, titanium dioxide(for example dispersions in ethanol), zinc and derivatives thereof (forexample ZnO, ZnSO₄), selenium and derivatives thereof (for exampleselenium methionine), stilbenes and derivatives thereof (for examplestilbene oxide, trans-stilbene oxide) and derivatives of these activesubstances suitable for the purposes of the invention (salts, esters,ethers, sugars, nucleotides, nucleosides, peptides and lipids).

Advantageous inorganic secondary light protection pigments are finelydispersed metal oxides and metal salts. The total quantity of inorganicpigments, in particular hydrophobic inorganic micro-pigments in thefinished cosmetic preparation according to the present invention isadvantageously from 0.1 to 30% by weight, preferably 0.5 to 10.0% byweight, in each case based on the total weight of the preparation.

Also preferred are particulate UV filters or inorganic pigments, whichcan optionally be hydrophobed, can be used, such as the oxides oftitanium (TiO₂), zinc (ZnO), iron (Fe₂O₃), zirconium (ZrO₂), silicon(SiO₂), manganese (e.g. MnO), aluminium (Al₂O₃), cerium (e.g. Ce₂O₃),and/or mixtures thereof.

Actives modulating skin and/or hair pigmentation: The cosmetic orpharmaceutical, preferably dermatological, composition according to thepresent invention may include active ingredients for skin and/or hairlightening. Preferred active ingredients for skin and/or hair lighteningare selected from the group consisting of kojic acid(5-hydroxy-2-hydroxymethyl-4-pyranone), kojic acid derivatives,preferably kojic acid dipalmitate, arbutin, ascorbic acid, ascorbic acidderivatives, preferably magnesium ascorbyl phosphate, hydroquinone,hydroquinone derivatives, resorcinol, resorcinol derivatives, preferably4-alkylresorcinols and 4-(1-phenylethyl)1,3-dihydroxybenzene(phenylethyl resorcinol), cyclohexylcarbamates, sulfur-containingmolecules, preferably glutathione or cysteine, alpha-hydroxy acids(preferably citric acid, lactic acid, malic acid), salts and estersthereof, N-acetyl tyrosine and derivatives, undecenoyl phenylalanine,gluconic acid, chromone derivatives, preferably aloesin, flavonoids,1-aminoethyl phosphinic acid, thiourea derivatives, ellagic acid,nicotinamide (niacinamide), zinc salts, preferably zinc chloride or zincgluconate, thujaplicin and derivatives, triterpenes, preferably maslinicacid, sterols, preferably ergosterol, benzofuranones, preferablysenkyunolide, vinyl guiacol, ethyl guiacol, dionic acids, preferablyoctodecene dionic acid and/or azelaic acid, inhibitors of nitrogen oxidesynthesis, preferably L-nitroarginine and derivatives thereof,2,7-dinitroindazole or thiocitrulline, metal chelators (preferablyalpha-hydroxy fatty acids, phytic acid, humic acid, bile acid, bileextracts, EDTA, EGTA and derivatives thereof), retinoids, soy milk andextract, serine protease inhibitors or lipoic acid or other synthetic ornatural active ingredients for skin and hair lightening, the latterpreferably used in the form of an extract from plants, preferablybearberry extract, rice extract, papaya extract, turmeric extract,mulberry extract, bengkoang extract, nutgrass extract, liquorice rootextract or constituents concentrated or isolated therefrom, preferablyglabridin or licochalcone A, artocarpus extract, extract of rumex andramulus species, extracts of pine species (pinus), extracts of vitisspecies or stilbene derivatives isolated or concentrated therefrom,saxifrage extract, scutelleria extract, grape extract and/or microalgaeextract, in particular Tetraselmis suecica Extract.

Preferred skin lighteners are kojic acid and phenylethyl resorcinol astyrosinase inhibitors, beta- and alpha-arbutin, hydroquinone,nicotinamide, dioic acid, Mg ascorbyl phosphate and vitamin C and itsderivatives, mulberry extract, Bengkoang extract, papaya extract,turmeric extract, nutgrass extract, licorice extract (containingglycyrrhizin), alpha-hydroxy-acids, 4-alkylresorcinols,4-hydroxyanisole. These skin lighteners are preferred due to their verygood activity, in particular in combination with sclareolide accordingto the present invention. In addition, said preferred skin lightenersare readily available.

Advantageous skin and hair tanning active ingredients in this respectare substrates or substrate analogues of tyrosinase such as L-tyrosine,N-acetyl tyrosine, L-DOPA or L-dihydroxyphenylalanine, xanthinealkaloids such as caffeine, theobromine and theophyl-line andderivatives thereof, proopiomelanocortin peptides such as ACTH,alpha-MSH, peptide analogues thereof and other substances which bind tothe melanocortin receptor, peptides such as Val-Gly-Val-Ala-Pro-Gly,Lys-Ile-Gly-Arg-Lys or Leu-Ile-Gly-Lys, purines, pyrimidines, folicacid, copper salts such as copper gluconate, chloride or pyrrolidonate,1,3,4-oxadiazole-2-thiols such as5-pyrazin-2-yl-1,3,4-oxadiazole-2-thiol, curcumin, zinc diglycinate(Zn(Gly)2), manganese(II) bicarbonate complexes (“pseudocat-alases”),tetrasubstituted cyclohexene derivatives, isoprenoids, melaninderivatives such as Melasyn-100 and MelanZe, diacyl glycerols, aliphaticor cyclic diols, psoralens, prostaglandins and analogues thereof,activators of adenylate cyclase and compounds which activate thetransfer of melanosomes to keratinocytes such as serine proteases oragonists of the PAR-2 receptor, extracts of plants and plant parts ofthe chrysanthemum species, sanguisorba species, walnut extracts, urucumextracts, rhubarb extracts, microalgae extracts, in particularIsochrysis galbana, trehalose, erythrulose and dihydroxyacetone.Flavonoids which bring about skin and hair tinting or brown-ing (e.g.quercetin, rhamnetin, kaempferol, fisetin, genistein, daidzein, chrysinand apigenin, epicatechin, diosmin and diosmetin, morin, quercitrin,naringenin, hesperidin, phloridzin and phloretin) can also be used.

Hair growth activators or inhibitors: Cosmetic or pharmaceutical,preferably dermatological, compositions according to the presentinvention may also comprise one or more hair growth activators, i.e.agents to stimulate hair growth. Hair growth activators are preferablyselected from the group consisting of pyrimidine derivatives such as2,4-diaminopyrimidine-3-oxide (Aminexil),2,4-diamino-6-piperidinopyrimidine-3-oxide (Minoxidil) and derivativesthereof, 6-amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidineand its derivatives, xanthine alkaloids such as caffeine, theobromineand theophylline and derivatives thereof, quercetin and derivatives,dihydroquercetin (taxifolin) and derivatives, potassium channel openers,antiandrogenic agents, synthetic or natural 5-reductase inhibitors,nicotinic acid esters such as tocopheryl nicotinate, benzyl nicotinateand C1-C6 alkyl nicotinate, proteins such as for example the tripeptideLys-Pro-Val, diphencypren, hormones, finasteride, dutasteride,flutamide, bicalutamide, pregnane derivatives, progesterone and itsderivatives, cyproterone acetate, spironolactone and other diuretics,calcineurin inhibitors such as FK506 (Tacrolimus, Fujimycin) and itsderivatives, Cyclosporin A and derivatives thereof, zinc and zinc salts,polyphenols, procyanidins, proanthocyanidins, phytosterols such as forexample beta-sitosterol, biotin, eugenol, (±)-beta-citronellol,panthenol, glycogen for example from mussels, extracts frommicroorganisms, algae, plants and plant parts of for example the generadandelion (Leontodon or Taraxacum), Orthosiphon, Vitex, Coffea,Paullinia, Theobroma, Asiasarum, Cucurbita or Styphnolobium, Serenoarepens (saw palmetto), Sophora flavescens, Pygeum africanum, Panicummiliaceum, Cimicifuga racemosa, Glycine max, Eugenia caryophyllata,Cotinus coggygria, Hibiscus rosa-sinensis, Camellia sinensis, Ilexparaguariensis, Isochrysis galbana, licorice, grape, apple, barley orhops or/nd hydrolysates from rice or wheat.

Alternatively, the cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention mayinclude one or more hair growth inhibitors (as described above), i.e.agents to reduce or prevent hair growth. Hair growth inhibitors arepreferably selected from the group consisting of activin, activinderivatives or activin agonists, ornithine decarboxylase inhibitors suchas alpha-difluoromethylornithine or pentacyclic triterpenes like forexample ursolic acid, betulin, betulinic acid, oleanolic acid andderivatives thereof, 5alpha-reductase inhibitors, androgen receptorantagonists, S-adenosylmethionine decarboxylase inhibitors,gamma-glutamyl transpeptidase inhibitors, transglutaminase inhibitors,soybean-derived serine protease inhibitors, extracts frommicroorganisms, algae, different microalgae or plants and plant parts offor example the families Leguminosae, Solanaceae, Graminae,Asclepiadaceae or Cucurbitaceae, the genera Chondrus, Gloiopeltis,Ceramium, Durvillea, Glycine max, Sanguisorba officinalis, Calendulaofficinalis, Hamamelis virginiana, Arnica montana, Salix alba, Hypericumperforatum or Gymnema sylvestre.

Enzyme inhibitors: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention maycomprise one or more enzyme inhibitors. Suitable enzyme inhibitors are,for example, esterase inhibitors. These are preferably trialkylcitrates, such as trimethyl citrate, tripropyl citrate, triisopropylcitrate, tributyl citrate and, in particular, triethyl citrate (HydagenCAT). The substances inhibit enzyme activity, thereby reducing theformation of odour. Other substances which are suitable esteraseinhibitors are sterol sulfates or phosphates, such as, for example,lanosterol, cholesterol, campesterol, stigmasterol and sitosterolsulfate or phosphate, dicarboxylic acids and esters thereof, such as,for example, glutaric acid, monoethyl glutarate, diethyl glutarate,adipic acid, monoethyl adipate, diethyl adipate, malonic acid anddiethyl malonate, hydroxycarboxylic acids and esters thereof, such as,for example, citric acid, malic acid, tartaric acid or diethyl tartrate,and zinc glycinate.

Odour absorbers and/or antiperspirant active agents: The cosmetic orpharmaceutical, preferably dermatological, composition according to thepresent invention may include one or more odour absorbers and/orantiperspirant active agents (antiperspirants). Suitable odour absorbersare substances which are able to absorb and largely retain odour-formingcompounds. They lower the partial pressure of the individual components,thus also reducing their rate of diffusion. It is important thatperfumes must remain unimpaired in this process. Odour absorbers are noteffective against bacteria. They comprise, for example, as mainconstituent, a complex zinc salt of ricinoleic acid or specific, largelyodour-neutral fragrances which are known to the person skilled in theart as “fixatives”, such as, for example, extracts of labdanum or styraxor certain abietic acid derivatives. The odour masking agents arefragrances or perfume oils, which, in addition to their function asodour masking agents, give the deodorants their respective fragrancenote. Perfume oils which may be mentioned are, for example, mixtures ofnatural and synthetic fragrances. Natural fragrances are extracts fromflowers, stems and leaves, fruits, fruit peels, roots, woods, herbs andgrasses, needles and branches, and resins and balsams. Also suitable areanimal products, such as, for example, civet and castoreum. Typicalsynthetic fragrance compounds are products of the ester, ether,aldehyde, ketone, alcohol, and hydrocarbon type. Fragrance compounds ofthe ester type are, for example, benzyl acetate, p-tert-butylcyclohexylacetate, linalyl acetate, phenylethyl acetate, linalyl benzoate, benzylformate, allyl cyclohexylpropionate, styrallyl propionate and benzylsalicylate. The ethers include, for example, benzyl ethyl ether, and thealdehydes include, for example, the linear alkanals having 8 to 18carbon atoms, citral, citronellal, citronellyloxyacetaldehyde, cyclamenaldehyde, hydroxycitronellal, lilial and bourgeonal, the ketonesinclude, for example, the ionones and methyl cedryl ketone, the alcoholsinclude anethole, citronellol, eugenol, isoeugenol, geraniol, linalool,phenylethyl alcohol and terpineol, and the hydrocarbons include mainlythe terpenes and balsams. Preference is, however, given to usingmixtures of different fragrances which together produce a pleasingfragrance note. Essential oils of relatively low volatility, which aremostly used as aroma components, are also suitable as perfume oils, e.g.sage oil, camomile oil, oil of cloves, melissa oil, mint oil, cinnamonleaf oil, linden flower oil, juniperberry oil, vetiver oil, olibanumoil, galbanum oil, labdanum oil and lavandin oil. Preference is given tousing bergamot oil, dihydromyrcenol, lilial, lyral, citronellol,phenylethyl alcohol, α-hexylcinnamaldehyde, geraniol, benzylacetone,cyclamen aldehyde, linalool, boisambrene forte, ambroxan, indole,hedione, sandelice, lemon oil, mandarin oil, orange oil, allyl amylglycolate, cyclovertal, lavandin oil, clary sage oil, β-damascone,geranium oil bourbon, cyclohexyl salicylate, Vertofix coeur,iso-E-super, Fixolide NP, evernyl, iraldein gamma, phenylacetic acid,geranyl acetate, benzyl acetate, rose oxide, romilat, irotyl andfloramat alone or in mixtures.

Suitable astringent antiperspirant active ingredients are primarilysalts of aluminium, zirconium or of zinc. Such suitable antihydroticactive ingredients are, for example, aluminium chloride, aluminiumchlorohydrate, aluminium dichlorohydrate, aluminium sesquichlorohydrateand complex compounds thereof, e.g. with 1,2-propylene glycol, aluminiumhydroxyallantoinate, aluminium chloride tartrate, aluminium zirconiumtrichlorohydrate, aluminium zirconium tetrachlorohydrate, aluminiumzirconium pentachlorohydrate and complex compounds thereof, e.g. withamino acids, such as glycine.

Film formers: The cosmetic or pharmaceutical, preferably dermatological,composition according to the present invention may include one or morefilm formers. Standard film formers are preferably chitosan,microcrystalline chitosan, quaternized chitosan, polyvinyl pyrrolidone,vinyl pyrrolidone/vinyl acetate copolymers, polymers of the acrylic acidseries, quaternary cellulose derivatives, collagen, hyaluronic acid andsalts thereof and similar compounds.

Carriers and hydrotropes: The cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention maycomprise a carrier or a mixture of different carriers. Preferredcosmetics carrier materials are solid or liquid at 25° C. and 1013 mbar(including highly viscous substances) as for example glycerol,1,2-propylene glycol, 1,2-butylene glycol, 1,3-propylene glycol,1,3-butylene glycol, ethanol, water, and mixtures of two or more of saidliquid carrier materials with water. Optionally, these preparationsaccording to the invention may be produced using preservatives orsolubilizers. Other preferred liquid carrier substances, which may be acomponent of a preparation according to the invention are selected fromthe group consisting of oils such as vegetable oil, neutral oil andmineral oil.

Preferred solid carrier materials, which may be a component of thecosmetic or pharmaceutical, preferably dermatological, compositionaccording to the invention are hydrocolloids, such as starches, degradedstarches, chemically or physically modified starches, dextrins,(powdery) maltodextrins (preferably with a dextrose equivalent value of5 to 25, preferably of 10-20), lactose, silicon dioxide, glucose,modified celluloses, gum arabic, ghatti gum, traganth, karaya,carrageenan, pullulan, curdlan, xanthan gum, gellan gum, guar flour,carob bean flour, alginates, agar, pectin, inulin, and mixtures of twoor more of these solids, in particular maltodextrins (preferably with adextrose equivalent value of 15-20), lactose, silicon dioxide and/orglucose.

In addition, hydrotropes, for example ethanol, isopropyl alcohol orpolyols, may be used to improve flow behaviour. Suitable polyolspreferably contain 2 to 15 carbon atoms and at least two hydroxylgroups. The polyols may contain other functional groups, more especiallyamino groups, or may be modified with nitrogen. Typical examples are

-   -   glycerol;    -   alkylene glycols such as, for example, ethylene glycol,        diethylene glycol, propylene glycol, butylene glycol, hexylene        glycol and polyethylene glycols with an average molecular weight        of 100 to 1000 Dalton;    -   technical oligoglycerol mixtures with a degree of        self-condensation of 1.5 to 10, such as for example technical        diglycerol mixtures with a diglycerol content of 40 to 50% by        weight;    -   methylol compounds such as, in particular, trimethylol ethane,        trimethylol propane, trimethylol butane, pentaerythritol and        dipentaerythritol;    -   lower alkyl glucosides, particularly those containing 1 to 8        carbon atoms in the alkyl group, for example methyl and butyl        glucoside;    -   sugar alcohols containing 5 to 12 carbon atoms, for example        sorbitol or mannitol,    -   sugars containing 5 to 12 carbon atoms, for example glucose or        sucrose;    -   amino sugars, for example glucamine;    -   dialcoholamines, such as diethanolamine or        2-aminopropane-1,3-diol.

Dyes: The cosmetic or pharmaceutical, preferably dermatological,composition according to the present invention may comprise one or moredyes. Suitable dyes are any of the substances suitable and approved forcosmetic purposes. Examples include cochineal red A (CI. 16255), patentblue V (CI. 42051), indigotin (CI. 73015), chlorophyllin (CI. 75810),quinoline yellow (CI. 47005), titanium dioxide (CI. 77891), indanthreneblue RS (CI. 69800) and madder lake (CI. 58000). Luminol may also bepresent as a luminescent dye. Advantageous coloured pigments are forexample titanium dioxide, mica, iron oxides (e.g. Fe₂O₃ Fe₃O₄, FeO(OH))and/or tin oxide. Advantageous dyes are for example carmine, Berlinblue, chromium oxide green, ultramarine blue and/or manganese violet.

In addition to the above-described substances, further ingredientscommonly used in the cosmetic or pharmaceutical industry or the homecareproduct industry, which are suitable or customary in the compositions ofthe present invention, can be used.

The 1,2-heptanediol or the 2,3-heptanediol or the mixture comprising1,2-heptanediol and 2,3-heptanediol is present in the cosmetic orpharmaceutical, preferably dermatological, composition or homecareproduct according to the first aspect of the present invention, in anamount of 0.001 to 15.0% by weight, based on the total weight of thecomposition or homecare product. In a preferred variant, the cosmetic orpharmaceutical, preferably dermatological, composition or homecareproduct comprises the 1,2-heptanediol or the 2,3-heptanediol or themixture comprising 1,2-heptanediol and 2,3-heptanediol in an amount of0.01 to 10.0% by weight, based on the total weight of the composition.In a more preferred variant, the 1,2-heptanediol or the 2,3-heptanediolor the mixture comprising 1,2-heptanediol and 2,3-heptanediol isadvantageously used in the cosmetic or pharmaceutical, preferablydermatological, composition or homecare product in an amount of at 0.1to 5.0% by weight, based on the total weight of the composition orhomecare product. In a still more preferred variant, the 1,2-heptanediolor the 2,3-heptanediol or the mixture comprising 1,2-heptanediol and2,3-heptanediol is advantageously used in the cosmetic orpharmaceutical, preferably dermatological, composition or homecareproduct in an amount of at 0.3 to 3.0% by weight, based on the totalweight of the composition or homecare product. In a most preferredvariant, the 1,2-heptanediol or 2,3-heptanediol or the mixturecomprising 1,2-heptanediol and 2,3-heptanediol is advantageously used inthe cosmetic or pharmaceutical composition or homecare product in anamount of 0.5 to 1.0% by weight, based on the total weight of thecomposition or homecare product.

For the heptanediol mixture, the above amounts relate to the totalcontent of the 1,2-heptanediol and the 2,3-heptanediol in the mixture,i.e., the amount is the sum of the content of the 1,2-heptanediol andthe content of the 2,3-heptanediol in the mixture.

The at least one linear alkanediol or the mixture comprising at leastone first linear alkanediol and one or more second linear alkanediolaccording to the second aspect of the present invention is present inthe cosmetic or pharmaceutical composition or homecare product in anamount of 0.001 to 15.0% by weight, based on the total weight of thecomposition or homecare product. In a preferred variant, the cosmetic orpharmaceutical composition or homecare product comprises the at leastone linear alkanediol or the mixture comprising at least one firstlinear alkanediol and one or more second linear alkanediol in an amountof 0.01 to 10.0% by weight, based on the total weight of the compositionor homecare product. In a more preferred variant, the at least onelinear alkanediol or the mixture comprising at least one first linearalkanediol and one or more second linear alkanediol is advantageouslyused in the cosmetic or pharmaceutical composition or homecare productin an amount of at 0.1 to 5.0% by weight, based on the total weight ofthe composition. In a still more preferred variant, the at least onelinear alkanediol or the mixture comprising at least one first linearalkanediol and one or more second linear alkanediol is advantageouslyused in the cosmetic or pharmaceutical composition or homecare productin an amount of at 0.3 to 3.0% by weight, based on the total weight ofthe composition. In a most preferred variant, the at least one linearalkanediol or the mixture comprising at least one first linearalkanediol and one or more second linear alkanediol is advantageouslyused in the cosmetic or pharmaceutical composition or homecare productin an amount of at 0.5 to 1.0% by weight, based on the total weight ofthe composition or homecare product.

For the alkane mixture, the above amounts relate to the total content ofthe first linear alkanediol and the second linear alkanediol in themixture, i.e. the amount is the sum of the content of the first linearalkanediol and the second linear alkanediol in the mixture.

In a particular preferred variant according to the first aspect of thepresent invention, the cosmetic or pharmaceutical composition or thehomecare product comprises the 2,3-heptanediol or the 2,3-heptanediol ofthe mixture comprising 1,2-heptanediol and 2,3-heptanediol in an amountof 0.001 to 15.0% by weight, preferred in an amount of 0.01 to 10.0% byweight, more preferred in an amount of 0.1 to 5.0% by weight, still morepreferred in an amount of 0.3 to 3.0% by weight, and most preferred inan amount of 0.5 to 1.0% by weight, based on the total weight of thecomposition or homecare product.

Even more preferred, the cosmetic or pharmaceutical composition or thehomecare product comprises the 2,3-heptanediol or the 2,3-heptanediol ofthe mixture comprising 1,2-heptanediol and 2,3-heptanediol in an amountof 0.001 to 0.5% weight, preferably in an amount of 0.005 to 0.1% byweight and most preferably in an amount of 0.01 to 0.075% by weight,based on the total weight of the composition or homecare product.

In a particular preferred variant according to the second aspect of thepresent invention, the cosmetic or pharmaceutical composition or thehomecare product comprises the 2,3-alkandediol as linear alkanediol orof the mixture comprising at least one first linear alkanediol and oneor more second linear alkanediol in an amount of 0.001 to 15.0% byweight, preferably in an amount of 0.01 to 10.0% by weight, morepreferred in an amount of 0.1 to 5.0% by weight, still more preferred inan amount of 0.3 to 3.0% by weight, and most preferred in an amount of0.5 to 1.0% by weight, based on the total weight of the composition orhomecare product.

Even more preferred, the cosmetic or pharmaceutical composition or thehomecare product comprises the 2,3-alkanediol as linear alkanediol or ofthe mixture comprising at least one first linear alkanediol and one ormore second linear alkanediol in an amount of 0.001 to 0.5% weight ofthe composition or homecare product, preferably in an amount of 0.005 to0.1% by weight and most preferably in an amount of 0.01 to 0.075% byweight, based on the total weight of the composition or homecareproduct.

The antioxidant is present in the cosmetic or pharmaceutical, preferablydermatological, composition or homecare product according to the presentinvention, in an amount of 0.0001% to 10.0 by weight, based on the totalweight of the composition. In a preferred variant, the cosmetic orpharmaceutical, preferably dermatological, composition comprises theantioxidant in an amount of 0.005 to 8.0% by weight, based on the totalweight of the composition. In a particular preferred variant, theantioxidant is advantageously used in the cosmetic or pharmaceutical,preferably dermatological, composition in an amount of at 0.001 to 5.0%by weight, based on the total weight of the composition.

The cosmetic or pharmaceutical, preferably dermatological, compositionaccording to the first or second aspect of the present invention isintended for topical applications. The term “topical” is understood tomean external applications on a mammal's skin, which are in particularfor the treatment, protection, care and cleansing of the skin, scalp,eyelashes, eyebrows, nails, mucous membranes and hair. The mammal ispreferably a human.

For topical application, the cosmetic or pharmaceutical composition iseither a rinse off or leave on preparation.

The cosmetic or pharmaceutical, in particular dermatological,composition according to the first or second aspect of the presentinvention can be present in different forms of, e.g., in the form of adispersion, in the form of a water free formulation, in the form of aliquid surfactant formulation, in the form of a solid surfactantformulation or in the form of an aqueous or aqueous/alcoholic,particularly aqueous/ethanolic, or aqueous/glycolic based solution.

In a particular variant, the cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention is a coldformulation, which can be prepared without a heating step.

The cosmetic or pharmaceutical, preferably dermatological, compositionaccording to the first or second aspect of the present invention ispreferably a dispersion. The term “dispersion” in the context of thepresent invention means, that the cosmetic or pharmaceutical compositionis a disperse two-phase system consisting of colloidal particles(disperse phase) and a medium in which they are suspended (dispersemedium). Both phases are not miscible with each other, only with anemulsifier. Such dispersions, for example emulsions, comprise the atleast oil component preferably in an amount of 1% by weight, morepreferably in an amount of 3% by weight.

If the cosmetic or pharmaceutical composition according to the presentinvention is a dispersion, preferably an emulsion, the oil component ispresent in the cosmetic or pharmaceutical composition in an amount of0.01% to 50.0 by weight, based on the total weight of the composition.In a preferred variant, the cosmetic or pharmaceutical comprises the oilcomponent in an amount of 1.0 to 40.0% by weight, based on the totalweight of the composition. In a particular preferred variant, the oilcomponent is advantageously used in the cosmetic or pharmaceuticalcomposition in an amount of at 3.0 to 30% by weight, based on the totalweight of the composition.

Preferably, the cosmetic or pharmaceutical composition according to thefirst or second aspect of the present invention takes various forms suchas an emulsion, in particular a O/W emulsion, a W/O emulsion, a multipleemulsion, a hydro dispersion gel, a balm, a multiple emulsion of thewater-in-oil type (W/0/WO) or of the oil-in-water type (O/W/O), PITemulsion, Pickering emulsion, a micro-emulsion, a liquid, a lotion, asuspension, a milk, an ointment, a paste, a gel, a cream based, an oilbased or a liposome based formulation.

In a further variant, the cosmetic or pharmaceutical, preferablydermatological, composition according to the first or second aspect ofthe present invention is a water free formulation, i.e., an oilformulation. The term water free formulation in the context of thepresent invention means that the at least one liquid lipophiliccomponent is present in an amount of 60% by weight, preferably in anamount of 90% by weight.

Such water free formulations include e.g., oils, skin butters, powders,lip stick, antiperspirant/deo stick, and decorative cosmetics, etc.

In a further alternative, the cosmetic or pharmaceutical compositionaccording to the present invention is a liquid surfactant formulation.

If the cosmetic or pharmaceutical composition according to the presentinvention is a liquid surfactant formulation, the surfactant componentis present in the cosmetic or pharmaceutical, preferably dermatological,composition in an amount of 1 to 40% by weight, preferably in an amountof 3 to 30% by weight, more preferably in an amount of 5 to 25% byweight, based on the total weight of the composition.

Such liquid surfactant formulations include for example shampoo, showergel, micellar water, liquid soap, cleansing preparations.

In a further alternative, the cosmetic or pharmaceutical compositionaccording to the present invention is a solid surfactant formulation.

Such solid surfactant formulations include for example solid shampoos,solid body wash, bar soaps, etc.

Alternatively, the cosmetic or pharmaceutical composition as disclosedherein is an aqueous or aqueous/alcoholic or aqueous/glycolic basedsolution. The aqueous/alcoholic or aqueous/glycolic based solutioncomprises an aliphatic alcohol or a glycol in an amount of 0.1 to ≤50%by weight, based on the total weight of the solution. The aliphaticalcohol is preferably selected from the group consisting of ethanol,isopropanol, n-propanol. The glycol is preferably selected from thegroup consisting of glycerin, propylene glycol, butylene glycol ordipropylene glycol. Preferably, the overall water content in the finalcomposition of such compositions can be ≥60%, more preferably ≥70%, evenmore preferably ≥80%, and even more preferably ≥90%. New applicationssuch as those including solutions for water wipes have high watercontent. In a particular variant, the inventive compositions can be usedfor such wet wipe applications. They may then most preferably contain≥95% water, or even ≥98% water.

Such aqueous or aqueous/alcoholic or aqueous/glycolic based solutionsinclude for example deo/antiperspirant preparations, after shave,cleansing preparations, anti-acne preparations, or wet wipe solutions.

In one preferred variant, the cosmetic or pharmaceutical, preferablydermatological, composition according to the present invention is in theform of an emulsion as defined herein, advantageously in the form of anoil-in-water (O/W) emulsion comprising an oily phase dispersed in anaqueous phase in the presence of an O/W emulsifier.

In an alternative preferred variant, the cosmetic or pharmaceuticalcomposition according to the present invention is in the form of anaqueous or aqueous/alcoholic, preferably aqueous/ethanolic, oraqueous/glycolic based solution. Typically, this could be glycerin inwater compositions.

These cosmetic or pharmaceutical ready-to-use compositions orformulations are prepared according to usual and known methods.

Surprisingly, it turns out that the composition according to the firstor second aspect of the present invention has a significantantioxidative capacity, has a superior ROS scavenging activity, hassuperior performance in suppressing interleukin 8 (IL-8) expressionand/or in suppressing matrix metalloproteinases expression.

Surprisingly, it was found, as described in more detail in the followingExample 1, oxidative degradation of a composition according to thepresent invention can considerably be reduced or minimized with anantioxidant in the presence of a 1,2-alkanediol, in particular1,2-heptanediol, 1,2-octanediol, 1,2-nonanediol, or 1,2-decanediol. Thesame effect was achieved with a 2,3-alkanediol, in particular2,3-octanediol. A superior antioxidative effect was achieved with a homoalkanediol mixture comprising a 1,2-alkanediol and a 2,3-alkanediols asdefined herein. Advantageous antioxidative effects were also achievedwith hetero alkanediol mixtures comprising a first linear alkanediol anda second linear alkanediol as defined herein.

This means that the composition is more stable against oxidativedegradation. This comes along with a lower acid value, which is ameasure of decomposition of triglycerides, and a less rancid odor. Bycontrast, 1,2-alkanediol alone do not show any antioxidant performance.

Moreover, the use of a 1,2-heptanediol and/or 2,3-heptanediol or alinear alkanediol or a mixture of a first linear alkanediol with asecond linear alkanediol allows for the use of less antioxidant.

Surprisingly, it was found, as described in more detail in the followingExample 3, the addition of 1,2-alkanediols, in particular1,2-pentanediol, 1,2-hexanediol, 1,2-heptanediol, 1,2-octanediol,1,2-nonanediol or 1,2-undecanediol to a composition according to thepresent invention including an antioxidant leads to an improved ROSscavenging effect, i.e., to a better ROS score. The same effect wasachieved with 2,3-alkanediol, in particular 2,3-heptanediol,2,3-octanediol or 2,3-undecanediol.

Surprisingly, with the synergistic combination of an antioxidant and1,2-heptanediol or 2,3-heptanediol or a mixture comprising1,2-heptanediol and 2,3-heptanediol or a linear alkanediol, preferably a2,3-alkanediol, or a homo alkanediol mixture or a hetero alkanediolmixture comprising at least one first linear alkanediol and one or moresecond linear alkanediol as defined herein, the interleukin 8 (IL-8)expression can be significantly reduced as it is demonstrated by Example5.

Surprisingly, with the synergistic combination of an antioxidant and1,2-heptanediol or 2,3-heptanediol or a mixture comprising1,2-heptanediol and 2,3-heptanediol or a linear alkanediol, preferably a2,3-alkanediol, or a homo alkanediol mixture or a hetero alkanediolmixture comprising at lest one first linear alkanediol and one or moresecond linear alkanediol as defined herein, it is achieved that thematrix metalloproteinases expression is significantly suppressed.

Due to its beneficial antioxidative properties and its advantageouslyinfluence on ROS scavenging, interleukin 8 expression and/or matrixmetalloproteinases expression, the present invention pertains in afurther aspect to the cosmetic and/or non-therapeutic use of thecomposition according to the present invention for personal care, skinprotection, skin care, scalp protection, scalp care, hair care, nailcare, in particular for the prevention and/or treatment of skinconditions, intolerant or sensitive skin, skin irritation, skinreddening, wheals, pruritus (itching), skin aging, wrinkle formation,loss of skin volume, loss of skin elasticity, pigment spots, pigmentabnormalities, skin dryness, flaking, greasiness, hypopigmentationand/or hyperpigmentation of the skin; or for animal care.

Advantageously, the cosmetic composition according to the presentinvention is used as anti-wrinkle or anti-aging formulation.

Examples of personal care are preferably anti-ageing preparations, skincare emulsions, body oils, body lotions, cleansing lotions, face or bodybalms, after shave balms, after sun balms, deo emulsions, cationicemulsions, body gels, treatment creams, skin protection ointments,moisturizing gels, face and/or body moisturizers, light protectivepreparations (sunscreens), micellar water, hair spray, colour protectionhair care products, skin lightening product, anti-dark spotpreparations, etc.

Alternatively, the composition according to the present invention is apreparation for medical use.

The pharmaceutical, in particular dermatological, composition accordingto the present invention is a preparation for the prevention andtreatment of a condition of the skin or mucosa or of inflammatorydiseases which come along with excess intracellular reactive oxygenspecies.

Preferably, the pharmaceutical composition according to the first orsecond aspect of the present invention is used in the prevention and/ortreatment of dysfunctions of human hair, skin and/or nails, inparticular dermatological or keratological diseases, wherein thedermatological or keratological diseases are selected from the groupconsisting of atopic dermatitis (neurodermitis), psoriasis, acneiformexanthema, sebostasis, xerosis, eczema, hyper seborrhea and hyposeborrhea, dermatitis, rosacea, wheals, erythema, pruritus (itching),inflammation, irritation, fibrosis, lichen planus, pityriasis rosea,pityriasis versicolor, autoimmune bullous diseases, urticaria,angioedema, allergic skin reactions, wound healing, tissue regeneration,or inflammatory diseases.

In order to be used, the cosmetic or pharmaceutical, in particulardermatological, composition according to the first or second aspect ofthe present invention is applied to the skin, hair, scalp and/or nailsin an adequate amount in such manner as is customary with cosmetics anddermatological products.

Surprisingly, the use of 1,2-heptanediol or 2,3-heptanediol or a mixturecomprising 1,2-heptanediol and 2,3-heptanediol or of at least one linearalkanediol, preferably a 2,3-alkanediol, or of a homo alkanediol mixtureor a hetero alkanediol mixture comprising at least one first linearalkanediol and one or more second linear alkanediol as defined hereinconsiderably improves the antioxidative performance of an antioxidant asdescribed above.

Due to the improved antioxidant performance, with the use of1,2-heptanediol or 2,3-heptanediol or a mixture comprising1,2-heptanediol and 2,3-heptanediol or of at least one linearalkanediol, preferably 2,3-alkandeiol, or of a homo alkanediol mixtureor a heteroalakanediol mixture comprising at least one first linearalkanediol and one or more second linear alkanediol in an antioxidantcontaining cosmetic or pharmaceutical, preferably dermatological,composition or homecare product, a higher antioxidative performance canbe achieved with the same amounts of antioxidant or, vice versa, thesame performance can be achieved with less amounts antioxidant.

In particular, the enhanced antioxidative effect has a beneficial effecton ROS scavenging performance of an antioxidant; and/or interleukin 8(IL-8) secretion; and/or matrix metal proteinases expression.

Thus, the present invention relates in a final aspect to the use of1,2-heptanediol or 2,3-heptanediol or a mixture comprising1,2-heptanediol and 2,3-heptanediol or of at least one linearalkanediol, preferably a 2,3-alkanediol, or of a homo alkanediol mixtureor a hetero alkane mixture comprising at least one first linearalkanediol and one or more second linear alkanediol

-   -   for enhancing the antioxidative effect of an antioxidant in a        cosmetic or pharmaceutical composition or homecare product;        and/or    -   for enhancing the antioxidative effect of an antioxidant upon        application, for example on the skin; and/or    -   for enhancing the ROS scavenging performance of an antioxidant;        and/or    -   for enhancing the inhibition of the interleukin 8 (IL-8)        secretion by an antioxidant;    -   and/or    -   for enhancing the inhibition of the matrix metal proteinases        expression by an antioxidant.

The present invention shall now be described in detail with reference tothe following examples, which are merely illustrative of the presentinvention, such that the content of the present invention is not limitedby or to the following examples.

EXAMPLES

To evaluate the influence of 1,2-alkanediols or of 2,3-alkanediols onthe antioxidative capacity of antioxidants, two different tests wereperformed:

-   -   (1) Oxipres treatment to simulate product protection; and    -   (2) Evaluation of reactive oxygen species (ROS) for skin        protection.

The following tests were performed with sunflower oil +/− antioxidantand +/− alkanediols. Sunflower oil was used because it is primarilycomposed of less stable polyunsaturated and monounsaturated fatty acids.Treating it with heat and oxygen triggers and accelerates oxidationeasily.

Example 1: Oxipres Test to Simulate Product Protection

An Oxipres test was performed in order to evaluate the antioxidativecapacity of different test samples as described below.

Test samples:

-   -   Sample 1: Sunflower oil without additives    -   Sample 2: Sunflower oil plus 0.1% tocopherol    -   Sample 3: Sunflower oil plus 0.1% tocopherol plus 0.5%        1,2-heptanediol    -   Sample 4: Sunflower oil plus 0.1% tocopherol plus 0.5% of an        alkanediol blend of 95% 1,2-heptanediol plus 0.5% 2,3        heptanediol    -   Sample 5: Sunflower oil plus 0.5% 1,2-heptanediol    -   Sample 6: Sunflower oil plus 0.5% 2,3-heptanediol    -   Sample 7: Sunflower oil plus 0.5% 1,2-nonanediol    -   Sample 8: Sunflower oil plus 0.1% tocopherol plus 0.5%        1,2-nonanediol    -   Sample 9: Sunflower oil plus 0.1% 1,2-decanediol    -   Sample 10: Sunflower oil plus 0.1% tocopherol plus 0.1%        1,2-decanediol    -   Sample 11: Sunflower oil plus 0.5% 2,3-octanediol    -   Sample 12: Sunflower oil plus 0.1% tocopherol plus 0.5%        2,3-octanediol    -   Sample 13: Sunflower oil without additives    -   Sample 14: Sunflower oil plus 0.1% tocopherol    -   Sample 15: Sunflower oil plus 0.1% tocopherol plus 0.5%        1,2-heptanediol    -   Sample 16: Sunflower oil plus 0.1% tocopherol plus 0.5%        2,3-heptanediol    -   Sample 17: Sunflower oil plus 0.1% tocopherol plus 0.5%    -   blend of 1,2-heptanediol and 2,3-heptanediol; ratio 98:2    -   Sample 18: Sunflower oil plus 0.1% tocopherol plus 0.5% blend of        1,2-heptanediol and 2,3-heptanediol; ratio 99:1    -   Sample 19: Sunflower oil without additives    -   Sample 20: Sunflower oil plus 0.1% tocopherol    -   Sample 21: Sunflower oil plus 0.1% tocopherol plus 0.5%        1,2-hexanediol    -   Sample 22: Sunflower oil plus 0.1% tocopherol plus 0.5%        2,3-hexanediol    -   Sample 23: Sunflower oil plus 0.1% tocopherol plus 0.5% blend of        1,2-hexanediol and 2,3-hexanediol; ratio 95:5    -   Sample 24: Sunflower oil plus 0.1% tocopherol plus 0.5% blend of        1,2-hexanediol and 2,3-hexanediol; ratio 50:50    -   Sample 25: Sunflower oil plus 0.1% tocopherol plus 0.5%        1,2-octanediol    -   Sample 26: Sunflower oil plus 0.1% tocopherol plus 0.5%        2,3-octanediol    -   Sample 27: Sunflower oil plus 0.1% tocopherol plus 0.5% blend of        1,2-octanediol and 2,3-octanediol; ratio 50:50    -   Sample 28: Sunflower oil plus 0.1% tocopherol plus 0.5%        1,2-decanediol    -   Sample 29: Sunflower oil plus 0.1% tocopherol plus 0.5%        2,3-decanediol    -   Sample 30: Sunflower oil plus 0.1% tocopherol plus 0.5% blend of        1,2-decanediol and 2,3-decanediol; ratio 95:5    -   Sample 31: Sunflower oil plus 0.1% tocopherol plus 0.5% blend of        1,2-decanediol and 2,3-decanediol; ratio 50:50    -   Sample 32: Sunflower oil without additives    -   Sample 33: Sunflower oil plus 0.1% tocopherol    -   Sample 34: Sunflower oil plus 0.1% tocopherol plus 0.5%        1,2-heptanediol    -   Sample 35: Sunflower oil plus 0.1% tocopherol plus 0.5%        2,3-hexanediol    -   Sample 36: Sunflower oil plus 0.1% tocopherol plus 0.5% blend of        1,2-heptanediol and 2,3-hexanediol; ratio 50:50    -   Sample 37: Sunflower oil plus 0.1% tocopherol plus 0.5%        2,3-octanediol    -   Sample 38: Sunflower oil plus 0.1% tocopherol plus 0.5% blend of        1,2-heptanediol and 2,3-octanediol; ratio 95:5    -   Sample 39: Sunflower oil without additives    -   Sample 40: Sunflower oil plus 0.1% tocopherol    -   Sample 41: Sunflower oil plus 0.1% tocopherol plus 0.5%        1,2-nonanediol    -   Sample 42: Sunflower oil plus 0.1% tocopherol plus 0.5%        2,3-nonanediol    -   Sample 43: Sunflower oil plus 0.1% tocopherol plus 0.5% blend of        1,2-nonanediol and 2,3-nonanediol; ratio 50:50    -   Sample 44: Sunflower oil without additives    -   Sample 45: Sunflower oil plus 2.0% Symdecanox HA* *INCI        Symdecanox HA:    -   Sample 46: Sunflower oil plus 2.0% Symdecanox HA plus 0.5%        1,2-heptanediol    -   Sample 47: Sunflower oil plus 2.0% Symdecanox HA plus 0.5%        1,2-heptanediol    -   Sample 48: Sunflower oil plus 2.0% Symdecanox HA plus 0.5% blend        of 1,2-heptanediol and 2,3-heptanediol; ratio 95:5    -   Sample 49: Sunflower oil plus 2.0% Symdecanox HA plus 0.5%        1,2-octanediol    -   Sample 50: Sunflower oil plus 2.0% Symdecanox HA plus 0.5%        2,3-octanediol    -   Sample 51: Sunflower oil plus 2.0% Symdecanox HA plus 0.5% blend        of 1,2-octanediol and 2,3-octanediol; ratio 95:5    -   Sample 52: Sunflower oil without additives    -   Sample 53: Sunflower oil plus 0.1% Pentaerythrityl        Tetra-di-t-butyl Hydroxyhydrocinnamate (Tinogard Sample TT)    -   Sample 54: Sunflower oil plus 0.1% Pentaerythrityl        Tetra-di-t-butyl Hydroxyhydrocinnamate (Tinogard TT) plus 0.5%        1,2-heptandiol    -   Sample 55: Sunflower oil plus 0.1% Pentaerythrityl        Tetra-di-t-butyl Hydroxyhydrocinnamate (Tinogard TT) plus 0.5%        2,3-heptanediol    -   Sample 56: Sunflower oil plus 0.1% Pentaerythrityl        Tetra-di-t-butyl Hydroxyhydrocinnamate (Tinogard TT) plus 0.5%        blend of 1,2-octanediol and 2,3-octanediol; ratio 95:5    -   Sample 57: Sunflower oil without additives    -   Sample 58: Sunflower oil plus 0.5% Hydroxyacetophenone    -   Sample 59: Sunflower oil plus 0.5% Hydroxyacetophenone plus 0.5%        1,2-heptanediol    -   Sample 60: Sunflower oil plus 0.5% Hydroxyacetophenone plus 0.5%        2,3-heptanediol    -   Sample 61: Sunflower oil without additives    -   Sample 62: Sunflower oil plus 0.05% Ascorbyl Palmitate    -   Sample 63: Sunflower oil plus 0.05% Ascorbyl Palmitate plus 0.5%        1,2-heptanediol    -   Sample 64: Sunflower oil plus 0.05% Ascorbyl Palmitate plus 0.5%        2,3-heptanediol

Caprylic Capric Triglyceride, Hydroxymethoxyphenyl Decanonenone

Test procedure: For the evaluation of the antioxidative capacity of theabove-described samples, an Oxipres test was conducted. The Oxipresmethod is bases on oxygen consumption at high temperatures and pressuresand allows the determination of oxidative resistance (shelf life) ofe.g. oils. The test runs under elevated pressure and temperature, wherethe process is accelerated. In the Oxipres test the sample is placedinside a hermetically closed iron vessel that is subjected to highoxygen pressures and temperatures of 90 to 120° C. The above-describedsamples were treated in Oxipres device for 48 hours at 80° C. and 5 barpressure and determination of induction period. The consumption ofoxygen results in a pressure drop in the vessel during the test. Higherdecrease of pressure indicates more consumption of oxygen and higheroxidation of the test product. Oils with a high degree of unsaturationare most susceptible to autoxidation.

The induction period is the period during which a fat or oil showsstability against oxidation because of its content of antioxidants,either naturally or added. In the test, the antioxidants are oxidizedpreferentially before the oxidizable fat or oil is oxidized. Thus, theantioxidants protect the fat or oil against oxidation. After this thereis a sudden and large consumption of oxygen and the fat becomes rancid.This can be defined by the induction period (IP) in hours. A lower IPcorrelates with a faster oxidation.

Equipment: The tests were performed with an Oxipres device ex Mikrolab.The instrument is a modification of the bomb method (ASTM D941), whichis based on oxidation with oxygen.

Before and after Oxipres treatment additionally an odor evaluation ofthe samples was performed and the acid value of the samples before andafter Oxipres treatment was determined. The principle of acid valuedetermination: Neutralization of the free acids by titration withethanolic or aqueous solution of potassium hydroxide. It shows thenumber of milligram (mg) KOH required in order to neutralize the freeacids in 1 g test substance. The titration according to the IFUrespectively § 64 LFGB (formerly § 35 LMBG) is carried outpotentiometrically with potassium hydroxide solution to a pH value of8.1.

The following Table 1 gives an overview of the samples, theantioxidants, the alkanediols and the resulting induction period (IP)value.

TABLE 1 Overview Antioxidants, alkanediol and Induction Period (IP)Sample No. Antioxidant Alkanediol IP 1 No no 22.6 2 0.1% tocopherol no29.5 3 0.1% tocopherol 0.5% 1,2-heptanediol 31.2 4 0.1% tocopherol 0.5%(blend of 1,2-heptanediol 31.7 and 2,3-heptanediol; ratio 95:5) 5 No0.5% 1,2-heptanediol 23.6 6 No 0.5% 2,3-heptanediol 24.3 7 No 0.5%1,2-nonanediol 22.7 8 0.1% tocopherol 0.5% 1,2-nonanediol 32.4 9 No 0.5%1,2-decanediol 25 10 0.1% tocopherol 0.1% 1,2-decanediol 30 11 No 0.5%2,3-decanediol 19.8 12 0.1% tocopherol 0.5% 2,3-octanediol 32.3 13 no no25.4 14 0.1% tocopherol no 31.6 15 0.1% tocopherol 0.5% 1,2-heptanediol31.0 16 0.1% tocopherol 0.5% 2,3-heptanediol 30.9 17 0.1% tocopherol0.5% (blend of 1,2-heptanediol 32.0 and 2,3-heptanediol; ratio 98:2) 180.1% tocopherol 0.5% (blend of 1,2-heptanediol 32.0 and 2,3-heptanediol;ratio 99:1) 19 no no 24.5 20 0.1% tocopherol no 31.2 21 0.1% tocopherol0.5% 1,2-hexanediol 30.3 22 0.1% tocopherol 0.5% 2,3-hexanediol 31.6 230,1% tocopherol 0.5% (blend of 1,2-hexanediol 31.2 and 2,3-hexanediol;ratio 95:5) 24 0.1% tocopherol 0.5% (blend of 1,2-hexanediol 32.8 and2,3-hexanediol; ratio 50:50) 25 0.1% tocopherol 0.5% 1,2-octanediol 32.226 0.1% tocopherol 0.5% 2,3-octanediol 31.7 27 0.1% tocopherol 0.5%(blend of 1,2-octanediol 32.9 and 2,3-octanediol; ratio 50:50) 28 0.1%tocopherol 0.5% 1,2-decanediol 31.7 29 0.1% tocopherol 0.5%2,3-decanediol 31.8 30 0.1% tocopherol 0.5% (blend of 1,2-decanediol31.9 and 2,3-decanediol; ratio 95:5) 31 0.1% tocopherol 0.5% (blend of1,2-decanediol 32.4 and 2,3-decanediol; ratio 50:50) 32 no no 25.9 330.1% tocopherol no 31.6 34 0.1% tocopherol 0.5% 1,2-heptanediol 32.3 350.1% tocopherol 0.5% 2,3-hexanediol 32.9 36 0.1% tocopherol 0.5% (blendof 1,2-heptanediol 33.2 and 2,3-hexanediol; ratio 50:50) 37 0.1%tocopherol 0.5% 2,3-octanediol 31.2 38 0.1% tocopherol 0.5% (blend of1,2-heptanediol 32.2 and 2,3-octanediol; ratio 95:5) 39 no no 16.2 400.1% tocopherol no 23.5 41 0.1% tocopherol 0.5% 1,2-nonanediol 24.1 420.1% tocopherol 0.5% 2,3-nonanediol 25.4 43 0.1% tocopherol 0.5% (blendof 1,2-nonanediol 25.7 and 2,3-nonanediol; ratio 50:50) 44 no no 23.1 452% Symdecanox HA no 24.4 46 2% Symdecanox HA 0.5% 1,2-heptanediol 24.447 2% Symdecanox HA 0.5% 1,2-heptanediol 24.7 48 2% Symdecanox HA 0.5%(blend of 1,2-heptanediol 25.3 and 2,3-heptanediol; ratio 95:5) 49 2%Symdecanox HA 0.5% 1,2-octanediol 23.9 50 2% Symdecanox HA 0.5%2,3-octanediol 24.0 51 2% Symdecanox HA 0.5% (blend of 1,2-octanediol25.1 and 2,3-octanediol; ratio 95:5) 52 no no 21.9 53 0.01%Pentaerythrityl no 25.8 Tetra-di-t-butyl Hydroxyhydrocinnamate (TinogardTT) 54 0.01% Pentaerythrityl 0.5% 1,2-heptandiol 27.7 Tetra-di-t-butylHydroxyhydrocinnamate (Tinogard TT) 55 0.01% Pentaerythrityl0.5%2,3-heptanediol 27.6 Tetra-di-t-butyl Hydroxyhydrocinnamate(Tinogard TT) 56 0.01% Pentaerythrityl 0.5% (blend of 1,2-octanediol28.1 Tetra-di-t-butyl and 2,3-octanediol; ratio 95:5)Hydroxyhydrocinnamate (Tinogard TT) 57 no no 22.9 58 0.5% no 23.2Hydroxyacetophenone 59 0.5 % 0.5% 1,2-heptanediol 24.4Hydroxyacetophenone 60 0.5 % 0.5% 2,3-heptanediol 24.3Hydroxyacetophenone 61 no no 23.5 62 0.05% Ascorbyl Palmitate no 25.5 630.05% Ascorbyl Palmitate 0.5% 1,2-heptanediol 26.7 64 0.05% AscorbylPalmitate 0.5% 2,3-heptanediol 26.6

TABLE 2 Results of induction period (IP) and acid value after Oxiprestreatment (for samples 1 to 12) Induction Acid value Acid value Sampleperiod (mg KOH/g) (mg KOH/g) No. (h) start after treatment 1 22.6 0.28.5 2 29.5 0.2 6.1 3 31.2 0.1 5.1 4 31.7 0.1 5.2 5 23.6 0.2 8.2 6 24.30.1 8.7 7 22.7 0 7.5 8 32.4 0 5.6 9 25.0 0 8.6 10 30.0 0 6.6 11 19.8 08.0 12 32.3 0 3.9

The results in Table 1 clearly show that sample 3 (sunflower oil plus0.1% tocopherol plus 0.5% 1,2-heptanediol), sample 4 (sunflower oil plus0.1% tocopherol plus 0.5% of an alkanediol blend of 95% 1,2-heptanedioland 0.5% 2,3 heptanediol), sample 8 (sunflower oil plus 0.1% tocopherolplus 0.5% 1,2-nonanediol), sample 10 (sunflower oil plus 0.1% tocopherolplus 0.1% 1,2-decanediol) and sample 12 (sunflower oil plus 0.1%tocopherol plus 0.5% 2,3-octanediol), i.e., samples containing anantioxidant in combination with an 1,2-alkanediol and/or an2,3-alkanediol or a mixture thereof have prolonged induction periods(indicating longer shelf life). This means that the samples are morestable against oxidative degradation than the comparative samples. Thesamples with 1,2-alkanediol or 2,3-alkanediol alone have noantioxidative effect.

The above advantageous results are confirmed by a lower acid value. Theacid value is defined as the number of milligrams of potassium hydroxiderequired to neutralize the free fatty acids present in one gram of fat.It is a relative measure of rancidity as free fatty acids are normallyformed during decomposition of triglycerides. Hence, the acid valuecorrelates with the rancidity degree in an oil. In comparison,comparative sample 1 (sunflower oil without antioxidant or alkanediol,comparative sample 2 (sunflower oil with tocopherol) and comparativesamples 5 and 6 (sunflower oil with alkanediols without tocopherol) hada shorter induction period (IP) (indicating shorter shelf life), whichmeans that oxidation degradation starts earlier in comparison to thesamples containing an antioxidant plus an alkanediol. The comparativesamples showed also higher acid vales.

In addition, for the above samples delta values of IP points werecalculated versus the corresponding IP points of sunflower oil withoutadditives as indicated in Table 1. The results of the ROS tests aresummarized in the following tables:

TABLE 3 delta IP versus IP sunflower Sample value oil without No.Heptanediol (h) additive 1 sunflower oil without additive 22.6 2 plus0.1% tocopherol 29.5 6.9 3 plus 0.1% tocopherol + 0.5% 1,2-heptanediol31.2 8.6 4 plus 0.1% tocopherol plus 31.7 9.1 0.5% blend of1,2-heptanediol and 2,3- heptanediol (ratio 95:5)

The results are shown in FIG. 13 . As can be seen from FIG. 13 , bothsample 3 and sample 4 have prolonged induction periods (indicatinglonger shelf life). This means that these samples are more stableagainst oxidative degradation than the comparative samples.

TABLE 4 delta IP vs IP sunflower Sample value oil wo No. Heptanediol (h)additive 13 sunflower oil without additive 25.4 14 plus 0.1% tocopherol31.6 6.2 15 plus 0.1% tocopherol plus 0.5% 1,2- 31 5.6 heptanediol 16plus 0.1% tocopherol plus 0.5% 2,3- 30.9 5.5 heptanediol 17 plus 0.1%tocopherol plus 0.5% blend of 1,2- 32 6.6 and 2,3-heptanediol (ratio98:2)

The results are shown in FIG. 14 . As can be seen from FIG. 14 , a blendof 1,2-heptanediol and 2,3-heptanediol (98:2) results in prolongedinduction periods (indicating longer shelf life). This means that thesample is more stable against oxidative degradation than the comparativesamples.

TABLE 5 delta IP versus IP sunflower Sample value oil without No.Heptanediol (h) additive 13 sunflower oil without additive 25.4 14 plus0.1% tocopherol 31.6 6.2 15 plus 0.1% tocopherol plus 0.5% 1,2- 31 5.6heptanediol 16 plus 0.1% tocopherol plus 0.5% 2,3- 30.9 5.5 heptanediol18 plus 0.1% tocopherol plus 0.5% blend of 1,2- 32 6.6 and2,3-heptanediol (ratio 99:1)

The results are shown in FIG. 15 . As can be seen from FIG. 15 , a blendof 1,2-heptanediol and 2,3-heptanediol (99:1) results in prolongedinduction periods (indicating longer shelf life). This means that thesample is more stable against oxidative degradation than the comparativesamples.

TABLE 6 delta IP versus IP sunflower Sample value oil without No.Hexanediol (h) additive 19 sunflower oil without additive 24.5 20 plus0.1% tocopherol 31.2 6.7 21 plus 0.1% tocopherol plus 0.5% 1,2- 30.3 5.8hexanediol 22 plus 0.1% tocopherol plus 0.5% 2,3- 31.6 7.1 hexanediol 23plus 0.1% tocopherol plus 0.5% blend of 1,2- 31.2 6.7 and 2,3-hexanediol(ratio 95:5)

The results are shown in FIG. 16 . As can be seen from FIG. 16 ,2,3-hexanediol results in prolonged induction periods (indicating longershelf life). This means that the sample is more stable against oxidativedegradation than the comparative sample.

TABLE 7 delta IP versus IP sunflower oil Sample value without No.Hexanediol (h) additive 19 sunflower oil without additive 24.5 20 plus0.1% tocopherol 31.2 6.7 21 plus 0.1% tocopherol plus 0.5% 1,2- 30.3 5.8hexanediol 22 plus 0.1% tocopherol plus 0.5% 2,3- 31.6 7.1 hexanediol 24plus 0.1% tocopherol plus 0.5% blend of 32.8 8.3 1,2- and 2,3-hexanediol(ratio 50:50)

The results are shown in FIG. 17 . As can be seen from FIG. 17 , bothsample 22 and sample 24 results in prolonged induction periods(indicating longer shelf life). This means that the sample is morestable against oxidative degradation than the comparative samples.

TABLE 8 IP delta IP versus Sample value sunflower oil No. Octanediol (h)without additive 19 sunflower oil without additive 24.5 20 plus 0.1%tocopherol 31.2 6.7 25 plus 0.1% tocopherol plus 0.5% 1,2- 32.2 7.7octanediol 26 plus 0.1% tocopherol plus 0.5% 2,3- 31.7 7.2 octanediol 27plus 0.1% tocopherol plus 0.5% blend of 32.9 8.4 1,2-octanediol and2,3-octanediol (ratio 50:50)

The results are shown in FIG. 18 . As can be seen from FIG. 18 , a blendof 1,2-octanediol and 2,3-octanediol (50:50) results in prolongedinduction periods (indicating longer shelf life). This means that thesample is more stable against oxidative degradation than the comparativesamples.

TABLE 9 delta IP versus IP sunflower oil Sample value without No.Decanediol (h) additive 19 sunflower oil without additive 24.5 20 plus0.1% tocopherol 31.2 6.7 28 plus 0.1% tocopherol plus 0.5% 1,2- 31.7 7.2decanediol 29 plus 0.1% tocopherol plus 0.5% 2,3- 31.8 7.3 decanediol 30plus 0.1% tocopherol plus 0.5% blend of 31.9 7.4 1,2- decanediol and2,3-decanediol (ratio 95:5)

The results are shown in FIG. 19 . As can be seen from FIG. 19 , a blendof 1,2-decanediol and 2,3-decanediol (95:5) results in prolongedinduction periods (indicating longer shelf life). This means that thesample is more stable against oxidative degradation than the comparativesamples.

TABLE 10 IP delta IP versus Sample value sunflower oil No. Decanediol(h) without additive 19 sunflower oil without additive 24.5 20 plus 0.1%tocopherol 31.2 6.7 28 plus 0.1% tocopherol plus 0.5% 31.7 7.21,2-decanediol 29 plus 0.1% tocopherol plus 0.5% 31.8 7.3 2,3-decanediol31 plus 0.1% tocopherol plus 0.5% 32.4 7.9 blend of 1,2-decanediol and2,3-decanediol (ratio 50:50)

The results are shown in FIG. 20 . As can be seen from FIG. 20 , a blendof 1,2-decanediol and 2,3-decanediol (50:50) results in prolongedinduction periods (indicating longer shelf life). This means that thesample is more stable against oxidative degradation than the comparativesamples. The induction period is even higher compared to a blend of1,2-decanediol and 2,3-decanediol (95:5).

TABLE 11 IP delta IP versus Sample value sunflower oil No.Heptanediol/Hexanediol (h) without additive 32 sunflower oil withoutadditive 25.9 33 plus 0.1% tocopherol 31.6 5.7 34 plus 0.1% tocopherol +0.5% 32.3 6.9 1,2-heptanediol 35 plus 0.1% tocopherol plus 0.5% 32.9 7.52,3-hexanediol 36 plus 0.1% tocopherol plus 0.5% 33.2 7.8 blend of1,2-heptanediol and 2,3-hexanediol (ratio 50:50)

The results are shown in FIG. 21 . As can be seen from FIG. 21 , a blendof 1,2-heptanediol and 2,3-hexanediol (50:50) results in prolongedinduction periods (indicating longer shelf life). This means that thesample is more stable against oxidative degradation than the comparativesamples.

TABLE 12 delta IP versus sunflower oil Sample without No.Heptanediol/Octanediol additive 32 sunflower oil without additive 25.933 plus 0.1% tocopherol 31.2 5.3 34 plus 0.1% tocopherol plus 0.5% 32.36.4 1,2-heptanediol 37 plus 0.1% tocopherol plus 0.5% 31.2 5.32,3-octanediol 38 plus 0.1% tocopherol plus 0.5% 32.2 6.3 blend of1,2-heptanediol and 2,3-octanediol (ratio 95:5)

The results are shown in FIG. 22 . As can be seen from FIG. 22 , aslightly improvement of he ROS score was obtained with a blend of1,2-heptanediol asn 2,3-octanediol in a ratio of 95:5.

TABLE 13 delta IP versus IP sunflower oil Sample value without No.Nonanediol (h) additive 39 sunflower oil without additive 16.2 40 plus0.1% tocopherol 23.5 7.3 41 plus 0.1% tocopherol + 0.5% 24.1 7.91,2-nonanediol 42 plus 0.1% tocopherol + 0.5% 25.4 9.2 2,3-nonanediol 43plus 0.1% tocopherol plus 0.5% 25.7 9.5 blend of 1,2-nonanediol and2,3-nonanediol (ratio 50:50)

The results are shown in FIG. 23 . As can be seen from FIG. 23 , sample41 and sample results in prolonged induction periods (indicating longershelf life). However, a blend of 1,2-nonanediol and 2,3-nonanediolconsiderably prolonged the induction period. This means that the samplesare more stable against oxidative degradation than the comparativesamples.

TABLE 14 delta IP versus IP sunflower oil Sample value without No.Heptanediol (h) additive 44 sunflower oil without additive 23.1 45 plus2.0% Symdecanox HA 24.4 1.3 46 plus 2.0% Symdecanox HA 24.4 1.3 plus0.5% 1,2-heptanediol 47 plus 2.0% Symdecanox HA 24.7 1.6 plus 0.5%2,3-heptanediol 48 plus 2.0% Symdecanox HA plus 25.3 2.2 0.5% blend of1,2-heptanediol and 2,3-heptanediol (ratio 95:5)

The results are shown in FIG. 24 . As can be seen from FIG. 24 , sample47 results in prolonged induction periods (indicating longer shelflife). However, a blend of 1,2-heptanediol and 2,3-heptanediol (95:5)considerably prolonged the induction period. This means that the samplesare more stable against oxidative degradation than the comparativesamples.

TABLE 15 delta IP versus IP sunflower oil Sample value without No.Octanediol (h) additive 44 sunflower oil without additive 23.1 45 plus2.0% Symdecanox HA 24.4 1.3 49 plus 2.0% Symdecanox HA plus 23.9 0.80.5% 1,2-octanediol 50 plus 2.0% Symdecanox HA plus 24 0.9 0.5%2,3-octanediol 51 plus 2.0% Symdecanox HA plus 25.1 2 0.5% blend of1,2-octanediol and 2,3-octanediol (ratio 95:5)INCI Symdecanox HA: Caprylic/Capric Triglyceride, Hydroxymethyoxyphenyldecanone

The results are shown in FIG. 25 . As can be seen from FIG. 25 , sample51 results in prolonged induction periods (indicating longer shelflife). This means that the samples are more stable against oxidativedegradation than the comparative samples.

TABLE 16 delta IP versus sunflower IP oil Sample value without No.Heptanediol (h) additive 52 sunflower oil without additive 21.9 53 plus0.01% Pentaerythrityl 25.8 3.9 Tetra-di-t-butyl Hydroxyhydrocinnamate 54plus 0.01% Pentaerythrityl 27.7 5.8 Tetra-di-t-butylHydroxyhydrocinnamate plus 0.5% 1,2-heptanediol 55 plus 0.01%Pentaerythrityl 27.6 5.7 Tetra-di-t-butyl Hydroxyhydrocinnamate plus0.5% 2,3-heptanediol 56 plus 0.01% Pentaerythrityl 28.1 6.2Tetra-di-t-butyl Hydroxyhydrocinnamate plus 0.5% blend of1,2-heptanediol and 2,3-heptanediol (ratio 95:5)

The results are shown in FIG. 26 . As can be seen from FIG. 26 , bothsample 54 and sample 55 results in prolonged induction periods(indicating longer shelf life). However, a blend of 1,2-heptanediol and2,3-heptanediol (95:5) considerably prolonged the induction period. Thismeans that the samples are more stable against oxidative degradationthan the comparative samples.

TABLE 17 delta IP versus sunflower IP oil Sample value without No.Heptanediol (h) additive 57 sunflower oil without additive 22.9 58 plus0.5% Hydroxyacetophenone 23.2 0.3 59 plus 0.5% Hydroxyacetophenone 24.41.5 plus 0.5% 1,2-heptanediol 60 plus 0.5% Hydroxyacetophenone 24.3 1.4plus 0.5% 2,3-heptanediol

The results are shown in FIG. 27 . As can be seen from FIG. 27 , both1,2-heptanediol and 2,3-heptanediol in combination withHydroxyacetophenone result in remarkably prolonged induction periods(indicating longer shelf life). This means that the samples are morestable against oxidative degradation than the comparative samples.

TABLE 18 IP delta IP versus Sample value sunflower oil No. Heptanediol(h) without additive 61 sunflower oil without additive 23.5 62 plus0.05% Ascorbyl Palmitate 25.5 2.0 63 plus 0.05% Ascorbyl Palmitate 26.73.2 plus 0.5% 1,2-heptanediol 64 plus 0.05% Ascorbyl Palmitate 26.6 3.1plus 0.5% 2,3-heptanediol

The results are shown in FIG. 28 . As can be seen from FIG. 28 , both1,2-heptanediol and 2,3-heptanediol in combination with AscorbylPalmitate result in remarkably prolonged induction periods (indicatinglonger shelf life). This means that the samples are more stable againstoxidative degradation than the comparative samples.

As it is demonstrated by the above example, the induction period of thesamples can be extended with an antioxidant (tocopherol) and can be evenmore, i.e., synergistically, improved with a combination of anantioxidant in combination with an alkanediol. Hence, the oxidationprocess of sample including an oil can be decelerated with theconcurrent use of an antioxidant and an alkanediol.

Example 2: Odor Evaluation of the Samples 1 to 12 of Example 1

A sensory evaluation of the samples of Example 1 after Oxipres treatmentwas performed with 12 untrained panelists. The panelists evaluated therancid odor of each sample on a scale from 1 to 5 (5=strong rancid odor;1=no rancid odor).

Test samples:

-   -   Sample 1: Sunflower oil without additives    -   Sample 2: Sunflower oil plus 0.1% tocopherol    -   Sample 3: Sunflower oil plus 0.1% tocopherol and 0.5%        1,2-heptanediol    -   Sample 4: Sunflower oil plus 0.1% tocopherol and 0.5% of an        alkanediol blend of 95% 1,2-heptanediol and 0.5% 2,3-heptanediol    -   Sample 5: Sunflower oil plus 0.5% 1,2-heptanediol    -   Sample 6: Sunflower oil plus 0.5% 2,3-heptanediol    -   Sample 7: Sunflower oil plus 0.5% 1,2-nonanediol    -   Sample 8: Sunflower oil plus 0.1% tocopherol and 0.5%        1,2-nonanediol    -   Sample 9: Sunflower oil plus 0.1% 1,2-decanediol    -   Sample 10: Sunflower oil plus 0.1% tocopherol and 0.1%        1,2-decanediol    -   Sample 11: Sunflower oil plus 0.5% 2,3-octanediol    -   Sample 12: Sunflower oil plus 0.1% tocopherol and 0.5%        2,3-octanediol

The results of the sensory evaluation are summarized in Table 19.

TABLE 19 Results of sensory evaluation Sample Sample Sample SampleSample Sample Sample Sample Sample Sample Sample Sample Panelists 1 2 34 5 6 7 8 9 10 11 12 A 5 4 3 2 5 5 5 3 5 2 5 2 B 5 4 2 3 4 4 4 4 4 3 4 2C 5 4 2 2 4 5 3 3 3 2 3 1 D 4 2 2 2 5 5 4 2 4 3 4 3 E 5 4 4 3 4 4 5 4 33 4 3 mean 4.8 3.6 2.6 2.4 4.4 4.6 4.2 3.2 3.8 2.6 4.0 2.2 value

The values in Table 19 clearly show that sample 3 (sunflower oil plus0.1% tocopherol plus 0.5% 1,2-heptanediol), sample 4 (sunflower oil plus0.1% tocopherol plus 0.5% of an alkanediol blend of 95% 1,2-heptanedioland 0.5% 2,3 heptanediol), sample 8 (sunflower oil plus 0.1% tocopherolplus 0.5% 1,2-nonanediol), sample 10 (sunflower oil plus 0.1% tocopherolplus 0.1% 1,2-decanediol) and sample 12 (sunflower oil plus 0.1%tocopherol plus 0.5% 2,3-octanediol), i.e. samples containing anantioxidant in combination with 1,2-heptanediol and/or 2,3-heptanediolhave a better odor, i.e. the samples showed less rancid odor than thecomparative examples. Comparative sample 1 (sunflower oil withoutantioxidant or alkanediol, comparative sample 2 (sunflower oil withtocopherol) and comparative samples 5 and 6 (sunflower oil withalkanediols without tocopherol) had a stronger rancid odor.

As it is demonstrated by the above tests, oxidative degradation can bereduced or minimized with an antioxidant (tocopherol) and can be evenmore reduced, i.e., boosted, with the addition of and antioxidant incombination with an alkanediol.

A distinguished efficacy for antioxidative boosting (prolonged inductiontime, less rancidity and reduced acid value) could be shown for1,2-heptanediol as well as for 1,2-nonediol, 1,2-decanediol and2,3-octanediol.

The above results allow the conclusion that the samples comprising anantioxidant in combination with an alkanediol have an antioxidativeeffect which is clearly above the one provided with an antioxidantalone.

Example 3: Antioxidant Potential on Ex Vivo Skin Biopsies (Lipophilic orAqueous/Alcoholic (Ethanolic) Test Samples)

A dichlorofluorescein test (DCF) assay was performed in order todetermine the amount of reactive oxygen species (ROS) on ex vivo skintreated with different test samples in a lipophilic or anaqueous/alcoholic system as described below.

DCF assay—assay principle: Ex vivo skin was incubated with2′,7′-dichlorodihydrofluorescein diacetate at 37° C., 5% CO2. After PBSwashing, samples were exposed or not to cumene hydroperoxide.Immediately after exposure, ex vivo skin samples were frozen in liquidnitrogen and 5 μm cryostat sections were made and fixed with acetone toallow the visualisation of fluorescence generated by ROS in cells of thereconstructed skins. The resulting fluorescence was measured at EX/EM504/524 nm. Green fluorescence was quantified in ex vivo skin usingImageJ software. The depth of immunostaining was measured as follows:green DCFH-DE positive cells were automatically detected using Histolabsoftware and the distance between dermal epidermal junction and thedeepest positive cells were measured in each condition. Means werecompared using a student's test. Two means were considered statisticallydifferent when p<0.005.

The image acquisition was performed by using Olympus BX51 microscope andOlympus DP70 camera. For each skin sample two skin sections have beentaken and the related fluorescent images acquired and analyzed. Thus,for each test condition, 12 images have been acquired and analyzed (i.e.12 data). The analysis of fluorescence has been performed within thedermis area. For each image the upper dermis has been analyzed byevaluating the fluorescence through modified Image-J application (NIH,USA). The analyzed area is selected from the upper part by following theperimeter of the basal lamina, to the deep dermis, by carefully avoidingthe risk of including irregularities and agglomerates, such as bloodvessels, sebaceous glands, hair follicles. The obtained value has beennormalized upon the dimension of the selected area.

In addition, as positive control an AOX mix is always co-tested, i.e.,as bench mark for the ROS analysis. The AOX mix is a mixture of thefollowing antioxidants: 15% vitamin C, 1% vitamin E, 0.5% ferulic acidin a EtOH/H₂O (50:50) mixture.

ROS score method description: The pigmentation score is based on thefollowing process steps:

-   -   (1) Analysis of the image based on pixel grey intensities;    -   (2) Selection of an informative area excluding the pixel area        not covered from tissue;    -   (3) Transformation of pixel grey intensities in degrees of L*;    -   (4) Normalization of the obtained values on the ratio between        the selected area and the area of the slide.

An increased level of ROS (reactive oxygen species) led to an increasedamount of fluorescence.

The chemical principle of the dichlorofluorescein (DCF) assay isdepicted below:

The chemical equation illustrates the conversion of2′,7′-dichlorodihydrofluorescein diacetate (H2DCFDA) by esterases in theintracellular environment and its subsequent two-step-oxidation in thepresence of radical species (mainly ROS).

Example 3.1: DCF-Assay in Biopsy Antioxidation Test: 1,2-alkanediols or2,3-alkanediols Plus/Minus Tocopherol for Lipophilic Test Samples

The dichlorofluorescein test (DCF) as described before was performedwith different test samples in a lipophilic test system as describedbelow:

Test Samples:

-   -   Sample A: Vehicle: sunflower oil without additives    -   Sample B: Sunflower oil plus 0.1% tocopherol    -   Sample C: Sunflower oil plus 0.1% tocopherol plus 0.3%        1,2-pentanediol    -   Sample D: Sunflower oil plus 0.1% tocopherol plus 0.3%        1,2-hexanediol    -   Sample E: Sunflower oil plus 0.1% tocopherol plus 0.3%        1,2-heptanediol    -   Sample F: Sunflower oil plus 0.1% tocopherol plus 0.3%        2,3-heptanediol    -   Sample K: Sunflower oil plus 0.5% 1,2-pentanediol    -   Sample L: Sunflower oil plus 0.5% 1,2-hexanediol    -   Sample M: Sunflower oil plus 0.5% 1,2-heptanediol    -   Sample O: Sunflower oil plus 0.5% 2,3-heptanediol    -   Sample P: Sunflower oil plus 0.5% 1,2-nonanediol

The ROS scores of the above specified samples are summarized in Table20.

TABLE 20 Results ROS score Cumene hydroperoxide 0.5M No A cumeneUntreated AOX sunflower Test Untreated cumene mix oil B C D E F 1 0.0004.438 0.001 0.001 1.320 0.008 0.001 0.000 0.003 2 0.001 5.004 0.2831.319 0.871 0.862 0.001 0.003 0.001 3 0.004 2.456 0.002 0.967 0.8140.331 0.002 0.081 0.000 4 0.013 4.701 0.055 2.109 1.206 0.505 0.0010.106 0.099 5 0.001 2.241 0.002 1.969 1.336 0.035 0.437 0.006 0.593 60.007 2.039 0.459 2.570 0.417 0.500 0.001 1.159 0.167 7 0.002 1.9260.002 1.481 0.896 0.002 0.008 0.616 0.019 8 0.000 0.926 0.010 2.0200.433 0.911 0.130 0.019 0.046 9 0.001 3.068 0.003 2.027 1.522 0.1300.001 0.295 0.001 10 0.000 2.644 0.001 1.233 0.823 0.062 0.002 0.0000.013 11 0.001 3.488 0.175 1.624 0.395 0.582 0.006 0.113 0.000 12 0.2531.708 0.000 2.497 0.783 0.001 0.002 0.003 0.003 Mean 0.02 2.89 0.08 1.650.90 0.33 0.05 0.20 0.08 Score St. Dev 0.07 1.28 0.15 0.72 0.38 0.340.13 0.35 0.17 D percent vs untreated cumene −97% −43% −69% −89% −98%−93% −97% D percent vs sample A cumene (sunflower oil) −45% −80% −97%−88% −95% D percent vs sample B cumene (sunflower oil plus plus −64%−95% −78% −91% 0.1% tocopherol) Cumene hydroperoxide 0.5M No A cumeneUntreated AOX sunflower Test Untreated cumene mix oil K L M O P 1 0.0000.302 0.001 0.301 0.560 0.033 0.533 0.306 0.695 2 0.000 0.342 0.0000.141 0.071 0.001 0.314 0.204 0.895 3 0.035 0.056 0.001 0.451 1.1730.272 0.401 0.112 1.079 4 0.003 0.005 0.001 0.119 0.426 0.336 0.1850.038 0.802 5 0.005 0.930 0.000 0.589 0.085 0.091 0.747 0.001 0.271 60.000 0.772 0.000 0.495 0.112 0.008 0.515 0.111 0.972 7 0.005 0.1340.001 0.256 0.323 0.161 0.225 0.103 1.171 8 0.003 0.000 0.001 0.0340.182 0.261 0.013 0.443 0.728 9 0.002 0.039 0.000 0.579 0.308 0.4850.335 0.399 1.220 10 0.001 0.001 0.001 0.477 0.193 0.281 0.872 0.3950.523 11 0.005 0.003 0.000 0.014 0.382 0.143 0.002 0.047 0.532 12 0.0000.001 0.000 0.656 0.579 0.200 0.001 0.593 0.153 Mean 0.00 0.22 0.00 0.340.37 0.19 0.35 0.23 0.75 Score St. Dev 0.01 0.32 0.00 0.23 0.31 0.150.29 0.19 0.34 SEM 0.00 0.09 0.00 0.07 0.09 0.04 0.08 0.06 0.10 Dpercent vs untreated cumene −100% 59% 70% −12% 60%  6% 250% D percent vsA cumene  7% −45%  1% −33% 120%

The ROS score results from Table 20 are visualized in FIGS. 1 a and 1 b.

The results in Table 20 and FIGS. 1 a and 1 b clearly demonstrate thatthe addition of 1,2-alkanediols or 2,3-alkanediols to a sample (C, D, Eor F) including sunflower oil plus an antioxidant (tocopherol) leads tomore than 60% reduced ROS scores versus a sample of sunflower oil withonly tocopherol and without the addition of a 1,2 alkanediol or a2,3-alkanediol. The samples K, L, M, O and P including only a1,2-alkanediol or a 2,3-alkanediol without an antioxidant do not have anantioxidative efficacy.

From the above it can be concluded, that the addition of an1,2-alkanediol or an 2,3-alkanediol to a composition comprising anantioxidant results in a considerably reduced ROS scores. In otherwords: the combination of an antioxidant plus 1,2-alkanediol and/or2,3-alkanediol shows an improved ROS scavenging efficacy.

Example 3.2: DCF-Assay in Biopsy Antioxidation Test: 1,2-alkanediols or2,3-alkanediols Plus/Minus Tocopherol for Aqueous/Alcoholic Test Samples

The dichlorofluorescein test (DCF) as described before was performedwith different test samples in an aqueous/alcoholic (ethanolic) testsystem as described below:

Test samples:

-   -   Sample 1: Vehicle (EtOH/H₂O)    -   Sample 2: Vehicle plus 0.1% tocopherol    -   Sample 3: Vehicle plus 0.1% tocopherol plus 0.5% 1,2-heptanediol    -   Sample 4: Vehicle plus 0.1% tocopherol plus 0.5% 2,3-heptanediol    -   Sample 5: Vehicle plus 0.1% tocopherol plus alkanediol blend        (0.5% 1,2-heptanediol and 0.5% 2,3-heptanediol)    -   Sample 6: Vehicle plus 0.1% tocopherol plus 0.5% 1,2-octanediol    -   Sample 7: Vehicle plus 0.1% tocopherol plus 0.5% 2,3-octanediol    -   Sample 8: Vehicle plus 0.1% tocopherol plus alkanediol blend        (0.5% 1,2-octanediol and 0.5% 2,3-octanediol)    -   Sample 10: Vehicle plus 0.1% tocopherol plus 0.5% 1,2-nonanediol    -   Sample 11: Vehicle plus 0.1% tocopherol plus 0.5%        1,2-undecanediol    -   Sample 12: Vehicle plus 0.1% tocopherol plus 0.5%        2,3-undecanediol    -   Sample 13: Vehicle plus 0.5% 1,2-heptanediol    -   Sample 14: Vehicle plus 0.5% 2,3-heptanediol    -   Sample 15: Vehicle plus 0.5% 1,2-octanediol    -   Sample 16: Vehicle plus 0.5% 2,3-octanediol    -   Sample 17: Vehicle plus 0.5% 1,2-nonanediol    -   Sample 18: Vehicle plus 0.5% 1,2-undecanediol    -   Sample 19: Vehicle plus 0.5% 2,3-undecanediol

The ROS scores are summarized in Table 21.

TABLE 21 Results ROS score No Cumene Hydroperoxide 0.5M cumene UntreatedAOX Test Untreated cumene mix 1 2 3 4 5 6 7 8 10 11 12 1 0.003 0.3560.001 0.552 0.001 0.001 0.001 0.001 0.000 0.000 0.035 0.000 0.001 0.0042 0.001 0.617 0.017 0.795 0.000 0.001 0.022 0.000 0.001 0.000 0.0010.022 0.012 0.029 3 0.001 0.421 0.002 0.196 0.001 0.001 0.002 0.0020.000 0.003 0.038 0.001 0.000 0.000 4 0.080 0.769 0.003 0.880 0.0380.029 0.000 0.000 0.074 0.014 0.001 0.000 0.000 0.001 5 0.001 0.9990.000 0.528 0.180 0.001 0.001 0.001 0.000 0.001 0.000 0.001 0.001 0.0026 0.000 0.584 0.149 0.067 0.679 0.001 0.009 0.001 0.001 0.000 0.0020.001 0.109 0.000 7 0.370 1.005 0.036 0.288 0.001 0.002 0.000 0.0010.016 0.010 0.002 0.001 0.000 0.043 8 0.009 0.642 0.001 0.441 0.0180.000 0.001 0.001 0.001 0.001 0.001 0.002 0.015 0.008 9 0.000 0.4170.001 0.546 0.011 0.000 0.001 0.001 0.000 0.001 0.028 0.093 0.000 0.00210 0.003 0.861 0.001 0.623 0.192 0.001 0.006 0.000 0.001 0.018 0.0250.001 0.000 0.054 11 0.018 0.349 0.001 0.547 0.437 0.001 0.000 0.0010.019 0.001 0.130 0.001 0.000 0.000 12 0.000 1.327 0.001 0.043 0.1700.000 0.001 0.002 0.001 0.007 0.002 0.000 0.002 0.051 Mean 0.04  0.70 0.02  0.46  0.14  0.00  0.00  0.00  0.01  0.00  0.02  0.01  0.01  0.02 Score St. 0.11  0.31  0.04  0.26  0.21  0.01  0.01  0.00  0.02  0.01 0.04  0.03  0.03  0.02  Dev SEM 0.03  0.09  0.01  0.08  0.06  0.00 0.00  0.00  0.01  0.00  0.01  0.01  0.01  0.01  D percent vs untreated−97% −34% −79% −100%  −99% −100% −99% −99% −97% −99% −98% −98% Cumene Dpercent vs 1 cumene (vehicle −69% −99% −99% −100% −98% −99% −95% −98%−97% −96% (EtOH/H₂O)) D percent vs 2 cumene (vehicle plus 0.1% −98% −97% −99% −93% −97% −85% −93% −92% −89% tocopherol) No Cumene Hydroperoxide0.5M cumene Untreated AOX Test Untreated cumene mix 1 2 13 14 15 16 1718 19 1 0.003 0.356 0.001 0.552 0.001 0.779 0.645 0.595 0.438 1.1600.186 0.655 2 0.001 0.617 0.017 0.795 0.000 0.319 0.646 1.058 0.4320.284 0.043 0.447 3 0.001 0.421 0.002 0.196 0.001 0.479 0.469 0.4610.270 0.287 0.169 0.394 4 0.080 0.769 0.003 0.880 0.038 0.042 0.3130.410 0.502 0.431 0.756 0.365 5 0.001 0.999 0.000 0.528 0.180 0.4380.992 0.334 0.326 0.539 0.720 0.876 6 0.000 0.584 0.149 0.067 0.6790.089 0.574 0.664 0.323 0.429 0.724 1.300 7 0.370 1.005 0.036 0.2880.001 0.379 0.521 0.454 0.157 0.364 0.292 0.290 8 0.009 0.642 0.0010.441 0.018 0.527 0.238 0.816 0.379 0.412 0.001 0.775 9 0.000 0.4170.001 0.546 0.011 0.086 0.211 0.627 0.442 0.145 0.842 1.268 10 0.0030.861 0.001 0.623 0.192 0.663 0.158 0.551 0.245 0.022 0.001 0.529 110.018 0.349 0.001 0.547 0.437 0.444 0.513 0.217 0.175 0.523 0.558 0.43512 0.000 1.327 0.001 0.043 0.170 1.199 0.195 0.365 0.357 0.121 0.4020.205 Mean 0.04  0.70  0.02  0.46  0.14  0.45  0.46  0.55  0.34  0.39 0.39  0.63  Score St. 0.11  0.31  0.04  0.26  0.21  0.33  0.25  0.23 0.11  0.29  0.32  0.36  Dev SEM 0.03  0.09  0.01  0.08  0.06  0.09 0.07  0.07  0.03  0.08  0.09  0.10  D percent vs untreated −97% −34%−79% −35% −34% −21% −52% −43% −44% −10% cumene D percent vs 1 cumene(vehicle −69%  −1%  −1%  19% −26% −14% −15%  37% (EtOH/H₂O)) D percentvs 2 cumene (vehicle plus 0.1% 215% 217% 279% 134% 173% 172% 336%tocopherol)

The ROS score results from Table 21 are visualized in FIGS. 2 a and 2 b.

The results in Table 21 and FIGS. 2 a and 2 b clearly demonstrate thatthe addition of 1,2-alkanediols or 2,3-alkanediols to a sample includingan aqueous alcoholic vehicle plus an antioxidant (tocopherol) leads tomore than 80% reduced ROS scores versus a sample of an aqueous/alcoholicvehicle with only tocopherol and without the addition of a 1,2alkanediol or a 2,3-alkanediol. The samples including only the vehicleand a 1,2-alkanediol or a 2,3-alkanediol do not have an antioxidativeefficacy.

From the above it can be concluded, that the addition of an1,2-alkanediol or an 2,3-alkanediol to a composition comprising anantioxidant results in a considerably reduced ROS scores. In otherwords: the combination of an antioxidant plus 1,2-alkanediol and/or2,3-alkanediol shows an improved ROS scavenging efficacy.

Example 3.3: DCF-Assay in Biopsy Antioxidation Test: 1,2-alkanediols or2,3-alkanediols Plus/Minus Dihydroavenanthramide D for Aqueous/AlcoholicTest Samples

The dichlorofluorescein test (DCF) as described before was performedwith different test samples in an aqueous/alcoholic (ethanolic) testsystem as described below:

Test Samples:

-   -   Sample 1: Vehicle (EtOH/H₂O)    -   Sample 2: Vehicle plus 50 ppm Dihydroavenanthramide D    -   Sample 3: Vehicle plus 50 ppm Dihydroavenanthramide D plus 0.5%        1,2-heptanediol    -   Sample 4: Vehicle plus 50 ppm Dihydroavenanthramide D plus 0.5%        2,3-heptanediol    -   Sample 5: Vehicle plus 50 ppm Dihydroavenanthramid D plus 0.5%        alkanediol blend of 1,2-heptanediol and 2,3-heptanediol (ratio        95:5)

The ROS scores are summarized in Table 22.

TABLE 22 Results ROS score Cumene Hydroperoxide 0.5M No Cumene AOXUNTREATED UNTREATED mix 1 2 3 4 5 1 2.397 0.894 1.552 0.748 0.116 0.6942 0.132 3.447 0.021 3.201 2.083 0.709 0.414 0.322 3 0.120 2.359 0.3052.012 1.367 0.288 0.919 0.289 4 0.163 2.648 0.067 1.044 2.338 0.8740.552 0.802 5 0.061 4.630 0.167 2.820 1.245 0.071 0.274 0.409 6 0.1100.680 0.263 3.397 1.929 0.079 1.685 0.230 7 0.008 2.754 0.227 2.535outlier 1.060 1.009 outlier 8 0.186 1.355 0.330 0.931 1.230 0.718 0.2300.921 9 0.088 0.994 0.212 0.828 2.420 1.073 0.344 1.693 10 0.159 1.1610.314 1.230 1.706 1.580 0.414 0.661 11 0.057 1.431 0.021 1.316 1.4661.375 1.357 0.481 Mean 0.11 2.17 0.19 1.84 1.73 0.78 0.66 0.65 Score St.Dev 0.06 1.19 0.12 0.99 0.44 0.49 0.51 0.43 SEM 0.02 0.36 0.04 0.30 0.140.15 0.15 0.14 D percent vs Untr No 1900%  78% 1594% 1499% 619% 513%500% Cumene D percent vs Untr Cumene −91%  −15%  −20% −64% −69% −70% Dpercent vs −A Cumene  −6% −58% −64% −65%

The ROS score results from Table 22 are visualized in FIG. 29 .

The results in Table 22 and FIG. 29 clearly demonstrate that theaddition of 1,2-heptanediol or 2,3-heptanediol or an alkanediol mixtureincluding 1,2-heptanediol and 2,3-heptanediol to a sample including anaqueous alcoholic vehicle plus an antioxidant (Dihydroavenanthramide D)leads to more than 60% reduced ROS scores versus a sample of anaqueous/alcoholic vehicle with only Dihydroavenanthramide and withoutthe addition of 1,2-heptanediol or 2,3-heptanediol. The samplesincluding only the vehicle and 1,2-heptanediol or 2,3-heptanediol do nothave an antioxidative efficacy.

From the above it can be concluded, that the addition of an1,2-alkanediol or an 2,3-alkanediol to a composition comprising anantioxidant results in a considerably reduced ROS scores. In otherwords: the combination of an antioxidant plus 1,2-alkanediol and/or2,3-alkanediol shows an improved ROS scavenging efficacy.

Example 3.4: DCF-Assay in Biopsy Antioxidation Test: 1,2-alkanediols or2,3-alkanediols Plus/Minus Cannabidiol for Aqueous/Alcoholic TestSamples

The dichlorofluorescein test (DCF) as described before was performedwith different test samples in an aqueous/alcoholic (ethanolic) testsystem as described below:

Test samples:

-   -   Sample 1: Vehicle (EtOH/H₂O)    -   Sample 2: Vehicle plus 5 ppm Cannabidiol    -   Sample 3: Vehicle plus 5 ppm Cannabidiol plus 0.5%        1,2-heptanediol    -   Sample 4 Vehicle plus 5 ppm Cannabidiol plus 0.5%        2,3-heptanediol    -   Sample 5: Vehicle plus 5 ppm Cannabidiol plus 0.5% alkanediol        blend of 1,2-heptanediol and 2,3-heptanediol (ratio 95:5)

The ROS scores are summarized in Table 23.

TABLE 23 Results Cumene Hydroperoxide 0.5M ROS No Cumene AOX scoreUNTREATED UNTREATED mix A B C D E 1 0.003 1.800 0.069 1.602 0.560 0.0020.003 0.047 2 0.006 3.127 0.498 2.370 0.362 0.054 0.410 0.017 3 0.1040.903 0.008 3.935 0.621 0.016 0.075 0.147 4 0.028 1.980 0.001 1.9270.200 0.114 0.082 0.018 5 0.111 1.903 0.402 2.072 1.230 0.673 outlier0.028 6 0.030 0.719 0.007 2.770 1.096 0.182 0.027 0.414 7 0.005 1.7050.007 1.016 0.010 0.587 0.006 0.028 8 outlier 3.104 0.157 2.499 1.0250.127 0.188 0.164 9 0.060 1.330 0.196 0.932 0.304 0.080 0.350 0.065 100.007 2.331 0.234 0.952 0.005 0.586 0.313 0.484 11 0.144 2.578 0.0112.034 0.014 0.098 0.562 0.016 Mean 0.05 1.95 0.14 2.01 0.49 0.23 0.200.13 Score St. Dev 0.05 0.80 0.17 0.90 0.45 0.25 0.20 0.17 SEM 0.02 0.240.05 0.27 0.14 0.08 0.06 0.05 D percent vs Untr No 3810% 190% 3924% 887%359% 304% 160% Cumene D percent vs Untr Cumene −93%   3% −75% −88% −90%−93% D percent vs −1 Cumene −75% −89% −90% −94%

The ROS score results from Table 23 are visualized in FIG. 30 .

The results in Table 23 and FIG. 30 clearly demonstrate that theaddition of 1,2-heptanediol or 2,3-heptanediol or an alkanediol mixtureincluding 1,2-heptanediol and 2,3-heptanediol to a sample including anaqueous alcoholic vehicle plus an antioxidant (Cannabidiol) leads tomore than 70% reduced ROS scores versus a sample of an aqueous/alcoholicvehicle with only Cannabidiol and without the addition of1,2-heptanediol or 2,3-heptanediol. The samples including only thevehicle and 1,2-heptanediol or 2,3-heptanediol do not have anantioxidative efficacy.

From the above it can be concluded, that the addition of an1,2-alkanediol or an 2,3-alkanediol to a composition comprising anantioxidant results in a considerably reduced ROS scores. In otherwords: the combination of an antioxidant plus 1,2-alkanediol and/or2,3-alkanediol shows an improved ROS scavenging efficacy.

Example 4: Antioxidant Potential on Monolayer Cells

A dichlorofluorescein test (DCF) assay was performed in order todetermine the amount of reactive oxygen species (ROS) on monolayer cellswith different test samples as described below.

DCF assay—assay principle (2D): One procedure to quantify intracellularradicals in a cell model is by using the dichlorofluorescein (DCF)assay. The cell-permeant 2′,7′-dichlorodihydrofluorescein diacetate(H₂DCF-DA) is a chemically reduced form of fluorescein used as anindicator-dye for reactive oxygen species (ROS) in cells. Byintracellular esterases and oxidation, the nonfluorescent H₂DCFDA isconverted to the highly fluorescent 2′,7′-dichlorofluorescein (DCF). Thenonfluorescent fluorescein (2′,7′-dichlorofluorescein diacetate(DCFH-DA)) passes the cell membranes. In the cytoplasm, it is cleaved byintracellular esterases and cannot leave the cell in this form. Theoxidation by intracellularly existing ROS (reactive oxygen species)modifies the molecule so that will become DCF and emits fluorescence.ROS stimulation is done by exposure to 300 μM H₂O₂ for 1 h.

The determination of the anti-oxidative capacity is performed in 96-wellmicroplates from Nunc (Wiesbaden, Germany) and with the microplatereader “Spark” from Tecan (Crailsheim, Germany). Cells are seeded in ablack 96 well microplate with transparent bottom and incubated at 37° C.After 24 h the supernatant is decanted and fresh media with 0.1% FBS isadded. Further 24 hours later the supernatant is decanted again and thetest samples are added and incubated for 24 h. As a positive controlTrolox is always co-tested. 300 μM H₂O₂ is used as ROS source (1 hexposure) The emitted fluorescence is measured from bottom of well atEX/EM 485/528 nm.

The antioxidative capacity is expressed as relative reduction of thestimulated control, which can be determined by rule of proportion incombination with the control.

Example 4.1: Tocopherol Plus 1,2-heptanediol

TABLE 24 Mean, ROS Compound Concentration concentration (%) Untreated100 1,2-heptanediol 500 μM 112 alpha-Tocopherol 100 μM 58alpha-Tocopherol + 100 μM + 500 μM 44 1,2-heptanediol alpha-Tocopherol 50 μM 45 alpha-Tocopherol +  50 μM + 500 μM 40 1,2-heptanediol

The ROS concentration results from Table 24 are visualized in FIG. 3 .

1,2-heptanediol alone does not show a ROS reducing capacity, as the ROSvalue is with 112% not reduced. In contrast, it enhances the tocopherolactivity in a concentration of 100 μM by 12%, as the ROS concentrationis reduced from 58% to 44%, when 1,2-heptanediol is added. An enhancedtocopherol activity can also be achieved in combination with1,2-heptanediol, even when the concentration of tocopherol is reducedhalf.

Example 4.2: Carnosine Plus 1,2-heptanediol

TABLE 25 Mean, ROS Compound Concentration concentration (%) Untreated100 1,2-heptanediol 500 μM 112 Carnosine  10 mM 96 Carnosine + 10 mM +500 μM 91 1,2-heptanediol

The ROS concentration results from Table 25 are visualized in FIG. 4 .

1,2-heptanediol alone does not show a ROS reducing capacity, as the ROSvalue is with 112% not reduced. In contrast, it enhances the Carnosineactivity in a concentration of 10 mM by 5%, as the ROS concentration isreduced from 96% to 91%, when 1,2-heptanediol is added.

Example 4.3: Retinol Plus 1,2-heptanediol

TABLE 26 Mean, ROS Compound Concentration concentration (%) Untreated100 1,2-heptanediol 500 μM 112 all trans-Retinol  50 μM 100 alltrans-Retinol + 50 μM + 500 μM 75 1,2-heptanediol

The ROS concentration results from Table 26 are visualized in FIG. 5 .

1,2-heptanediol alone does not show a ROS reducing capacity, as the ROSvalue is with 112% not reduced. In contrast, it enhances the Retinolactivity in a concentration of 50 μM by 25%, as the ROS concentration isreduced from 100% to 75%, when 1,2-heptanediol is added.

Example 4.4: Green Tea Extract Plus 1,2-heptanediol

TABLE 27 Mean, ROS Compound Concentration concentration (%) Untreated100 1,2-heptanediol 500 μM 112 Green Tea Extract 0.002% 94 Green TeaExtract + 0.002% + 500 μM 75 1,2-heptanediol Green Tea Extract 0.001% 79Green Tea Extract + 0.001% + 500 μM 76 1,2-heptanediol

The ROS concentration results from Table 27 are visualized in FIG. 6 .

1,2-heptanediol alone does not show a ROS reducing capacity, as the ROSvalue is with 112% not reduced. In contrast, it enhances the Green TeaExtract activity by 19%, as the ROS concentration is reduced from 94% to75%, when 1,2-heptanediol is added. An enhanced Green Tea Extractactivity can also be achieved in combination with 1,2-heptanediol, evenwhen the concentration of green tea extract is reduced half.

Example 4.5: Zingiber Officinale (Ginger) Root Extract (SymVitalAgeRepair 3040) plus 1,2-heptanediol

TABLE 28 Concen- Mean, ROS Compound tration concentration (%) Untreated100 1,2-heptanediol 500 μM 112 SymVital AgeRepair 3040 0.0003% 26SymVital AgeRepair 3040 + 0.0003% + 12 1,2-heptanediol 500 μM

The ROS concentration results from Table 28 are visualized in FIG. 7 .

1,2-heptanediol alone does not show a ROS reducing capacity, as the ROSvalue is with 112% not reduced. In contrast, it enhances the SymVitalAgeRepair 3040 activity by 14%, as the ROS concentration is reduced from26% to 12%, when 1,2-heptanediol is added.

Example 4.6: Hydroxypinacolone Retinoate Plus 1,2-heptanediol

TABLE 29 Mean, ROS Compound Concentration concentration (%) Untreated100 1,2-heptanediol 500 μM 112 Hydroxypinacolone 5 μM + 500 μM 53Retinoate Hydroxypinacolone 5 μM + 500 μM 18 Retinoate + 1,2-heptanediol

The ROS concentration results from Table 29 are visualized in FIG. 8 .

1,2-heptanediol alone does not show a ROS reducing capacity, as the ROSvalue is with 112% not reduced. In contrast, it enhances theHydroxypinacolone Retinoate activity by 35%, as the ROS concentration isreduced from 53% to 18%, when 1,2-heptanediol is added.

Example 4.7: beta-aspartyl Arginine (SymReserve) Plus 1,2-heptanediol

TABLE 30 Mean, ROS concentration Compound Concentration (%) Untreated100 1,2-heptanediol  500 μM 112 beta-aspartyl arginine 10000 μM 103beta-aspartyl arginine + 10000 μM + 93 1,2-heptanediol 500 μM

The ROS concentration results from Table 30 are visualized in FIG. 9 .

1,2-heptanediol alone does not show a ROS reducing capacity, as the ROSvalue is with 112% not reduced. In contrast, it enhances thebeta-aspartyl arginine (SymReserve) activity by 10%, as the ROSconcentration is reduced from 103% to 93%, when 1,2-heptanediol isadded.

Example 4.8: Zingiber Officinale (Ginger) Root (SymVital AgeRepair 3040)Plus 2,3-octanediol or 1,2-octancediol Plus 2,3-octanediol

TABLE 31 Mean, ROS Concen- concen- tration tration Compound μM (%)2,3-octanediol 500 μM 98 Zingiber Officinale (Ginger) 0.0003% 37 RootExtract 2,3-octanediol + 500 μM + 26 Zingiber Officinale (Ginger)0.0003% Root Extract 1,2-octanediol:2,3-octanediol 500 μM 100 (95:5)Zingiber Officinale (Ginger) 0.0003% 24 Root Extract1,2-octanediol:2,3-octanediol 500 μM + 20 (95:5) + 0.0003% ZingiberOfficinale (Ginger) Root Extract

The ROS concentration results from Table 31 are visualized in FIGS. 10and 11 .

2,3-Octanediol alone does not show a ROS reducing capacity, as the ROSvalue is with 98% not reduced. In contrast, it enhances the ZingiberOfficinale (Ginger) Root (SymVital AgeRepair 3040) activity by 11%, asthe ROS concentration is reduced from 37% to 26%, when 2,3-octanediol isadded.

A similar effect is achieved, when a mixture of 1,2-octanediol and2,3-octanediol is added to the Zingiber Officinale (Ginger) RootExtract.

Example 5: Interleukin 8 (IL-8) ELISA

Interleukin 8 (IL-8) is increased by various kinds of stress includingUV and oxidant stress, which thereby cause the recruitment ofinflammatory cells and induces further increase in oxidant stressmediators, making it a key parameter in localized inflammation.

An IL-8 ELISA (enzyme lined immunosorbance assay) was performed in orderto determine IL-8 produced and secreted by cells from the cellsupernatant utilizing antibodies detecting the IL-8.

Experimental procedure: HaCaT cells (spontaneously transformed aneuploidimmortal keratinocyte cell line from adult human skin) were seeded in ablack 96 well microplate with transparent bottom and incubated at 37° C.After 24 hours the supernatant is decanted and the test samples (100μl/well) are added and incubated for 24 hours at 37° C. Then IL 1-alpha(1 ng/ml per 100 μl/well) was added as stimulant. Then the medium waschanged (100 μl/well) and incubated at 37° C. After 4 h a 70 μl samplewas recovered from the cell supernatant. Thereafter, an IL-8 ELISA iscarried out with the cell supernatant sample.

The lower the IL-8 concentration the better the proinflammatory effectof the antioxidant of the sample.

Example 5.1: Retinol Plus 1,2-heptanediol

TABLE 32 IL-8 concentration Compound Concentration (pg/ml)1,2-heptanediol 500 μM 959.85 Retinol  50 μM 670.84 Retinol +  50 μM608.62 1,2-heptanediol 500 μM Stimulated control 876.58 Unstimulated95.15 control

The IL8 concentration results from Table 32 are visualized in FIG. 12 .

1,2-heptanediol alone does not show a IL-8 reducing capacity, as theIL-8 concentration is with 959.8 not reduced in comparison to thestimulated control. In contrast, Retinol inhibits IL-8 secrection;1,2-heptanediol enhances the Retinol activity by 9.25%, as the IL-8value is reduced from 670.8 to 608.6.

Example 6: Solubility of Alkanediols in Water

For the determination of the maximum water solubility of an alkanediol.water and different concentrations of the respective alkanediol wereblended by stirring. The assessment of solubility was carried out atambient temperature after 24 h storage at 5° C. The determination ofwhether the alkanediol has dissolved in water is based entirely onvisual observation. An alkanediol compound has dissolved if the mixtureis clear and shows no signs of cloudiness or precipitation.

TABLE 33 Maximum Tradename/ solubility in water Chemical name INCI (% byweight) Hydrolite ® 5 green Pentylene Glycol 50 Hydrolite ® 6 Hexanediol50 1,2-heptanediol Heptanediol 2.5 Hydrolite ® 8 Caprylyl Glycol 0.5SymDiol ® 68 Hexanediol. Caprylyl 1.0 Glycol 1,2-nonanediol Nonanediol0.1 Sym Clariol ® Decylene Glycol — 1,2-undecanediol Undecanediol —2,3-heptanediol — 3.6 2,3-octanediol — 1.5 2,3-nonanediol — 0.32,3-undecanediol — —

Example 7: Formulation Examples

The following formulations according to the present invention wereprepared:

-   -   Skin Renewing Cream    -   Anti-Aging Hand and Body cream    -   Daily Anti-Wrinkle Face Cream; SPF 20    -   Night Repair Cream WIG    -   Body Lotion    -   Body Lotion (sprayable)    -   Aseptic wound cream    -   Anti-Acne Balm    -   Barrier Repair & Anti-Aging Cream    -   Skin Soothing Lotion    -   Baby Nappy Rash Cream (w/o)    -   Skin Lightening Day Cream (o/w)    -   After Shave Tonic    -   Antidandruff Hair Conditioner    -   Hair Conditioner, Leave On    -   Deodorant Stick    -   Antiperspirant Stick    -   Sunscreen Lotion (ow; broadband protection)    -   Sun Protection Soft Cream (w/o; SPF 40)    -   After Sun Lotion    -   Syndet Antimicrobial Soap Bar    -   Syndet Soap Bar    -   Antimicrobial Toilet Soap Bar    -   Shaving Foam    -   Skin Oil    -   Body, Face and Hair Care Oil    -   Beard Care    -   Solid Skin Care Concentrate    -   Solid Shampoo    -   Fresh Hair Shampoo    -   Hair Refresher Mist    -   Sensi-SCALP (Green Solid Shampoo)    -   Shampoo Sulfate Free

In the following formulation examples the following five perfume oilsPFO1 PFO2, PFO3, PFO4 or PFO5 were each used as fragrance.

TABLE 34 Composition of perfume oil 1; PO1 (amounts in % by weight)Ingredients Amount ALDEHYDE C14 SO-CALLED 2 ALLYL AMYL GLYCOLATE 10% DPG5 ANISIC ALDEHYDE PURE 5 APPLE OLIFFAC TYPE 10 Benzylacetate 50 BERGAMOTIDENTOIL ® COLOURLESS 15 CANTHOXAL 5 CETALOX 10% IPM 3 CITRONELLOL 95040 DAMASCENONE TOTAL 1% DPG 5 DAMASCONE ALPHA 10% DPG 5 DAMASCONE DELTA10% DPG 2 DIMETHYL BENZYL CARBINYL BUTYRATE 2 DIPROPYLENE GLYCOL 178EBANOL 2 ETHYL DECADIENOATE TRANS CIS-2.4 10% IPM 2 FLOROSA 5FRAMBINON ® 10% DPG 7 GALAXOLIDE 50% IN IPM 100 GALBEX TYPE BASE 1GERANYL ACETATE PURE 2 HEDIONE 30 HELIOTROPIN 10 HEXENYL ACETATE CIS-310% DPG 1 HEXENYL SALICYLATE CIS-3 5 HEXYL CINNAMIC ALDEHYDE ALPHA 70HEXYL SALICYLATE 50 HYDROXY CITRONELLAL 10 ISO E SUPER 15 ISORALDEINE 7020 LEAFOVERT ® 1 LILIAL 60 LINALOOL 60 LINALYL ACETATE 20 LYRAL 7MANZANATE 2 PHENOXANOL 7 PHENYLETHYL ALCOHOL 120 SANDAL MYSORE CORE 2SANDRANOL ® 7 STYRALYL ACETATE 3 TAGETES RCO 10% TEC 2 TERPINEOL PURE 20TETRAHYDROGERANIOL 10% DPG 5 TONALIDE 7 VERTOCITRAL 10% DPG 5 VERTOFIX15 Total: 1000

TABLE 35 Composition of perfume oil 2; PO2 (amounts in % by weight)Ingredients Amount Acetophenone, 10% in DPG 10 n-Undecanal 5 AldehydeC14 (peach aldehyde) 15 Allylamyl glycolate, 10% in DPG 20 Amylsalicylate 25 Benzyl acetate 60 Citronellol 80 d-Limonene 50 Decenoltrans-9 15 Dihydromyrcenol 50 Dimethylbenzylcarbinyl acetate 30Diphenyloxide 5 Eucalyptol 10 Geraniol 40 Nerol 20 Geranium oil 15Hexenol cis-3. 10% in DPG 5 Hexenyl salicylate cis-3 20 Indole. 10% inDPG 10 Alpha-ionone 15 Beta-ionone 5 Lilial ®(2-methyl-3-(4-tert-butyl-phenyl)propanal) 60 Linalool 40 Methylphenylacetate 10 Phenylethyl alcohol 275 Styrolyl acetate 20 Terpineol 30Tetrahydrolinalool 50 Cinnamyl alcohol 10 Total: 1000

TABLE 36 Composition of perfume oil 3; PO3 (amounts in % by weight)Ingredients Amount Benzyl acetate 60 Citronellyl acetate 60Cyclamenaldehyde (2-methyl-3-(4-isopropyl- 20 phenyl)propanalDipropylene glycol (DPG) 60 Ethyllinalool 40 Florol(2-isobutyl-4-methyltetrahydro-2H-pyran-4-ol) 30 Globanone ®[(E/Z)-8-cyclohexadecen-1-one] 180 Hedione ® (methyldihydrojasmonate)140 Hexenyl salicylate. cis-3 10 Vertocitral(2.4-dimethyl-3-cyclohexenecarboxaldehyde) 5 Hydratropaldehyde. 10% inDPG 5 Isodamascone (1-(2.4.4-trimethyl-2-cyclohexen-1-yl)- 52-buten-1-one. 10% in DPG Isomuscone (cyclohexadecanone) 40 Jacinthaflor(2-methyl-4-phenyl-1.3-dioxolane) 10 Cis-jasmone. 10% in DPG 20 Linalool50 Linalyl acetate 30 Methyl benzoate. 10% in DPG 25 para-Methyl cresol.10% in DPG 10 Nerol 20 Phenylpropylaldehyde 5 2-Phenylethyl alcohol 82Tetrahydrogeraniol 13 2.2-Dimethyl-3-cyclohexyl-1-propanol 80 Total:1000

TABLE 37 Composition of perfume oil 4; PO4 (amounts in % by weight)Ingredients Amount AMBRETTOLIDE (MACRO) 10 AMBROXIDE 10% in IPM 10BENZYL ACETATE 20 BENZYL SALICYLATE 15 BERGAMOT OIL. bergapten-free 60CALONE ® 1951 10% in DPG 15 COUMARIN 5 CYCLOGALBANATER 10% in DPG 10ALPHA -DAMASCONE 1% in DPG 20 DIHYDROMYRCENOL 10 ETHYL LINALOOL 75 ETHYLLINALYLACETATE 50 ETHYL MALTOL 1% in DEP 10 ETHYLENE BRASSYLATE (MACRO)80 FLOROSA 40 GERANYLACETATE 10 HEDIONE ® HC/30 35 HEDIONE ® 210HELIONAL ® 15 HELVETOLIDE ® (ALICYC) 30 HEXENYLSALICYLATE CIS-3 20 ISO ESUPER ® 40 LEAFOVERT ® 10% in DEP 10 LILIAL ® 80 LYRAL ® 20 MANDARIN OIL10 STYRALYL ACETATE 5 SYMROSE ® 15 VANILLIN 10% in DEP 20 DIPROPYLENEGLYCOL (DPG) 50 TOTAL: 1000

TABLE 38 Composition of perfume oil 5; PO5 (amounts in % by weight)Ingredients Amount AMAROCITE ® 10 AMBROCENIDE ® 10% in DPG 5 AMBROXIDE15 AURELIONE ® (7/8-Cyclohexadecenone) (MACRO) 70 BERGAMOT OIL.bergapten-free 90 CALONE ® 1951 10% in DPG 20 CARAWAY OIL 10 CITRAL 20COUMARIN 10 ALPHA-DAMASCONE 1% in DPG 15 DIHYDROMYRCENOL 70 ESTRAGON OIL10 ETHYL LINALOOL 100 ETHYL LINALYLACETATE 90 EUGENOL 10 EVERNYL ® 5FRUCTATE ® 5 GERANIUM OIL 5 HEDIONE ® HC/30 100 HELIONAL ® 10 INDOLE 10%in DPG 5 ISO E SUPER ® 100 KEPHALIS ® 5 LAVENDER OIL 40 CITRUS OIL 80LILIAL ® 30 MANDARIN OIL 20 MUSCENONE (MACRO) 5 SANDRANOL ® 10 VANILLIN10% in DPG 5 DIPROPYLENE GLYCOL 30 TOTAL: 1000

The above perfume oils PP1, PO2, PO3, PO4, or PO5 were incorporated intothe formulations presented below.

Cosmetic formulations (compositions); amounts are indicated as % byweight for all formulations.

TABLE 39 Skin Renewing Cream Ingredients INCI Amount Dracorin ® CEGlyceryl Stearate Citrate 1.0 Lanette ® O Cetearyl Alcohol 2.0 Cutina ®GMS-V Glyceryl Stearate 1.0 Sodium Ascorbyl Phosphate Sodium AscorbylPhosphate 0.5 Hydroxypinacolone Retinoate Hydroxypinacolone Retinoate0.1 Vitamin A Retinol 0.1 SymRelief Bisabolol, Zingiber Officinale 0.2(Ginger) Root Extract Tegosoft ® MM Myristyl Myristate 1.0 TocopherolTocopherol 0.5 Hydrolite-6 Hexanediol 1.0 Xiameter ® UMX-0246.Cyclohexasiloxane (and) 0.5 Cyclosiloxane Cyclopentasiloxane Dragoxat ®89 Ethylhexyl Isononanoate 2.0 PCL-Liquid 100 Cetearyl Ethylhexanoate4.0 Neutral Oil Caprylic/Capric Triglyceride 4.0 Carbopol ® Ultrez 21Acrylates/C10-30 Alkyl 0.2 Acrylate Crosspolymer Keltrol ® CG-T XanthanGum 0.1 Water Water (Aqua) ad 100 Dragosine Carnosine 0-1 Glycerol 99.5P. Glycerol 3.0 1.2-Propylene Glycol 99 P GC Propylene Glycol 2.0 SodiumBenzoate Sodium Benzoate 0.1 Sodium Hydroxide Sodium Hydroxide 0.5 10%solution Perfume oil PO1, PO2, Perfume 0.3 PO3, PO4, or PO5 SymSave ® HHydroxyacetophenone 0.5 1,2-heptanediol 1,2-heptanediol 1.02,3-heptanediol 2,3-heptanediol 0.02 1,2-octanediol Caprylyl Glycol 0.32,3-octanediol 1,2-octanediol/2,3-octanediol 0.05

TABLE 40 Anti Aging Hand and Body cream Ingredients INCI AmountDracorin ® GOC Glyceryl Oleate Citrate, 2.0 Caprylic/Capric TriglyceridePCL-Solid Stearyl Heptanoate, Stearyl 2.5 Caprylate Lanette ® O CetearylAlcohol 1.5 Tocopherol Tocopherol Acetate 0.3 SymVital ® AR 3040Zingiber Officinale (Ginger) 0.1 Root Extract Cutina ® GMS-V GlycerylStearate 1.0 Dragoxat ® 89 Ethylhexyl Isononanoate 3.0 PCL-Liquid 100Cetearyl Ethylhexanoate 7.0 Isodragol ® Triisononanoin 4.0 Xiameter ®UMX-0345 Cyclopentasiloxane (and) 0.5 Cyclosiloxane CyclohexasiloxaneWater Water (Aqua) ad 100 Carbopol ® Ultrez 21 Acrylates/C10-30 AlkylAcrylate 0.2 Crosspolymer Keltrol ® CG-RD Xanthan Gum 0.1 Glycerol 85 P.Glycerol 3.0 DragoBetaGlucan Water (Aqua). Butylene Glycol. 1.5Glycerol. Avena Sativa (Oat) Kernel Extract Dragosine Carnosine 0.2Potassium Sorbate Potassium Sorbate 0.1 Sodium Hydroxide SodiumHydroxide 0.5 10% solution Perfume oil PO1, PO2, Perfume 0.2 PO3, PO4,or PO5 Sym Save ® H Hydroxyacetophenone 0.3 1,2-heptanediol1,2-heptanediol 1.0 2,3-heptanediol 2,3-heptanediol 1.0

TABLE 41 Daily Anti Wrinkle Face Cream (SPF 20) Ingredients AmountSymOcide PH Phenoxyethanol, Hydroxyacetophenone, 1 Caprylyl Glycol,Water (Aqua) Ascorbyl Palmitate Ascorbyl Palmitate 0.1 BiotiveL-Arginine Arginine 0.2 Buriti oil Mauritia Flexuosa Fruit Oil 1 Cocoabutter Theobroma Cacao (Cocoa) Seed Butter 2 Dimethicone Dimethicone 0.5Disodium EDTA Disodium EDTA 0.1 Dragosantol 100 Bisabolol 0.1 Dragoxat89 Ethylhexyl Isononanoate 5 Emulsiphos Potassium Cetyl Phosphate,Hydrogenated 2 Palm Glycerides Extrapone Corail Glycerin, Aqua,Hydrolyzed Corallina Officinalis 1 Glycerin Glycerin 3 IsoadipateDiisopropyl Adipate 5 Jojoba Wax Flakes Hydrogenated Jojoba Oil 1Keltrol CG-T Xanthan Gum 0.1 Lanette O Cetearyl Alcohol 5 Vitamin ETocopherol 0.2 Lanette 16 Cetyl Alcohol 1 Lanette 22 Behenyl Alcohol 1Neo Heliopan 357 Butyl Methoxydibenzoylmethane 3 Neo Heliopan HMSHomosalate 10 Neo Heliopan Hydro used as a 25% aq. Solution 8neutralized by arginine Phenylbenzimidazole Sulfonic Acid Neo HeliopanOS Ethylhexyl Salicylate 5 Orgasol Caresse Polyamide-5 1 Perfume oilPO1, PO2, PO3, PO4, or PO5 0.1 Shea butter Butyrospermum Parkii (Shea)Butter 3 Simugel EG Sodium Acrylate/Sodium Acryloyldimethyl 1 TaurateCopolymer, Isohexadecane, Polysorbate 80 SymFinity 1298 EchinaceaPurpurea Extract 0.1 SymMatrix Maltodextrin. Rubus Fructicosus(Blackberry) 0.1 Leaf Extract SymSitive 1609 Pentylene Glycol,4-t-Butylcyclohexanol 1 Tegosoft TN C12-15 Alkyl Benzoate 4 Hydrolite-8(Caprylyl Glycol) 0.5 1,2-heptanediol/2,3-heptanediol blend (95:5 w/w %)1.0 Water Aqua ad 100

TABLE 42 Night Repair Cream m W/O Ingredients INCI Amount1,2-heptanediol 1,2-heptanediol 3.0 2,3-heptanediol 2,3-heptanediol 0.12,3-octanediol 2,3-octanediol 0.5 Aloe Vera Gel Water (Aqua), AloeBarbadensis 3.0 Concentrate 10/1 * Leaf Juice Alugel 34 TH AluminiumStearate 1.0 Dragosan W/O P* Sorbitan Isostearate, 6.0 HydrogenatedCastor Oil, Ceresin, Beeswax (Cera Alba) Dragosantol ® 100* Bisabolol0.2 Extrapone ® Witch Hazel Propylene Glycol, Hamamelis 1.0 Distillatecolourless Virginiana (Witch Hazel) Water, Water (Aqua), HamamelisVirginiana (Witch Hazel) Extract Perfume oil PO1, PO2, Perfume 0.4 PO3,PO4, or PO5 Glycerol 85 % Glycerin 2.0 Karion F Sorbitol 2.0 MagnesiumChloride Magnesium Chloride 0.7 Isoadipate Diisoadipate 2.0 PCL Liquid100 Cetearyl Ethylhexoate 12.0 Retinyl Palmitate in Oil RetinylPalmitate 0.05 Hydroxypinacolone Hydroxypinacolone Retinoate 0.05Retinoate Sun Flower Oil Helianthus Annuus (Sunflower) 5.0 Seed OilSweet Almond Oil Prunus dulcis 5.0 SymMatrix ® Maltodextrin. RubusFruticosus 1.0 (Blackberry) Leaf Extract SymOcide PS Phenoxyethanol.Decylene 1.0 glycol. 1.2-Hexanediol SymVital ® AgeRepair ZingiberOfficinale (Ginger) 0.1 Root Extract Vitamin E Tocopherol 3.0 Water(demineralized) Water (Aqua) ad 100

TABLE 43 Moisturizing Body lotion Ingredients Amount Cetearyl Alcohol2.0 Ethylhexyl Isononanoate 5.0 Tocopherylacetate 0.3 CetearylEthylhexanoate. Isopropyl Myristate 3.0 Glyceryl Oleate Citrate.Caprylic/Capric Triglyceride 4.0 Water (Aqua) ad 100 Carbomer 0.3 SodiumBenzoate 0.1 Urea 3.0 Propylene Glycol 5.0 Sodium Hydroxide 30% aqueoussolution 0.3 Perfume oil PO1, PO2, PO3, PO4, or PO5 0.3 SymSave H(Hydroxyacetophenone) 0.3 1,2-heptanediol 0.2 2,3-octanediol 0.2

TABLE 44 Calming Body lotion (sprayable) Ingredients INCI Amount1,2-heptanediol/ 1,2-heptanediol/ 1.5 2,3-heptanediol 2,3-heptanediolblend (95:5 w/w %) blend (95:5 w/w %) Potassium Sorbate PotassiumSorbate 0.2 Dow Corning 345 Fluid Cyclomethicone 0.5 Dracorin ® GOCGlyceryl Oleate Citrate, 2.0 Caprylic/Capric Triglyceride Drago-CalmWater, Glycerin, Avena Sativa 1.0 (Oat) Kernel Extract Dragosantol ®100* Bisabolol 0.1 Perfume oil PO1, PO2, Perfume 0.3 PO3, PO4, or PO5Hydrolite ®-5 Pentylene Glycol 5.0 Neutral Oil Caprylic/CapricTriglyceride 4.0 Paraffin Oil Mineral Oil 4.0 PCL Liquid 100 CetearylEthylhexoate 7.0 Pemulen TR-2 Acrylates/C10-30 Alkyl 0.2 AcrylateCrosspolymer Sodium Hydroxide Sodium Hydroxide 0.4 (10% sol.) SymDeo ®MPP Dimethyl Phenylbutanol 0.5 SymCalmin ® Butylene Glycol, Pentylene2.0 Glycol, Hydroxyphenyl Propamidobenzoic acid SymRelief ® 100Bisabolol, Zingiber Officinale 0.1 (Ginger) Root Extract Water(demineralized) Water (Aqua) ad 100

TABLE 45 Aseptic wound cream Ingredients Amount Sorbitan Isostearate.Hydrogenated Castor Oil. 6.0 Ceresin. Beeswax (Cera Alba) Petrolatum21.0 Bisabolol 0.2 Cera Alba 5.0 Cetearyl Alcohol 7.0 Cocos Nucifera(Coconut) Oil 7.0 Lanolin 5.0 Paraffinum Liquidum 12.0 Perfume oil PO1,PO2, PO3, PO4, or PO5 0.3 Water (Aqua) ad 100 Panthenol 7.0 MagnesiumSulfate 0.7 Pentylene Glycol 1.0 Tocopheryl Acetate 1.0 Octenidinedihydrochloride 0.1 Phenoxyethanol 0.5 1.2-heptanediol 0.42.3-heptanediol 0.01

TABLE 46 Anti Acne Balm Ingredients INCI Amount 1,2-heptanediol/1,2-heptanediol/ 3.0 1,2-octanediol 1,2-octanediol blend (1:1 w/w %)blend (1:1 w/w %) SymClariol Decylene Glycol 0.2 Vitamin E TocopherolAbil 350 Dimethicone 1.0 Allantoin Allantoin 0.1 Aloe Vera Gel Water(Aqua), Aloe 3.0 Concentrate 10/1 * Barbadensis Leaf Juice Azelaic AcidAzelaic Acid 5.0 Cetiol OE Dicaprylyl Ether 4.0 Cetiol SB 45Butyrospermum Parkii 1.0 (Shea Butter) D-Panthenol Panthenol 1.0Emulsiphos ® Potassium Cetyl Phosphate. 2.0 Hydrogenated Palm GlyceridesPerfume oil PO1, PO2, Perfume 0.2 PO3, PO4, or PO5 Frescolat ®ML cryst.Menthyl Lactate 0.8 Glycerol 85% Glycerin 4.0 Hydroviton ® PLUS Water,Pentylene Glycol, 1.0 Glycerin, Fructose, Urea, Citric Acid, SodiumHydroxide, Maltose, Sodium PCA, Sodium Chloride, Sodium Lactate,Trehalose, Allantoin, Sodium hyaluronate, Glucose Lara Care A-200Galactoarabinan 0.3 Pemulen TR-2 Acrylates/C10-30 Alkyl 0.2 AcrylateCrosspolymer Sodium Hydroxide Sodium Hydroxide 0.4 (10% sol.) SymOcidePH Hydroxyacetophenone, 1.0 Phenoxyethanol, Caprylyl glycol, AquaTegosoft TN C12-15 Alkyl Benzoate 5.0 Tocopherol Acetate TocopherylAcetate 0.5 Water (demineralized) Water (Aqua) ad 100

TABLE 47 Barrier Repair & Anti Aging Cream Ingredients INCI Amount2,3-octanediol 2,3-octanediol 0.5 1,2-heptanediol/ 1,2-heptanediol/ 0.52,3-heptanediol 2,3-heptanediol blend (95:5 w/w %) blend (95:5 w/w %)Abil 350 Dimethicone 0.5 Allantoin Allantoin 0.25 Dracorin ® CE GlycerylStearate Citrate 1.5 Dragoxat ® 89 Ethylhexylisononanoate 2.0Emulsiphos ® Potassium Cetyl Phosphate, 2.0 Hydrogenated Palm GlyceridesExtrapone ® Glycerin, Water (Aqua), 0.5 Rosemary GW Rosmarinusofficinalis (Rosemary) Leaf Extract Perfume oil PO1, PO2, Perfume 0.1PO3, PO4, or PO5 Glycerol 85% Glycerin 3.0 Dragosine Carnosine GlycerylStearate Glyceryl Stearate 2.0 Hydroviton ® 24 Water, Glycerin, SodiumLactate, 1.0 TEA Lactate, Serine, Lactic Acid, Urea, Sorbitol, SodiumChloride, Lauryl Diethylenediaminoglycine, Lauryl Aminopropylglycine.Allantoin Isodragol ® Triisononanoin 3.0 Lanette O Cetearyl Alcohol 2.0NaOH 10% sol. Sodium Hydroxide 0.3 Neutral Oil Caprylic/CapricTriglyceride 10.0 SymCalmin ® Pentylene Glycol, Butylene 1.0 Glycol,Hydroxyphenyl Propamidobenzoic Acid SymRepair ® 100 Hexyldecanol,Bisabolol, 2.0 Cetylhydroxyproline Palmitamide, Stearic Acid, BrassicaCampestris (Rapeseed) Sterols Vitamin E Tocopherol 0.3 Sym TriolCaprylyl glycol, 1,2-Hexanediol, 1.0 Methylbenzyl alcohol Tegosoft PC 31Polyglyceryl 3-Caprate 0.3 Tocopherol Acetate Tocopheryl Acetate 0.3Water (demineralized) Water (Aqua) ad 100

TABLE 48 Skin Soothing Lotion Ingredients INCI Amount 2,3-heptanediol2,3-heptanediol 0.5 2,3-octanediol 2,3-octanediol 0.5 Abil 350Dimethicone 2.0 Allantoin Allantoin 0.2 Carbopol Ultrez-10 Carbomer 0.1Ceramide BIO* Cetylhydroxyproline Palmitamide 0.1 Citric Acid 10% sol.Citric Acid 0.4 Emulsiphos ® Potassium Cetyl Phosphate, 2.0 HydrogenatedPalm Glycerides Extrapone ® Green Glycerin, Water (Aqua), Camellia 0.2Tea GW Sinensis Leaf Extract Extrapone ® Rosemary Glycerin, Water(Aqua), 0.3 GW Rosmarinus officinalis (Rosemary) Leaf Extract Perfumeoil PO1, PO2, Perfume 0.3 PO3, PO4, or PO5 Glycerol 85 % Glycerin 2.0Glyceryl Stearate Glyceryl Stearate 2.0 Isodragol ® Triisononanoin 2.0Keltrol RD Xanthan Gum 0.1 Lanette O Cetearyl Alcohol 3.0 Neo PCL wssl.N Trideceth-9. PEG-5 1.0 Ethylhexanoate. Water PCL Liquid 100 CetearylEthylhexanoate 5.0 Vitamin E Tococpherol 0.3 PCL Solid StearylHeptanoate. Stearyl 2.0 Caprylate Propylene Glycol Propylene Glycol 5.0Sodium Hydroxide Sodium Hydroxide 0.3 (10% sol.) SymCalmin ® PentyleneGlycol, Butylene 2.0 Glycol, Hydroxyphenyl Propamidobenzoic AcidSymMatrix ® Maltodextrin, Rubus Fruticosus 0.1 (Blackberry) Leaf ExtractSymSave H Hydroxyacetophenone 0.4 2-Phenoxyethyl Alcohol Phenoxyethanol0.4 SymSitive ®1609 Pentylene Glycol, 4-t- 1.5 Butylcyclohexanol Water(demineralized) Water (Aqua) ad 100

TABLE 49 Baby nappy rash cream W/O Ingredients Amount SymOcide PHPhenoxyethanol, Hydroxyacetophenone, 1 Caprylyl Glycol, Water (Aqua)Cupuaçu butter Theobroma Grandiflorum Seed Butter 1 Cutina HR PowderHydrogenated Castor Oil 1.5 Dehymuls PGPH Polyglyceryl-2Dipolyhydroxystearate 5 Glycerin Glycerin 5 Jojoba oil SimmondsiaChinensis (Jojoba) Seed Oil 5 Magnesium Sulfate Hepta Hydrate MagnesiumSulfate 0.5 Monomuls 90-O18 Glyceryl Oleate 1 Neutral oilCaprylic/capric triglyceride 8 Vitamin E Tocopherol 0.5 SymDecanox HACaprylic/Capric Triglyceride, 2 Hydroxymethoxyphenyl Decanone PCL Liquid100 Cetearyl Ethylhexanoate 5 SymCalmin Butylene Glycol. PentyleneGlycol. 1 Hydroxyphenyl Propamidobenzoic Acid Tamanu oil CalophyllumInophyllum Seed Oil 0.2 Tetrasodium EDTA Tetrasodium EDTA 0.1 Titandioxide Titan dioxide 4 Water Aqua ad 100 Wheat germ oil TriticumVulgare (Wheat) Germ Oil 2 Zinc oxide Zinc oxide 10 1,2-heptanediol 1.0

TABLE 50 Skin Lightening Day Cream O/W Ingredients INCI Amount1,2-heptanediol/ 1,2-heptanediol/ 3.0 2,3-heptanediol 2,3-heptanediolblend (95:5 w/w %) blend (95:5 w/w %) Abil 350 Dimethicone 0.5Dracorin ® CE Glyceryl Stearate Citrate 2.5 Dracorin ® GOC GlycerylOleate Citrate, 0.5 Caprylic/Capric Triglyceride Drago-Beta-Glucan Water(Aqua), Butylene 0.3 Glycol, Glycerin, Avena Sativa (Oat), KernelExtract Dragosantol ® 100* Bisabolol 0.2 HydroxypinacoloneHydroxypinacolone 0.1 Retinoate Retinoate Perfume oil PO1, PO2, Perfume0.1 PO3, PO4, or PO5 Frescolat ®MGA Menthone Glycerol Acetal 0.5Glycerol 85% Glycerin 3.0 Isopropyl Palmitate Isopropyl Palmitate 4.0Keltrol RD Xanthan Gum 0.2 Lanette 16 Cetyl Alcohol 1.0 Neo Heliopan ®AV Ethylhexyl Methoxycinnamate 5.0 Vitamin E Tocopherol 0.3 Neutral OilCaprylic/Capric Triglyceride 6.0 Isoadipate Diisopropyl Adipate 3.0 PCLLiquid 100 Cetearyl Ethylhexoate 3.0 Sodium Benzoate Sodium Benzoate 0.1Symdiol ®68T 1,2-Hexanediol, Caprylyl- 0.5 glycol, Tropolone SymVital ®AgeRepair Zingiber Officinale (Ginger) 0.1 Root Extract SymWhite ®377Phenylethylresorcinol 0.5 Water (demineralized) Water (Aqua) ad 100

TABLE 51 After Shave Tonic Ingredients INCI Amount SymSol ® PF-3 Water(Aqua), Pentylene Glycol, 3.0 Sodium Lauryl Sulfoacetate, Sodium OleoylSarcosinate, Sodium Chloride, Disodium Sulfoacetate, SodiumOleate.Sodium Sulfate SymSitive ® 1609 Pentylene Glycol, 4-t- 1.0Butylcyclohexanol SymRelief 100 Bisabolol, Zingiber Officinalis 0.3(Ginger) Root Extract Glycerol 99.5 P. Glycerol 5.0 Water Water (Aqua)ad 100 Extrapone ® Glacier Glycerol, Water (Aqua) 1.0 Water GW SymCalmin ® Butylene Glycol, Pentylene 0.5 Glycol, HydroxyphenylPropamidobenzoic Acid Dragosine ® Carnosine 0.1 Hydrolite ® 5 PentyleneGlycol 5.0 5 Ethanol 96% Alcohol 5.0 Colour Pigment Colour Pigment 0.05Perfume oil PO1, PO2, Perfume 0.15 PO3, PO4, or PO5 1,2-octanediol/2,3-1,2-octanediol/2,3-octanediol 0.5 octanediol blend (99:1) blend (99:1)

TABLE 52 Anti-dandruff Hair Conditioner Ingredients INCI AmountLanette ® O Cetearyl Alcohol 4.0 Dragoxat 89 Ethylhexyl Isononanoate 2.0Genamin ® KDM-P Behentrimonium Chloride 1.0 SF 1550 Phenyl Trimethicone0.1 Neo Heliopan ® BB Benzophenone-3 0.1 Crinipan ® AD Climbazole 0.4Crinipan ® PMC Green Propanediol Caprylate 1.0 Glycerol 99.5 P. Glycerol6.0 Sym Control Scalp Water (Aqua), Glycerin, 1.0 Mannitol, TetraselmisSuecica Extract Water Water (Aqua) ad 100 Extrapone ® Bamboo P PropyleneGlycol, Water (Aqua), 0.5 Butylene Glycol, Bambusa Vulgaris ShootExtract Sodium Hydroxide Sodium Hydroxide 0.4 10% solution Colour IColour 0.6 Colour II Colour 0.3 Perfume oil PO1, PO2, Perfume 0.4 PO3,PO4, or PO5 Preservative Methylparaben 0.3 2,3-heptanediol2,3-heptanediol 0.3 2,3-octanediol 2,3-octanediol 0.3

TABLE 53 Hair Conditioner, Leave on Ingredients INCI Amount1,2-heptanediol/ 1,2-heptanediol/ 1.0 2,3-heptanediol 2,3-heptanediolblend (95:5 w/w %) blend (95:5 w/w %) Dehyquart A CA CetrimoniumChloride 0.2 Dehyquart SP Quaternium-52 2.0 Dracorin ® CE GlycerylStearate Citrate 1.0 Drago-Calm Water, Glycerin, Avena Sativa 2.0 (Oat)Kernel Extract Farnesol Farnesol Perfume oil PO1, PO2, Perfume 0.5 PO3,PO4, or PO5 Lara Care A-200 Galactoarabinan 0.1 Polymer JR 400Polyquaternium-10 0.1 Propylene Glycol Propylene Glycol 0.8 Neo ActiponeOrganic Maltodextrin, Camellia Sinensis 1.0 Green Tea Leaf ExtractSymMollient ® WS Trideceth-9, PEG-5 1.0 Isononanoate, WaterSymSol ®PF3 * Water, Pentylene Glycol, Sodium 1.5 Lauryl Sulfoacetate,Sodium Oleoyl Sarcosinate, Sodium Chloride, Disodium Sulfoacetate,Sodium Oleate, Sodium Sulfate SymSave ® H Hydroxyacetophenone 0.2 SymTriol ® Caprylyl Glycol, 1,2-Hexanediol, 1.0 Methylbenzyl Alcohol Water(demineralized) Water (Aqua) ad 100

TABLE 54 Deodorant Stick Ingredients Amount Sodium stearate 8.0 PPG-3Myristyl ether 70.0 1,2-propylene glycol 10.01,1-dimethyl-3-phenylpropanol 0.2 2-butyloctanoic acid 0.2 Perfume oilPO1, PO2, PO3, PO4, or PO5 0.6 Magnesium Ascorbyl Phosphate 0.5 Water ad100 SymDeo Plus 0.5 (Jasmol (2-benzlheptanol), 1-Dodecanol (LaurylAlcohol), 1.2-Decanediol (Decylene Glycol), 2-Phenoxyethyl Alcohol(Phenoxyethanol)) 2,3-heptanediol 0.1 2,3-octanediol 0.1

TABLE 55 Antiperspirant Stick Ingredients INCI Amount PCL Liquid 100Cetearyl ethylhexanonate ad 100 Silicone Fluid 345 Cyclomethicone 10.0CRODACOL C90 Cetyl Alcohol 8.0 SYNCROWAX HGLC C18-36 Triglyceride 8.0CRODAMOL PTC Pentaerythritol 5.0 Tetracaprylate/Caprate SYNCROWAX HRCTribehenin 4.0 VOLPO N5 Oleth-5 1.0 Vitamin E Tocopherol 0.3 TitaniumDioxide Titanium Dioxide 1.0 Rezal 36GP Aluminium Tetrachlorohydrex 20.0GLY Dry Flo C Aluminium Starch Octenyl 22.5 Succinate PreservativePhenoxyethanol 0.8 Perfume oil PO1, PO2, Perfume 0.6 PO3, PO4, or PO51,2-heptanediol/ 1,2-heptanediol/ 1.5 2,3-heptanediol 2,3-heptanediolblend (95:5 w/w %) blend (95:5 w/w %)

TABLE 56 Sunscreen Lotion (ow; broadband protection) Ingredients INCIAmount 1,2-heptanediol 1,2-heptanediol 0.15 1,2-octanediol/1,2-octanediol/ 0.5 2,3-octanediol 2,3-octanediol blend (95:5 w/w %)blend (95:5 w/w %) Carbopol Ultrez-10 Carbomer 0.2 Dow Corning 246 FluidCyclohexasiloxane and 2.0 Cyclopentasiloxane Dragosantol ® 100*Bisabolol 0.3 EDETA BD Disodium EDTA 0.1 Emulsiphos Potassium CetylPhosphate, 1.5 Hydrogenated Palm Glycerides Perfume oil PO1, PO2,Perfume 0.4 PO3, PO4, or PO5 Frescolat ®MGA Menthone Glycerol Acetal 0.3Glycerol 85% Glycerin 4.7 Dragosine Carnosine 0.2 Keltrol RD Xanthan Gum0.2 Lanette O Cetearyl Alcohol 1.0 Neo Heliopan ® 357 ButylMethoxy-dibenzoyl- 1.0 methane Neo Heliopan ® AP Disodium Phenyl 10.0(10% as sodium salt) Dibenzimidazole Tetrasulfonate Neo Heliopan ® AVEthylhexyl Methoxy-cinnamate 3.0 Neo Heliopan ® HydroPhenylbenz-imidazole Sulfonic 6.7 (15% as sodium salt) Acid NeoHeliopan ® MBC 4-Methylbenzyl-idene Camphor 1.5 Neo Heliopan ® OSEthylhexyl Salicylate 5.0 Neutral Oil Caprylic/Capric Triglyceride 2.0SymMatrix ® Maltodextrin. Rubus Fruticosus 0.3 (Blackberry) Leaf ExtractSymOcide ® BHO Hydroxyacetophenone. Benzyl alcohol. Caprylyl glycol.Aqua Tegosoft TN C12-15 Alkyl Benzoate 5.0 Tocopherol Acetate TocopherylAcetate 0.5 Triethanolamine. 99% Triethanolamine 0.5 Water(demineralized) Water (Aqua) ad 100

TABLE 57 Sun Protection Soft Cream W/O; SPF 40 Ingredients INCI AmountDehymuls PGPH Polyglyceryl-2 5.0 dipolyhydroxystearate Copherol 1250Tocopheryl acetate 0.5 Permulgin 3220 Ozocerite 0.5 Zinc stearate Zincstearate 0.5 Tegosoft TN C12-15 Alkyl benzoate 10.0 Neo Heliopan ® E1000Isoamyl-p-methoxycinnamate 2.0 Ubiquinone 10 Ubiquinone-10 0,1 NeoHeliopan ® 303 Octocrylene 5.0 Neo Heliopan ® MBC 4-Methylbenzylidenecamphor 3.0 Zinc oxide. neutral Zinc oxide 5.0 Water. Distilled Water(aqua) ad 100 EDETA BD Disodium EDTA 0.1 Glycerol Glycerol 4.0 Magnesiumsulfate Magnesium sulfate 0.5 Perfume oil PO1, PO2, Perfume 0.3 PO3,PO4, or PO5 Symdiol ® 68 Hexanediol, Caprylylglycol 0.5 1,2-heptanediol1,2-heptanediol 0.15

TABLE 58 After sun balm Ingredients INCI Amount SymSol ® PF-3 Water(Aqua), Pentylene Glycol, 3.0 Sodium Lauryl Sulfoacetate, Sodium OleoylSarcosinate, Sodium Chloride, Disodium Sulfoacetate, Sodium Oleate,Sodium Sulfate Glycerol 99.5 P. Glycerol 5.0 Vitamin E Tocopherol 0.3Sunflower Oil Helianthus Annuus (Sunflower) 1.0 Oil SymUrban ®Benzylidene 0.1 Dimethoxydimethylin danone Water Water (Aqua) ad 100Pemulen ® TR-2 Acrylates/C10-30 Alkyl 1.0 Acrylate CrosspolymerD-Panthenol 75 W Panthenol 0.5 SymFinity ® 1298 Echinacea PurpureaExtract 0.1 Extrapone ® Pearl GW Water (Aqua), Glycerol, 1.0 HydrolyzedPearl, Xanthan Gum Tinogard TT Pentaerythrityl Tetra-di-t-butyl 0.1Hydroxyhydrocinnamate Sodium Hydroxide Sodium Hydroxide 2.5 10% solutionEthanol 96% Alcohol 15.0 Perfume oil PO1, PO2, Perfume 0.2 PO3, PO4, orPO5 SymOcide ® PS Phenoxyethanol. 1.2- 0.8 Hexanediol. Decyleneglycol1,2-heptanediol 1,2-heptanediol 0.15 2,3-octanediol 2,3-octanediol 0.05

TABLE 59 After Sun Lotion Ingredients Amount Acrylate/C10-30alkylacrylate crosspolymer 0.4 Cetearylethyl hexanoate 15.0 Bisabolol0.2 Helianthus Annuus (Sunflower) Oil 0.3 Tocopheryl acetate 1.0Panthenol 1.0 Alcohol 15.0 Glycerol 3.0 Perfume oil PO1, PO2, PO3, PO4,or PO5 0.30 1,2-Hexanediol 1.0 4-Hydroxyacetophenone 0.3 Pentyleneglycol 4.0 Aqua dem. ad 100 Triethanolamine 0.2 1,2-heptanediol 0.22,3-octanediol 0.1

TABLE 60 Syndet Antimicrobial Soap Bar Ingredients INCI Amount Zetesap813 A Disodium Lauryl Sulfosuccinate, ad 100 Sodium Lauryl Sulfate, CornStarch, Cetearyl Alcohol, Paraffin, Titanium Dioxide Amphotensid GB 2009Disodium Cocoamphodiacetate 6.0 Allantoin Allantoin 1.0 Vitamin ETocopherol 0.3 Perfume oil PO1, PO2, PO3, Perfume 1.0 PO4, or PO5Tinogard DA Dilauryl Thiodipropionate 0.3 SymOcide C o-cymen-5-ol 0.11,2-heptanediol/2,3-heptanediol 1,2-heptanediol/2,3-heptanediol 5.0blend (95:5 w/w %) blend (95:5 w/w %)

TABLE 61 Syndet Soap Bar Ingredients INCI Amount Fenopon AC-78 SodiumCocoyl Isethionate 20.0 Natriumlaurylsulfoacetate Sodium LaurylSulfoacetate 16.0 Paraffin Paraffin 19.0 Wax. MicrocrystallineMicrocrystalline Wax 1.0 Corn Starch Corn Starch 8.0 Coconut oil Coconutoil 2.0 Tocopherol Tocopherol 0.3 Lauric acid diethanol amide LauramideDEA 2.0 Dextrin Dextrin 21.0 Lactic acid. 88% Lactic Acid 1.0 SymGuardCD 3-Phenylpropanol, o-cymen- 0.3 5-ol, Decylene glycol Thymol Thymol0.05 Water Water ad 100 Perfume oil PO1, PO2, PO3, Perfume 1.0 PO4, orPO5 1,2-heptanediol/2,3-heptanediol 1,2-heptanediol/2,3-heptanediol 3.0blend (95:5 w/w %) blend (95:5 w/w %)

TABLE 62 Antimicrobial Toilet Soap Bar Ingredients Amount Sodium soapfrom tallow 60.0 Sodium soap from palm oil 27.0 Glycerol 2.0 SodiumChloride 0.5 1-Hydroxyethane-1,1-diphosphonic acid, 0.3 tetrasodium saltTocopherol 0.1 Pigment Yellow 1 0.02 Water ad 100 Perfume oil PO1, PO2,PO3, PO4, or PO5 3.0 Farnesol 0.2 2,3-heptanediol 1.0 2,3-octanediol 1.0

TABLE 63 Shaving Foam Ingredients Amount Dem. Water ad 100Triethanolamine 4.0 Edenor L2 SM (Stearinic acid. Palmitinic acid)(Cognis) 5.3 Laureth-23 3.0 Stearylalcohol 0.5 Vitamin E 0.2 TocopherolSymOcide BHO 1.0 (Hydroxacetophenone, Benzyl alcohol, Caprylyl glycolWater) 1,2-octanediol/2,3-octanediol blend (95:5 w/w %) 0.3 Sodiumlauryl sulfate 3.0 Extrapone Seaweed (water, propylene glycol, potassiumiodide, 1.0 Fucus Vesiculosus Extract) Dragosantol (Bisabolol, Farnesol)0.1 Perfume oil PO1, PO2, PO3, PO4, or PO5 1.0 Propane, butane 4.2 Bar4.0

TABLE 64 Skin Oil Ingredients INCI Amount Neutral Oil Caprylic CapricTriglyceride ad 100 Sunflower Oil Helianthus Annuus (Sunflower) 20.0Seed Oil PCL Liquid 100 Cetearyl Ethylhexanoate 15.0 Dragosantol 100Bisabolol 0.2 Vitamin E Acetate Tocopheryl Acetate 0.3 Perfume oil PO1,PO2, PO3, Perfume 0.2 PO4, or PO5 1,2-heptanediol/2,3-heptanediol1,2-heptanediol 3.0 blend (90:10 w/w %) 2,3-heptanediol

TABLE 65 Body, Face and Hair Care Oil Ingredients INCI Amount SweetAlmond) Oil Prunus Amygdalus Dulcis 15.0 (Sweet Almond) Oil CaprylicCapric Triglyceride Caprylic Capric Triglyceride ad 100 Tegosoft OPEthylhexyl Palmitate 14.0 Covasilk 15 Silica Dimethyl Silylate 1.0Isoadipate Diisopropyl Adipate 20.0 Dragosantol 100 Bisabolol 0.2Vitamin E Acetate Tocopheryl Acetate 0.3 Perfume oil PO1, PO2, PO3,Perfume 0.2 PO4, or PO5 1,2-heptanediol 1,2-heptanediol 1.02,3-heptanediol 2,3-heptanediol 0.05

TABLE 66 Beard Care Ingredients INCI Amount Eutanol G Octyldodecanol16.0 Gelling Agent GP-1 Dibutyl Lauroyl Glutamide 2.4 Gelling AgentEB-21 Dibutyl Ethylhexanoyl Glutamide 1.6 Jojoba Oil SimmondsiaChinensis (Jojoba) 10.0 Seed Oil Sweet Almond Oil Prunus AmygdalusDulcis ad 100 (Sweet Almond) Oil SymClariol Decylene Glycol 0.1 Dragoxat89 Ethylhexyl Isononanoate 14.0 Vitamin E Acetate Tocopheryl Acetate 0.3Perfume oil PO1, PO2, PO3, Perfume 0.2 PO4, or PO5 SymMollient PDCCPropanediol Caprylate Caprate 10.0 Symlite G8 Glyceryl Caprylate 0.5Hydrolite-5 Pentylene Glycol 0.5 1,2-heptanediol 1,2-heptanediol 1.52,3-heptanediol 2,3-heptanediol 0.05

TABLE 67 Solid Skin Care Concentrate Ingredients INCI Amount MangoButter Mangifera Indica Seed Butter ad 100 Carnauba Wax CoperniciaCerifera (Carnauba) 6.0 Wax Rice Bran Wax Oryza Sativa (Rice) Bran Wax6.0 Cannabis Sativa Seed Oil Cannabis Sativa Seed Oil 5.0 Cacao ButterTheobroma Cacao (Cocoa) 5.0 Seed Butter ImerCare Pharma 00T Talc 2.0Vitamin E Tocoherol 1.0 SymReboot L 19 Maltodextrin. 0.5 LactobacillusFerment Perfume oil PO1, PO2, PO3, Perfume 0.2 PO4, or PO5 SymVital AgeRepair 3040 Zingiber Officinale (Ginegr) Root 0.2 Extract Sunflower OilHelianthus Annuus (Sunflower) 20.0 Seed Oil Symlite G8 GlycerylCaprylate 0.5 Argan Oil Argania Spinosa Kernel Oil 6.01,2-octanediol/2,3-octanediol 1,2-octanediol/2,3-octanediol 2.0 blend(95:5 w/w %) blend (95:5 w/w %) 1,2-heptanediol 1,2-heptanediol 1.0

TABLE 68 Solid Shampoo Ingredients INCI Amount Amisoft MS-11 SodiumMyriostoyl Glutamate ad 100 Elfan AT 84 Sodium Cocoyl Isethionate 15.0ImerCare 02K-S Kaolin 18.8 Hydrolite-5 Green Pentylene Glycol 1.0 CetiolSB45 Bytyrrospermum Parkii Butter 20.0 Sym Decanox HA Caprylic CapricTriglycerides 2.0 Hydroxymethoxyphenyl Decanone Water Water (Aqua) 15.0Perfume oil PO1, PO2, PO3, Perfume 1.0 PO4, or PO51,2-heptanediol/2,3-heptanediol 1,2-heptanediol 3.0 blend (98:2 w/w %)2,3-heptanediol

TABLE 69 Fresh Hair Shampoo Ingredients INCI Amount Aqua Aqua ad 100EDTA B Powder Disodium EDTA 0.1 Carbopol ® Aqua SF-1 Polymer Acrylatescopolymer 11.0 Texapon ® NSO UP Sodium Laureth sulfate 35.0 Dehyton ® KCocamidopropyl betaine 8.0 Plantacare ® 2000 UP Decyl Glucoside 4.0Perfume oil PO1, PO2, PO3, Perfume 1.0 PO4, or PO5 SymSave ® HHydroxyacetophenone 0.5 Hydrolite ® 6 1,2-Hexanediol 1.01,2-heptanediol, 2,3-heptanediol 1,2-heptanediol, 2,3-heptanediol 0.5(w/w % 95:5) 1,2-heptandiol 1,2-heptanediol 0.5 SymClariol ® DecyleneGlycol 0.5 SymLite ® G8 Glyceryl Caprylate 0.2 Frescolat ® ML crystMenthyl Lactate 1.0 SymCalmin ® Pentylene Glycol, Butylene 0.2 Glycol,Hydroxyphenyl SymControl Scalp Water (Aqua), Glycerin, 1.0 Mannitol,Tetraselmis Suecica Extract Crinipan ® AD Climbazole 0.2 PropyleneGlycol Propylene Glycol 2.0 SymHair ® Shield Pentylene Glycol, Aqua, 1.0Glycerin, Triticum vulgare bran extract, 1,2-Hexanediol, Caprylyl SodiumHydroxide 10% solution Aqua, Sodium hydroxide 2.2 Actipone ® Alpha-PulpAqua, Butylene Glycol, Malic 0.2 acid, Actinidia chinensis fruitextract, citrus aurantium dulcis juice, citrus paradise juice, pyrusmalus juice

TABLE 70 Hair Refresher Mist Ingredients INCI Amount SymDeo ® PlusLauryl alcohol, 0.5 Phenoxyethanol, 2- Benzyleptanol, Decylene GlycolPerfume oil PO1, PO2, Perfume 0.1 PO3, PO4, or PO5 Frescolat ® ML natMentyl Lactate 0.3 Crinipan ® PMC green Propanediol Caprylate 0.3Solubilizer PEG-40 5.0 Hydrogenated Castor oil, Trideceth-9, Propyleneglycol, Aqua SymCalmin ® Pentylene Glycol, 0.2 Butylene Glycol,Hydroxyphenyl Propamidobenzoic acid Rutin Rutin 0.05 SymControl ® ScalpWater (Aqua), 2.0 Glycerin, Mannitol, Tetraselmis Suecica Extract1,2-octanediol, 2,3- 1,2-octanediol, 2,3- 0.3 octanediol (w/w % 98:2)octanediol 1,2-heptanediol, 2,3- 1,2-heptanediol, 2,3- 0.6 heptanediol(w/w % heptanediol 95:5) Propylene Glycol Propylene Glycol 3.0 ButyleneGlycol Butylene Glycol 3.0 Aqua Aqua ad 100 Edeta ® BD Disodium EDTA 0.1Symdiol 68 T Hexanediol, Caprylyl Glycol, 0.5 Tropolone Color Color 0.5Actipone ® Rosemary GW Glycerin, Aqua, Rosmarinus 0.5 officinalis leafextract

TABLE 71 Sensi-SCALP (Green Solid Shampoo) Ingredients INCI AmountAMISOFT ® MS-11 Sodium Myristoyl Glutamate 30.0 ELFAN ® AT 84 SodiumCocoyl Isethionate 15.0 ImerCare ® 02K-S Kaolin 18.8 Hydrolite ® 5 greenPentylene Glycol 1.5 1,2-octanediol, 2,3-octanediol 1,2-octanediol,2,3-octanediol 0.3 (w/w % 95:5) 1,2-heptanediol, 2,3-heptanediol1,2-heptanediol, 2,3-heptanediol 0.5 (w/w % 99:1) Dragosantol ® 100Bisabolol 0.1 SymSave H Hydroxyacetophenone 0.3 Aqua/Water Aqua ad 100SymDecanox ™ HA Caprylic/Capric Triglyceride, 2.0 Hydroxymethoxyphenyldecanone Cetiol ® SB45 Butyrospermum parkii butter 13.0 Extrapone ®Rooibus GW Aqua, Glycerin, Aspalathus 1.0 Linearis leaf extractSymReboot ™ L19 Maltodextrin, Lactobacillus 0.5 Ferment SymOleo ® Vita7Glycine soja oil, Gossypium 1.0 herbaceum seed oil, mangifera idica seedbutter, olea europaea fruitoil, persea gratissima oil, prununs amygdalusdulcis (sweet almond) oil, Theobroma cacao seed butter Perfume oil PO1,PO2, PO3, Perfume 1.2 PO4, or PO5

TABLE 72 Shampoo Sulfate-Free Ingredients EU INCI Amount Aqua/Water Aquaad 100 Akypo ® Foam RL 40 Sodium Laureth-5 Carboxylate 15.0 Plantacare ®2000 UP Decyl Glucoside 5.0 EDTA NA2 Disodium EDTA 0.1 SymOcide ® PHPhenoxyethanol, 1.5 Hydroxyacetophenone, Caprylyl Glycol, AquaAqua/Water Aqua 10.0 Novethix ™ L-10 Polymer Acrylates/Beheneth-25 7.0Methacrylate Copolymer Dehyton ® PK 45 Cocamidopropyl Betaine 10.01,2-octanediol, 2,3-octanediol 1,2-octanediol, 2,3-octanediol 0.1 (w/w %98:2) 1,2-heptanediol, 2,3-heptanediol 1,2-heptanediol, 2,3-heptanediol0.1 (w/w % 95:5) SymDecanox DPG Dipropylene Glycol, 1.0Hydroxymethoxyphenyl Decanone SymMollient ® W/S Trideceth-9, PEG-5 0.5Isononanoate, Aqua SymCalmin ® Pentylene Glycol, Butylene 1.0 Glycol,Hydroxyphenyl Propamidobenzoic acid Antil ® 141 Liquid Propylene Glycol,PEG-55 2.0 Proplyene Glycol Oleate AcusoI™ OP 301 Styrene/AcrylatesCopolymer 1.0 SymHair ® Restore Glycerin, Triticum Vulgare 1.0 Protein,Aqua Perfume oil PO1, PO2, PO3, Perfume 1.0 PO4, or PO5

TABLE 73 Air freshener (A/F spray water based) No Ingredients Amount 1Fragrance 4 2 Ethanol 8 3 PEG-40 Hydrogenated Castor Oil 5 41,2-heptanediol 1 5 Hydroxyacetophenone 0.3 6 Aqua add to 100Colorless liquid, pH neutral

TABLE 74 All-purpose cleaner No Ingredients Amount 1Fettalkoholethoxylat 4 2 Sulfonic acid, C 13-17-sec-Alkyl-, Sodium salt6.2 3 2-octyl-2H-isothiazol-3-one 0.1 4 Fragrance 3.5 5 Tocopherol 0.1 61,2-heptanediol 1 7 Aqua add to 100Colorless liquid, pH 7

TABLE 75 All-purpose cleaner No Ingredients Amount 1Fettalkoholethoxylat 4 2 Sulfonic acid, C 13-17-sec-Alkyl-, Sodium salt6.2 3 2-octyl-2H-isothiazol-3-one 0.1 4 Fragrance 3.5 5 2,3-octanediol0.1 6 1,2-heptanediol 0.9 7 Tocopherol 0.2 8 Aqua add to 100Colorless liquid, pH 7

TABLE 76 All-purpose cleaner, alkaline No Ingredients Amount 1Coco-Glycoside 1 2 Benzalkonium Chloride 0.2 3 Sodiumbicarbonat 0.1 4Tri-sodiumcitrate-dihydrate 0.1 5 Methylglycinediacetic acid 0.1 61,2-Benzisothiazol-3(2H)-on 0.1 7 Fragrance 0.1 8 1,2-heptanediol 0.5 9Aqua add to 100Colorless liquid, pH 9

TABLE 77 Cleaner, liquid, citric acid No Ingredients Amount 1 Sulfonicacid, C 13-17-sec-Alkyl-, Sodium salt 1 2 Citric Acid 5 3 Xanthan Gum0.5 4 1,2-heptanediol 0.5 5 Fragrance 0.3 6 Tocopherol 0.05 7 Aqua add100Liquid of low viscosity, pH 2

TABLE 78 Cleaner, liquid, citric acid No Ingredient Amount 1 Sulfonicacid, C 13-17-sec-Alkyl-, Sodium salt 1 2 Citric Acid 5 3 Xanthan Gum0.5 4 1,2-heptanediol/2,3 heptanediol 90:10 0.5 5 Fragrance 0.3 6 Aquaadd 100Liquid of low viscosity, pH 2

TABLE 79 Detergent liquid light duty No Ingredients Amount  1 Cocosfatty acid 0.85  2 potassium hydroxide 0.45  32-octyl-2H-isothiazol-3-one 0.2  4 Sulfonic acid, C 13-17-sec-Alkyl-,Sodium salt 20  5 Sodium Laureth Sulfate 3  6 Trideceth-9 5  7 SodiumChloride 1.3  8 2,3-octanediol 0.1  9 1,2-heptanediol 0.9 10 Fragrance0.5 11 Tocopherol 0.1 12 Aqua add to 100

Liquid, pH 7.3

TABLE 80 Detergent liquid light duty No Ingredients Amount  1 Cocosfatty acid 0.85  2 potassium hydroxide 0.45  32-octyl-2H-isothiazol-3-one 0.2  4 Sulfonic acid, C 13-17-sec-Alkyl-,Sodium salt 20  5 Sodium Laureth Sulfate 3  6 Trideceth-9 5  7 SodiumChloride 1.3  8 2,3-heptanediol 0.1  9 1,2-heptanediol 0.9 10 Fragrance0.5 11 Aqua add to 100

Liquid, pH 7.3

TABLE 81 Dishwash liquid manual No Ingredients Amount  1 Sodium LaurethSulfate add 100  2 Ethanol 2.9  3 lauramine oxide 7.7  4 propyleneglycol 1.9  5 Phenoxyethanol 0.1  6 Benzisothiazolinone,Methylisothiazolinone, 0.1 Laurylamine Dipropylenediamine  71,2-heptanediol 0.5  8 sodium chloride 3.85  9 Tocopherol 0.05 10Fragrance 0.3Colorless liquid, pH 8.5

TABLE 82 Fabric softener No Ingredients Amount 1 Di-(Talg Carboxyethyl)Hydroxyethyl 5.5 methylammonium-methosulfat 2 Simethicone 0.3 32-octyl-2H-isothiazol-3-one 0.1 4 1,2-heptanediol 0.5 5 Fragrance 0.2 6Tocopherol 0.2 7 Aqua add 100

Liquid, pH 3

TABLE 83 Fabric softener concentrate, encapsulated No Ingredients Amount 1 Di-(Talg Carboxyethyl) Hydroxyethyl 16.6 methylammonium-methosulfat 2 2-octyl-2H-isothiazol-3-one 0.1  3 Simethicone 0.3  4 magnesiumchloride 0.8  5 encapsulated perfume oil 0.3  6 crosslinked cationicpolymer 0.15  7 1,2-heptanediol 0.5  8 Fragrance 0.6  9 Tocopherol 0.210 Aqua add 100White liquid, pH 2.5

TABLE 84 Fabric softener concentrate, encapsulated No Ingredients Amount 1 Di-(Talg Carboxyethyl) Hydroxyethyl 16.6 methylammonium-methosulfat 2 2-octyl-2H-isothiazol-3-one 0.1  3 Simethicone 0.3  4 magnesiumchloride 0.8  5 encapsulated perfume oil 0.3  6 crosslinked cationicpolymer 0.15  7 2,3-heptanediol 0.05  8 1,2-heptanediol 0.5  9 Fragrance0.6 10 Tocopherol 0.2 11 Aqua add 100White liquid, pH 2.5

TABLE 85 Hand soap, liquid No Ingredients Amount  1 Sodium LaurethSulfate 18  2 Cocoamidopropylbetaine 6  3 Cocamide DEA 3  4 citric acid0.5  5 sodium chloride 1.9  6 Glycerol 2  7 Fragrance 0.2  81,2-heptanediol 0.25  9 Tocopherol 0.1 10 Aqua add 100Slightly colored liquid, pH 6

TABLE 86 Rim block gel No ingredients Amount 1 Sodium Laureth Sulfate 112 Trideceth-9 2 3 Xanthan gum 2 4 Hydroxyethylcellulose 0.5 5 CitricAcid 0.4 6 Ethanol 6 7 Fragrance 5 8 1,2-heptanediol 0.5 9 Aqua add 100Colorless paste/gel, pH=4.5

TABLE 87 Scent Lotion with capsules No ingredients Amount 1microcrystalline cellulose/cellulose gum 1 2 PEG-40 hydrogenated Castoroil/Trideceth-9 0.5 3 encapsulated perfume oil 1 42-octyl-2H-isothiazol-3-one 0.1 5 Fragrance 5 6 1,2-heptanediol 1 7Tocopherol 0.15 8 Aqua add 100White emulsion, pH neutral

TABLE 88 Cleaner, liquid, lactic acid No ingredients Amount 1 SodiumLaureth Sulfate 1.8 2 Trideceth-9 2.1 3 Xanthan gum 0.35 4 Lactic Acid2.8 5 1,2-heptanediol 1 6 Fragrance 0.3 7 Hydroxyacetophenone 0.3 8 Aquaadd 100Colorless liquid, pH 2.0

TABLE 89 Cleaner, liquid, citric acid No ingredients Amount 1 Sulfonicacid, C 13-17-sec-Alkyl-, Sodium salt 1 2 Xanthan gum 0-3 3 citric acid5 4 1,2heptanediol 0.25 5 Fragrance 0.3 6 Aqua add 100

Liquid, pH 2

1. A cosmetic or pharmaceutical composition or homecare product,comprising: (a1) 1,2-heptanediol; (b1) at least one antioxidant; and(c1) optionally at least one active substance for a cosmetic orpharmaceutical composition or homecare product and/or additive; or (a2)2,3-heptanediol; (b2) at least one antioxidant; and (c2) optionally atleast one active substance for a cosmetic or pharmaceutical compositionor homecare product and/or additive; or (a1) 1,2-heptanediol and/or2,3-heptanediol; (b1) at least one antioxidant; and (c1) optionally atleast one active substance and/or additive for a cosmetic orpharmaceutical composition or homecare product.
 2. A cosmetic orpharmaceutical composition or homecare product, comprising: (a) at leastone first linear alkanediol having a carbon chain of 5 to 14 carbonatoms or a mixture comprising at least one first linear alkanediolhaving a carbon chain of 5 to 14 carbon atoms and one or more secondlinear alkanediol having a carbon chain of 5 to 14 carbon atoms which isdifferent to the first linear alkanediol; (b) at least one antioxidant;and (c) optionally at least one active substance for a cosmetic orpharmaceutical composition or homecare product and/or additive.
 3. Acosmetic or pharmaceutical composition or homecare product according toclaim 2, wherein the at least one linear alkanediol or the first linearalkanediol is selected from the group consisting of pentanediol,hexanediol, heptanediol, octanediol, nonanediol, decanediol,undecanediol, dodecanediol, and tridecanediol.
 4. (canceled)
 5. Acosmetic or pharmaceutical composition or homecare product according toclaim 2, wherein the second linear alkanediol is selected from the groupconsisting of pentanediol, hexanediol, heptanediol, octanediol,nonanediol, decanediol, undecanediol, dodecanediol and tridecanediol. 6.A cosmetic or pharmaceutical composition or homecare product accordingto claim 2, wherein the at least one linear alkanediol, the first linearalkanediol or the second linear alkanediol is a (x,x+1) or a (x,x+2)constitutional isomer, wherein x stands for the number of the carbonatom in the alkanediol chain to which the OH groups of the alkanediolare chemically bonded.
 7. A cosmetic or pharmaceutical composition orhomecare product according to claim 2, wherein the at least one linearalkanediol or the first linear alkanediol is selected from the groupconsisting of 1,2-pentanediol, 2,3-pentanediol, 1,3-pentanediol,1,2-hexanediol, 2,3-hexanediol, 1,3-hexanediol, 1,2-heptanediol,2,3-heptanediol, 1,3-heptanediol, 1,2-octanediol, 2,3-octanediol,1,3-octanediol, 1,2-nonanediol, 2,3-nonanediol, 1,3-nonanediol,1,2-decanediol, 2,3-decanediol, 1,3-decanediol, 1,2-undecanediol,2,3-undecanediol, 1,3-undecanediol, 1,2-dodecanediol, 2,3-dodecanediol,1,3-dodecanediol, 1,2-tridecanediol, 2,3-tridecanediol,1,3-tridecanediol, and mixtures thereof; and/or wherein the secondlinear alkanediol is selected from the group consisting of1,2-pentanediol, 2,3-pentanediol, 1,3-pentanediol, 1,2-hexanediol,2,3-hexanediol, 1,3-hexanediol, 1,2-heptanediol, 2,3-heptanediol,1,3-heptanediol, 1,2-octanediol, 2,3-octanediol, 1,3-octanediol,1,2-nonanediol, 2,3-nonanediol, 1,3-nonanediol, 1,2-decanediol,2,3-decanediol, 1,3-decanediol, 1,2-undecanediol, 2,3-undecanediol,1,3-undecanediol, 1,2-dodecanediol, 2,3-dodecanediol, 1,3-dodecanediol,1,2-tridecanediol, 2,3-tridecanediol, 1,3-tridecanediol, and mixturesthereof.
 8. A cosmetic or pharmaceutical composition or homecare productaccording to claim 7, wherein the mixture comprising at least one firstlinear alkanediol and one or more second linear alkanediol is selectedfrom the group consisting of a mixture comprising 1,2-pentanediol and2,3-pentanediol; a mixture comprising 1,2-hexanediol and 2,3-hexanediol;a mixture comprising 1,2-heptanediol and 2,3-heptanediol; a mixturecomprising 1,2-octanediol and 2,3-octanediol; a mixture comprising1,2-nonanediol and 2,3-nonanediol; a mixture comprising 1,2-decanedioland 2,3-decanediol; a mixture comprising 1,2-undecanediol and2,3-undecanediol; a mixture comprising 1,2-dodecanediol and2,3-dodecanediol; a mixture comprising 1,2-tridecanediol and2,3-tridecanediol; a mixture comprising 1,2-hexanediol and2,3-octanediol; a mixture comprising 1,2-octanediol and 2,3-hexanediol;and a mixture comprising 1,2-octanediol and 2,3-heptanediol. 9.(canceled)
 10. A cosmetic or pharmaceutical composition or homecareproduct according to claim 7, wherein the mixture comprising at leastone first linear alkanediol and one or more second linear alkanediol isselected from the group consisting of a mixture comprising1,2-pentanediol and 2,3-hexanediol; a mixture comprising 1,2-pentanedioland 1,2-heptanediol; a mixture comprising 1,2-pentanediol and2,3-heptanediol; a mixture 1,2-pentanediol and 2,3-octanediol; a mixture1,2-pentanediol and 1,2-nonanediol; a mixture 1,2-pentanediol and2,3-nonanediol; a mixture comprising 1,2-heptanediol and 1,2-octanediol;a mixture comprising 1,2-heptanediol and 2,3-octanediol; a mixture1,2-heptanediol and 1,2-nonanediol; and a mixture 1,2-heptanediol and2,3-nonanediol.
 11. (canceled)
 12. A cosmetic or pharmaceuticalcomposition or homecare product according to claim 7, wherein the atleast one linear alkanediol, the first linear alkanediol, and/or thesecond linear alkanediol is selected from the group consisting of2,3-pentanediol, 2,3-hexanediol, 2,3-heptanediol, 2,3-octanediol,2,3-nonanediol, 2,3-decanediol, 2,3-undecanediol, 2,3-dodecanediol,2,3-tridecanediol and mixtures thereof.
 13. A cosmetic or pharmaceuticalcomposition or homecare product according to claim 2, wherein the atleast one linear alkanediol, the first linear alkanediol or the secondlinear alkanediol is an alkanediol having a maximum water solubility ofless than or equal to 10% by weight.
 14. A cosmetic or pharmaceuticalcomposition or homecare product according to claim 2, wherein themixture comprising at least one first linear alkanediol and one or moresecond linear alkanediol(s) comprises the first linear alkanediol andthe second linear alkanediol in a ratio in a range of 50:50 to 99.9:0.1.15. A cosmetic or pharmaceutical composition or homecare productaccording to claim 2, wherein the at least one antioxidant is selectedfrom the group consisting of arbutin, amino acids and their derivatives,tert-butylhydroquinone, caffeic acid, chlorogenic acid, imidazoles andtheir derivatives, cannabidiol and its extracts, kojic acid, peptidessuch as D,L-carnosine, D-carnosine, L-carnosine and their derivatives,hydroxyphenyl propamidobenzoic acid (dihydroavenanthramide D),diethylhexyl syringylidene malonate, phenylethyl resorcinol, gallic acidand their derivatives, quercetin, hydroxyacetophenone, rosmarinic acid,carotenoids, carotenes, phytoene, phytofluene and their derivatives,lipoic acid and its derivatives, aurothioglucose, propylthiouracil andother thiols and their salts, dilauryl thiodipropionate, pentaerythrityltetra-di-t-butyl hydroxyhydrocinnamate, di stearyl thiodipropionate,thiodipropionic acid and their derivatives as well as sulphoximinecompounds, lactobacillus, (metal) chelating agents and theirderivatives, unsaturated fatty acids and their derivatives, folic acidand its derivatives, ubiquinone and ubiquinol and their derivatives,triethyl citrate, Vitamin C and its derivatives, tocopherols and theirderivatives, dexpanthenol, Vitamin A and its derivatives, coniferylbenzoate of benzoin resin, rutinic acid and its derivatives, ferrulicacid and its derivatives, butylhydroxytoluene, butylhydroxyani sole,hydroxymethoxyphenyl decanone, nordihydroguaiacic acid,nordihydroguaiaretic acid, allantoin, tropolone,trihydroxybutyrophenone, uric acid and its derivatives, urea, mannoseand its derivatives, hydroxy acetophenone (ortho/para), zinc and itsderivatives, beta-aspartyl arginine, selenium and its derivatives, VitisVinifera (Grape) seed extract, oat extract, Cichorium intubybus(chicory) leaf extract, Leon-topodium Alpinum extract, green teaextract, Curcumin, Zingiber Officinalis (Root) Extract, Silymarin,stilbenes and their derivatives, derivatives of said antioxidants, andmixtures of two or more of said antioxidants.
 16. A cosmetic orpharmaceutical composition or homecare product according to claim 2,wherein the at least one active substance for a cosmetic orpharmaceutical composition or homecare product and/or additive isselected from the group consisting of agents against ageing of the skin,anti-microbial agents, antioxidants, chelating agents, emulsifiers,surfactants, preservatives, green and synthetic polymers, skin-coolingagents, rheology additives, oils, fragrances or perfume oils, polyols,and mixtures of two or more of the aforementioned substances.
 17. Acosmetic or pharmaceutical composition or homecare product according toclaim 2, comprising the at least one linear alkanediol or the mixturecomprising at least one first linear alkanediol and one or more secondlinear alkanediol in an amount of 0.001 to 15.0% by weight based on thetotal weight of the composition or homecare product.
 18. A cosmetic orpharmaceutical composition or homecare product according to claim 1,comprising the 2,3-heptanediol or the 2,3-heptanediol of the mixturecomprising 1,2-heptanediol and 2,3-heptanediol in an amount of 0.001 to15.0% by weight, based on the total weight of the composition orhomecare product.
 19. A cosmetic or pharmaceutical composition orhomecare product according to claim 2, comprising the at least oneantioxidant in an amount of 0.0001 to 10.0% by weight, based on thetotal weight of the composition.
 20. A cosmetic or pharmaceuticalcomposition or homecare product according to claim 2, wherein thecomposition or homecare product is a dispersion comprising an oilcomponent in an amount of ≥1% by weight, and wherein the composition orhomecare product is in the form of an emulsion, a liquid, a lotion, assuspension, a milk, an ointment, a paste, a gel, a cream basedformulation, an oil based formulation or a liposome-based formulation;or the composition or homecare product is a water free oil formulation;or the composition or homecare product is a liquid surfactantformulation; or the composition or homecare product is a solidsurfactant formulation; or the composition or homecare product is anaqueous or aqueous/alcoholic or aqueous/glycolic based solution,comprising the alcohol or glycol in an amount of 0.1% to ≤50% by weight,based on the total weight of the solution.
 21. A method of enhancing aneffect of an antioxidant in a cosmetic or pharmaceutical composition orhomecare product, comprising formulating the composition or homecareproduct as a composition or homecare product according to claim 2,wherein the effect is scavenging reactive oxygen species (ROS);inhibiting interleukin 8 (IL-8) secretion, inhibiting matrixmetalloproteinases expression, the antioxidative effect, theantioxidative effect upon application, or a combination thereof. 22-23.(canceled)
 24. A method of preventing and/or treating a dermatologicalor keratological diseases in a patient in need thereof, comprisingadministering a therapeutically effective amount of a pharmaceuticalcomposition of claim
 2. 25. (canceled)
 26. The method of claim 24,wherein the dermatological or keratological disease is selected from thegroup consisting of atopic dermatitis (neurodermitis), psoriasis,acneiform exanthema, sebostasis, xerosis, eczema, hyper seborrhea andhypo seborrhea, dermatitis, rosacea, wheals, erythema, pruritus,inflammation, irritation, fibrosis, lichen planus, pityriasis rosea,pityriasis versicolor, autoimmune bullous diseases, urticaria,angioedema, allergic skin reactions, wound healing, tissue regeneration,and inflammatory diseases